| Dataset | MPP.MPP_Pheno.cls#Group3_versus_Group4.MPP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_G2M_CHECKPOINT |
| Enrichment Score (ES) | 0.5000345 |
| Normalized Enrichment Score (NES) | 1.737902 |
| Nominal p-value | 0.04517454 |
| FDR q-value | 0.08654397 |
| FWER p-Value | 0.098 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Racgap1 | 16 | 1.179 | 0.0256 | Yes |
| 2 | Aurkb | 35 | 1.037 | 0.0479 | Yes |
| 3 | Kif2c | 41 | 0.999 | 0.0700 | Yes |
| 4 | Cdc25b | 89 | 0.879 | 0.0873 | Yes |
| 5 | Kif23 | 165 | 0.789 | 0.1011 | Yes |
| 6 | Plk1 | 275 | 0.703 | 0.1112 | Yes |
| 7 | Knl1 | 288 | 0.694 | 0.1261 | Yes |
| 8 | Cenpa | 313 | 0.686 | 0.1403 | Yes |
| 9 | Stmn1 | 326 | 0.679 | 0.1549 | Yes |
| 10 | Marcks | 352 | 0.664 | 0.1685 | Yes |
| 11 | Hmmr | 439 | 0.624 | 0.1780 | Yes |
| 12 | Jpt1 | 529 | 0.598 | 0.1868 | Yes |
| 13 | Kif11 | 536 | 0.595 | 0.1998 | Yes |
| 14 | Ccnd1 | 542 | 0.592 | 0.2128 | Yes |
| 15 | Espl1 | 670 | 0.549 | 0.2186 | Yes |
| 16 | Nusap1 | 756 | 0.534 | 0.2261 | Yes |
| 17 | Ndc80 | 762 | 0.533 | 0.2378 | Yes |
| 18 | Amd1 | 790 | 0.525 | 0.2482 | Yes |
| 19 | Kif20b | 827 | 0.516 | 0.2579 | Yes |
| 20 | Top2a | 917 | 0.502 | 0.2645 | Yes |
| 21 | Mad2l1 | 925 | 0.501 | 0.2754 | Yes |
| 22 | Ccnf | 934 | 0.499 | 0.2862 | Yes |
| 23 | Incenp | 962 | 0.495 | 0.2959 | Yes |
| 24 | Cenpe | 1004 | 0.483 | 0.3046 | Yes |
| 25 | Mki67 | 1137 | 0.463 | 0.3081 | Yes |
| 26 | Ccnb2 | 1144 | 0.462 | 0.3182 | Yes |
| 27 | Prc1 | 1211 | 0.452 | 0.3249 | Yes |
| 28 | Cdkn3 | 1268 | 0.442 | 0.3319 | Yes |
| 29 | Bard1 | 1311 | 0.436 | 0.3395 | Yes |
| 30 | Kif4 | 1425 | 0.424 | 0.3431 | Yes |
| 31 | Tpx2 | 1460 | 0.420 | 0.3508 | Yes |
| 32 | Plk4 | 1563 | 0.408 | 0.3547 | Yes |
| 33 | Tent4a | 1577 | 0.406 | 0.3631 | Yes |
| 34 | Traip | 1621 | 0.401 | 0.3699 | Yes |
| 35 | Cdk1 | 1624 | 0.401 | 0.3787 | Yes |
| 36 | Tmpo | 1768 | 0.385 | 0.3800 | Yes |
| 37 | Prmt5 | 1851 | 0.377 | 0.3842 | Yes |
| 38 | Kif15 | 1876 | 0.375 | 0.3913 | Yes |
| 39 | Ccna2 | 1953 | 0.368 | 0.3956 | Yes |
| 40 | Smc2 | 2050 | 0.359 | 0.3987 | Yes |
| 41 | Cenpf | 2075 | 0.356 | 0.4055 | Yes |
| 42 | Fbxo5 | 2110 | 0.354 | 0.4116 | Yes |
| 43 | Stil | 2142 | 0.352 | 0.4179 | Yes |
| 44 | Prim2 | 2230 | 0.346 | 0.4212 | Yes |
| 45 | Exo1 | 2253 | 0.343 | 0.4277 | Yes |
| 46 | Sqle | 2384 | 0.329 | 0.4284 | Yes |
| 47 | Odc1 | 2424 | 0.328 | 0.4337 | Yes |
| 48 | Efna5 | 2427 | 0.327 | 0.4409 | Yes |
| 49 | Upf1 | 2484 | 0.326 | 0.4453 | Yes |
| 50 | Birc5 | 2604 | 0.316 | 0.4463 | Yes |
| 51 | Cks1b | 2685 | 0.309 | 0.4490 | Yes |
| 52 | Nup98 | 2793 | 0.301 | 0.4502 | Yes |
| 53 | E2f2 | 3178 | 0.275 | 0.4365 | Yes |
| 54 | Ewsr1 | 3228 | 0.272 | 0.4401 | Yes |
| 55 | Smc4 | 3230 | 0.272 | 0.4462 | Yes |
| 56 | Hnrnpu | 3376 | 0.263 | 0.4445 | Yes |
| 57 | Cdc20 | 3399 | 0.262 | 0.4493 | Yes |
| 58 | Bub1 | 3408 | 0.262 | 0.4547 | Yes |
| 59 | Suv39h1 | 3548 | 0.255 | 0.4533 | Yes |
| 60 | Dbf4 | 3585 | 0.253 | 0.4571 | Yes |
| 61 | Lmnb1 | 3586 | 0.253 | 0.4628 | Yes |
| 62 | Rad54l | 3670 | 0.248 | 0.4640 | Yes |
| 63 | Bub3 | 3765 | 0.242 | 0.4646 | Yes |
| 64 | Mcm2 | 3811 | 0.240 | 0.4676 | Yes |
| 65 | Polq | 3959 | 0.231 | 0.4652 | Yes |
| 66 | Pbk | 3972 | 0.231 | 0.4698 | Yes |
| 67 | Tacc3 | 3976 | 0.230 | 0.4748 | Yes |
| 68 | Cks2 | 3985 | 0.230 | 0.4795 | Yes |
| 69 | Hif1a | 4021 | 0.228 | 0.4828 | Yes |
| 70 | H2az1 | 4033 | 0.227 | 0.4873 | Yes |
| 71 | Troap | 4126 | 0.224 | 0.4875 | Yes |
| 72 | G3bp1 | 4194 | 0.219 | 0.4890 | Yes |
| 73 | Mcm5 | 4313 | 0.214 | 0.4877 | Yes |
| 74 | Map3k20 | 4445 | 0.208 | 0.4856 | Yes |
| 75 | Srsf2 | 4604 | 0.199 | 0.4818 | Yes |
| 76 | Snrpd1 | 4622 | 0.198 | 0.4854 | Yes |
| 77 | Kpnb1 | 4661 | 0.196 | 0.4878 | Yes |
| 78 | Rasal2 | 4671 | 0.196 | 0.4917 | Yes |
| 79 | Xpo1 | 4748 | 0.191 | 0.4921 | Yes |
| 80 | Gspt1 | 4791 | 0.188 | 0.4941 | Yes |
| 81 | Hmgb3 | 4838 | 0.185 | 0.4959 | Yes |
| 82 | Ube2s | 4839 | 0.185 | 0.5000 | Yes |
| 83 | H2az2 | 5027 | 0.176 | 0.4943 | No |
| 84 | Rad23b | 5322 | 0.161 | 0.4827 | No |
| 85 | Cdc25a | 5348 | 0.160 | 0.4850 | No |
| 86 | Pole | 5371 | 0.159 | 0.4874 | No |
| 87 | Kif22 | 5450 | 0.156 | 0.4869 | No |
| 88 | Ttk | 5539 | 0.153 | 0.4858 | No |
| 89 | Notch2 | 5707 | 0.148 | 0.4804 | No |
| 90 | Dtymk | 5779 | 0.145 | 0.4800 | No |
| 91 | Chmp1a | 5817 | 0.143 | 0.4813 | No |
| 92 | Mapk14 | 5890 | 0.140 | 0.4807 | No |
| 93 | Srsf1 | 5923 | 0.138 | 0.4821 | No |
| 94 | Syncrip | 5931 | 0.138 | 0.4849 | No |
| 95 | Ddx39a | 6192 | 0.126 | 0.4742 | No |
| 96 | Tra2b | 6299 | 0.121 | 0.4714 | No |
| 97 | Chek1 | 6354 | 0.119 | 0.4713 | No |
| 98 | Orc5 | 6461 | 0.115 | 0.4684 | No |
| 99 | Chaf1a | 6551 | 0.111 | 0.4663 | No |
| 100 | Nasp | 6657 | 0.107 | 0.4633 | No |
| 101 | Sfpq | 6729 | 0.104 | 0.4619 | No |
| 102 | Ctcf | 6770 | 0.102 | 0.4621 | No |
| 103 | Hira | 6853 | 0.099 | 0.4601 | No |
| 104 | Rbl1 | 6864 | 0.099 | 0.4618 | No |
| 105 | Slc7a1 | 6899 | 0.097 | 0.4622 | No |
| 106 | Cdc45 | 7049 | 0.092 | 0.4566 | No |
| 107 | Hus1 | 7083 | 0.091 | 0.4569 | No |
| 108 | Mcm6 | 7177 | 0.087 | 0.4540 | No |
| 109 | Pds5b | 7399 | 0.079 | 0.4444 | No |
| 110 | Cdkn2c | 7597 | 0.073 | 0.4358 | No |
| 111 | Kmt5a | 7724 | 0.069 | 0.4308 | No |
| 112 | Ilf3 | 7730 | 0.068 | 0.4321 | No |
| 113 | Rad21 | 7772 | 0.067 | 0.4315 | No |
| 114 | Hnrnpd | 7809 | 0.065 | 0.4311 | No |
| 115 | Cbx1 | 7822 | 0.065 | 0.4319 | No |
| 116 | Casp8ap2 | 7836 | 0.064 | 0.4327 | No |
| 117 | Brca2 | 7935 | 0.061 | 0.4289 | No |
| 118 | Nsd2 | 7960 | 0.060 | 0.4290 | No |
| 119 | Cdc7 | 8196 | 0.051 | 0.4180 | No |
| 120 | Srsf10 | 8205 | 0.051 | 0.4188 | No |
| 121 | H2ax | 8378 | 0.044 | 0.4108 | No |
| 122 | Numa1 | 8482 | 0.041 | 0.4064 | No |
| 123 | Hmga1b | 8502 | 0.040 | 0.4063 | No |
| 124 | Atrx | 8515 | 0.039 | 0.4066 | No |
| 125 | Pttg1 | 8575 | 0.037 | 0.4044 | No |
| 126 | Tgfb1 | 8581 | 0.037 | 0.4049 | No |
| 127 | Dkc1 | 8675 | 0.033 | 0.4009 | No |
| 128 | Cdc6 | 8735 | 0.031 | 0.3985 | No |
| 129 | Uck2 | 8742 | 0.031 | 0.3989 | No |
| 130 | Cul1 | 8810 | 0.029 | 0.3961 | No |
| 131 | Nek2 | 8864 | 0.027 | 0.3939 | No |
| 132 | Cdc27 | 8881 | 0.026 | 0.3937 | No |
| 133 | Ube2c | 8885 | 0.026 | 0.3941 | No |
| 134 | Pafah1b1 | 9011 | 0.022 | 0.3881 | No |
| 135 | E2f3 | 9082 | 0.019 | 0.3849 | No |
| 136 | Nup50 | 9147 | 0.017 | 0.3820 | No |
| 137 | Lig3 | 9331 | 0.010 | 0.3727 | No |
| 138 | Odf2 | 9366 | 0.009 | 0.3712 | No |
| 139 | Ss18 | 9405 | 0.008 | 0.3694 | No |
| 140 | Dmd | 9410 | 0.008 | 0.3694 | No |
| 141 | Smad3 | 9478 | 0.006 | 0.3661 | No |
| 142 | Tfdp1 | 9511 | 0.006 | 0.3645 | No |
| 143 | Lbr | 9529 | 0.005 | 0.3638 | No |
| 144 | Myc | 9550 | 0.004 | 0.3628 | No |
| 145 | Ezh2 | 9769 | -0.000 | 0.3516 | No |
| 146 | Fancc | 10062 | -0.010 | 0.3367 | No |
| 147 | Mcm3 | 10259 | -0.017 | 0.3269 | No |
| 148 | Cul5 | 10283 | -0.018 | 0.3261 | No |
| 149 | Pura | 10313 | -0.018 | 0.3250 | No |
| 150 | Cul3 | 10319 | -0.018 | 0.3252 | No |
| 151 | Mtf2 | 10329 | -0.019 | 0.3251 | No |
| 152 | Wrn | 10370 | -0.021 | 0.3235 | No |
| 153 | Aurka | 10413 | -0.022 | 0.3219 | No |
| 154 | Foxn3 | 10562 | -0.028 | 0.3148 | No |
| 155 | Slc7a5 | 10691 | -0.032 | 0.3089 | No |
| 156 | Smarcc1 | 10761 | -0.035 | 0.3061 | No |
| 157 | Mnat1 | 10941 | -0.042 | 0.2978 | No |
| 158 | Mybl2 | 11154 | -0.049 | 0.2879 | No |
| 159 | Katna1 | 11268 | -0.053 | 0.2833 | No |
| 160 | Smc1a | 11471 | -0.060 | 0.2741 | No |
| 161 | Hspa8 | 11497 | -0.061 | 0.2742 | No |
| 162 | Ythdc1 | 11511 | -0.061 | 0.2749 | No |
| 163 | Slc38a1 | 11997 | -0.076 | 0.2515 | No |
| 164 | Meis1 | 12041 | -0.078 | 0.2510 | No |
| 165 | Bcl3 | 12115 | -0.080 | 0.2490 | No |
| 166 | Kif5b | 12518 | -0.094 | 0.2303 | No |
| 167 | Stag1 | 12959 | -0.110 | 0.2100 | No |
| 168 | Top1 | 13113 | -0.116 | 0.2047 | No |
| 169 | Rpa2 | 13410 | -0.127 | 0.1922 | No |
| 170 | Gins2 | 13419 | -0.127 | 0.1947 | No |
| 171 | Pola2 | 13459 | -0.129 | 0.1955 | No |
| 172 | Pml | 13540 | -0.133 | 0.1944 | No |
| 173 | Prpf4b | 13574 | -0.134 | 0.1957 | No |
| 174 | Tle3 | 13707 | -0.139 | 0.1919 | No |
| 175 | Orc6 | 13712 | -0.139 | 0.1949 | No |
| 176 | Rps6ka5 | 13736 | -0.140 | 0.1968 | No |
| 177 | Egf | 14000 | -0.149 | 0.1865 | No |
| 178 | Nolc1 | 14503 | -0.169 | 0.1643 | No |
| 179 | Ncl | 14588 | -0.173 | 0.1639 | No |
| 180 | Cul4a | 14648 | -0.175 | 0.1647 | No |
| 181 | Arid4a | 15093 | -0.191 | 0.1460 | No |
| 182 | Abl1 | 15481 | -0.211 | 0.1307 | No |
| 183 | E2f1 | 15859 | -0.230 | 0.1164 | No |
| 184 | Atf5 | 16041 | -0.241 | 0.1124 | No |
| 185 | Meis2 | 16077 | -0.243 | 0.1161 | No |
| 186 | Cdk4 | 16155 | -0.248 | 0.1176 | No |
| 187 | H2bc12 | 16210 | -0.250 | 0.1204 | No |
| 188 | Cdkn1b | 16501 | -0.268 | 0.1114 | No |
| 189 | Tnpo2 | 16728 | -0.282 | 0.1060 | No |
| 190 | Dr1 | 16861 | -0.291 | 0.1057 | No |
| 191 | Sap30 | 17204 | -0.312 | 0.0950 | No |
| 192 | Slc12a2 | 17309 | -0.320 | 0.0968 | No |
| 193 | E2f4 | 17881 | -0.373 | 0.0756 | No |
| 194 | Ccnt1 | 18065 | -0.392 | 0.0749 | No |

