| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group4.MPP_Pheno.cls#Group2_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.29511422 |
| Normalized Enrichment Score (NES) | 1.3361088 |
| Nominal p-value | 0.10909091 |
| FDR q-value | 0.6356457 |
| FWER p-Value | 0.738 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Lgmn | 208 | 0.726 | 0.0054 | Yes |
| 2 | Mcm2 | 306 | 0.668 | 0.0153 | Yes |
| 3 | Cyp51 | 361 | 0.644 | 0.0269 | Yes |
| 4 | Mcm4 | 424 | 0.619 | 0.0375 | Yes |
| 5 | Vldlr | 462 | 0.607 | 0.0491 | Yes |
| 6 | Hspa4 | 467 | 0.606 | 0.0624 | Yes |
| 7 | Hmgcr | 469 | 0.605 | 0.0758 | Yes |
| 8 | Tmem97 | 478 | 0.603 | 0.0889 | Yes |
| 9 | Hk2 | 543 | 0.583 | 0.0986 | Yes |
| 10 | Hmgcs1 | 561 | 0.580 | 0.1106 | Yes |
| 11 | Nfkbib | 767 | 0.535 | 0.1119 | Yes |
| 12 | Etf1 | 837 | 0.525 | 0.1201 | Yes |
| 13 | Stip1 | 865 | 0.519 | 0.1302 | Yes |
| 14 | Edem1 | 910 | 0.510 | 0.1393 | Yes |
| 15 | Sc5d | 949 | 0.504 | 0.1486 | Yes |
| 16 | Sqle | 1000 | 0.496 | 0.1571 | Yes |
| 17 | Rpn1 | 1004 | 0.496 | 0.1680 | Yes |
| 18 | Hspa9 | 1141 | 0.476 | 0.1715 | Yes |
| 19 | Pgk1 | 1218 | 0.464 | 0.1780 | Yes |
| 20 | Ung | 1347 | 0.448 | 0.1813 | Yes |
| 21 | Cdkn1a | 1446 | 0.437 | 0.1860 | Yes |
| 22 | Stard4 | 1487 | 0.430 | 0.1935 | Yes |
| 23 | Hspd1 | 1495 | 0.429 | 0.2027 | Yes |
| 24 | Cdc25a | 1496 | 0.429 | 0.2123 | Yes |
| 25 | Cops5 | 1984 | 0.378 | 0.1955 | Yes |
| 26 | Canx | 2118 | 0.363 | 0.1967 | Yes |
| 27 | Txnrd1 | 2184 | 0.358 | 0.2013 | Yes |
| 28 | Actr2 | 2206 | 0.357 | 0.2082 | Yes |
| 29 | Hspa5 | 2230 | 0.355 | 0.2149 | Yes |
| 30 | Ssr1 | 2304 | 0.347 | 0.2189 | Yes |
| 31 | Calr | 2355 | 0.344 | 0.2240 | Yes |
| 32 | Slc1a4 | 2470 | 0.335 | 0.2255 | Yes |
| 33 | Nampt | 2484 | 0.334 | 0.2323 | Yes |
| 34 | Gla | 2553 | 0.329 | 0.2361 | Yes |
| 35 | Ube2d3 | 2752 | 0.314 | 0.2329 | Yes |
| 36 | Gpi1 | 2766 | 0.314 | 0.2392 | Yes |
| 37 | Bub1 | 2817 | 0.310 | 0.2436 | Yes |
| 38 | Fdxr | 2843 | 0.308 | 0.2491 | Yes |
| 39 | Tfrc | 2900 | 0.305 | 0.2530 | Yes |
| 40 | Rpa1 | 2933 | 0.303 | 0.2581 | Yes |
| 41 | Plod2 | 2978 | 0.301 | 0.2626 | Yes |
| 42 | Actr3 | 2992 | 0.300 | 0.2686 | Yes |
| 43 | Uso1 | 3117 | 0.293 | 0.2687 | Yes |
| 44 | Psmc4 | 3249 | 0.284 | 0.2683 | Yes |
| 45 | Cct6a | 3271 | 0.282 | 0.2735 | Yes |
| 46 | Egln3 | 3320 | 0.279 | 0.2772 | Yes |
| 47 | Slc37a4 | 3382 | 0.277 | 0.2802 | Yes |
| 48 | Pnp | 3433 | 0.275 | 0.2838 | Yes |
| 49 | Gtf2h1 | 3506 | 0.270 | 0.2860 | Yes |
| 50 | Ykt6 | 3525 | 0.268 | 0.2911 | Yes |
| 51 | Bhlhe40 | 3621 | 0.262 | 0.2920 | Yes |
| 52 | Pitpnb | 3713 | 0.256 | 0.2930 | Yes |
| 53 | Ddx39a | 3829 | 0.250 | 0.2926 | Yes |
| 54 | Psmd14 | 3923 | 0.243 | 0.2932 | Yes |
| 55 | Hsp90b1 | 4232 | 0.225 | 0.2823 | Yes |
| 56 | Psat1 | 4269 | 0.223 | 0.2854 | Yes |
| 57 | Nmt1 | 4305 | 0.221 | 0.2886 | Yes |
| 58 | Nfyc | 4474 | 0.215 | 0.2846 | Yes |
| 59 | Psph | 4484 | 0.214 | 0.2890 | Yes |
| 60 | Ppia | 4526 | 0.212 | 0.2916 | Yes |
| 61 | Pfkl | 4736 | 0.201 | 0.2852 | Yes |
| 62 | Nup205 | 4788 | 0.198 | 0.2870 | Yes |
| 63 | Skap2 | 4805 | 0.197 | 0.2906 | Yes |
| 64 | Rrm2 | 4867 | 0.194 | 0.2917 | Yes |
| 65 | Ctsc | 4886 | 0.193 | 0.2951 | Yes |
| 66 | Gsk3b | 4973 | 0.189 | 0.2949 | No |
| 67 | Plk1 | 5257 | 0.175 | 0.2841 | No |
| 68 | Shmt2 | 5294 | 0.173 | 0.2861 | No |
| 69 | Hmbs | 5307 | 0.172 | 0.2893 | No |
| 70 | Acly | 5365 | 0.169 | 0.2901 | No |
| 71 | Immt | 5576 | 0.159 | 0.2828 | No |
| 72 | Atp2a2 | 5644 | 0.156 | 0.2828 | No |
| 73 | Slc2a1 | 5762 | 0.151 | 0.2801 | No |
| 74 | Fgl2 | 6004 | 0.138 | 0.2707 | No |
| 75 | Rab1a | 6034 | 0.137 | 0.2723 | No |
| 76 | Niban1 | 6148 | 0.132 | 0.2694 | No |
| 77 | Insig1 | 6201 | 0.129 | 0.2696 | No |
| 78 | Aurka | 6290 | 0.125 | 0.2678 | No |
| 79 | Serp1 | 6337 | 0.123 | 0.2682 | No |
| 80 | Ebp | 6583 | 0.114 | 0.2580 | No |
| 81 | Pno1 | 6584 | 0.114 | 0.2606 | No |
| 82 | Pik3r3 | 6589 | 0.114 | 0.2629 | No |
| 83 | Nupr1 | 6674 | 0.110 | 0.2610 | No |
| 84 | Wars1 | 6684 | 0.109 | 0.2630 | No |
| 85 | M6pr | 6926 | 0.097 | 0.2527 | No |
| 86 | Srd5a1 | 6939 | 0.097 | 0.2542 | No |
| 87 | Cacybp | 6962 | 0.096 | 0.2552 | No |
| 88 | Ddit3 | 7017 | 0.093 | 0.2545 | No |
| 89 | Ak4 | 7206 | 0.085 | 0.2467 | No |
| 90 | Sec11a | 7210 | 0.085 | 0.2484 | No |
| 91 | Psme3 | 7239 | 0.084 | 0.2488 | No |
| 92 | Ldlr | 7431 | 0.077 | 0.2407 | No |
| 93 | Ccnf | 7605 | 0.071 | 0.2333 | No |
| 94 | Idh1 | 7702 | 0.067 | 0.2299 | No |
| 95 | Psmd12 | 7853 | 0.061 | 0.2235 | No |
| 96 | Xbp1 | 7932 | 0.058 | 0.2207 | No |
| 97 | Elovl5 | 7960 | 0.056 | 0.2206 | No |
| 98 | Add3 | 8003 | 0.055 | 0.2196 | No |
| 99 | Lta4h | 8066 | 0.052 | 0.2176 | No |
| 100 | Ufm1 | 8130 | 0.050 | 0.2154 | No |
| 101 | Slc7a11 | 8209 | 0.047 | 0.2124 | No |
| 102 | Tpi1 | 8350 | 0.041 | 0.2061 | No |
| 103 | Hspe1 | 8359 | 0.041 | 0.2066 | No |
| 104 | Me1 | 8389 | 0.040 | 0.2060 | No |
| 105 | Ppa1 | 8585 | 0.031 | 0.1966 | No |
| 106 | Ppp1r15a | 8612 | 0.030 | 0.1959 | No |
| 107 | Psmc6 | 8632 | 0.029 | 0.1956 | No |
| 108 | Gsr | 8765 | 0.024 | 0.1893 | No |
| 109 | Gga2 | 8873 | 0.019 | 0.1842 | No |
| 110 | Acaca | 8917 | 0.017 | 0.1823 | No |
| 111 | Nufip1 | 8999 | 0.015 | 0.1785 | No |
| 112 | Pdap1 | 9282 | 0.005 | 0.1640 | No |
| 113 | Tes | 9605 | -0.005 | 0.1474 | No |
| 114 | Cyb5b | 9693 | -0.008 | 0.1431 | No |
| 115 | Rdh11 | 9868 | -0.015 | 0.1345 | No |
| 116 | Pgm1 | 9920 | -0.017 | 0.1322 | No |
| 117 | Psma4 | 10022 | -0.021 | 0.1275 | No |
| 118 | Cxcr4 | 10175 | -0.027 | 0.1202 | No |
| 119 | Phgdh | 10204 | -0.029 | 0.1194 | No |
| 120 | Rrp9 | 10237 | -0.030 | 0.1184 | No |
| 121 | Dhcr24 | 10287 | -0.032 | 0.1166 | No |
| 122 | Pdk1 | 10554 | -0.042 | 0.1037 | No |
| 123 | Aldoa | 10577 | -0.043 | 0.1036 | No |
| 124 | Elovl6 | 11048 | -0.062 | 0.0806 | No |
| 125 | Asns | 11093 | -0.063 | 0.0798 | No |
| 126 | Gmps | 11337 | -0.073 | 0.0688 | No |
| 127 | Eef1e1 | 11364 | -0.074 | 0.0691 | No |
| 128 | Psmd13 | 11590 | -0.083 | 0.0593 | No |
| 129 | Got1 | 11593 | -0.083 | 0.0611 | No |
| 130 | Slc6a6 | 11660 | -0.087 | 0.0596 | No |
| 131 | Psmc2 | 11824 | -0.094 | 0.0532 | No |
| 132 | Ero1a | 11830 | -0.095 | 0.0551 | No |
| 133 | Acsl3 | 11881 | -0.097 | 0.0547 | No |
| 134 | Dhcr7 | 12050 | -0.104 | 0.0483 | No |
| 135 | Tm7sf2 | 12117 | -0.107 | 0.0472 | No |
| 136 | Adipor2 | 12215 | -0.111 | 0.0447 | No |
| 137 | Fads1 | 12235 | -0.111 | 0.0462 | No |
| 138 | Ifrd1 | 12596 | -0.124 | 0.0303 | No |
| 139 | Dhfr | 12842 | -0.134 | 0.0206 | No |
| 140 | Sla | 12859 | -0.135 | 0.0228 | No |
| 141 | Rit1 | 13026 | -0.142 | 0.0174 | No |
| 142 | Itgb2 | 13030 | -0.143 | 0.0204 | No |
| 143 | Ccng1 | 13103 | -0.146 | 0.0199 | No |
| 144 | Uchl5 | 13408 | -0.161 | 0.0078 | No |
| 145 | Abcf2 | 13653 | -0.172 | -0.0010 | No |
| 146 | Slc1a5 | 13656 | -0.172 | 0.0027 | No |
| 147 | Sord | 13709 | -0.173 | 0.0039 | No |
| 148 | Gbe1 | 13799 | -0.178 | 0.0033 | No |
| 149 | Tbk1 | 13944 | -0.184 | -0.0001 | No |
| 150 | Ddit4 | 14083 | -0.191 | -0.0030 | No |
| 151 | Eno1b | 14175 | -0.195 | -0.0033 | No |
| 152 | Slc7a5 | 14235 | -0.198 | -0.0019 | No |
| 153 | Fkbp2 | 14318 | -0.202 | -0.0017 | No |
| 154 | Tomm40 | 14393 | -0.206 | -0.0009 | No |
| 155 | Slc2a3 | 14394 | -0.206 | 0.0037 | No |
| 156 | Prdx1 | 14443 | -0.208 | 0.0058 | No |
| 157 | Tubg1 | 14452 | -0.209 | 0.0100 | No |
| 158 | Btg2 | 14622 | -0.217 | 0.0061 | No |
| 159 | Glrx | 14864 | -0.229 | -0.0012 | No |
| 160 | Serpinh1 | 14907 | -0.232 | 0.0018 | No |
| 161 | Cfp | 14938 | -0.233 | 0.0054 | No |
| 162 | Eif2s2 | 15002 | -0.237 | 0.0074 | No |
| 163 | Psmg1 | 15062 | -0.240 | 0.0097 | No |
| 164 | G6pdx | 15183 | -0.246 | 0.0090 | No |
| 165 | Idi1 | 15274 | -0.251 | 0.0099 | No |
| 166 | Atp6v1d | 15288 | -0.252 | 0.0149 | No |
| 167 | Tcea1 | 15386 | -0.257 | 0.0156 | No |
| 168 | Sytl2 | 15416 | -0.259 | 0.0198 | No |
| 169 | Fads2 | 15471 | -0.261 | 0.0229 | No |
| 170 | Sqstm1 | 15663 | -0.272 | 0.0191 | No |
| 171 | Ifi30 | 15734 | -0.277 | 0.0216 | No |
| 172 | Mthfd2 | 15753 | -0.278 | 0.0269 | No |
| 173 | Sdf2l1 | 15983 | -0.292 | 0.0215 | No |
| 174 | Gclc | 16219 | -0.303 | 0.0161 | No |
| 175 | Tuba4a | 16281 | -0.307 | 0.0198 | No |
| 176 | Mllt11 | 16316 | -0.310 | 0.0250 | No |
| 177 | Psma3 | 16367 | -0.313 | 0.0294 | No |
| 178 | Qdpr | 16599 | -0.326 | 0.0247 | No |
| 179 | Ldha | 17234 | -0.371 | 0.0001 | No |
| 180 | Nfil3 | 17248 | -0.372 | 0.0078 | No |
| 181 | Mthfd2l | 17329 | -0.378 | 0.0121 | No |
| 182 | Map2k3 | 17358 | -0.381 | 0.0191 | No |
| 183 | Psmb5 | 17377 | -0.382 | 0.0267 | No |
| 184 | Dapp1 | 17389 | -0.384 | 0.0347 | No |
| 185 | P4ha1 | 17723 | -0.413 | 0.0267 | No |
| 186 | Arpc5l | 17777 | -0.418 | 0.0332 | No |
| 187 | Trib3 | 18214 | -0.466 | 0.0211 | No |
| 188 | Polr3g | 18407 | -0.493 | 0.0221 | No |
| 189 | Bcat1 | 18417 | -0.496 | 0.0327 | No |
| 190 | Cd9 | 18507 | -0.509 | 0.0395 | No |
| 191 | Coro1a | 18801 | -0.561 | 0.0368 | No |

