| Dataset | Mast.Mast_Pheno.cls #Group2_versus_Group4.Mast_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | Mast_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.22887991 |
| Normalized Enrichment Score (NES) | -0.8336095 |
| Nominal p-value | 0.6510204 |
| FDR q-value | 0.945685 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Xpo1 | 15 | 1.108 | 0.0222 | No |
| 2 | Ssrp1 | 64 | 0.876 | 0.0368 | No |
| 3 | Dclre1b | 94 | 0.818 | 0.0517 | No |
| 4 | Nup153 | 149 | 0.751 | 0.0631 | No |
| 5 | Srsf1 | 240 | 0.681 | 0.0702 | No |
| 6 | Pms2 | 704 | 0.512 | 0.0432 | No |
| 7 | Cdk1 | 794 | 0.488 | 0.0462 | No |
| 8 | Ak2 | 804 | 0.485 | 0.0558 | No |
| 9 | Dnmt1 | 995 | 0.448 | 0.0497 | No |
| 10 | Lbr | 1109 | 0.432 | 0.0496 | No |
| 11 | H2az1 | 1439 | 0.381 | 0.0308 | No |
| 12 | Shmt1 | 1452 | 0.380 | 0.0379 | No |
| 13 | Ddx39a | 1457 | 0.379 | 0.0455 | No |
| 14 | Pds5b | 1465 | 0.379 | 0.0530 | No |
| 15 | Espl1 | 1638 | 0.353 | 0.0464 | No |
| 16 | Rad50 | 1710 | 0.344 | 0.0478 | No |
| 17 | Wee1 | 1778 | 0.333 | 0.0494 | No |
| 18 | Ube2s | 2047 | 0.302 | 0.0339 | No |
| 19 | Nup107 | 2052 | 0.302 | 0.0400 | No |
| 20 | Prim2 | 2157 | 0.286 | 0.0375 | No |
| 21 | Pole4 | 2272 | 0.275 | 0.0340 | No |
| 22 | Spc25 | 2297 | 0.271 | 0.0378 | No |
| 23 | Asf1b | 2323 | 0.270 | 0.0414 | No |
| 24 | Atad2 | 2519 | 0.250 | 0.0308 | No |
| 25 | Rnaseh2a | 2830 | 0.224 | 0.0102 | No |
| 26 | Syncrip | 2833 | 0.223 | 0.0148 | No |
| 27 | Ung | 2857 | 0.221 | 0.0175 | No |
| 28 | Hus1 | 2906 | 0.216 | 0.0182 | No |
| 29 | Ccp110 | 3026 | 0.203 | 0.0128 | No |
| 30 | Cdkn2c | 3090 | 0.198 | 0.0118 | No |
| 31 | Mcm3 | 3134 | 0.194 | 0.0124 | No |
| 32 | Stmn1 | 3146 | 0.193 | 0.0156 | No |
| 33 | Ipo7 | 3192 | 0.188 | 0.0159 | No |
| 34 | Mcm5 | 3197 | 0.187 | 0.0195 | No |
| 35 | Dck | 3293 | 0.178 | 0.0155 | No |
| 36 | Gins3 | 3338 | 0.175 | 0.0156 | No |
| 37 | Msh2 | 3344 | 0.175 | 0.0189 | No |
| 38 | Ppm1d | 3444 | 0.168 | 0.0143 | No |
| 39 | Tmpo | 3513 | 0.160 | 0.0122 | No |
| 40 | Tfrc | 3728 | 0.141 | -0.0023 | No |
| 41 | Gins1 | 3803 | 0.136 | -0.0055 | No |
| 42 | Rpa2 | 3813 | 0.135 | -0.0034 | No |
| 43 | Rpa1 | 3824 | 0.134 | -0.0013 | No |
| 44 | Pa2g4 | 3849 | 0.133 | -0.0005 | No |
| 45 | Chek2 | 3868 | 0.131 | 0.0008 | No |
| 46 | Lsm8 | 4022 | 0.121 | -0.0091 | No |
| 47 | Tk1 | 4087 | 0.117 | -0.0119 | No |
| 48 | Tbrg4 | 4151 | 0.111 | -0.0147 | No |
| 49 | Rbbp7 | 4193 | 0.108 | -0.0158 | No |
| 50 | Cdkn1b | 4198 | 0.107 | -0.0138 | No |
| 51 | Gins4 | 4253 | 0.102 | -0.0161 | No |
| 52 | Rpa3 | 4279 | 0.099 | -0.0160 | No |
| 53 | Mre11a | 4305 | 0.098 | -0.0160 | No |
| 54 | Nop56 | 4427 | 0.089 | -0.0240 | No |
| 55 | Tipin | 4533 | 0.080 | -0.0309 | No |
| 56 | Cdkn1a | 4579 | 0.077 | -0.0329 | No |
| 57 | Brca2 | 4677 | 0.069 | -0.0394 | No |
| 58 | Srsf2 | 4686 | 0.068 | -0.0386 | No |
| 59 | Ubr7 | 4758 | 0.064 | -0.0430 | No |
| 60 | Ezh2 | 4785 | 0.063 | -0.0438 | No |
| 61 | Ncapd2 | 4807 | 0.061 | -0.0443 | No |
| 62 | Nasp | 4845 | 0.058 | -0.0461 | No |
| 63 | Cdc25a | 4867 | 0.057 | -0.0466 | No |
| 64 | Brms1l | 4892 | 0.056 | -0.0473 | No |
| 65 | Nup205 | 4904 | 0.055 | -0.0471 | No |
| 66 | Hmmr | 4926 | 0.053 | -0.0477 | No |
| 67 | Dctpp1 | 4936 | 0.053 | -0.0473 | No |
| 68 | Cenpm | 5104 | 0.042 | -0.0600 | No |
| 69 | Rad21 | 5232 | 0.034 | -0.0697 | No |
| 70 | Ctcf | 5247 | 0.033 | -0.0701 | No |
| 71 | Mcm6 | 5451 | 0.020 | -0.0862 | No |
| 72 | Phf5a | 5463 | 0.019 | -0.0867 | No |
| 73 | Xrcc6 | 5476 | 0.018 | -0.0873 | No |
| 74 | Kif18b | 5560 | 0.013 | -0.0938 | No |
| 75 | Ilf3 | 5593 | 0.010 | -0.0962 | No |
| 76 | Exosc8 | 5654 | 0.006 | -0.1010 | No |
| 77 | Tubb5 | 5676 | 0.004 | -0.1026 | No |
| 78 | Tra2b | 5793 | -0.003 | -0.1120 | No |
| 79 | Orc6 | 5825 | -0.006 | -0.1144 | No |
| 80 | Nbn | 5859 | -0.009 | -0.1169 | No |
| 81 | Racgap1 | 5882 | -0.010 | -0.1185 | No |
| 82 | Chek1 | 5922 | -0.013 | -0.1214 | No |
| 83 | Cdc25b | 6217 | -0.034 | -0.1447 | No |
| 84 | Hells | 6246 | -0.036 | -0.1462 | No |
| 85 | Trp53 | 6295 | -0.039 | -0.1493 | No |
| 86 | Mms22l | 6560 | -0.058 | -0.1697 | No |
| 87 | Mybl2 | 6674 | -0.065 | -0.1775 | No |
| 88 | Smc1a | 6690 | -0.067 | -0.1773 | No |
| 89 | Donson | 6708 | -0.068 | -0.1773 | No |
| 90 | Luc7l3 | 6739 | -0.069 | -0.1783 | No |
| 91 | Stag1 | 6741 | -0.070 | -0.1769 | No |
| 92 | Anp32e | 6816 | -0.075 | -0.1813 | No |
| 93 | Eed | 6916 | -0.081 | -0.1877 | No |
| 94 | Rrm2 | 6990 | -0.086 | -0.1918 | No |
| 95 | Hnrnpd | 7014 | -0.088 | -0.1919 | No |
| 96 | Ran | 7070 | -0.092 | -0.1944 | No |
| 97 | Nap1l1 | 7095 | -0.094 | -0.1944 | No |
| 98 | Rad51ap1 | 7111 | -0.095 | -0.1936 | No |
| 99 | Rfc3 | 7288 | -0.106 | -0.2057 | No |
| 100 | Timeless | 7430 | -0.115 | -0.2148 | No |
| 101 | Mcm4 | 7443 | -0.116 | -0.2133 | No |
| 102 | Depdc1a | 7449 | -0.116 | -0.2113 | No |
| 103 | Spc24 | 7496 | -0.119 | -0.2125 | No |
| 104 | Eif2s1 | 7562 | -0.123 | -0.2152 | No |
| 105 | Lig1 | 7592 | -0.125 | -0.2150 | No |
| 106 | Dscc1 | 7613 | -0.128 | -0.2139 | No |
| 107 | Usp1 | 7625 | -0.128 | -0.2121 | No |
| 108 | Prps1 | 7637 | -0.129 | -0.2102 | No |
| 109 | Pola2 | 7641 | -0.129 | -0.2078 | No |
| 110 | Spag5 | 7666 | -0.131 | -0.2070 | No |
| 111 | Pold1 | 7697 | -0.132 | -0.2066 | No |
| 112 | Kif4 | 7709 | -0.133 | -0.2047 | No |
| 113 | Diaph3 | 7765 | -0.137 | -0.2063 | No |
| 114 | Pcna | 7850 | -0.142 | -0.2102 | No |
| 115 | Trip13 | 7901 | -0.146 | -0.2112 | No |
| 116 | Smc3 | 7902 | -0.146 | -0.2081 | No |
| 117 | Rfc1 | 7928 | -0.147 | -0.2070 | No |
| 118 | Dut | 8098 | -0.160 | -0.2174 | No |
| 119 | Pttg1 | 8154 | -0.164 | -0.2185 | No |
| 120 | Prdx4 | 8174 | -0.165 | -0.2165 | No |
| 121 | Birc5 | 8221 | -0.169 | -0.2167 | No |
| 122 | Cdk4 | 8296 | -0.174 | -0.2191 | No |
| 123 | Pan2 | 8301 | -0.175 | -0.2157 | No |
| 124 | Aurka | 8325 | -0.177 | -0.2138 | No |
| 125 | Pole | 8347 | -0.179 | -0.2118 | No |
| 126 | Kif2c | 8412 | -0.183 | -0.2131 | No |
| 127 | Ube2t | 8476 | -0.187 | -0.2143 | No |
| 128 | Rad1 | 8597 | -0.195 | -0.2200 | No |
| 129 | Smc4 | 8616 | -0.197 | -0.2173 | No |
| 130 | Cenpe | 8624 | -0.198 | -0.2137 | No |
| 131 | Wdr90 | 8636 | -0.198 | -0.2104 | No |
| 132 | Zw10 | 8665 | -0.201 | -0.2085 | No |
| 133 | Plk1 | 8916 | -0.221 | -0.2242 | Yes |
| 134 | Cdkn3 | 8922 | -0.221 | -0.2200 | Yes |
| 135 | Tacc3 | 8946 | -0.223 | -0.2171 | Yes |
| 136 | Jpt1 | 8952 | -0.224 | -0.2128 | Yes |
| 137 | Mcm7 | 9016 | -0.228 | -0.2131 | Yes |
| 138 | Cdca3 | 9108 | -0.236 | -0.2156 | Yes |
| 139 | Plk4 | 9143 | -0.240 | -0.2133 | Yes |
| 140 | Cdca8 | 9327 | -0.253 | -0.2229 | Yes |
| 141 | Gspt1 | 9366 | -0.256 | -0.2206 | Yes |
| 142 | Pop7 | 9374 | -0.256 | -0.2157 | Yes |
| 143 | Pold3 | 9396 | -0.258 | -0.2120 | Yes |
| 144 | Pnn | 9413 | -0.259 | -0.2078 | Yes |
| 145 | Bub1b | 9470 | -0.263 | -0.2069 | Yes |
| 146 | Nudt21 | 9484 | -0.264 | -0.2023 | Yes |
| 147 | Ing3 | 9510 | -0.267 | -0.1987 | Yes |
| 148 | Cdc20 | 9646 | -0.276 | -0.2039 | Yes |
| 149 | Melk | 9713 | -0.281 | -0.2034 | Yes |
| 150 | Slbp | 9731 | -0.283 | -0.1988 | Yes |
| 151 | Mlh1 | 9855 | -0.293 | -0.2027 | Yes |
| 152 | Cks1b | 9899 | -0.297 | -0.1999 | Yes |
| 153 | Lyar | 9915 | -0.299 | -0.1948 | Yes |
| 154 | Pold2 | 9977 | -0.304 | -0.1933 | Yes |
| 155 | Brca1 | 10047 | -0.311 | -0.1924 | Yes |
| 156 | Mki67 | 10107 | -0.317 | -0.1905 | Yes |
| 157 | Ppp1r8 | 10160 | -0.321 | -0.1880 | Yes |
| 158 | Rfc2 | 10212 | -0.327 | -0.1853 | Yes |
| 159 | Tubg1 | 10392 | -0.347 | -0.1925 | Yes |
| 160 | Prkdc | 10434 | -0.351 | -0.1885 | Yes |
| 161 | Asf1a | 10455 | -0.352 | -0.1827 | Yes |
| 162 | Cit | 10470 | -0.354 | -0.1764 | Yes |
| 163 | Kif22 | 10492 | -0.356 | -0.1706 | Yes |
| 164 | Hmgb3 | 10515 | -0.359 | -0.1648 | Yes |
| 165 | Cks2 | 10599 | -0.369 | -0.1638 | Yes |
| 166 | Orc2 | 10684 | -0.379 | -0.1626 | Yes |
| 167 | Suv39h1 | 10732 | -0.385 | -0.1583 | Yes |
| 168 | Mad2l1 | 10752 | -0.387 | -0.1517 | Yes |
| 169 | Hmgb2 | 10759 | -0.388 | -0.1440 | Yes |
| 170 | Smc6 | 10785 | -0.390 | -0.1378 | Yes |
| 171 | Nme1 | 10823 | -0.394 | -0.1325 | Yes |
| 172 | H2ax | 10888 | -0.402 | -0.1292 | Yes |
| 173 | Dlgap5 | 10931 | -0.408 | -0.1240 | Yes |
| 174 | Top2a | 11022 | -0.421 | -0.1225 | Yes |
| 175 | Nolc1 | 11316 | -0.462 | -0.1367 | Yes |
| 176 | Psip1 | 11364 | -0.469 | -0.1306 | Yes |
| 177 | Myc | 11429 | -0.480 | -0.1257 | Yes |
| 178 | Aurkb | 11522 | -0.495 | -0.1227 | Yes |
| 179 | Lmnb1 | 11593 | -0.509 | -0.1177 | Yes |
| 180 | Snrpb | 11612 | -0.513 | -0.1083 | Yes |
| 181 | Mthfd2 | 11656 | -0.522 | -0.1008 | Yes |
| 182 | Mcm2 | 11703 | -0.530 | -0.0934 | Yes |
| 183 | Ranbp1 | 11713 | -0.532 | -0.0829 | Yes |
| 184 | Cse1l | 11969 | -0.610 | -0.0908 | Yes |
| 185 | Paics | 12140 | -0.674 | -0.0905 | Yes |
| 186 | Ccnb2 | 12186 | -0.701 | -0.0793 | Yes |
| 187 | Bard1 | 12223 | -0.721 | -0.0670 | Yes |
| 188 | Dek | 12231 | -0.724 | -0.0523 | Yes |
| 189 | Psmc3ip | 12298 | -0.786 | -0.0411 | Yes |
| 190 | Cnot9 | 12307 | -0.798 | -0.0249 | Yes |
| 191 | E2f8 | 12319 | -0.827 | -0.0083 | Yes |
| 192 | Cbx5 | 12349 | -0.862 | 0.0075 | Yes |

