| Dataset | Mast.Mast_Pheno.cls #Group1_versus_Group2.Mast_Pheno.cls #Group1_versus_Group2_repos |
| Phenotype | Mast_Pheno.cls#Group1_versus_Group2_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.17703599 |
| Normalized Enrichment Score (NES) | 0.83303666 |
| Nominal p-value | 0.8412017 |
| FDR q-value | 0.9439763 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Phgdh | 24 | 1.032 | 0.0198 | Yes |
| 2 | Mthfd2 | 26 | 1.015 | 0.0412 | Yes |
| 3 | Fads2 | 53 | 0.914 | 0.0584 | Yes |
| 4 | Vldlr | 111 | 0.790 | 0.0705 | Yes |
| 5 | Ddit3 | 307 | 0.632 | 0.0679 | Yes |
| 6 | Itgb2 | 413 | 0.593 | 0.0719 | Yes |
| 7 | Mcm2 | 422 | 0.589 | 0.0837 | Yes |
| 8 | Tomm40 | 514 | 0.557 | 0.0880 | Yes |
| 9 | Xbp1 | 599 | 0.535 | 0.0925 | Yes |
| 10 | Acaca | 609 | 0.529 | 0.1030 | Yes |
| 11 | Qdpr | 747 | 0.493 | 0.1022 | Yes |
| 12 | Gbe1 | 767 | 0.489 | 0.1110 | Yes |
| 13 | Gsr | 812 | 0.480 | 0.1175 | Yes |
| 14 | Bub1 | 1015 | 0.442 | 0.1104 | Yes |
| 15 | Gga2 | 1017 | 0.440 | 0.1196 | Yes |
| 16 | Cops5 | 1034 | 0.438 | 0.1276 | Yes |
| 17 | Uso1 | 1135 | 0.421 | 0.1283 | Yes |
| 18 | Plod2 | 1144 | 0.419 | 0.1365 | Yes |
| 19 | Psmc6 | 1221 | 0.405 | 0.1389 | Yes |
| 20 | Gtf2h1 | 1240 | 0.403 | 0.1459 | Yes |
| 21 | Ebp | 1331 | 0.390 | 0.1468 | Yes |
| 22 | Actr2 | 1619 | 0.354 | 0.1309 | Yes |
| 23 | Rrp9 | 1662 | 0.347 | 0.1348 | Yes |
| 24 | Psph | 1664 | 0.347 | 0.1421 | Yes |
| 25 | Cd9 | 1677 | 0.346 | 0.1484 | Yes |
| 26 | Gclc | 1859 | 0.324 | 0.1405 | Yes |
| 27 | Psme3 | 1874 | 0.321 | 0.1461 | Yes |
| 28 | Ldha | 1944 | 0.314 | 0.1471 | Yes |
| 29 | Ccng1 | 2000 | 0.308 | 0.1492 | Yes |
| 30 | Atp6v1d | 2018 | 0.307 | 0.1543 | Yes |
| 31 | Pfkl | 2024 | 0.306 | 0.1604 | Yes |
| 32 | Ssr1 | 2048 | 0.305 | 0.1649 | Yes |
| 33 | Cfp | 2061 | 0.303 | 0.1703 | Yes |
| 34 | Stard4 | 2220 | 0.288 | 0.1635 | Yes |
| 35 | Tuba4a | 2251 | 0.284 | 0.1671 | Yes |
| 36 | Srd5a1 | 2274 | 0.282 | 0.1713 | Yes |
| 37 | Rrm2 | 2298 | 0.280 | 0.1753 | Yes |
| 38 | Tm7sf2 | 2394 | 0.271 | 0.1733 | Yes |
| 39 | Pdk1 | 2419 | 0.269 | 0.1770 | Yes |
| 40 | Canx | 2562 | 0.256 | 0.1709 | No |
| 41 | Arpc5l | 2715 | 0.244 | 0.1636 | No |
| 42 | Psmd14 | 2766 | 0.240 | 0.1646 | No |
| 43 | Ube2d3 | 2885 | 0.229 | 0.1599 | No |
| 44 | Cxcr4 | 2902 | 0.227 | 0.1634 | No |
| 45 | Stip1 | 2906 | 0.227 | 0.1679 | No |
| 46 | Wars1 | 2967 | 0.222 | 0.1677 | No |
| 47 | Sord | 3185 | 0.207 | 0.1544 | No |
| 48 | Fkbp2 | 3200 | 0.206 | 0.1576 | No |
| 49 | Lta4h | 3214 | 0.205 | 0.1609 | No |
| 50 | Slc7a5 | 3229 | 0.203 | 0.1640 | No |
| 51 | Acly | 3356 | 0.193 | 0.1578 | No |
| 52 | Add3 | 3407 | 0.190 | 0.1578 | No |
| 53 | Hspa5 | 3523 | 0.181 | 0.1522 | No |
| 54 | Idh1 | 3640 | 0.172 | 0.1464 | No |
| 55 | Dhfr | 3671 | 0.170 | 0.1475 | No |
| 56 | Gpi1 | 3688 | 0.169 | 0.1498 | No |
| 57 | Slc1a5 | 3810 | 0.161 | 0.1434 | No |
| 58 | Edem1 | 3811 | 0.161 | 0.1468 | No |
| 59 | Asns | 3869 | 0.157 | 0.1454 | No |
| 60 | Bhlhe40 | 3935 | 0.151 | 0.1433 | No |
| 61 | Cdc25a | 3995 | 0.148 | 0.1416 | No |
| 62 | Idi1 | 4075 | 0.143 | 0.1382 | No |
| 63 | Psmd13 | 4113 | 0.140 | 0.1382 | No |
| 64 | Cyb5b | 4141 | 0.138 | 0.1389 | No |
| 65 | Hsp90b1 | 4340 | 0.124 | 0.1253 | No |
| 66 | Eif2s2 | 4429 | 0.118 | 0.1207 | No |
| 67 | Hmgcr | 4615 | 0.107 | 0.1078 | No |
| 68 | Hmgcs1 | 4649 | 0.105 | 0.1074 | No |
| 69 | Aldoa | 4682 | 0.102 | 0.1069 | No |
| 70 | Hk2 | 4710 | 0.101 | 0.1068 | No |
| 71 | Skap2 | 4823 | 0.093 | 0.0997 | No |
| 72 | Tes | 4839 | 0.092 | 0.1004 | No |
| 73 | Tbk1 | 4892 | 0.089 | 0.0981 | No |
| 74 | Gmps | 5265 | 0.063 | 0.0691 | No |
| 75 | Ung | 5275 | 0.062 | 0.0696 | No |
| 76 | Btg2 | 5323 | 0.060 | 0.0671 | No |
| 77 | Psmg1 | 5401 | 0.055 | 0.0619 | No |
| 78 | Nampt | 5483 | 0.048 | 0.0563 | No |
| 79 | Rdh11 | 5500 | 0.047 | 0.0560 | No |
| 80 | Serp1 | 5871 | 0.022 | 0.0263 | No |
| 81 | Slc37a4 | 5918 | 0.020 | 0.0230 | No |
| 82 | Rit1 | 5979 | 0.016 | 0.0184 | No |
| 83 | M6pr | 5986 | 0.016 | 0.0183 | No |
| 84 | Rpa1 | 6157 | 0.003 | 0.0045 | No |
| 85 | Mcm4 | 6235 | -0.001 | -0.0018 | No |
| 86 | Aurka | 6240 | -0.001 | -0.0021 | No |
| 87 | Hspd1 | 6347 | -0.009 | -0.0105 | No |
| 88 | Mllt11 | 6504 | -0.018 | -0.0229 | No |
| 89 | Elovl6 | 6564 | -0.023 | -0.0272 | No |
| 90 | Psat1 | 6614 | -0.025 | -0.0306 | No |
| 91 | Ufm1 | 6676 | -0.028 | -0.0350 | No |
| 92 | Adipor2 | 6731 | -0.031 | -0.0388 | No |
| 93 | Psma3 | 6863 | -0.038 | -0.0486 | No |
| 94 | Mthfd2l | 6877 | -0.039 | -0.0489 | No |
| 95 | Sec11a | 6891 | -0.040 | -0.0491 | No |
| 96 | Ddx39a | 7058 | -0.052 | -0.0615 | No |
| 97 | Ctsc | 7248 | -0.065 | -0.0756 | No |
| 98 | Insig1 | 7304 | -0.069 | -0.0786 | No |
| 99 | Fads1 | 7353 | -0.072 | -0.0810 | No |
| 100 | Ifrd1 | 7446 | -0.079 | -0.0868 | No |
| 101 | Psmd12 | 7564 | -0.087 | -0.0945 | No |
| 102 | Nfyc | 7580 | -0.088 | -0.0939 | No |
| 103 | Atp2a2 | 7636 | -0.092 | -0.0964 | No |
| 104 | Slc2a3 | 7670 | -0.093 | -0.0971 | No |
| 105 | Sdf2l1 | 7732 | -0.098 | -0.1000 | No |
| 106 | Psma4 | 7766 | -0.099 | -0.1006 | No |
| 107 | Abcf2 | 7812 | -0.102 | -0.1021 | No |
| 108 | Psmb5 | 7925 | -0.111 | -0.1089 | No |
| 109 | Dhcr24 | 8066 | -0.120 | -0.1178 | No |
| 110 | Rab1a | 8172 | -0.128 | -0.1237 | No |
| 111 | Sqle | 8200 | -0.130 | -0.1231 | No |
| 112 | Cdkn1a | 8279 | -0.134 | -0.1267 | No |
| 113 | Slc2a1 | 8382 | -0.141 | -0.1320 | No |
| 114 | Tfrc | 8393 | -0.142 | -0.1298 | No |
| 115 | Fgl2 | 8404 | -0.143 | -0.1276 | No |
| 116 | Nfkbib | 8419 | -0.143 | -0.1257 | No |
| 117 | Sqstm1 | 8461 | -0.146 | -0.1260 | No |
| 118 | Sla | 8482 | -0.147 | -0.1245 | No |
| 119 | Txnrd1 | 8614 | -0.156 | -0.1319 | No |
| 120 | Tcea1 | 8735 | -0.164 | -0.1382 | No |
| 121 | Pgm1 | 8791 | -0.170 | -0.1391 | No |
| 122 | Uchl5 | 8836 | -0.174 | -0.1390 | No |
| 123 | Pik3r3 | 9031 | -0.189 | -0.1508 | No |
| 124 | Cacybp | 9089 | -0.193 | -0.1514 | No |
| 125 | Map2k3 | 9101 | -0.194 | -0.1482 | No |
| 126 | Acsl3 | 9148 | -0.197 | -0.1478 | No |
| 127 | Etf1 | 9171 | -0.199 | -0.1454 | No |
| 128 | G6pdx | 9279 | -0.206 | -0.1497 | No |
| 129 | Ddit4 | 9393 | -0.215 | -0.1544 | No |
| 130 | Shmt2 | 9411 | -0.216 | -0.1512 | No |
| 131 | Egln3 | 9421 | -0.217 | -0.1474 | No |
| 132 | Pno1 | 9425 | -0.217 | -0.1430 | No |
| 133 | Nufip1 | 9431 | -0.218 | -0.1389 | No |
| 134 | Got1 | 9561 | -0.229 | -0.1445 | No |
| 135 | Niban1 | 9564 | -0.229 | -0.1399 | No |
| 136 | Slc6a6 | 9632 | -0.234 | -0.1404 | No |
| 137 | Hspa4 | 9644 | -0.234 | -0.1363 | No |
| 138 | Ppa1 | 9651 | -0.235 | -0.1319 | No |
| 139 | Cyp51 | 9659 | -0.236 | -0.1275 | No |
| 140 | Ppp1r15a | 9673 | -0.237 | -0.1235 | No |
| 141 | P4ha1 | 9699 | -0.239 | -0.1205 | No |
| 142 | Tmem97 | 9726 | -0.241 | -0.1175 | No |
| 143 | Hspa9 | 9745 | -0.243 | -0.1139 | No |
| 144 | Tubg1 | 9783 | -0.246 | -0.1117 | No |
| 145 | Rpn1 | 9799 | -0.247 | -0.1077 | No |
| 146 | Elovl5 | 9911 | -0.255 | -0.1113 | No |
| 147 | Coro1a | 9973 | -0.261 | -0.1108 | No |
| 148 | Prdx1 | 9986 | -0.262 | -0.1062 | No |
| 149 | Pitpnb | 10088 | -0.270 | -0.1088 | No |
| 150 | Dapp1 | 10140 | -0.275 | -0.1071 | No |
| 151 | Gsk3b | 10149 | -0.276 | -0.1019 | No |
| 152 | Ppia | 10247 | -0.284 | -0.1039 | No |
| 153 | Ykt6 | 10381 | -0.297 | -0.1084 | No |
| 154 | Psmc4 | 10564 | -0.318 | -0.1166 | No |
| 155 | Ccnf | 10711 | -0.334 | -0.1214 | No |
| 156 | Fdxr | 10728 | -0.335 | -0.1156 | No |
| 157 | Eef1e1 | 10868 | -0.354 | -0.1195 | No |
| 158 | Calr | 10944 | -0.364 | -0.1179 | No |
| 159 | Dhcr7 | 10955 | -0.365 | -0.1110 | No |
| 160 | Pgk1 | 10999 | -0.373 | -0.1067 | No |
| 161 | Gla | 11000 | -0.373 | -0.0988 | No |
| 162 | Plk1 | 11142 | -0.394 | -0.1020 | No |
| 163 | Polr3g | 11202 | -0.404 | -0.0982 | No |
| 164 | Nup205 | 11300 | -0.417 | -0.0973 | No |
| 165 | Ldlr | 11377 | -0.431 | -0.0944 | No |
| 166 | Cct6a | 11442 | -0.441 | -0.0903 | No |
| 167 | Nmt1 | 11485 | -0.448 | -0.0843 | No |
| 168 | Tpi1 | 11495 | -0.449 | -0.0755 | No |
| 169 | Sc5d | 11675 | -0.483 | -0.0799 | No |
| 170 | Ero1a | 11810 | -0.512 | -0.0800 | No |
| 171 | Pdap1 | 11859 | -0.523 | -0.0729 | No |
| 172 | Pnp | 12075 | -0.587 | -0.0780 | No |
| 173 | Actr3 | 12204 | -0.650 | -0.0747 | No |
| 174 | Immt | 12334 | -0.761 | -0.0692 | No |
| 175 | Glrx | 12353 | -0.785 | -0.0540 | No |
| 176 | Hmbs | 12375 | -0.829 | -0.0382 | No |
| 177 | Psmc2 | 12398 | -0.885 | -0.0213 | No |
| 178 | Hspe1 | 12432 | -1.171 | 0.0007 | No |

