| Dataset | Mast.Mast_Pheno.cls #Group1_versus_Group4.Mast_Pheno.cls #Group1_versus_Group4_repos |
| Phenotype | Mast_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | -0.27352768 |
| Normalized Enrichment Score (NES) | -0.98709536 |
| Nominal p-value | 0.47113594 |
| FDR q-value | 0.60133725 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Xpo1 | 24 | 0.973 | 0.0165 | No |
| 2 | Ssrp1 | 87 | 0.823 | 0.0271 | No |
| 3 | Nup153 | 101 | 0.800 | 0.0413 | No |
| 4 | Mcm5 | 140 | 0.752 | 0.0525 | No |
| 5 | Rad50 | 310 | 0.640 | 0.0509 | No |
| 6 | Espl1 | 397 | 0.601 | 0.0553 | No |
| 7 | Cdkn1b | 522 | 0.558 | 0.0558 | No |
| 8 | Nasp | 625 | 0.526 | 0.0575 | No |
| 9 | Tbrg4 | 719 | 0.502 | 0.0594 | No |
| 10 | Mybl2 | 796 | 0.481 | 0.0624 | No |
| 11 | Dck | 874 | 0.464 | 0.0649 | No |
| 12 | Rad21 | 1147 | 0.411 | 0.0505 | No |
| 13 | Nup107 | 1205 | 0.399 | 0.0534 | No |
| 14 | Wee1 | 1238 | 0.394 | 0.0583 | No |
| 15 | Rnaseh2a | 1324 | 0.381 | 0.0586 | No |
| 16 | Ung | 1360 | 0.377 | 0.0630 | No |
| 17 | Cks1b | 1404 | 0.370 | 0.0665 | No |
| 18 | H2az1 | 1413 | 0.369 | 0.0728 | No |
| 19 | Ddx39a | 1433 | 0.367 | 0.0783 | No |
| 20 | Pms2 | 1569 | 0.347 | 0.0739 | No |
| 21 | Dnmt1 | 1661 | 0.337 | 0.0728 | No |
| 22 | Asf1b | 1667 | 0.335 | 0.0788 | No |
| 23 | Zw10 | 1734 | 0.328 | 0.0797 | No |
| 24 | Dclre1b | 1790 | 0.322 | 0.0813 | No |
| 25 | Srsf1 | 1853 | 0.315 | 0.0822 | No |
| 26 | Timeless | 1957 | 0.303 | 0.0796 | No |
| 27 | Gins1 | 2183 | 0.279 | 0.0665 | No |
| 28 | Pan2 | 2210 | 0.277 | 0.0697 | No |
| 29 | Pole4 | 2260 | 0.273 | 0.0708 | No |
| 30 | Mthfd2 | 2339 | 0.265 | 0.0695 | No |
| 31 | Ipo7 | 2378 | 0.261 | 0.0714 | No |
| 32 | Ctcf | 2456 | 0.252 | 0.0699 | No |
| 33 | Tk1 | 2578 | 0.242 | 0.0646 | No |
| 34 | Lbr | 2596 | 0.240 | 0.0678 | No |
| 35 | Rpa2 | 2626 | 0.238 | 0.0700 | No |
| 36 | Cdc25a | 2853 | 0.215 | 0.0556 | No |
| 37 | Brms1l | 3088 | 0.193 | 0.0402 | No |
| 38 | Syncrip | 3215 | 0.183 | 0.0334 | No |
| 39 | Mms22l | 3235 | 0.182 | 0.0353 | No |
| 40 | Pcna | 3281 | 0.179 | 0.0350 | No |
| 41 | Chek2 | 3340 | 0.175 | 0.0336 | No |
| 42 | Pds5b | 3414 | 0.168 | 0.0308 | No |
| 43 | Trp53 | 3510 | 0.161 | 0.0261 | No |
| 44 | Rrm2 | 3517 | 0.160 | 0.0287 | No |
| 45 | Rpa1 | 3645 | 0.150 | 0.0212 | No |
| 46 | Ak2 | 3684 | 0.147 | 0.0209 | No |
| 47 | Mcm6 | 3710 | 0.145 | 0.0216 | No |
| 48 | Exosc8 | 3713 | 0.145 | 0.0242 | No |
| 49 | Lig1 | 3718 | 0.144 | 0.0266 | No |
| 50 | Ccp110 | 3738 | 0.142 | 0.0277 | No |
| 51 | Eif2s1 | 3797 | 0.138 | 0.0256 | No |
| 52 | Chek1 | 4143 | 0.114 | -0.0004 | No |
| 53 | Usp1 | 4789 | 0.065 | -0.0518 | No |
| 54 | Mre11a | 4860 | 0.060 | -0.0564 | No |
| 55 | Wdr90 | 4943 | 0.054 | -0.0620 | No |
| 56 | Nbn | 5008 | 0.050 | -0.0663 | No |
| 57 | Hells | 5029 | 0.049 | -0.0670 | No |
| 58 | Xrcc6 | 5039 | 0.049 | -0.0668 | No |
| 59 | Tmpo | 5045 | 0.048 | -0.0663 | No |
| 60 | Stmn1 | 5199 | 0.037 | -0.0781 | No |
| 61 | Mcm2 | 5205 | 0.037 | -0.0778 | No |
| 62 | Cdk1 | 5342 | 0.027 | -0.0884 | No |
| 63 | Rad1 | 5492 | 0.017 | -0.1002 | No |
| 64 | Cenpm | 5517 | 0.016 | -0.1019 | No |
| 65 | Tfrc | 5544 | 0.014 | -0.1037 | No |
| 66 | Hnrnpd | 5561 | 0.013 | -0.1048 | No |
| 67 | Ubr7 | 5596 | 0.011 | -0.1074 | No |
| 68 | Cnot9 | 5661 | 0.006 | -0.1125 | No |
| 69 | Hmmr | 5874 | -0.006 | -0.1297 | No |
| 70 | Spc24 | 5877 | -0.006 | -0.1297 | No |
| 71 | Atad2 | 5920 | -0.010 | -0.1330 | No |
| 72 | Nolc1 | 5943 | -0.011 | -0.1345 | No |
| 73 | Ncapd2 | 5967 | -0.013 | -0.1362 | No |
| 74 | Cdkn2c | 5974 | -0.013 | -0.1364 | No |
| 75 | Tacc3 | 6066 | -0.018 | -0.1435 | No |
| 76 | Brca1 | 6192 | -0.026 | -0.1532 | No |
| 77 | Melk | 6204 | -0.026 | -0.1536 | No |
| 78 | Smc3 | 6284 | -0.032 | -0.1594 | No |
| 79 | Cdkn1a | 6512 | -0.047 | -0.1771 | No |
| 80 | Pa2g4 | 6601 | -0.052 | -0.1833 | No |
| 81 | Ran | 6620 | -0.054 | -0.1837 | No |
| 82 | Msh2 | 6652 | -0.055 | -0.1852 | No |
| 83 | Ppm1d | 6680 | -0.056 | -0.1863 | No |
| 84 | Racgap1 | 6725 | -0.059 | -0.1888 | No |
| 85 | Dscc1 | 6900 | -0.071 | -0.2017 | No |
| 86 | Luc7l3 | 6941 | -0.073 | -0.2035 | No |
| 87 | Cdc25b | 6953 | -0.074 | -0.2030 | No |
| 88 | Brca2 | 6956 | -0.074 | -0.2018 | No |
| 89 | Rbbp7 | 7016 | -0.078 | -0.2051 | No |
| 90 | Phf5a | 7103 | -0.083 | -0.2105 | No |
| 91 | Prkdc | 7131 | -0.085 | -0.2111 | No |
| 92 | Hus1 | 7189 | -0.089 | -0.2141 | No |
| 93 | Mcm4 | 7236 | -0.093 | -0.2161 | No |
| 94 | Gspt1 | 7308 | -0.097 | -0.2200 | No |
| 95 | Donson | 7371 | -0.102 | -0.2231 | No |
| 96 | Orc2 | 7491 | -0.110 | -0.2307 | No |
| 97 | Bub1b | 7527 | -0.113 | -0.2315 | No |
| 98 | Nop56 | 7579 | -0.116 | -0.2334 | No |
| 99 | Rfc3 | 7662 | -0.121 | -0.2378 | No |
| 100 | Tubb5 | 7665 | -0.122 | -0.2357 | No |
| 101 | Smc1a | 7698 | -0.124 | -0.2359 | No |
| 102 | Mlh1 | 7726 | -0.126 | -0.2357 | No |
| 103 | Pola2 | 7744 | -0.127 | -0.2347 | No |
| 104 | Mcm7 | 7780 | -0.130 | -0.2351 | No |
| 105 | Pold2 | 7848 | -0.134 | -0.2380 | No |
| 106 | Suv39h1 | 7864 | -0.136 | -0.2366 | No |
| 107 | Tra2b | 7868 | -0.136 | -0.2343 | No |
| 108 | Cdkn3 | 8066 | -0.149 | -0.2476 | No |
| 109 | Kif22 | 8106 | -0.152 | -0.2478 | No |
| 110 | Ezh2 | 8147 | -0.154 | -0.2482 | No |
| 111 | Cit | 8176 | -0.157 | -0.2475 | No |
| 112 | Kif18b | 8216 | -0.160 | -0.2476 | No |
| 113 | Cse1l | 8242 | -0.161 | -0.2466 | No |
| 114 | Prdx4 | 8301 | -0.165 | -0.2482 | No |
| 115 | Prim2 | 8328 | -0.167 | -0.2471 | No |
| 116 | Gins4 | 8357 | -0.169 | -0.2462 | No |
| 117 | Psip1 | 8531 | -0.181 | -0.2569 | No |
| 118 | Paics | 8596 | -0.186 | -0.2586 | No |
| 119 | Aurka | 8707 | -0.194 | -0.2639 | No |
| 120 | Spag5 | 8732 | -0.196 | -0.2621 | No |
| 121 | Hmgb2 | 8831 | -0.205 | -0.2662 | No |
| 122 | Lmnb1 | 8849 | -0.206 | -0.2637 | No |
| 123 | Lsm8 | 8852 | -0.206 | -0.2599 | No |
| 124 | Slbp | 8952 | -0.214 | -0.2639 | No |
| 125 | Ing3 | 9068 | -0.221 | -0.2691 | No |
| 126 | Bard1 | 9102 | -0.223 | -0.2676 | No |
| 127 | Shmt1 | 9176 | -0.229 | -0.2692 | Yes |
| 128 | Kif4 | 9199 | -0.231 | -0.2666 | Yes |
| 129 | Pole | 9261 | -0.235 | -0.2671 | Yes |
| 130 | Ilf3 | 9280 | -0.237 | -0.2641 | Yes |
| 131 | Nap1l1 | 9353 | -0.243 | -0.2653 | Yes |
| 132 | Anp32e | 9379 | -0.246 | -0.2627 | Yes |
| 133 | Nme1 | 9391 | -0.247 | -0.2589 | Yes |
| 134 | Smc6 | 9427 | -0.250 | -0.2570 | Yes |
| 135 | Pnn | 9467 | -0.254 | -0.2553 | Yes |
| 136 | Kif2c | 9500 | -0.257 | -0.2531 | Yes |
| 137 | Hmgb3 | 9540 | -0.260 | -0.2513 | Yes |
| 138 | Depdc1a | 9568 | -0.262 | -0.2485 | Yes |
| 139 | Spc25 | 9757 | -0.278 | -0.2586 | Yes |
| 140 | Pop7 | 9788 | -0.281 | -0.2557 | Yes |
| 141 | Aurkb | 9821 | -0.284 | -0.2529 | Yes |
| 142 | Nudt21 | 9825 | -0.284 | -0.2477 | Yes |
| 143 | Gins3 | 9861 | -0.288 | -0.2451 | Yes |
| 144 | Pttg1 | 9879 | -0.289 | -0.2410 | Yes |
| 145 | Mad2l1 | 9900 | -0.291 | -0.2371 | Yes |
| 146 | Top2a | 9959 | -0.297 | -0.2362 | Yes |
| 147 | Rad51ap1 | 9968 | -0.298 | -0.2312 | Yes |
| 148 | Mki67 | 9983 | -0.299 | -0.2266 | Yes |
| 149 | Prps1 | 9994 | -0.300 | -0.2218 | Yes |
| 150 | Tipin | 10086 | -0.307 | -0.2234 | Yes |
| 151 | Cdc20 | 10104 | -0.308 | -0.2189 | Yes |
| 152 | Smc4 | 10220 | -0.319 | -0.2222 | Yes |
| 153 | Eed | 10261 | -0.322 | -0.2194 | Yes |
| 154 | Mcm3 | 10277 | -0.324 | -0.2144 | Yes |
| 155 | Orc6 | 10303 | -0.326 | -0.2103 | Yes |
| 156 | Ppp1r8 | 10430 | -0.340 | -0.2141 | Yes |
| 157 | Dctpp1 | 10530 | -0.352 | -0.2155 | Yes |
| 158 | Birc5 | 10608 | -0.362 | -0.2149 | Yes |
| 159 | Nup205 | 10639 | -0.365 | -0.2104 | Yes |
| 160 | Cdk4 | 10797 | -0.384 | -0.2159 | Yes |
| 161 | Lyar | 10843 | -0.390 | -0.2122 | Yes |
| 162 | Pold3 | 10895 | -0.396 | -0.2088 | Yes |
| 163 | Psmc3ip | 10940 | -0.401 | -0.2048 | Yes |
| 164 | Rfc1 | 11044 | -0.416 | -0.2053 | Yes |
| 165 | Cdca8 | 11070 | -0.419 | -0.1993 | Yes |
| 166 | Ube2s | 11093 | -0.422 | -0.1931 | Yes |
| 167 | Pold1 | 11131 | -0.426 | -0.1880 | Yes |
| 168 | Dut | 11165 | -0.431 | -0.1825 | Yes |
| 169 | Ube2t | 11225 | -0.442 | -0.1789 | Yes |
| 170 | Cenpe | 11408 | -0.476 | -0.1847 | Yes |
| 171 | Dlgap5 | 11426 | -0.480 | -0.1770 | Yes |
| 172 | Trip13 | 11463 | -0.485 | -0.1707 | Yes |
| 173 | Stag1 | 11525 | -0.498 | -0.1662 | Yes |
| 174 | Cks2 | 11539 | -0.501 | -0.1578 | Yes |
| 175 | Diaph3 | 11557 | -0.504 | -0.1496 | Yes |
| 176 | Cdca3 | 11564 | -0.506 | -0.1404 | Yes |
| 177 | H2ax | 11715 | -0.536 | -0.1425 | Yes |
| 178 | Jpt1 | 11869 | -0.583 | -0.1439 | Yes |
| 179 | Dek | 11875 | -0.584 | -0.1332 | Yes |
| 180 | Tubg1 | 11911 | -0.597 | -0.1247 | Yes |
| 181 | Snrpb | 12034 | -0.634 | -0.1226 | Yes |
| 182 | Rpa3 | 12036 | -0.634 | -0.1106 | Yes |
| 183 | Ccnb2 | 12101 | -0.665 | -0.1032 | Yes |
| 184 | Rfc2 | 12110 | -0.668 | -0.0911 | Yes |
| 185 | Plk1 | 12159 | -0.698 | -0.0817 | Yes |
| 186 | Srsf2 | 12180 | -0.711 | -0.0699 | Yes |
| 187 | Myc | 12227 | -0.743 | -0.0595 | Yes |
| 188 | Cbx5 | 12236 | -0.747 | -0.0459 | Yes |
| 189 | Plk4 | 12249 | -0.766 | -0.0323 | Yes |
| 190 | E2f8 | 12269 | -0.785 | -0.0190 | Yes |
| 191 | Ranbp1 | 12302 | -0.818 | -0.0060 | Yes |
| 192 | Asf1a | 12363 | -0.909 | 0.0064 | Yes |

