| Dataset | MPP.MPP_Pheno.cls#Group3_versus_Group4.MPP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.48228002 |
| Normalized Enrichment Score (NES) | 1.4699156 |
| Nominal p-value | 0.13849287 |
| FDR q-value | 0.44492722 |
| FWER p-Value | 0.517 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Racgap1 | 16 | 1.179 | 0.0261 | Yes |
| 2 | Aurkb | 35 | 1.037 | 0.0489 | Yes |
| 3 | Kif2c | 41 | 0.999 | 0.0715 | Yes |
| 4 | Cdc25b | 89 | 0.879 | 0.0891 | Yes |
| 5 | Tcf19 | 162 | 0.795 | 0.1036 | Yes |
| 6 | Cdca8 | 178 | 0.774 | 0.1205 | Yes |
| 7 | Plk1 | 275 | 0.703 | 0.1316 | Yes |
| 8 | Stmn1 | 326 | 0.679 | 0.1445 | Yes |
| 9 | Hmmr | 439 | 0.624 | 0.1530 | Yes |
| 10 | Cdca3 | 445 | 0.621 | 0.1669 | Yes |
| 11 | Spc25 | 517 | 0.602 | 0.1770 | Yes |
| 12 | Jpt1 | 529 | 0.598 | 0.1901 | Yes |
| 13 | Espl1 | 670 | 0.549 | 0.1954 | Yes |
| 14 | Ung | 705 | 0.543 | 0.2061 | Yes |
| 15 | Cnot9 | 778 | 0.529 | 0.2144 | Yes |
| 16 | Top2a | 917 | 0.502 | 0.2188 | Yes |
| 17 | Mad2l1 | 925 | 0.501 | 0.2298 | Yes |
| 18 | Depdc1a | 937 | 0.499 | 0.2407 | Yes |
| 19 | Bub1b | 1003 | 0.484 | 0.2484 | Yes |
| 20 | Cenpe | 1004 | 0.483 | 0.2594 | Yes |
| 21 | Ncapd2 | 1014 | 0.482 | 0.2700 | Yes |
| 22 | Shmt1 | 1063 | 0.474 | 0.2783 | Yes |
| 23 | Mki67 | 1137 | 0.463 | 0.2852 | Yes |
| 24 | Ccnb2 | 1144 | 0.462 | 0.2954 | Yes |
| 25 | Cdkn3 | 1268 | 0.442 | 0.2991 | Yes |
| 26 | Bard1 | 1311 | 0.436 | 0.3069 | Yes |
| 27 | Spc24 | 1361 | 0.431 | 0.3142 | Yes |
| 28 | Dclre1b | 1420 | 0.424 | 0.3209 | Yes |
| 29 | Kif4 | 1425 | 0.424 | 0.3304 | Yes |
| 30 | Spag5 | 1500 | 0.416 | 0.3361 | Yes |
| 31 | Plk4 | 1563 | 0.408 | 0.3422 | Yes |
| 32 | Cdk1 | 1624 | 0.401 | 0.3483 | Yes |
| 33 | Tubb5 | 1667 | 0.395 | 0.3551 | Yes |
| 34 | Tmpo | 1768 | 0.385 | 0.3588 | Yes |
| 35 | Dlgap5 | 1840 | 0.378 | 0.3637 | Yes |
| 36 | Wee1 | 1844 | 0.378 | 0.3722 | Yes |
| 37 | Trip13 | 1850 | 0.377 | 0.3806 | Yes |
| 38 | Cit | 1866 | 0.376 | 0.3884 | Yes |
| 39 | Kif18b | 1941 | 0.369 | 0.3930 | Yes |
| 40 | Hmgb2 | 2011 | 0.363 | 0.3977 | Yes |
| 41 | Slbp | 2049 | 0.359 | 0.4040 | Yes |
| 42 | Prim2 | 2230 | 0.346 | 0.4026 | Yes |
| 43 | Prdx4 | 2282 | 0.341 | 0.4077 | Yes |
| 44 | Diaph3 | 2350 | 0.333 | 0.4119 | Yes |
| 45 | Exosc8 | 2514 | 0.324 | 0.4108 | Yes |
| 46 | Nop56 | 2530 | 0.323 | 0.4174 | Yes |
| 47 | Birc5 | 2604 | 0.316 | 0.4209 | Yes |
| 48 | Dck | 2668 | 0.311 | 0.4247 | Yes |
| 49 | Cks1b | 2685 | 0.309 | 0.4309 | Yes |
| 50 | Atad2 | 2745 | 0.304 | 0.4348 | Yes |
| 51 | E2f8 | 2881 | 0.294 | 0.4346 | Yes |
| 52 | Asf1b | 2971 | 0.289 | 0.4366 | Yes |
| 53 | Cdkn2a | 3035 | 0.284 | 0.4398 | Yes |
| 54 | Smc4 | 3230 | 0.272 | 0.4360 | Yes |
| 55 | Wdr90 | 3304 | 0.268 | 0.4383 | Yes |
| 56 | Cenpm | 3366 | 0.264 | 0.4412 | Yes |
| 57 | Cdc20 | 3399 | 0.262 | 0.4455 | Yes |
| 58 | Suv39h1 | 3548 | 0.255 | 0.4437 | Yes |
| 59 | Lmnb1 | 3586 | 0.253 | 0.4476 | Yes |
| 60 | Tk1 | 3615 | 0.251 | 0.4519 | Yes |
| 61 | Pold1 | 3651 | 0.249 | 0.4558 | Yes |
| 62 | Mcm2 | 3811 | 0.240 | 0.4530 | Yes |
| 63 | Cbx5 | 3920 | 0.233 | 0.4528 | Yes |
| 64 | Tacc3 | 3976 | 0.230 | 0.4552 | Yes |
| 65 | Cks2 | 3985 | 0.230 | 0.4600 | Yes |
| 66 | Ube2t | 4022 | 0.228 | 0.4633 | Yes |
| 67 | H2az1 | 4033 | 0.227 | 0.4680 | Yes |
| 68 | Hells | 4065 | 0.225 | 0.4716 | Yes |
| 69 | Mcm5 | 4313 | 0.214 | 0.4637 | Yes |
| 70 | Melk | 4387 | 0.211 | 0.4647 | Yes |
| 71 | Asf1a | 4392 | 0.210 | 0.4693 | Yes |
| 72 | Ubr7 | 4415 | 0.209 | 0.4729 | Yes |
| 73 | Brca1 | 4432 | 0.208 | 0.4769 | Yes |
| 74 | Srsf2 | 4604 | 0.199 | 0.4726 | Yes |
| 75 | Timeless | 4648 | 0.197 | 0.4749 | Yes |
| 76 | Xpo1 | 4748 | 0.191 | 0.4741 | Yes |
| 77 | Gspt1 | 4791 | 0.188 | 0.4762 | Yes |
| 78 | Hmgb3 | 4838 | 0.185 | 0.4780 | Yes |
| 79 | Ube2s | 4839 | 0.185 | 0.4823 | Yes |
| 80 | Mxd3 | 5050 | 0.175 | 0.4754 | No |
| 81 | Nudt21 | 5206 | 0.167 | 0.4712 | No |
| 82 | Gins4 | 5259 | 0.164 | 0.4723 | No |
| 83 | Cdc25a | 5348 | 0.160 | 0.4714 | No |
| 84 | Pole | 5371 | 0.159 | 0.4739 | No |
| 85 | Kif22 | 5450 | 0.156 | 0.4734 | No |
| 86 | Ipo7 | 5492 | 0.154 | 0.4748 | No |
| 87 | Dek | 5608 | 0.150 | 0.4723 | No |
| 88 | Lig1 | 5737 | 0.147 | 0.4690 | No |
| 89 | Ssrp1 | 5787 | 0.144 | 0.4698 | No |
| 90 | Rfc2 | 5798 | 0.144 | 0.4725 | No |
| 91 | Srsf1 | 5923 | 0.138 | 0.4693 | No |
| 92 | Syncrip | 5931 | 0.138 | 0.4721 | No |
| 93 | Gins1 | 6097 | 0.131 | 0.4665 | No |
| 94 | Ddx39a | 6192 | 0.126 | 0.4645 | No |
| 95 | Rbbp7 | 6252 | 0.123 | 0.4643 | No |
| 96 | Cdkn1a | 6269 | 0.122 | 0.4663 | No |
| 97 | Ak2 | 6273 | 0.122 | 0.4689 | No |
| 98 | Tra2b | 6299 | 0.121 | 0.4704 | No |
| 99 | Gins3 | 6331 | 0.120 | 0.4715 | No |
| 100 | Chek1 | 6354 | 0.119 | 0.4731 | No |
| 101 | Pole4 | 6571 | 0.110 | 0.4644 | No |
| 102 | Dctpp1 | 6626 | 0.108 | 0.4641 | No |
| 103 | Nasp | 6657 | 0.107 | 0.4650 | No |
| 104 | Dnmt1 | 6725 | 0.104 | 0.4639 | No |
| 105 | Ctcf | 6770 | 0.102 | 0.4640 | No |
| 106 | Rrm2 | 6814 | 0.101 | 0.4641 | No |
| 107 | Usp1 | 6856 | 0.099 | 0.4642 | No |
| 108 | Rfc1 | 6952 | 0.096 | 0.4615 | No |
| 109 | Rad51ap1 | 7071 | 0.091 | 0.4574 | No |
| 110 | Hus1 | 7083 | 0.091 | 0.4589 | No |
| 111 | Mms22l | 7106 | 0.090 | 0.4599 | No |
| 112 | Mcm6 | 7177 | 0.087 | 0.4582 | No |
| 113 | Smc3 | 7254 | 0.085 | 0.4562 | No |
| 114 | Pms2 | 7390 | 0.079 | 0.4511 | No |
| 115 | Pds5b | 7399 | 0.079 | 0.4525 | No |
| 116 | Mre11a | 7512 | 0.075 | 0.4484 | No |
| 117 | Rad51c | 7571 | 0.074 | 0.4471 | No |
| 118 | Cdkn2c | 7597 | 0.073 | 0.4474 | No |
| 119 | Rad50 | 7624 | 0.072 | 0.4477 | No |
| 120 | Ilf3 | 7730 | 0.068 | 0.4439 | No |
| 121 | Rad21 | 7772 | 0.067 | 0.4433 | No |
| 122 | Hnrnpd | 7809 | 0.065 | 0.4429 | No |
| 123 | Mcm4 | 7879 | 0.063 | 0.4408 | No |
| 124 | Tbrg4 | 7885 | 0.063 | 0.4419 | No |
| 125 | Brca2 | 7935 | 0.061 | 0.4408 | No |
| 126 | H2ax | 8378 | 0.044 | 0.4189 | No |
| 127 | Ranbp1 | 8387 | 0.044 | 0.4195 | No |
| 128 | Eed | 8431 | 0.042 | 0.4182 | No |
| 129 | Hmga1b | 8502 | 0.040 | 0.4155 | No |
| 130 | Pttg1 | 8575 | 0.037 | 0.4126 | No |
| 131 | Chek2 | 8648 | 0.035 | 0.4097 | No |
| 132 | Rpa1 | 8665 | 0.034 | 0.4096 | No |
| 133 | Anp32e | 8678 | 0.033 | 0.4098 | No |
| 134 | Brms1l | 8691 | 0.033 | 0.4099 | No |
| 135 | Rpa3 | 8698 | 0.033 | 0.4103 | No |
| 136 | Mthfd2 | 8834 | 0.028 | 0.4040 | No |
| 137 | Psmc3ip | 8862 | 0.027 | 0.4032 | No |
| 138 | Xrcc6 | 8869 | 0.027 | 0.4035 | No |
| 139 | Phf5a | 8890 | 0.026 | 0.4030 | No |
| 140 | Ppp1r8 | 8913 | 0.025 | 0.4025 | No |
| 141 | Paics | 8956 | 0.023 | 0.4008 | No |
| 142 | Ccp110 | 9120 | 0.018 | 0.3928 | No |
| 143 | Zw10 | 9141 | 0.017 | 0.3922 | No |
| 144 | Nup205 | 9195 | 0.015 | 0.3898 | No |
| 145 | Nap1l1 | 9425 | 0.008 | 0.3781 | No |
| 146 | Nup107 | 9473 | 0.007 | 0.3758 | No |
| 147 | Dut | 9516 | 0.006 | 0.3738 | No |
| 148 | Lbr | 9529 | 0.005 | 0.3733 | No |
| 149 | Myc | 9550 | 0.004 | 0.3723 | No |
| 150 | Ezh2 | 9769 | -0.000 | 0.3610 | No |
| 151 | Rfc3 | 9831 | -0.002 | 0.3579 | No |
| 152 | Pan2 | 9890 | -0.004 | 0.3550 | No |
| 153 | Ing3 | 9933 | -0.006 | 0.3530 | No |
| 154 | Mlh1 | 9996 | -0.008 | 0.3500 | No |
| 155 | Luc7l3 | 10079 | -0.011 | 0.3460 | No |
| 156 | Tfrc | 10115 | -0.012 | 0.3444 | No |
| 157 | Lsm8 | 10182 | -0.015 | 0.3413 | No |
| 158 | Mcm3 | 10259 | -0.017 | 0.3378 | No |
| 159 | Donson | 10280 | -0.018 | 0.3372 | No |
| 160 | Msh2 | 10362 | -0.020 | 0.3334 | No |
| 161 | Aurka | 10413 | -0.022 | 0.3314 | No |
| 162 | Smc6 | 10442 | -0.023 | 0.3304 | No |
| 163 | Tubg1 | 10483 | -0.025 | 0.3289 | No |
| 164 | Psip1 | 11133 | -0.048 | 0.2964 | No |
| 165 | Mybl2 | 11154 | -0.049 | 0.2965 | No |
| 166 | Smc1a | 11471 | -0.060 | 0.2815 | No |
| 167 | Prkdc | 11777 | -0.068 | 0.2673 | No |
| 168 | Ppm1d | 11801 | -0.069 | 0.2677 | No |
| 169 | Ran | 11961 | -0.075 | 0.2612 | No |
| 170 | Nbn | 12374 | -0.089 | 0.2419 | No |
| 171 | Cse1l | 12540 | -0.095 | 0.2355 | No |
| 172 | Pold3 | 12560 | -0.095 | 0.2367 | No |
| 173 | Eif2s1 | 12740 | -0.101 | 0.2297 | No |
| 174 | Pop7 | 12896 | -0.107 | 0.2242 | No |
| 175 | Nme1 | 12906 | -0.107 | 0.2262 | No |
| 176 | Stag1 | 12959 | -0.110 | 0.2260 | No |
| 177 | Nup153 | 13158 | -0.118 | 0.2184 | No |
| 178 | Orc2 | 13326 | -0.124 | 0.2126 | No |
| 179 | Rpa2 | 13410 | -0.127 | 0.2112 | No |
| 180 | Pola2 | 13459 | -0.129 | 0.2117 | No |
| 181 | Rad1 | 13471 | -0.130 | 0.2141 | No |
| 182 | Lyar | 13513 | -0.132 | 0.2150 | No |
| 183 | Orc6 | 13712 | -0.139 | 0.2079 | No |
| 184 | Nolc1 | 14503 | -0.169 | 0.1709 | No |
| 185 | Pcna | 14665 | -0.176 | 0.1666 | No |
| 186 | Pnn | 15113 | -0.192 | 0.1478 | No |
| 187 | Mcm7 | 15153 | -0.194 | 0.1502 | No |
| 188 | Pold2 | 15849 | -0.229 | 0.1195 | No |
| 189 | Rnaseh2a | 16024 | -0.240 | 0.1160 | No |
| 190 | Cdk4 | 16155 | -0.248 | 0.1149 | No |
| 191 | Trp53 | 16300 | -0.255 | 0.1132 | No |
| 192 | Pa2g4 | 16496 | -0.268 | 0.1093 | No |
| 193 | Cdkn1b | 16501 | -0.268 | 0.1152 | No |
| 194 | Tipin | 16915 | -0.294 | 0.1005 | No |
| 195 | Snrpb | 17008 | -0.300 | 0.1026 | No |
| 196 | Dscc1 | 17519 | -0.337 | 0.0839 | No |
| 197 | Ccne1 | 18154 | -0.400 | 0.0602 | No |
| 198 | Prps1 | 18479 | -0.438 | 0.0535 | No |

