| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group4.MEP.mega_Pheno.cls #Group1_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.24113016 |
| Normalized Enrichment Score (NES) | -1.0656891 |
| Nominal p-value | 0.32304525 |
| FDR q-value | 0.5657958 |
| FWER p-Value | 0.968 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Hes6 | 351 | 0.654 | -0.0000 | No |
| 2 | Dhps | 524 | 0.597 | 0.0077 | No |
| 3 | Ap4b1 | 528 | 0.596 | 0.0243 | No |
| 4 | Cfb | 672 | 0.560 | 0.0325 | No |
| 5 | Ddc | 689 | 0.556 | 0.0472 | No |
| 6 | Alas1 | 765 | 0.538 | 0.0584 | No |
| 7 | Fbln1 | 789 | 0.532 | 0.0721 | No |
| 8 | Hgfac | 1073 | 0.488 | 0.0710 | No |
| 9 | Slc35b1 | 1183 | 0.472 | 0.0785 | No |
| 10 | Npc1 | 1205 | 0.468 | 0.0905 | No |
| 11 | Cda | 1432 | 0.437 | 0.0910 | No |
| 12 | Gart | 1937 | 0.384 | 0.0754 | No |
| 13 | Cdo1 | 2245 | 0.357 | 0.0694 | No |
| 14 | Atp2a2 | 2834 | 0.313 | 0.0475 | No |
| 15 | Cndp2 | 3019 | 0.302 | 0.0463 | No |
| 16 | Marchf6 | 3117 | 0.295 | 0.0495 | No |
| 17 | Tgfb2 | 3301 | 0.281 | 0.0479 | No |
| 18 | Ssr3 | 3597 | 0.264 | 0.0399 | No |
| 19 | Pts | 3698 | 0.257 | 0.0419 | No |
| 20 | Hmox1 | 3717 | 0.256 | 0.0481 | No |
| 21 | Dhrs1 | 3912 | 0.244 | 0.0448 | No |
| 22 | Enpep | 3949 | 0.241 | 0.0497 | No |
| 23 | Hnf4a | 4097 | 0.234 | 0.0485 | No |
| 24 | Pgd | 4279 | 0.227 | 0.0455 | No |
| 25 | Pdlim5 | 4521 | 0.215 | 0.0389 | No |
| 26 | Cyp2j6 | 4592 | 0.210 | 0.0411 | No |
| 27 | Id2 | 4656 | 0.206 | 0.0436 | No |
| 28 | Pdk4 | 4721 | 0.203 | 0.0459 | No |
| 29 | Pmm1 | 4876 | 0.196 | 0.0434 | No |
| 30 | Kynu | 4978 | 0.190 | 0.0434 | No |
| 31 | Gclc | 5320 | 0.175 | 0.0305 | No |
| 32 | F10 | 5387 | 0.172 | 0.0319 | No |
| 33 | Ugdh | 5597 | 0.161 | 0.0255 | No |
| 34 | Acox1 | 5790 | 0.150 | 0.0197 | No |
| 35 | Aldh9a1 | 5850 | 0.147 | 0.0207 | No |
| 36 | Smox | 5892 | 0.145 | 0.0226 | No |
| 37 | Acp2 | 6381 | 0.123 | 0.0006 | No |
| 38 | Il1r1 | 6459 | 0.120 | -0.0001 | No |
| 39 | Abcc3 | 6678 | 0.116 | -0.0082 | No |
| 40 | Tmem97 | 6738 | 0.113 | -0.0081 | No |
| 41 | Ninj1 | 6885 | 0.106 | -0.0128 | No |
| 42 | Pycr1 | 7109 | 0.095 | -0.0217 | No |
| 43 | Acp1 | 7266 | 0.088 | -0.0274 | No |
| 44 | Epha2 | 7580 | 0.073 | -0.0417 | No |
| 45 | Ccl25 | 7631 | 0.071 | -0.0423 | No |
| 46 | Papss2 | 7834 | 0.062 | -0.0511 | No |
| 47 | Aco2 | 7862 | 0.060 | -0.0509 | No |
| 48 | Mthfd1 | 7895 | 0.058 | -0.0509 | No |
| 49 | Tkfc | 7930 | 0.057 | -0.0511 | No |
| 50 | Ets2 | 8072 | 0.051 | -0.0570 | No |
| 51 | Csad | 8216 | 0.045 | -0.0632 | No |
| 52 | Pemt | 8344 | 0.039 | -0.0687 | No |
| 53 | Gcnt2 | 8603 | 0.029 | -0.0814 | No |
| 54 | Gnmt | 8624 | 0.028 | -0.0816 | No |
| 55 | Lcat | 8648 | 0.027 | -0.0821 | No |
| 56 | Cd36 | 8771 | 0.023 | -0.0878 | No |
| 57 | Spint2 | 8785 | 0.022 | -0.0879 | No |
| 58 | Bcat1 | 9079 | 0.010 | -0.1029 | No |
| 59 | Mccc2 | 9232 | 0.003 | -0.1108 | No |
| 60 | Angptl3 | 9443 | -0.002 | -0.1217 | No |
| 61 | Sar1b | 9463 | -0.003 | -0.1226 | No |
| 62 | Gsr | 9520 | -0.004 | -0.1254 | No |
| 63 | Aldh2 | 9925 | -0.022 | -0.1459 | No |
| 64 | Hsd11b1 | 9954 | -0.024 | -0.1467 | No |
| 65 | Man1a | 9986 | -0.026 | -0.1475 | No |
| 66 | Slc1a5 | 10042 | -0.029 | -0.1496 | No |
| 67 | Slc35d1 | 10109 | -0.032 | -0.1521 | No |
| 68 | Arg2 | 10275 | -0.040 | -0.1596 | No |
| 69 | Plg | 10331 | -0.042 | -0.1613 | No |
| 70 | Maoa | 10391 | -0.044 | -0.1632 | No |
| 71 | Abcc2 | 10399 | -0.044 | -0.1623 | No |
| 72 | Elovl5 | 10538 | -0.050 | -0.1681 | No |
| 73 | Entpd5 | 10564 | -0.051 | -0.1680 | No |
| 74 | Crot | 10764 | -0.061 | -0.1767 | No |
| 75 | Pros1 | 10810 | -0.063 | -0.1773 | No |
| 76 | Idh1 | 10956 | -0.069 | -0.1829 | No |
| 77 | Bphl | 11002 | -0.071 | -0.1833 | No |
| 78 | Ttpa | 11252 | -0.082 | -0.1939 | No |
| 79 | Ech1 | 11360 | -0.087 | -0.1971 | No |
| 80 | Cyfip2 | 11422 | -0.090 | -0.1978 | No |
| 81 | Pgrmc1 | 11423 | -0.090 | -0.1952 | No |
| 82 | Hacl1 | 11430 | -0.090 | -0.1930 | No |
| 83 | Esr1 | 11588 | -0.097 | -0.1985 | No |
| 84 | Lpin2 | 11626 | -0.099 | -0.1976 | No |
| 85 | Crp | 11736 | -0.104 | -0.2004 | No |
| 86 | Sertad1 | 11755 | -0.105 | -0.1984 | No |
| 87 | Atoh8 | 11764 | -0.106 | -0.1958 | No |
| 88 | Arpp19 | 11970 | -0.114 | -0.2033 | No |
| 89 | Comt | 11977 | -0.115 | -0.2004 | No |
| 90 | Ppard | 12158 | -0.123 | -0.2064 | No |
| 91 | Pcx | 12213 | -0.125 | -0.2057 | No |
| 92 | Gabarapl1 | 12664 | -0.143 | -0.2252 | No |
| 93 | Lonp1 | 12760 | -0.147 | -0.2260 | No |
| 94 | Gss | 12791 | -0.149 | -0.2234 | No |
| 95 | Abcd2 | 12976 | -0.157 | -0.2286 | No |
| 96 | Ephx1 | 12990 | -0.157 | -0.2249 | No |
| 97 | Gad1 | 13077 | -0.161 | -0.2249 | No |
| 98 | Pink1 | 13389 | -0.173 | -0.2363 | Yes |
| 99 | Aqp9 | 13439 | -0.176 | -0.2339 | Yes |
| 100 | Blvrb | 13491 | -0.178 | -0.2316 | Yes |
| 101 | Tmbim6 | 13632 | -0.184 | -0.2337 | Yes |
| 102 | Adh5 | 13706 | -0.188 | -0.2323 | Yes |
| 103 | Psmb10 | 13822 | -0.193 | -0.2329 | Yes |
| 104 | Tpst1 | 13872 | -0.195 | -0.2300 | Yes |
| 105 | Upp1 | 13873 | -0.195 | -0.2245 | Yes |
| 106 | Xdh | 14049 | -0.204 | -0.2279 | Yes |
| 107 | Por | 14061 | -0.205 | -0.2228 | Yes |
| 108 | Gstt2 | 14148 | -0.207 | -0.2214 | Yes |
| 109 | Mpp2 | 14180 | -0.209 | -0.2172 | Yes |
| 110 | Cyb5a | 14263 | -0.212 | -0.2156 | Yes |
| 111 | Irf8 | 14343 | -0.216 | -0.2136 | Yes |
| 112 | Fah | 14398 | -0.220 | -0.2103 | Yes |
| 113 | Dcxr | 14425 | -0.221 | -0.2055 | Yes |
| 114 | Etfdh | 14877 | -0.246 | -0.2221 | Yes |
| 115 | Nqo1 | 14954 | -0.248 | -0.2191 | Yes |
| 116 | Gch1 | 14969 | -0.249 | -0.2129 | Yes |
| 117 | Apoe | 15184 | -0.262 | -0.2167 | Yes |
| 118 | Dhrs7 | 15216 | -0.264 | -0.2110 | Yes |
| 119 | Casp6 | 15401 | -0.274 | -0.2129 | Yes |
| 120 | Igfbp4 | 15498 | -0.278 | -0.2101 | Yes |
| 121 | Retsat | 15504 | -0.279 | -0.2026 | Yes |
| 122 | Nfs1 | 15675 | -0.289 | -0.2033 | Yes |
| 123 | Acox3 | 16017 | -0.312 | -0.2124 | Yes |
| 124 | Car2 | 16199 | -0.323 | -0.2128 | Yes |
| 125 | Slc12a4 | 16385 | -0.336 | -0.2131 | Yes |
| 126 | Ddt | 16465 | -0.341 | -0.2077 | Yes |
| 127 | Ddah2 | 16548 | -0.347 | -0.2022 | Yes |
| 128 | Tnfrsf1a | 16569 | -0.348 | -0.1935 | Yes |
| 129 | Igf1 | 16593 | -0.350 | -0.1849 | Yes |
| 130 | Slc6a6 | 16616 | -0.352 | -0.1762 | Yes |
| 131 | Ptges | 16711 | -0.359 | -0.1711 | Yes |
| 132 | Rap1gap | 16757 | -0.362 | -0.1633 | Yes |
| 133 | Cyp26a1 | 16967 | -0.379 | -0.1636 | Yes |
| 134 | Asl | 17128 | -0.394 | -0.1609 | Yes |
| 135 | Nmt1 | 17192 | -0.398 | -0.1530 | Yes |
| 136 | Fas | 17219 | -0.401 | -0.1432 | Yes |
| 137 | Slc46a3 | 17295 | -0.408 | -0.1356 | Yes |
| 138 | Arg1 | 17483 | -0.425 | -0.1335 | Yes |
| 139 | Ptges3-ps | 17501 | -0.425 | -0.1225 | Yes |
| 140 | Shmt2 | 17723 | -0.444 | -0.1216 | Yes |
| 141 | Ndrg2 | 17777 | -0.451 | -0.1117 | Yes |
| 142 | Cyp27a1 | 17914 | -0.470 | -0.1057 | Yes |
| 143 | Fbp1 | 18150 | -0.505 | -0.1038 | Yes |
| 144 | Gsto1 | 18157 | -0.506 | -0.0899 | Yes |
| 145 | Gstm4 | 18239 | -0.520 | -0.0796 | Yes |
| 146 | Jup | 18388 | -0.546 | -0.0720 | Yes |
| 147 | Abhd6 | 18565 | -0.579 | -0.0650 | Yes |
| 148 | Tyr | 18712 | -0.616 | -0.0554 | Yes |
| 149 | Ptgr1 | 18797 | -0.642 | -0.0418 | Yes |
| 150 | Cat | 19042 | -0.748 | -0.0336 | Yes |
| 151 | Tmem176b | 19068 | -0.766 | -0.0135 | Yes |
| 152 | Cbr1 | 19222 | -0.925 | 0.0044 | Yes |

