| Dataset | MPP.MPP_Pheno.cls#Group3_versus_Group4.MPP_Pheno.cls#Group3_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_APICAL_JUNCTION |
| Enrichment Score (ES) | -0.20436879 |
| Normalized Enrichment Score (NES) | -0.8852923 |
| Nominal p-value | 0.6519115 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Itga3 | 83 | 0.886 | 0.0205 | No |
| 2 | Icam2 | 209 | 0.748 | 0.0350 | No |
| 3 | Pik3r3 | 250 | 0.721 | 0.0531 | No |
| 4 | Kcnh2 | 325 | 0.679 | 0.0683 | No |
| 5 | Mpzl1 | 350 | 0.665 | 0.0857 | No |
| 6 | Mapk11 | 712 | 0.542 | 0.0822 | No |
| 7 | Nectin2 | 742 | 0.538 | 0.0958 | No |
| 8 | Src | 1122 | 0.465 | 0.0892 | No |
| 9 | Fscn1 | 1181 | 0.456 | 0.0990 | No |
| 10 | Amigo2 | 1293 | 0.438 | 0.1055 | No |
| 11 | Adam15 | 1383 | 0.428 | 0.1129 | No |
| 12 | Amh | 2004 | 0.364 | 0.0911 | No |
| 13 | Irs1 | 2025 | 0.362 | 0.1001 | No |
| 14 | Pard6g | 2251 | 0.344 | 0.0981 | No |
| 15 | Nectin4 | 2315 | 0.336 | 0.1043 | No |
| 16 | Insig1 | 2385 | 0.329 | 0.1100 | No |
| 17 | Tspan4 | 2410 | 0.328 | 0.1179 | No |
| 18 | Evl | 2654 | 0.312 | 0.1141 | No |
| 19 | Myh9 | 2740 | 0.305 | 0.1182 | No |
| 20 | Nfasc | 3191 | 0.274 | 0.1027 | No |
| 21 | Epb41l2 | 3341 | 0.266 | 0.1024 | No |
| 22 | Ptk2 | 3396 | 0.262 | 0.1069 | No |
| 23 | Cldn4 | 3491 | 0.258 | 0.1093 | No |
| 24 | Itgb4 | 3543 | 0.256 | 0.1138 | No |
| 25 | Vav2 | 3614 | 0.252 | 0.1173 | No |
| 26 | Cdk8 | 3825 | 0.239 | 0.1131 | No |
| 27 | Vcam1 | 3840 | 0.238 | 0.1191 | No |
| 28 | Gtf2f1 | 3922 | 0.233 | 0.1214 | No |
| 29 | Cadm3 | 3966 | 0.231 | 0.1256 | No |
| 30 | Actb | 4035 | 0.227 | 0.1285 | No |
| 31 | Cntn1 | 4090 | 0.224 | 0.1320 | No |
| 32 | Myh10 | 4153 | 0.221 | 0.1350 | No |
| 33 | Adam23 | 4257 | 0.217 | 0.1357 | No |
| 34 | Traf1 | 4271 | 0.217 | 0.1411 | No |
| 35 | Ywhah | 4336 | 0.213 | 0.1438 | No |
| 36 | Map3k20 | 4445 | 0.208 | 0.1440 | No |
| 37 | Icam1 | 4737 | 0.191 | 0.1343 | No |
| 38 | Tmem8b | 4739 | 0.191 | 0.1396 | No |
| 39 | Cdh1 | 4953 | 0.180 | 0.1337 | No |
| 40 | Tjp1 | 4956 | 0.180 | 0.1386 | No |
| 41 | Pten | 5106 | 0.172 | 0.1357 | No |
| 42 | Alox8 | 5200 | 0.168 | 0.1356 | No |
| 43 | Mapk14 | 5890 | 0.140 | 0.1039 | No |
| 44 | Nectin1 | 6055 | 0.133 | 0.0992 | No |
| 45 | Itgb1 | 6099 | 0.131 | 0.1006 | No |
| 46 | Lamb3 | 6679 | 0.106 | 0.0736 | No |
| 47 | Cdh6 | 6754 | 0.103 | 0.0727 | No |
| 48 | Actn4 | 6840 | 0.099 | 0.0711 | No |
| 49 | Nlgn2 | 6841 | 0.099 | 0.0739 | No |
| 50 | Rasa1 | 6877 | 0.098 | 0.0748 | No |
| 51 | Nf2 | 6950 | 0.096 | 0.0738 | No |
| 52 | Nrtn | 6966 | 0.095 | 0.0757 | No |
| 53 | Mvd | 7125 | 0.089 | 0.0700 | No |
| 54 | Actn2 | 7163 | 0.088 | 0.0706 | No |
| 55 | Nrap | 7231 | 0.085 | 0.0695 | No |
| 56 | Plcg1 | 7359 | 0.080 | 0.0652 | No |
| 57 | Syk | 7403 | 0.079 | 0.0652 | No |
| 58 | Stx4a | 7432 | 0.078 | 0.0659 | No |
| 59 | Myl12b | 7523 | 0.075 | 0.0634 | No |
| 60 | Nrxn2 | 7654 | 0.071 | 0.0586 | No |
| 61 | Col16a1 | 7677 | 0.071 | 0.0595 | No |
| 62 | Mmp2 | 7818 | 0.065 | 0.0541 | No |
| 63 | Negr1 | 7870 | 0.063 | 0.0532 | No |
| 64 | Ptprc | 7997 | 0.058 | 0.0483 | No |
| 65 | Pals1 | 8166 | 0.052 | 0.0411 | No |
| 66 | Slit2 | 8207 | 0.051 | 0.0404 | No |
| 67 | Hras | 8294 | 0.048 | 0.0373 | No |
| 68 | Cd34 | 8359 | 0.045 | 0.0353 | No |
| 69 | Icam4 | 8369 | 0.045 | 0.0361 | No |
| 70 | Crat | 8533 | 0.038 | 0.0287 | No |
| 71 | Cd274 | 8549 | 0.038 | 0.0290 | No |
| 72 | B4galt1 | 8998 | 0.022 | 0.0065 | No |
| 73 | Msn | 9097 | 0.019 | 0.0020 | No |
| 74 | Tro | 9230 | 0.014 | -0.0045 | No |
| 75 | Rsu1 | 9240 | 0.014 | -0.0046 | No |
| 76 | Ikbkg | 9250 | 0.013 | -0.0047 | No |
| 77 | Pkd1 | 9278 | 0.012 | -0.0057 | No |
| 78 | Speg | 9291 | 0.012 | -0.0060 | No |
| 79 | Thy1 | 9666 | 0.001 | -0.0253 | No |
| 80 | Adamts5 | 9695 | 0.000 | -0.0267 | No |
| 81 | Cdh8 | 9708 | 0.000 | -0.0274 | No |
| 82 | Tial1 | 10060 | -0.010 | -0.0452 | No |
| 83 | Pfn1 | 10112 | -0.012 | -0.0475 | No |
| 84 | Fbn1 | 10456 | -0.024 | -0.0646 | No |
| 85 | Tubg1 | 10483 | -0.025 | -0.0652 | No |
| 86 | Akt3 | 10727 | -0.033 | -0.0768 | No |
| 87 | Lama3 | 10859 | -0.038 | -0.0825 | No |
| 88 | Exoc4 | 10920 | -0.041 | -0.0845 | No |
| 89 | Skap2 | 11392 | -0.057 | -0.1072 | No |
| 90 | Ldlrap1 | 11479 | -0.060 | -0.1100 | No |
| 91 | Jup | 11518 | -0.062 | -0.1102 | No |
| 92 | Thbs3 | 11556 | -0.063 | -0.1103 | No |
| 93 | Dhx16 | 11629 | -0.065 | -0.1122 | No |
| 94 | Cldn7 | 11667 | -0.066 | -0.1123 | No |
| 95 | Adam9 | 11766 | -0.068 | -0.1155 | No |
| 96 | Sgce | 11996 | -0.076 | -0.1252 | No |
| 97 | Lima1 | 12205 | -0.083 | -0.1336 | No |
| 98 | Gnai2 | 12310 | -0.086 | -0.1366 | No |
| 99 | Nectin3 | 12559 | -0.095 | -0.1467 | No |
| 100 | Cx3cl1 | 12588 | -0.096 | -0.1455 | No |
| 101 | Arpc2 | 12689 | -0.099 | -0.1478 | No |
| 102 | Pbx2 | 12716 | -0.101 | -0.1464 | No |
| 103 | Zyx | 12776 | -0.103 | -0.1465 | No |
| 104 | Gnai1 | 13047 | -0.113 | -0.1573 | No |
| 105 | Actg1 | 13076 | -0.115 | -0.1555 | No |
| 106 | Tsc1 | 13078 | -0.115 | -0.1524 | No |
| 107 | Sympk | 13108 | -0.116 | -0.1506 | No |
| 108 | Pecam1 | 13151 | -0.117 | -0.1495 | No |
| 109 | Bmp1 | 13378 | -0.126 | -0.1577 | No |
| 110 | Cap1 | 13455 | -0.129 | -0.1580 | No |
| 111 | Wasl | 13562 | -0.133 | -0.1598 | No |
| 112 | Shc1 | 13700 | -0.139 | -0.1630 | No |
| 113 | Akt2 | 13710 | -0.139 | -0.1595 | No |
| 114 | Dlg1 | 14092 | -0.152 | -0.1750 | No |
| 115 | Arhgef6 | 14108 | -0.153 | -0.1714 | No |
| 116 | Vcl | 14239 | -0.158 | -0.1737 | No |
| 117 | Nf1 | 14429 | -0.166 | -0.1789 | No |
| 118 | Amigo1 | 14548 | -0.171 | -0.1802 | No |
| 119 | Itga9 | 14555 | -0.171 | -0.1757 | No |
| 120 | Taok2 | 14757 | -0.180 | -0.1810 | No |
| 121 | Itga10 | 15022 | -0.189 | -0.1894 | No |
| 122 | Nexn | 15038 | -0.189 | -0.1849 | No |
| 123 | Ctnna1 | 15170 | -0.195 | -0.1862 | No |
| 124 | Map4k2 | 15266 | -0.200 | -0.1855 | No |
| 125 | Sorbs3 | 15433 | -0.209 | -0.1882 | No |
| 126 | Inppl1 | 15457 | -0.210 | -0.1835 | No |
| 127 | Nlgn3 | 15617 | -0.218 | -0.1856 | No |
| 128 | Baiap2 | 15636 | -0.220 | -0.1804 | No |
| 129 | Dsc1 | 15663 | -0.221 | -0.1756 | No |
| 130 | Rac2 | 15689 | -0.221 | -0.1707 | No |
| 131 | Rras | 15965 | -0.236 | -0.1783 | No |
| 132 | Mdk | 16110 | -0.245 | -0.1789 | No |
| 133 | Vasp | 16328 | -0.257 | -0.1829 | No |
| 134 | Itga2 | 16535 | -0.270 | -0.1860 | No |
| 135 | Cadm2 | 16892 | -0.293 | -0.1962 | Yes |
| 136 | Shroom2 | 16928 | -0.295 | -0.1897 | Yes |
| 137 | Icam5 | 16934 | -0.295 | -0.1817 | Yes |
| 138 | Cnn2 | 16945 | -0.295 | -0.1740 | Yes |
| 139 | Hadh | 16949 | -0.296 | -0.1659 | Yes |
| 140 | Sdc3 | 17117 | -0.307 | -0.1659 | Yes |
| 141 | Ctnnd1 | 17207 | -0.312 | -0.1617 | Yes |
| 142 | Actn1 | 17270 | -0.317 | -0.1561 | Yes |
| 143 | Atp1a3 | 17440 | -0.329 | -0.1556 | Yes |
| 144 | Wnk4 | 17585 | -0.345 | -0.1534 | Yes |
| 145 | Cdh11 | 17786 | -0.364 | -0.1535 | Yes |
| 146 | Crb3 | 17819 | -0.368 | -0.1449 | Yes |
| 147 | Jam3 | 18062 | -0.391 | -0.1464 | Yes |
| 148 | Mapk13 | 18109 | -0.396 | -0.1377 | Yes |
| 149 | Cd86 | 18189 | -0.404 | -0.1305 | Yes |
| 150 | Gamt | 18228 | -0.408 | -0.1210 | Yes |
| 151 | Cd276 | 18269 | -0.413 | -0.1115 | Yes |
| 152 | Cdh4 | 18514 | -0.444 | -0.1117 | Yes |
| 153 | Sirpa | 18667 | -0.466 | -0.1065 | Yes |
| 154 | Cercam | 18759 | -0.483 | -0.0977 | Yes |
| 155 | Actn3 | 18812 | -0.494 | -0.0866 | Yes |
| 156 | Pik3cb | 18898 | -0.511 | -0.0766 | Yes |
| 157 | Rhof | 19051 | -0.546 | -0.0692 | Yes |
| 158 | Tgfbi | 19066 | -0.552 | -0.0545 | Yes |
| 159 | Vwf | 19095 | -0.563 | -0.0401 | Yes |
| 160 | Layn | 19119 | -0.570 | -0.0254 | Yes |
| 161 | Cldn15 | 19210 | -0.607 | -0.0130 | Yes |
| 162 | Vcan | 19498 | -1.021 | 0.0007 | Yes |

