| Dataset | MPP.MPP_Pheno.cls#Group6_versus_Group8.MPP_Pheno.cls#Group6_versus_Group8_repos |
| Phenotype | MPP_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 4 |
| GeneSet | HALLMARK_G2M_CHECKPOINT |
| Enrichment Score (ES) | 0.23378131 |
| Normalized Enrichment Score (NES) | 0.8835307 |
| Nominal p-value | 0.54527164 |
| FDR q-value | 0.9608904 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cdc45 | 57 | 0.979 | 0.0253 | Yes |
| 2 | Pttg1 | 81 | 0.878 | 0.0494 | Yes |
| 3 | Ccnd1 | 234 | 0.740 | 0.0629 | Yes |
| 4 | Cdc7 | 237 | 0.736 | 0.0841 | Yes |
| 5 | Efna5 | 354 | 0.653 | 0.0969 | Yes |
| 6 | Odc1 | 355 | 0.653 | 0.1157 | Yes |
| 7 | Gins2 | 429 | 0.622 | 0.1299 | Yes |
| 8 | Pole | 459 | 0.611 | 0.1460 | Yes |
| 9 | Slc12a2 | 615 | 0.587 | 0.1549 | Yes |
| 10 | Prim2 | 818 | 0.545 | 0.1602 | Yes |
| 11 | Bard1 | 1342 | 0.448 | 0.1460 | Yes |
| 12 | Brca2 | 2003 | 0.401 | 0.1234 | Yes |
| 13 | Exo1 | 2017 | 0.399 | 0.1343 | Yes |
| 14 | Chaf1a | 2047 | 0.395 | 0.1442 | Yes |
| 15 | Fancc | 2109 | 0.388 | 0.1522 | Yes |
| 16 | Mcm3 | 2172 | 0.379 | 0.1599 | Yes |
| 17 | Dmd | 2270 | 0.369 | 0.1655 | Yes |
| 18 | Mybl2 | 2485 | 0.348 | 0.1645 | Yes |
| 19 | Ilf3 | 2502 | 0.347 | 0.1737 | Yes |
| 20 | Rad54l | 2880 | 0.314 | 0.1632 | Yes |
| 21 | Kpnb1 | 3037 | 0.302 | 0.1638 | Yes |
| 22 | Tra2b | 3097 | 0.300 | 0.1694 | Yes |
| 23 | Tacc3 | 3377 | 0.282 | 0.1631 | Yes |
| 24 | Dbf4 | 3510 | 0.277 | 0.1643 | Yes |
| 25 | Mki67 | 3624 | 0.270 | 0.1662 | Yes |
| 26 | Hnrnpu | 3669 | 0.266 | 0.1716 | Yes |
| 27 | Odf2 | 3783 | 0.263 | 0.1733 | Yes |
| 28 | Numa1 | 4203 | 0.250 | 0.1588 | Yes |
| 29 | Ezh2 | 4278 | 0.245 | 0.1621 | Yes |
| 30 | Tmpo | 4304 | 0.244 | 0.1678 | Yes |
| 31 | Mcm6 | 4407 | 0.237 | 0.1694 | Yes |
| 32 | Upf1 | 4597 | 0.231 | 0.1663 | Yes |
| 33 | Tent4a | 4622 | 0.229 | 0.1716 | Yes |
| 34 | Nup50 | 4680 | 0.225 | 0.1752 | Yes |
| 35 | Uck2 | 4690 | 0.225 | 0.1812 | Yes |
| 36 | Stmn1 | 4850 | 0.216 | 0.1792 | Yes |
| 37 | E2f3 | 4901 | 0.213 | 0.1827 | Yes |
| 38 | Smarcc1 | 5190 | 0.197 | 0.1735 | Yes |
| 39 | Notch2 | 5205 | 0.196 | 0.1784 | Yes |
| 40 | Katna1 | 5244 | 0.193 | 0.1820 | Yes |
| 41 | Nup98 | 5290 | 0.190 | 0.1852 | Yes |
| 42 | Lmnb1 | 5305 | 0.189 | 0.1899 | Yes |
| 43 | Aurka | 5309 | 0.189 | 0.1952 | Yes |
| 44 | Slc7a1 | 5366 | 0.186 | 0.1976 | Yes |
| 45 | Mcm5 | 5374 | 0.186 | 0.2026 | Yes |
| 46 | Espl1 | 5384 | 0.185 | 0.2075 | Yes |
| 47 | Tfdp1 | 5505 | 0.179 | 0.2065 | Yes |
| 48 | Hmgb3 | 5539 | 0.177 | 0.2099 | Yes |
| 49 | E2f1 | 5545 | 0.177 | 0.2147 | Yes |
| 50 | Cdc6 | 5606 | 0.174 | 0.2166 | Yes |
| 51 | Nsd2 | 5614 | 0.174 | 0.2213 | Yes |
| 52 | Pbk | 5663 | 0.172 | 0.2237 | Yes |
| 53 | Meis2 | 5705 | 0.170 | 0.2265 | Yes |
| 54 | Fbxo5 | 5865 | 0.162 | 0.2230 | Yes |
| 55 | Srsf2 | 5931 | 0.159 | 0.2242 | Yes |
| 56 | Meis1 | 6052 | 0.154 | 0.2224 | Yes |
| 57 | Cul5 | 6200 | 0.146 | 0.2190 | Yes |
| 58 | Polq | 6240 | 0.144 | 0.2212 | Yes |
| 59 | Smad3 | 6370 | 0.138 | 0.2185 | Yes |
| 60 | Smc1a | 6415 | 0.136 | 0.2201 | Yes |
| 61 | Kif11 | 6475 | 0.133 | 0.2209 | Yes |
| 62 | Orc6 | 6490 | 0.132 | 0.2239 | Yes |
| 63 | Kif15 | 6540 | 0.130 | 0.2252 | Yes |
| 64 | Plk1 | 6596 | 0.127 | 0.2260 | Yes |
| 65 | Stil | 6597 | 0.127 | 0.2296 | Yes |
| 66 | Abl1 | 6631 | 0.126 | 0.2316 | Yes |
| 67 | Mnat1 | 6711 | 0.121 | 0.2310 | Yes |
| 68 | Ddx39a | 6725 | 0.121 | 0.2338 | Yes |
| 69 | Kif22 | 6956 | 0.112 | 0.2251 | No |
| 70 | Kif23 | 6968 | 0.111 | 0.2277 | No |
| 71 | Racgap1 | 7256 | 0.098 | 0.2157 | No |
| 72 | Rbl1 | 7315 | 0.096 | 0.2155 | No |
| 73 | Rad23b | 7322 | 0.096 | 0.2179 | No |
| 74 | Pola2 | 7351 | 0.094 | 0.2192 | No |
| 75 | Lbr | 7353 | 0.094 | 0.2218 | No |
| 76 | Knl1 | 7378 | 0.093 | 0.2233 | No |
| 77 | Ncl | 7391 | 0.093 | 0.2253 | No |
| 78 | Bcl3 | 7506 | 0.088 | 0.2219 | No |
| 79 | Srsf10 | 7556 | 0.086 | 0.2219 | No |
| 80 | Orc5 | 7612 | 0.084 | 0.2215 | No |
| 81 | Ccna2 | 7641 | 0.083 | 0.2224 | No |
| 82 | Pds5b | 7661 | 0.082 | 0.2238 | No |
| 83 | Traip | 7693 | 0.081 | 0.2245 | No |
| 84 | Stag1 | 7724 | 0.080 | 0.2253 | No |
| 85 | Wrn | 7730 | 0.080 | 0.2273 | No |
| 86 | Xpo1 | 7878 | 0.073 | 0.2218 | No |
| 87 | Smc2 | 7889 | 0.073 | 0.2234 | No |
| 88 | Nasp | 7899 | 0.073 | 0.2250 | No |
| 89 | Slc7a5 | 7945 | 0.071 | 0.2248 | No |
| 90 | Cdkn2c | 8046 | 0.067 | 0.2215 | No |
| 91 | Cdc25a | 8090 | 0.065 | 0.2212 | No |
| 92 | Syncrip | 8115 | 0.064 | 0.2218 | No |
| 93 | Cenpf | 8128 | 0.064 | 0.2230 | No |
| 94 | E2f2 | 8295 | 0.057 | 0.2161 | No |
| 95 | Rasal2 | 8330 | 0.056 | 0.2159 | No |
| 96 | Chek1 | 8354 | 0.056 | 0.2163 | No |
| 97 | Cdkn3 | 8529 | 0.049 | 0.2088 | No |
| 98 | Atf5 | 8544 | 0.049 | 0.2094 | No |
| 99 | Top2a | 8677 | 0.044 | 0.2039 | No |
| 100 | Rps6ka5 | 8930 | 0.034 | 0.1918 | No |
| 101 | Map3k20 | 8961 | 0.033 | 0.1912 | No |
| 102 | Nek2 | 9129 | 0.027 | 0.1833 | No |
| 103 | Mtf2 | 9208 | 0.023 | 0.1800 | No |
| 104 | Birc5 | 9230 | 0.022 | 0.1795 | No |
| 105 | Pml | 9259 | 0.021 | 0.1787 | No |
| 106 | Cdc27 | 9412 | 0.016 | 0.1713 | No |
| 107 | G3bp1 | 9461 | 0.014 | 0.1692 | No |
| 108 | Cks1b | 9469 | 0.013 | 0.1692 | No |
| 109 | Hira | 9534 | 0.011 | 0.1662 | No |
| 110 | Ttk | 9566 | 0.010 | 0.1649 | No |
| 111 | Nolc1 | 9601 | 0.008 | 0.1633 | No |
| 112 | Hnrnpd | 9716 | 0.004 | 0.1576 | No |
| 113 | H2az2 | 9739 | 0.003 | 0.1565 | No |
| 114 | Lig3 | 10181 | -0.000 | 0.1337 | No |
| 115 | Kif5b | 10258 | -0.003 | 0.1299 | No |
| 116 | Atrx | 10309 | -0.005 | 0.1274 | No |
| 117 | Cdk4 | 10448 | -0.009 | 0.1205 | No |
| 118 | Mapk14 | 10592 | -0.013 | 0.1135 | No |
| 119 | Ythdc1 | 10715 | -0.016 | 0.1077 | No |
| 120 | Hif1a | 10764 | -0.018 | 0.1057 | No |
| 121 | Aurkb | 10837 | -0.021 | 0.1026 | No |
| 122 | Incenp | 11007 | -0.028 | 0.0947 | No |
| 123 | Ccnt1 | 11014 | -0.029 | 0.0952 | No |
| 124 | Troap | 11019 | -0.029 | 0.0958 | No |
| 125 | Foxn3 | 11022 | -0.029 | 0.0965 | No |
| 126 | Dr1 | 11056 | -0.030 | 0.0957 | No |
| 127 | Pura | 11121 | -0.033 | 0.0933 | No |
| 128 | Top1 | 11232 | -0.037 | 0.0887 | No |
| 129 | Casp8ap2 | 11271 | -0.038 | 0.0878 | No |
| 130 | Plk4 | 11289 | -0.039 | 0.0880 | No |
| 131 | Suv39h1 | 11407 | -0.044 | 0.0832 | No |
| 132 | Rpa2 | 11502 | -0.046 | 0.0797 | No |
| 133 | Cul1 | 11511 | -0.047 | 0.0806 | No |
| 134 | Kif4 | 11529 | -0.047 | 0.0811 | No |
| 135 | Rad21 | 11567 | -0.048 | 0.0806 | No |
| 136 | Slc38a1 | 11577 | -0.049 | 0.0815 | No |
| 137 | E2f4 | 11676 | -0.053 | 0.0780 | No |
| 138 | Dkc1 | 11720 | -0.055 | 0.0773 | No |
| 139 | Cul4a | 11891 | -0.061 | 0.0703 | No |
| 140 | Smc4 | 12006 | -0.066 | 0.0663 | No |
| 141 | Sfpq | 12036 | -0.068 | 0.0667 | No |
| 142 | H2bc12 | 12044 | -0.068 | 0.0683 | No |
| 143 | Tnpo2 | 12055 | -0.068 | 0.0698 | No |
| 144 | Tle3 | 12180 | -0.073 | 0.0655 | No |
| 145 | Ewsr1 | 12220 | -0.075 | 0.0656 | No |
| 146 | Mcm2 | 12347 | -0.078 | 0.0613 | No |
| 147 | Arid4a | 12495 | -0.083 | 0.0561 | No |
| 148 | Prpf4b | 12509 | -0.084 | 0.0579 | No |
| 149 | Hspa8 | 12544 | -0.085 | 0.0586 | No |
| 150 | Kif20b | 12653 | -0.090 | 0.0556 | No |
| 151 | Ctcf | 12662 | -0.090 | 0.0578 | No |
| 152 | Ube2s | 12670 | -0.090 | 0.0600 | No |
| 153 | Pafah1b1 | 12733 | -0.093 | 0.0595 | No |
| 154 | Srsf1 | 12818 | -0.097 | 0.0579 | No |
| 155 | Egf | 12925 | -0.102 | 0.0554 | No |
| 156 | Mad2l1 | 13089 | -0.107 | 0.0500 | No |
| 157 | Dtymk | 13104 | -0.108 | 0.0524 | No |
| 158 | Cenpa | 13408 | -0.120 | 0.0402 | No |
| 159 | Ccnf | 13463 | -0.122 | 0.0409 | No |
| 160 | Ccnb2 | 13496 | -0.124 | 0.0428 | No |
| 161 | Cul3 | 13597 | -0.128 | 0.0413 | No |
| 162 | Tpx2 | 13652 | -0.131 | 0.0423 | No |
| 163 | Sap30 | 13726 | -0.134 | 0.0424 | No |
| 164 | Bub1 | 13879 | -0.141 | 0.0386 | No |
| 165 | Ss18 | 14006 | -0.145 | 0.0363 | No |
| 166 | Cdk1 | 14093 | -0.150 | 0.0362 | No |
| 167 | Tgfb1 | 14198 | -0.155 | 0.0352 | No |
| 168 | Cks2 | 14532 | -0.171 | 0.0229 | No |
| 169 | Myc | 14566 | -0.173 | 0.0262 | No |
| 170 | Gspt1 | 14772 | -0.182 | 0.0208 | No |
| 171 | H2az1 | 14829 | -0.185 | 0.0233 | No |
| 172 | Prc1 | 14911 | -0.191 | 0.0246 | No |
| 173 | Ndc80 | 14978 | -0.195 | 0.0268 | No |
| 174 | Cenpe | 15250 | -0.209 | 0.0188 | No |
| 175 | Sqle | 15313 | -0.212 | 0.0217 | No |
| 176 | Cbx1 | 15442 | -0.219 | 0.0214 | No |
| 177 | Hmga1b | 15532 | -0.224 | 0.0232 | No |
| 178 | H2ax | 15821 | -0.240 | 0.0152 | No |
| 179 | Marcks | 15867 | -0.243 | 0.0199 | No |
| 180 | Bub3 | 16074 | -0.255 | 0.0166 | No |
| 181 | Cdc25b | 16174 | -0.262 | 0.0190 | No |
| 182 | Nusap1 | 16258 | -0.268 | 0.0225 | No |
| 183 | Hus1 | 16598 | -0.286 | 0.0132 | No |
| 184 | Snrpd1 | 16772 | -0.298 | 0.0128 | No |
| 185 | Hmmr | 16908 | -0.305 | 0.0146 | No |
| 186 | Kmt5a | 17169 | -0.321 | 0.0104 | No |
| 187 | Cdkn1b | 17224 | -0.324 | 0.0169 | No |
| 188 | Amd1 | 17353 | -0.331 | 0.0199 | No |
| 189 | Jpt1 | 17477 | -0.342 | 0.0233 | No |
| 190 | Kif2c | 18126 | -0.408 | 0.0016 | No |
| 191 | Cdc20 | 18530 | -0.467 | -0.0058 | No |
| 192 | Prmt5 | 18627 | -0.480 | 0.0031 | No |
| 193 | Chmp1a | 19096 | -0.592 | -0.0041 | No |
| 194 | Ube2c | 19464 | -0.887 | 0.0025 | No |

