| Dataset | MPP.MPP_Pheno.cls#Group6_versus_Group8.MPP_Pheno.cls#Group6_versus_Group8_repos |
| Phenotype | MPP_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 4 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.2709277 |
| Normalized Enrichment Score (NES) | 1.044234 |
| Nominal p-value | 0.402834 |
| FDR q-value | 0.80601746 |
| FWER p-Value | 0.991 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Pttg1 | 81 | 0.878 | 0.0171 | Yes |
| 2 | Slbp | 116 | 0.823 | 0.0354 | Yes |
| 3 | Tk1 | 248 | 0.728 | 0.0463 | Yes |
| 4 | Rrm2 | 397 | 0.635 | 0.0540 | Yes |
| 5 | Pole | 459 | 0.611 | 0.0657 | Yes |
| 6 | Wdr90 | 502 | 0.605 | 0.0782 | Yes |
| 7 | Prim2 | 818 | 0.545 | 0.0751 | Yes |
| 8 | Shmt1 | 1055 | 0.490 | 0.0748 | Yes |
| 9 | Dut | 1143 | 0.475 | 0.0819 | Yes |
| 10 | Ccp110 | 1147 | 0.474 | 0.0932 | Yes |
| 11 | Dclre1b | 1276 | 0.457 | 0.0977 | Yes |
| 12 | Bard1 | 1342 | 0.448 | 0.1052 | Yes |
| 13 | Mthfd2 | 1610 | 0.429 | 0.1018 | Yes |
| 14 | Brca2 | 2003 | 0.401 | 0.0913 | Yes |
| 15 | Rad51c | 2073 | 0.391 | 0.0972 | Yes |
| 16 | Tbrg4 | 2107 | 0.388 | 0.1049 | Yes |
| 17 | Dnmt1 | 2164 | 0.380 | 0.1112 | Yes |
| 18 | Mcm3 | 2172 | 0.379 | 0.1201 | Yes |
| 19 | Donson | 2234 | 0.373 | 0.1260 | Yes |
| 20 | Rpa1 | 2242 | 0.372 | 0.1346 | Yes |
| 21 | Mcm4 | 2376 | 0.359 | 0.1364 | Yes |
| 22 | Rfc1 | 2397 | 0.356 | 0.1441 | Yes |
| 23 | Mre11a | 2434 | 0.353 | 0.1508 | Yes |
| 24 | Mybl2 | 2485 | 0.348 | 0.1566 | Yes |
| 25 | Ilf3 | 2502 | 0.347 | 0.1642 | Yes |
| 26 | Cnot9 | 2663 | 0.331 | 0.1639 | Yes |
| 27 | Eif2s1 | 2668 | 0.330 | 0.1718 | Yes |
| 28 | Tfrc | 2692 | 0.328 | 0.1785 | Yes |
| 29 | Nbn | 2717 | 0.325 | 0.1852 | Yes |
| 30 | Cse1l | 2718 | 0.325 | 0.1931 | Yes |
| 31 | Nup205 | 2720 | 0.325 | 0.2009 | Yes |
| 32 | Cenpm | 2832 | 0.318 | 0.2029 | Yes |
| 33 | Tra2b | 3097 | 0.300 | 0.1965 | Yes |
| 34 | Pold2 | 3176 | 0.294 | 0.1996 | Yes |
| 35 | Cit | 3209 | 0.292 | 0.2050 | Yes |
| 36 | Atad2 | 3313 | 0.288 | 0.2067 | Yes |
| 37 | Msh2 | 3372 | 0.282 | 0.2105 | Yes |
| 38 | Tacc3 | 3377 | 0.282 | 0.2172 | Yes |
| 39 | Ipo7 | 3437 | 0.278 | 0.2209 | Yes |
| 40 | Rad51ap1 | 3573 | 0.273 | 0.2205 | Yes |
| 41 | Asf1b | 3597 | 0.271 | 0.2259 | Yes |
| 42 | Brms1l | 3611 | 0.270 | 0.2318 | Yes |
| 43 | Ak2 | 3614 | 0.270 | 0.2382 | Yes |
| 44 | Mki67 | 3624 | 0.270 | 0.2443 | Yes |
| 45 | Pold1 | 3630 | 0.269 | 0.2506 | Yes |
| 46 | Pnn | 3662 | 0.267 | 0.2555 | Yes |
| 47 | Rfc3 | 4124 | 0.251 | 0.2377 | Yes |
| 48 | Ezh2 | 4278 | 0.245 | 0.2357 | Yes |
| 49 | Tmpo | 4304 | 0.244 | 0.2403 | Yes |
| 50 | Mcm6 | 4407 | 0.237 | 0.2408 | Yes |
| 51 | Anp32e | 4602 | 0.231 | 0.2364 | Yes |
| 52 | Psmc3ip | 4730 | 0.222 | 0.2352 | Yes |
| 53 | Ube2t | 4820 | 0.217 | 0.2359 | Yes |
| 54 | Stmn1 | 4850 | 0.216 | 0.2396 | Yes |
| 55 | Ssrp1 | 4964 | 0.209 | 0.2388 | Yes |
| 56 | Rad50 | 4982 | 0.208 | 0.2430 | Yes |
| 57 | Diaph3 | 4989 | 0.208 | 0.2477 | Yes |
| 58 | Nop56 | 5079 | 0.202 | 0.2480 | Yes |
| 59 | Pan2 | 5199 | 0.196 | 0.2466 | Yes |
| 60 | Lmnb1 | 5305 | 0.189 | 0.2458 | Yes |
| 61 | Aurka | 5309 | 0.189 | 0.2502 | Yes |
| 62 | Mcm5 | 5374 | 0.186 | 0.2514 | Yes |
| 63 | Espl1 | 5384 | 0.185 | 0.2554 | Yes |
| 64 | Cbx5 | 5418 | 0.184 | 0.2582 | Yes |
| 65 | Spc25 | 5444 | 0.182 | 0.2613 | Yes |
| 66 | Trip13 | 5469 | 0.181 | 0.2645 | Yes |
| 67 | Hmgb3 | 5539 | 0.177 | 0.2652 | Yes |
| 68 | Prkdc | 5643 | 0.173 | 0.2641 | Yes |
| 69 | E2f8 | 5878 | 0.161 | 0.2559 | Yes |
| 70 | Tipin | 5898 | 0.161 | 0.2588 | Yes |
| 71 | Srsf2 | 5931 | 0.159 | 0.2610 | Yes |
| 72 | Ppm1d | 5958 | 0.158 | 0.2635 | Yes |
| 73 | Mms22l | 5981 | 0.157 | 0.2662 | Yes |
| 74 | Xrcc6 | 6009 | 0.156 | 0.2685 | Yes |
| 75 | Pcna | 6321 | 0.140 | 0.2558 | Yes |
| 76 | Paics | 6328 | 0.139 | 0.2589 | Yes |
| 77 | Prps1 | 6411 | 0.136 | 0.2580 | Yes |
| 78 | Smc1a | 6415 | 0.136 | 0.2611 | Yes |
| 79 | Orc6 | 6490 | 0.132 | 0.2605 | Yes |
| 80 | Prdx4 | 6554 | 0.130 | 0.2603 | Yes |
| 81 | Pole4 | 6574 | 0.128 | 0.2625 | Yes |
| 82 | Smc6 | 6588 | 0.128 | 0.2649 | Yes |
| 83 | Plk1 | 6596 | 0.127 | 0.2676 | Yes |
| 84 | Kif18b | 6612 | 0.126 | 0.2699 | Yes |
| 85 | Wee1 | 6707 | 0.121 | 0.2680 | Yes |
| 86 | Ddx39a | 6725 | 0.121 | 0.2701 | Yes |
| 87 | Pa2g4 | 6916 | 0.113 | 0.2630 | Yes |
| 88 | Kif22 | 6956 | 0.112 | 0.2637 | Yes |
| 89 | Phf5a | 6974 | 0.111 | 0.2655 | Yes |
| 90 | Dck | 6978 | 0.111 | 0.2680 | Yes |
| 91 | Brca1 | 6998 | 0.110 | 0.2697 | Yes |
| 92 | Melk | 7026 | 0.108 | 0.2709 | Yes |
| 93 | Racgap1 | 7256 | 0.098 | 0.2615 | No |
| 94 | Mlh1 | 7337 | 0.095 | 0.2596 | No |
| 95 | Pola2 | 7351 | 0.094 | 0.2612 | No |
| 96 | Lbr | 7353 | 0.094 | 0.2634 | No |
| 97 | Ranbp1 | 7604 | 0.085 | 0.2526 | No |
| 98 | Pds5b | 7661 | 0.082 | 0.2517 | No |
| 99 | Stag1 | 7724 | 0.080 | 0.2504 | No |
| 100 | Pms2 | 7784 | 0.077 | 0.2492 | No |
| 101 | Xpo1 | 7878 | 0.073 | 0.2462 | No |
| 102 | Nasp | 7899 | 0.073 | 0.2469 | No |
| 103 | Cdkn2c | 8046 | 0.067 | 0.2410 | No |
| 104 | Cdc25a | 8090 | 0.065 | 0.2403 | No |
| 105 | Nap1l1 | 8095 | 0.065 | 0.2417 | No |
| 106 | Syncrip | 8115 | 0.064 | 0.2423 | No |
| 107 | Chek1 | 8354 | 0.056 | 0.2313 | No |
| 108 | Lig1 | 8447 | 0.053 | 0.2278 | No |
| 109 | Cdkn3 | 8529 | 0.049 | 0.2248 | No |
| 110 | Rfc2 | 8576 | 0.048 | 0.2236 | No |
| 111 | Nup107 | 8579 | 0.047 | 0.2246 | No |
| 112 | Nup153 | 8599 | 0.047 | 0.2248 | No |
| 113 | Top2a | 8677 | 0.044 | 0.2219 | No |
| 114 | Tubg1 | 8699 | 0.043 | 0.2218 | No |
| 115 | Dscc1 | 8943 | 0.034 | 0.2100 | No |
| 116 | Birc5 | 9230 | 0.022 | 0.1958 | No |
| 117 | Cks1b | 9469 | 0.013 | 0.1838 | No |
| 118 | Nolc1 | 9601 | 0.008 | 0.1772 | No |
| 119 | Mcm7 | 9664 | 0.006 | 0.1741 | No |
| 120 | Hnrnpd | 9716 | 0.004 | 0.1716 | No |
| 121 | Pold3 | 10388 | -0.007 | 0.1370 | No |
| 122 | Cdk4 | 10448 | -0.009 | 0.1342 | No |
| 123 | Aurkb | 10837 | -0.021 | 0.1146 | No |
| 124 | Hells | 10876 | -0.023 | 0.1132 | No |
| 125 | Cdkn1a | 10951 | -0.026 | 0.1100 | No |
| 126 | Zw10 | 10980 | -0.027 | 0.1093 | No |
| 127 | Tcf19 | 11092 | -0.032 | 0.1043 | No |
| 128 | Plk4 | 11289 | -0.039 | 0.0951 | No |
| 129 | Suv39h1 | 11407 | -0.044 | 0.0901 | No |
| 130 | Rpa2 | 11502 | -0.046 | 0.0863 | No |
| 131 | Smc3 | 11514 | -0.047 | 0.0869 | No |
| 132 | Kif4 | 11529 | -0.047 | 0.0873 | No |
| 133 | Rad21 | 11567 | -0.048 | 0.0866 | No |
| 134 | Ccne1 | 11717 | -0.054 | 0.0802 | No |
| 135 | Ubr7 | 11740 | -0.055 | 0.0804 | No |
| 136 | Asf1a | 11787 | -0.057 | 0.0794 | No |
| 137 | Dctpp1 | 11893 | -0.061 | 0.0754 | No |
| 138 | Smc4 | 12006 | -0.066 | 0.0712 | No |
| 139 | Gins3 | 12030 | -0.067 | 0.0717 | No |
| 140 | Gins1 | 12103 | -0.070 | 0.0696 | No |
| 141 | Spag5 | 12171 | -0.073 | 0.0679 | No |
| 142 | Orc2 | 12252 | -0.076 | 0.0656 | No |
| 143 | Mcm2 | 12347 | -0.078 | 0.0627 | No |
| 144 | Rbbp7 | 12357 | -0.078 | 0.0641 | No |
| 145 | Ran | 12608 | -0.088 | 0.0533 | No |
| 146 | Ctcf | 12662 | -0.090 | 0.0527 | No |
| 147 | Ube2s | 12670 | -0.090 | 0.0546 | No |
| 148 | Srsf1 | 12818 | -0.097 | 0.0493 | No |
| 149 | Mad2l1 | 13089 | -0.107 | 0.0379 | No |
| 150 | Ppp1r8 | 13210 | -0.111 | 0.0344 | No |
| 151 | Bub1b | 13487 | -0.123 | 0.0231 | No |
| 152 | Ccnb2 | 13496 | -0.124 | 0.0257 | No |
| 153 | Usp1 | 13567 | -0.127 | 0.0252 | No |
| 154 | Psip1 | 13596 | -0.128 | 0.0268 | No |
| 155 | Gins4 | 13631 | -0.130 | 0.0282 | No |
| 156 | Exosc8 | 13656 | -0.131 | 0.0302 | No |
| 157 | Timeless | 13692 | -0.133 | 0.0316 | No |
| 158 | Lsm8 | 13966 | -0.144 | 0.0210 | No |
| 159 | Cdk1 | 14093 | -0.150 | 0.0181 | No |
| 160 | Chek2 | 14100 | -0.150 | 0.0214 | No |
| 161 | Lyar | 14146 | -0.153 | 0.0228 | No |
| 162 | Rad1 | 14206 | -0.155 | 0.0235 | No |
| 163 | Nudt21 | 14309 | -0.160 | 0.0221 | No |
| 164 | Eed | 14371 | -0.163 | 0.0229 | No |
| 165 | Dek | 14467 | -0.168 | 0.0221 | No |
| 166 | Cks2 | 14532 | -0.171 | 0.0229 | No |
| 167 | Myc | 14566 | -0.173 | 0.0254 | No |
| 168 | Gspt1 | 14772 | -0.182 | 0.0192 | No |
| 169 | Snrpb | 14804 | -0.184 | 0.0221 | No |
| 170 | H2az1 | 14829 | -0.185 | 0.0253 | No |
| 171 | Ung | 14887 | -0.189 | 0.0270 | No |
| 172 | Trp53 | 15084 | -0.201 | 0.0217 | No |
| 173 | Cenpe | 15250 | -0.209 | 0.0182 | No |
| 174 | Hmga1b | 15532 | -0.224 | 0.0091 | No |
| 175 | Nme1 | 15702 | -0.233 | 0.0060 | No |
| 176 | H2ax | 15821 | -0.240 | 0.0058 | No |
| 177 | Cdca8 | 15865 | -0.243 | 0.0094 | No |
| 178 | Rpa3 | 16096 | -0.257 | 0.0038 | No |
| 179 | Cdkn2a | 16133 | -0.260 | 0.0082 | No |
| 180 | Cdc25b | 16174 | -0.262 | 0.0125 | No |
| 181 | Luc7l3 | 16227 | -0.266 | 0.0162 | No |
| 182 | Rnaseh2a | 16530 | -0.281 | 0.0074 | No |
| 183 | Hus1 | 16598 | -0.286 | 0.0109 | No |
| 184 | Hmgb2 | 16710 | -0.293 | 0.0123 | No |
| 185 | Tubb5 | 16764 | -0.297 | 0.0167 | No |
| 186 | Spc24 | 16864 | -0.300 | 0.0189 | No |
| 187 | Hmmr | 16908 | -0.305 | 0.0241 | No |
| 188 | Ncapd2 | 16943 | -0.307 | 0.0298 | No |
| 189 | Dlgap5 | 17178 | -0.321 | 0.0255 | No |
| 190 | Cdkn1b | 17224 | -0.324 | 0.0310 | No |
| 191 | Depdc1a | 17418 | -0.337 | 0.0292 | No |
| 192 | Jpt1 | 17477 | -0.342 | 0.0345 | No |
| 193 | Ing3 | 18089 | -0.404 | 0.0127 | No |
| 194 | Kif2c | 18126 | -0.408 | 0.0207 | No |
| 195 | Cdca3 | 18264 | -0.426 | 0.0239 | No |
| 196 | Cdc20 | 18530 | -0.467 | 0.0216 | No |
| 197 | Mxd3 | 18826 | -0.515 | 0.0188 | No |
| 198 | Pop7 | 19282 | -0.687 | 0.0119 | No |

