| Dataset | MPP.MPP_Pheno.cls#Group3_versus_Group4.MPP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_KRAS_SIGNALING_UP |
| Enrichment Score (ES) | -0.2029008 |
| Normalized Enrichment Score (NES) | -0.85249466 |
| Nominal p-value | 0.7267327 |
| FDR q-value | 0.905401 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Dusp6 | 30 | 1.050 | 0.0304 | No |
| 2 | Hdac9 | 180 | 0.773 | 0.0462 | No |
| 3 | Lat2 | 229 | 0.731 | 0.0660 | No |
| 4 | Tnfaip3 | 347 | 0.666 | 0.0802 | No |
| 5 | Adgra2 | 386 | 0.647 | 0.0979 | No |
| 6 | Ptprr | 618 | 0.564 | 0.1031 | No |
| 7 | Fcer1g | 888 | 0.507 | 0.1046 | No |
| 8 | Spry2 | 901 | 0.505 | 0.1194 | No |
| 9 | Scg3 | 1074 | 0.472 | 0.1249 | No |
| 10 | Klf4 | 1143 | 0.462 | 0.1354 | No |
| 11 | Fuca1 | 1379 | 0.429 | 0.1363 | No |
| 12 | Plau | 1439 | 0.422 | 0.1461 | No |
| 13 | Cxcl10 | 1694 | 0.393 | 0.1449 | No |
| 14 | Car2 | 2187 | 0.349 | 0.1301 | No |
| 15 | Zfp639 | 2222 | 0.347 | 0.1389 | No |
| 16 | Reln | 2319 | 0.336 | 0.1442 | No |
| 17 | Cbr4 | 2562 | 0.320 | 0.1414 | No |
| 18 | H2bc3 | 2628 | 0.315 | 0.1476 | No |
| 19 | Csf2ra | 2988 | 0.287 | 0.1378 | No |
| 20 | Mtmr10 | 3371 | 0.264 | 0.1261 | No |
| 21 | G0s2 | 3486 | 0.258 | 0.1281 | No |
| 22 | Ppbp | 3489 | 0.258 | 0.1358 | No |
| 23 | Id2 | 3660 | 0.249 | 0.1346 | No |
| 24 | Galnt3 | 3781 | 0.241 | 0.1357 | No |
| 25 | Traf1 | 4271 | 0.217 | 0.1171 | No |
| 26 | Abcb1a | 4311 | 0.215 | 0.1216 | No |
| 27 | Nin | 4370 | 0.212 | 0.1250 | No |
| 28 | Plvap | 4452 | 0.207 | 0.1272 | No |
| 29 | Ets1 | 4512 | 0.204 | 0.1303 | No |
| 30 | Ammecr1 | 4518 | 0.203 | 0.1362 | No |
| 31 | Cd37 | 4971 | 0.179 | 0.1183 | No |
| 32 | Etv1 | 5535 | 0.153 | 0.0939 | No |
| 33 | Btbd3 | 5620 | 0.150 | 0.0941 | No |
| 34 | Itgbl1 | 5653 | 0.148 | 0.0970 | No |
| 35 | Kcnn4 | 5713 | 0.148 | 0.0985 | No |
| 36 | Irf8 | 5738 | 0.147 | 0.1017 | No |
| 37 | Tmem100 | 5757 | 0.146 | 0.1052 | No |
| 38 | Plaur | 5772 | 0.145 | 0.1089 | No |
| 39 | Cab39l | 5842 | 0.142 | 0.1096 | No |
| 40 | Ptcd2 | 5869 | 0.141 | 0.1126 | No |
| 41 | Map7 | 6186 | 0.126 | 0.1001 | No |
| 42 | Trib2 | 6238 | 0.124 | 0.1012 | No |
| 43 | Tmem176a | 6390 | 0.118 | 0.0970 | No |
| 44 | Satb1 | 6426 | 0.116 | 0.0987 | No |
| 45 | Ephb2 | 6696 | 0.106 | 0.0881 | No |
| 46 | Igf2 | 7187 | 0.087 | 0.0654 | No |
| 47 | Cbl | 7282 | 0.083 | 0.0631 | No |
| 48 | Cxcr4 | 7314 | 0.082 | 0.0640 | No |
| 49 | Etv4 | 7361 | 0.080 | 0.0640 | No |
| 50 | Lcp1 | 7404 | 0.079 | 0.0643 | No |
| 51 | Ccnd2 | 7414 | 0.079 | 0.0662 | No |
| 52 | Prelid3b | 7442 | 0.078 | 0.0672 | No |
| 53 | Gypc | 7707 | 0.069 | 0.0557 | No |
| 54 | Scn1b | 7852 | 0.064 | 0.0502 | No |
| 55 | Spp1 | 7921 | 0.061 | 0.0485 | No |
| 56 | Kif5c | 7928 | 0.061 | 0.0500 | No |
| 57 | Etv5 | 8719 | 0.032 | 0.0102 | No |
| 58 | Atg10 | 8738 | 0.031 | 0.0102 | No |
| 59 | Il10ra | 8763 | 0.030 | 0.0099 | No |
| 60 | Ikzf1 | 8951 | 0.024 | 0.0010 | No |
| 61 | Angptl4 | 9090 | 0.019 | -0.0056 | No |
| 62 | Fbxo4 | 9290 | 0.012 | -0.0155 | No |
| 63 | Rabgap1l | 9413 | 0.008 | -0.0215 | No |
| 64 | Epb41l3 | 9507 | 0.006 | -0.0262 | No |
| 65 | Lif | 9704 | 0.000 | -0.0363 | No |
| 66 | Nrp1 | 9808 | -0.002 | -0.0415 | No |
| 67 | Itgb2 | 9830 | -0.002 | -0.0426 | No |
| 68 | Wdr33 | 9885 | -0.004 | -0.0452 | No |
| 69 | Rbm4 | 10216 | -0.016 | -0.0618 | No |
| 70 | Adgrl4 | 10350 | -0.020 | -0.0680 | No |
| 71 | Il2rg | 10398 | -0.022 | -0.0698 | No |
| 72 | Mycn | 10529 | -0.026 | -0.0757 | No |
| 73 | Fgf9 | 10581 | -0.028 | -0.0775 | No |
| 74 | Dock2 | 10712 | -0.033 | -0.0832 | No |
| 75 | Mmp11 | 10839 | -0.038 | -0.0886 | No |
| 76 | Map3k1 | 10906 | -0.041 | -0.0907 | No |
| 77 | Tmem158 | 10959 | -0.043 | -0.0921 | No |
| 78 | Mafb | 11071 | -0.046 | -0.0964 | No |
| 79 | Emp1 | 11219 | -0.051 | -0.1025 | No |
| 80 | Ptbp2 | 11339 | -0.055 | -0.1069 | No |
| 81 | Birc3 | 11357 | -0.056 | -0.1061 | No |
| 82 | Yrdc | 11503 | -0.061 | -0.1117 | No |
| 83 | Tnfrsf1b | 11515 | -0.061 | -0.1104 | No |
| 84 | Jup | 11518 | -0.062 | -0.1087 | No |
| 85 | Zfp277 | 11855 | -0.071 | -0.1239 | No |
| 86 | Psmb8 | 11871 | -0.072 | -0.1224 | No |
| 87 | Crot | 11938 | -0.074 | -0.1236 | No |
| 88 | Ly96 | 11987 | -0.076 | -0.1238 | No |
| 89 | Glrx | 12391 | -0.090 | -0.1419 | No |
| 90 | Usp12 | 12426 | -0.091 | -0.1409 | No |
| 91 | Wnt7a | 12432 | -0.091 | -0.1384 | No |
| 92 | Gadd45g | 12496 | -0.093 | -0.1388 | No |
| 93 | Nr0b2 | 13083 | -0.115 | -0.1655 | No |
| 94 | Plek2 | 13091 | -0.115 | -0.1624 | No |
| 95 | Tspan13 | 13133 | -0.117 | -0.1610 | No |
| 96 | Pecam1 | 13151 | -0.117 | -0.1583 | No |
| 97 | Avl9 | 13278 | -0.122 | -0.1611 | No |
| 98 | Flt4 | 13359 | -0.125 | -0.1614 | No |
| 99 | Mmd | 13362 | -0.125 | -0.1577 | No |
| 100 | Adam17 | 13521 | -0.132 | -0.1619 | No |
| 101 | Laptm5 | 13606 | -0.135 | -0.1621 | No |
| 102 | Dnmbp | 13607 | -0.135 | -0.1580 | No |
| 103 | Akt2 | 13710 | -0.139 | -0.1590 | No |
| 104 | Tspan7 | 13804 | -0.142 | -0.1595 | No |
| 105 | Cfb | 13961 | -0.147 | -0.1631 | No |
| 106 | Eng | 14111 | -0.153 | -0.1661 | No |
| 107 | Evi5 | 14534 | -0.170 | -0.1827 | No |
| 108 | Ano1 | 14557 | -0.171 | -0.1787 | No |
| 109 | Sdccag8 | 14637 | -0.175 | -0.1774 | No |
| 110 | Map4k1 | 14742 | -0.179 | -0.1774 | No |
| 111 | Pdcd1lg2 | 14945 | -0.185 | -0.1821 | No |
| 112 | Cmklr1 | 14952 | -0.185 | -0.1768 | No |
| 113 | Scg5 | 15299 | -0.202 | -0.1885 | No |
| 114 | Ero1a | 15578 | -0.216 | -0.1963 | Yes |
| 115 | Il7r | 15695 | -0.222 | -0.1956 | Yes |
| 116 | Gprc5b | 15805 | -0.227 | -0.1943 | Yes |
| 117 | Ccser2 | 15861 | -0.230 | -0.1901 | Yes |
| 118 | Gng11 | 15911 | -0.233 | -0.1856 | Yes |
| 119 | Il1rl2 | 15984 | -0.238 | -0.1821 | Yes |
| 120 | Ctss | 16260 | -0.253 | -0.1886 | Yes |
| 121 | Tmem176b | 16338 | -0.257 | -0.1847 | Yes |
| 122 | Gucy1a1 | 16442 | -0.264 | -0.1820 | Yes |
| 123 | Gfpt2 | 16513 | -0.269 | -0.1774 | Yes |
| 124 | F13a1 | 16521 | -0.269 | -0.1696 | Yes |
| 125 | Itga2 | 16535 | -0.270 | -0.1621 | Yes |
| 126 | Gabra3 | 16543 | -0.271 | -0.1542 | Yes |
| 127 | Cdadc1 | 16604 | -0.274 | -0.1490 | Yes |
| 128 | Prdm1 | 16817 | -0.288 | -0.1512 | Yes |
| 129 | Arg1 | 16940 | -0.295 | -0.1485 | Yes |
| 130 | Cbx8 | 17363 | -0.324 | -0.1604 | Yes |
| 131 | Strn | 17492 | -0.334 | -0.1569 | Yes |
| 132 | Bpgm | 17546 | -0.341 | -0.1492 | Yes |
| 133 | Vwa5a | 17630 | -0.350 | -0.1429 | Yes |
| 134 | Tor1aip2 | 17962 | -0.382 | -0.1484 | Yes |
| 135 | Spon1 | 18146 | -0.398 | -0.1457 | Yes |
| 136 | Slpi | 18315 | -0.418 | -0.1417 | Yes |
| 137 | Ptgs2 | 18328 | -0.420 | -0.1295 | Yes |
| 138 | Hbegf | 18595 | -0.454 | -0.1295 | Yes |
| 139 | St6gal1 | 18600 | -0.455 | -0.1158 | Yes |
| 140 | Ppp1r15a | 18608 | -0.456 | -0.1023 | Yes |
| 141 | Hsd11b1 | 18617 | -0.458 | -0.0888 | Yes |
| 142 | Dcbld2 | 18685 | -0.469 | -0.0781 | Yes |
| 143 | Ank | 18730 | -0.477 | -0.0658 | Yes |
| 144 | Btc | 18818 | -0.495 | -0.0553 | Yes |
| 145 | Trib1 | 18972 | -0.525 | -0.0472 | Yes |
| 146 | Akap12 | 18975 | -0.525 | -0.0313 | Yes |
| 147 | Nr1h4 | 18995 | -0.528 | -0.0163 | Yes |
| 148 | Tfpi | 19256 | -0.628 | -0.0106 | Yes |
| 149 | Adam8 | 19434 | -0.782 | 0.0040 | Yes |

