| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group4.MPP_Pheno.cls#Group2_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_KRAS_SIGNALING_UP |
| Enrichment Score (ES) | -0.21038565 |
| Normalized Enrichment Score (NES) | -0.92266583 |
| Nominal p-value | 0.61904764 |
| FDR q-value | 0.9847023 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | H2bc3 | 132 | 0.795 | 0.0182 | No |
| 2 | Lif | 483 | 0.601 | 0.0190 | No |
| 3 | Tnfaip3 | 781 | 0.533 | 0.0205 | No |
| 4 | Ets1 | 844 | 0.524 | 0.0337 | No |
| 5 | Angptl4 | 1490 | 0.429 | 0.0139 | No |
| 6 | Map3k1 | 1600 | 0.417 | 0.0214 | No |
| 7 | Plau | 1658 | 0.411 | 0.0314 | No |
| 8 | Traf1 | 2010 | 0.375 | 0.0251 | No |
| 9 | Ptprr | 2231 | 0.355 | 0.0249 | No |
| 10 | Il1rl2 | 2252 | 0.352 | 0.0349 | No |
| 11 | Mtmr10 | 2432 | 0.338 | 0.0363 | No |
| 12 | Id2 | 2550 | 0.330 | 0.0406 | No |
| 13 | Zfp639 | 2605 | 0.326 | 0.0481 | No |
| 14 | Il10ra | 2723 | 0.317 | 0.0520 | No |
| 15 | Ammecr1 | 2736 | 0.316 | 0.0613 | No |
| 16 | Ephb2 | 2739 | 0.315 | 0.0711 | No |
| 17 | Ptcd2 | 2839 | 0.309 | 0.0757 | No |
| 18 | Rbm4 | 2844 | 0.308 | 0.0852 | No |
| 19 | Usp12 | 2910 | 0.304 | 0.0914 | No |
| 20 | Spry2 | 2929 | 0.303 | 0.1000 | No |
| 21 | Plaur | 3051 | 0.297 | 0.1031 | No |
| 22 | F13a1 | 3488 | 0.271 | 0.0891 | No |
| 23 | Flt4 | 3493 | 0.271 | 0.0974 | No |
| 24 | Cxcl10 | 3592 | 0.263 | 0.1007 | No |
| 25 | Akt2 | 3762 | 0.253 | 0.0999 | No |
| 26 | Cbr4 | 3768 | 0.253 | 0.1076 | No |
| 27 | Zfp277 | 4233 | 0.225 | 0.0907 | No |
| 28 | Gfpt2 | 4368 | 0.219 | 0.0907 | No |
| 29 | Tmem176a | 4764 | 0.200 | 0.0766 | No |
| 30 | Plvap | 4807 | 0.197 | 0.0806 | No |
| 31 | Cab39l | 5096 | 0.184 | 0.0715 | No |
| 32 | Lat2 | 5103 | 0.184 | 0.0770 | No |
| 33 | Adgra2 | 5375 | 0.168 | 0.0683 | No |
| 34 | Scg3 | 5525 | 0.161 | 0.0657 | No |
| 35 | Fcer1g | 5814 | 0.148 | 0.0554 | No |
| 36 | Wdr33 | 5881 | 0.144 | 0.0566 | No |
| 37 | Avl9 | 5939 | 0.141 | 0.0581 | No |
| 38 | Akap12 | 6062 | 0.135 | 0.0560 | No |
| 39 | Fuca1 | 6086 | 0.134 | 0.0591 | No |
| 40 | Btbd3 | 6283 | 0.126 | 0.0529 | No |
| 41 | Adam17 | 6327 | 0.124 | 0.0546 | No |
| 42 | G0s2 | 6507 | 0.117 | 0.0490 | No |
| 43 | Ccser2 | 6884 | 0.099 | 0.0327 | No |
| 44 | Tmem100 | 6905 | 0.098 | 0.0348 | No |
| 45 | Sdccag8 | 6907 | 0.098 | 0.0378 | No |
| 46 | Ppbp | 6967 | 0.095 | 0.0378 | No |
| 47 | Cdadc1 | 7016 | 0.093 | 0.0382 | No |
| 48 | Dusp6 | 7477 | 0.076 | 0.0169 | No |
| 49 | Cbx8 | 7492 | 0.075 | 0.0185 | No |
| 50 | Tspan7 | 7533 | 0.073 | 0.0188 | No |
| 51 | Pecam1 | 7831 | 0.063 | 0.0054 | No |
| 52 | Fgf9 | 8010 | 0.054 | -0.0021 | No |
| 53 | Mmd | 8101 | 0.051 | -0.0051 | No |
| 54 | Ly96 | 8165 | 0.048 | -0.0069 | No |
| 55 | Spon1 | 8295 | 0.043 | -0.0122 | No |
| 56 | Lcp1 | 8582 | 0.031 | -0.0260 | No |
| 57 | Tor1aip2 | 8603 | 0.030 | -0.0260 | No |
| 58 | Ppp1r15a | 8612 | 0.030 | -0.0255 | No |
| 59 | Cfb | 8636 | 0.029 | -0.0258 | No |
| 60 | Prelid3b | 8723 | 0.026 | -0.0294 | No |
| 61 | Crot | 8770 | 0.024 | -0.0311 | No |
| 62 | Emp1 | 8772 | 0.023 | -0.0304 | No |
| 63 | Klf4 | 8842 | 0.020 | -0.0333 | No |
| 64 | Gadd45g | 9135 | 0.010 | -0.0481 | No |
| 65 | Cbl | 9143 | 0.010 | -0.0481 | No |
| 66 | Strn | 9167 | 0.009 | -0.0490 | No |
| 67 | Kcnn4 | 9179 | 0.009 | -0.0493 | No |
| 68 | Nin | 9351 | 0.003 | -0.0580 | No |
| 69 | Arg1 | 9384 | 0.002 | -0.0596 | No |
| 70 | Itgbl1 | 9429 | 0.000 | -0.0619 | No |
| 71 | Abcb1a | 9529 | -0.001 | -0.0670 | No |
| 72 | Vwa5a | 9547 | -0.002 | -0.0678 | No |
| 73 | Ano1 | 9638 | -0.006 | -0.0722 | No |
| 74 | Mycn | 9928 | -0.018 | -0.0866 | No |
| 75 | Galnt3 | 10005 | -0.021 | -0.0899 | No |
| 76 | Scn1b | 10051 | -0.022 | -0.0915 | No |
| 77 | Tmem158 | 10125 | -0.025 | -0.0945 | No |
| 78 | Cxcr4 | 10175 | -0.027 | -0.0962 | No |
| 79 | Tspan13 | 10186 | -0.028 | -0.0958 | No |
| 80 | Mafb | 10220 | -0.029 | -0.0966 | No |
| 81 | Map7 | 10297 | -0.033 | -0.0995 | No |
| 82 | St6gal1 | 10303 | -0.033 | -0.0987 | No |
| 83 | Scg5 | 10307 | -0.033 | -0.0978 | No |
| 84 | Ikzf1 | 10352 | -0.035 | -0.0990 | No |
| 85 | Birc3 | 10660 | -0.046 | -0.1134 | No |
| 86 | Slpi | 10673 | -0.046 | -0.1126 | No |
| 87 | Dock2 | 10894 | -0.056 | -0.1222 | No |
| 88 | Dnmbp | 10899 | -0.056 | -0.1207 | No |
| 89 | Btc | 10971 | -0.059 | -0.1225 | No |
| 90 | Nr1h4 | 11002 | -0.060 | -0.1221 | No |
| 91 | Hbegf | 11173 | -0.067 | -0.1288 | No |
| 92 | Yrdc | 11564 | -0.082 | -0.1464 | No |
| 93 | Etv1 | 11607 | -0.084 | -0.1459 | No |
| 94 | Trib1 | 11675 | -0.087 | -0.1466 | No |
| 95 | Kif5c | 11740 | -0.090 | -0.1471 | No |
| 96 | Map4k1 | 11747 | -0.091 | -0.1445 | No |
| 97 | Ctss | 11800 | -0.093 | -0.1443 | No |
| 98 | Atg10 | 11801 | -0.093 | -0.1414 | No |
| 99 | Ero1a | 11830 | -0.095 | -0.1399 | No |
| 100 | Fbxo4 | 12093 | -0.106 | -0.1501 | No |
| 101 | Irf8 | 12238 | -0.112 | -0.1540 | No |
| 102 | Reln | 12529 | -0.123 | -0.1651 | No |
| 103 | Igf2 | 12531 | -0.123 | -0.1613 | No |
| 104 | Epb41l3 | 12868 | -0.135 | -0.1744 | No |
| 105 | Pdcd1lg2 | 12901 | -0.137 | -0.1717 | No |
| 106 | Ptbp2 | 13021 | -0.142 | -0.1734 | No |
| 107 | Itgb2 | 13030 | -0.143 | -0.1693 | No |
| 108 | Etv4 | 13418 | -0.161 | -0.1842 | No |
| 109 | Satb1 | 13619 | -0.170 | -0.1892 | No |
| 110 | Evi5 | 13788 | -0.177 | -0.1923 | No |
| 111 | Adgrl4 | 13962 | -0.185 | -0.1954 | No |
| 112 | Tnfrsf1b | 14162 | -0.195 | -0.1995 | No |
| 113 | Il2rg | 14181 | -0.195 | -0.1943 | No |
| 114 | Rabgap1l | 14188 | -0.196 | -0.1885 | No |
| 115 | Hdac9 | 14244 | -0.199 | -0.1851 | No |
| 116 | Laptm5 | 14478 | -0.210 | -0.1905 | No |
| 117 | Glrx | 14864 | -0.229 | -0.2032 | Yes |
| 118 | Wnt7a | 14888 | -0.231 | -0.1971 | Yes |
| 119 | Etv5 | 15001 | -0.237 | -0.1955 | Yes |
| 120 | Gypc | 15042 | -0.239 | -0.1900 | Yes |
| 121 | Spp1 | 15092 | -0.242 | -0.1849 | Yes |
| 122 | Tmem176b | 15429 | -0.259 | -0.1941 | Yes |
| 123 | Il7r | 15440 | -0.260 | -0.1864 | Yes |
| 124 | Adam8 | 15574 | -0.267 | -0.1849 | Yes |
| 125 | Dcbld2 | 15612 | -0.269 | -0.1783 | Yes |
| 126 | Nrp1 | 15822 | -0.283 | -0.1802 | Yes |
| 127 | Gucy1a1 | 16012 | -0.294 | -0.1808 | Yes |
| 128 | Gprc5b | 16129 | -0.300 | -0.1773 | Yes |
| 129 | Gabra3 | 16158 | -0.301 | -0.1693 | Yes |
| 130 | Cmklr1 | 16430 | -0.316 | -0.1733 | Yes |
| 131 | Ank | 16439 | -0.317 | -0.1638 | Yes |
| 132 | Trib2 | 16482 | -0.319 | -0.1559 | Yes |
| 133 | Psmb8 | 16664 | -0.330 | -0.1549 | Yes |
| 134 | Car2 | 17138 | -0.364 | -0.1679 | Yes |
| 135 | Ptgs2 | 17426 | -0.386 | -0.1705 | Yes |
| 136 | Plek2 | 17659 | -0.407 | -0.1697 | Yes |
| 137 | Hsd11b1 | 17691 | -0.410 | -0.1584 | Yes |
| 138 | Bpgm | 17917 | -0.433 | -0.1564 | Yes |
| 139 | Gng11 | 18567 | -0.518 | -0.1736 | Yes |
| 140 | Cd37 | 18618 | -0.527 | -0.1596 | Yes |
| 141 | Eng | 18811 | -0.563 | -0.1518 | Yes |
| 142 | Itga2 | 18846 | -0.570 | -0.1357 | Yes |
| 143 | Ccnd2 | 18993 | -0.609 | -0.1241 | Yes |
| 144 | Mmp11 | 19065 | -0.635 | -0.1078 | Yes |
| 145 | Prdm1 | 19171 | -0.680 | -0.0918 | Yes |
| 146 | Tfpi | 19329 | -0.787 | -0.0752 | Yes |
| 147 | Nr0b2 | 19344 | -0.797 | -0.0508 | Yes |
| 148 | Csf2ra | 19416 | -0.870 | -0.0271 | Yes |
| 149 | Jup | 19481 | -1.018 | 0.0016 | Yes |

