| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group4.MPP_Pheno.cls#Group2_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_HYPOXIA |
| Enrichment Score (ES) | -0.18678877 |
| Normalized Enrichment Score (NES) | -0.8204546 |
| Nominal p-value | 0.7946257 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Fos | 232 | 0.708 | 0.0058 | No |
| 2 | Myh9 | 394 | 0.630 | 0.0132 | No |
| 3 | Vldlr | 462 | 0.607 | 0.0250 | No |
| 4 | Hk2 | 543 | 0.583 | 0.0355 | No |
| 5 | Eno3 | 706 | 0.546 | 0.0408 | No |
| 6 | Tnfaip3 | 781 | 0.533 | 0.0503 | No |
| 7 | Ets1 | 844 | 0.524 | 0.0602 | No |
| 8 | Zfp36 | 860 | 0.520 | 0.0725 | No |
| 9 | Jun | 963 | 0.503 | 0.0798 | No |
| 10 | Klf6 | 1093 | 0.483 | 0.0853 | No |
| 11 | Pgk1 | 1218 | 0.464 | 0.0905 | No |
| 12 | Car12 | 1441 | 0.437 | 0.0900 | No |
| 13 | Cdkn1a | 1446 | 0.437 | 0.1007 | No |
| 14 | Angptl4 | 1490 | 0.429 | 0.1093 | No |
| 15 | Map3k1 | 1600 | 0.417 | 0.1141 | No |
| 16 | Wsb1 | 1697 | 0.406 | 0.1193 | No |
| 17 | Atf3 | 1713 | 0.405 | 0.1287 | No |
| 18 | Nr3c1 | 1848 | 0.393 | 0.1316 | No |
| 19 | Tpbg | 2187 | 0.358 | 0.1231 | No |
| 20 | Hspa5 | 2230 | 0.355 | 0.1298 | No |
| 21 | Stc2 | 2459 | 0.336 | 0.1265 | No |
| 22 | Gpc4 | 2654 | 0.322 | 0.1245 | No |
| 23 | Adora2b | 2667 | 0.321 | 0.1319 | No |
| 24 | Gpi1 | 2766 | 0.314 | 0.1347 | No |
| 25 | Hexa | 2773 | 0.313 | 0.1423 | No |
| 26 | Tgfbi | 2804 | 0.311 | 0.1485 | No |
| 27 | Vhl | 2848 | 0.308 | 0.1540 | No |
| 28 | Plaur | 3051 | 0.297 | 0.1510 | No |
| 29 | Hdlbp | 3207 | 0.286 | 0.1502 | No |
| 30 | Ier3 | 3305 | 0.281 | 0.1522 | No |
| 31 | Dcn | 3341 | 0.278 | 0.1573 | No |
| 32 | Slc37a4 | 3382 | 0.277 | 0.1622 | No |
| 33 | Bhlhe40 | 3621 | 0.262 | 0.1565 | No |
| 34 | Tgfb3 | 3767 | 0.253 | 0.1553 | No |
| 35 | Gck | 3968 | 0.240 | 0.1510 | No |
| 36 | Grhpr | 4033 | 0.237 | 0.1537 | No |
| 37 | Rbpj | 4119 | 0.233 | 0.1551 | No |
| 38 | Noct | 4408 | 0.217 | 0.1457 | No |
| 39 | Jmjd6 | 4556 | 0.211 | 0.1433 | No |
| 40 | Hs3st1 | 4638 | 0.207 | 0.1443 | No |
| 41 | Prkca | 4675 | 0.204 | 0.1476 | No |
| 42 | Pfkl | 4736 | 0.201 | 0.1495 | No |
| 43 | Gpc3 | 4738 | 0.201 | 0.1545 | No |
| 44 | Cavin1 | 4819 | 0.196 | 0.1553 | No |
| 45 | Dusp1 | 4866 | 0.194 | 0.1578 | No |
| 46 | Pfkp | 5095 | 0.184 | 0.1506 | No |
| 47 | Ppargc1a | 5205 | 0.178 | 0.1494 | No |
| 48 | Klhl24 | 5398 | 0.168 | 0.1437 | No |
| 49 | Maff | 5416 | 0.167 | 0.1470 | No |
| 50 | Bnip3l | 5426 | 0.166 | 0.1507 | No |
| 51 | Aldoc | 5624 | 0.157 | 0.1445 | No |
| 52 | Slc2a1 | 5762 | 0.151 | 0.1412 | No |
| 53 | Ppfia4 | 5802 | 0.148 | 0.1429 | No |
| 54 | S100a4 | 5839 | 0.147 | 0.1447 | No |
| 55 | Slc25a1 | 5858 | 0.146 | 0.1474 | No |
| 56 | Foxo3 | 5957 | 0.140 | 0.1459 | No |
| 57 | Akap12 | 6062 | 0.135 | 0.1439 | No |
| 58 | Pam | 6192 | 0.130 | 0.1405 | No |
| 59 | Hmox1 | 6433 | 0.121 | 0.1311 | No |
| 60 | Ugp2 | 6462 | 0.119 | 0.1327 | No |
| 61 | Sap30 | 6647 | 0.112 | 0.1259 | No |
| 62 | Mt1 | 6781 | 0.104 | 0.1217 | No |
| 63 | Dtna | 6797 | 0.103 | 0.1235 | No |
| 64 | Ankzf1 | 6824 | 0.102 | 0.1247 | No |
| 65 | Ndst1 | 6848 | 0.101 | 0.1260 | No |
| 66 | Ampd3 | 6877 | 0.099 | 0.1271 | No |
| 67 | Pim1 | 6954 | 0.096 | 0.1256 | No |
| 68 | Ddit3 | 7017 | 0.093 | 0.1247 | No |
| 69 | Ccng2 | 7113 | 0.089 | 0.1220 | No |
| 70 | Kif5a | 7132 | 0.088 | 0.1233 | No |
| 71 | Ak4 | 7206 | 0.085 | 0.1217 | No |
| 72 | Scarb1 | 7307 | 0.081 | 0.1185 | No |
| 73 | Errfi1 | 7350 | 0.080 | 0.1184 | No |
| 74 | Sdc4 | 7430 | 0.077 | 0.1162 | No |
| 75 | Nedd4l | 7571 | 0.072 | 0.1108 | No |
| 76 | Bgn | 7659 | 0.069 | 0.1081 | No |
| 77 | Anxa2 | 7832 | 0.063 | 0.1007 | No |
| 78 | Klf7 | 7839 | 0.062 | 0.1020 | No |
| 79 | Inha | 8002 | 0.055 | 0.0950 | No |
| 80 | Stbd1 | 8034 | 0.054 | 0.0947 | No |
| 81 | Eno2 | 8150 | 0.049 | 0.0900 | No |
| 82 | Pklr | 8157 | 0.049 | 0.0909 | No |
| 83 | Gaa | 8233 | 0.046 | 0.0882 | No |
| 84 | Cp | 8292 | 0.043 | 0.0863 | No |
| 85 | Tpi1 | 8350 | 0.041 | 0.0844 | No |
| 86 | Tiparp | 8452 | 0.037 | 0.0801 | No |
| 87 | Ppp1r15a | 8612 | 0.030 | 0.0726 | No |
| 88 | Nagk | 8738 | 0.025 | 0.0668 | No |
| 89 | Kdm3a | 8934 | 0.017 | 0.0571 | No |
| 90 | Chst2 | 9062 | 0.013 | 0.0509 | No |
| 91 | Large1 | 9418 | 0.000 | 0.0325 | No |
| 92 | Tes | 9605 | -0.005 | 0.0230 | No |
| 93 | Sdc2 | 9650 | -0.006 | 0.0209 | No |
| 94 | Tgm2 | 9755 | -0.010 | 0.0158 | No |
| 95 | Slc2a5 | 9802 | -0.012 | 0.0137 | No |
| 96 | Zfp292 | 9906 | -0.017 | 0.0088 | No |
| 97 | Pgm1 | 9920 | -0.017 | 0.0086 | No |
| 98 | Plin2 | 10065 | -0.023 | 0.0017 | No |
| 99 | Cxcr4 | 10175 | -0.027 | -0.0032 | No |
| 100 | Hk1 | 10203 | -0.028 | -0.0039 | No |
| 101 | Irs2 | 10278 | -0.032 | -0.0069 | No |
| 102 | Gpc1 | 10397 | -0.037 | -0.0121 | No |
| 103 | Ext1 | 10527 | -0.042 | -0.0177 | No |
| 104 | Pdk1 | 10554 | -0.042 | -0.0180 | No |
| 105 | Aldoa | 10577 | -0.043 | -0.0181 | No |
| 106 | Pfkfb3 | 10949 | -0.058 | -0.0358 | No |
| 107 | Siah2 | 10994 | -0.060 | -0.0366 | No |
| 108 | Col5a1 | 11140 | -0.066 | -0.0424 | No |
| 109 | Cdkn1b | 11230 | -0.069 | -0.0453 | No |
| 110 | Mxi1 | 11289 | -0.071 | -0.0465 | No |
| 111 | Gcnt2 | 11301 | -0.071 | -0.0453 | No |
| 112 | Slc6a6 | 11660 | -0.087 | -0.0616 | No |
| 113 | Tpd52 | 11756 | -0.091 | -0.0643 | No |
| 114 | Ero1a | 11830 | -0.095 | -0.0657 | No |
| 115 | Phkg1 | 12130 | -0.107 | -0.0784 | No |
| 116 | Fosl2 | 12693 | -0.128 | -0.1043 | No |
| 117 | Pygm | 12747 | -0.130 | -0.1037 | No |
| 118 | Fbp1 | 12787 | -0.132 | -0.1024 | No |
| 119 | Ids | 12890 | -0.136 | -0.1043 | No |
| 120 | Vegfa | 13223 | -0.151 | -0.1177 | No |
| 121 | Xpnpep1 | 13477 | -0.164 | -0.1266 | No |
| 122 | Gbe1 | 13799 | -0.178 | -0.1388 | No |
| 123 | Efna1 | 13905 | -0.183 | -0.1396 | No |
| 124 | Gapdhs | 14024 | -0.188 | -0.1410 | No |
| 125 | Ddit4 | 14083 | -0.191 | -0.1392 | No |
| 126 | Bcl2 | 14158 | -0.194 | -0.1381 | No |
| 127 | Eno1b | 14175 | -0.195 | -0.1341 | No |
| 128 | Plac8 | 14241 | -0.199 | -0.1325 | No |
| 129 | Slc2a3 | 14394 | -0.206 | -0.1352 | No |
| 130 | Glrx | 14864 | -0.229 | -0.1537 | No |
| 131 | Fam162a | 15147 | -0.244 | -0.1621 | No |
| 132 | Mif | 15293 | -0.252 | -0.1633 | No |
| 133 | Kdelr3 | 15354 | -0.255 | -0.1600 | No |
| 134 | Atp7a | 15686 | -0.274 | -0.1703 | No |
| 135 | Tmem45a | 15902 | -0.287 | -0.1742 | No |
| 136 | Ndst2 | 15972 | -0.291 | -0.1704 | No |
| 137 | Lxn | 15992 | -0.292 | -0.1641 | No |
| 138 | Pdk3 | 16432 | -0.316 | -0.1789 | Yes |
| 139 | Gys1 | 16524 | -0.321 | -0.1755 | Yes |
| 140 | B3galt6 | 16595 | -0.326 | -0.1709 | Yes |
| 141 | Ndrg1 | 16749 | -0.336 | -0.1704 | Yes |
| 142 | Casp6 | 17000 | -0.355 | -0.1745 | Yes |
| 143 | Rora | 17001 | -0.355 | -0.1656 | Yes |
| 144 | Prdx5 | 17072 | -0.360 | -0.1602 | Yes |
| 145 | Galk1 | 17073 | -0.360 | -0.1511 | Yes |
| 146 | Selenbp1 | 17083 | -0.360 | -0.1426 | Yes |
| 147 | Pnrc1 | 17116 | -0.363 | -0.1351 | Yes |
| 148 | Ldha | 17234 | -0.371 | -0.1319 | Yes |
| 149 | Nfil3 | 17248 | -0.372 | -0.1232 | Yes |
| 150 | Sdc3 | 17424 | -0.386 | -0.1226 | Yes |
| 151 | Rragd | 17430 | -0.386 | -0.1132 | Yes |
| 152 | P4ha2 | 17476 | -0.391 | -0.1057 | Yes |
| 153 | Cav1 | 17721 | -0.413 | -0.1080 | Yes |
| 154 | P4ha1 | 17723 | -0.413 | -0.0977 | Yes |
| 155 | Pdgfb | 17897 | -0.432 | -0.0958 | Yes |
| 156 | Csrp2 | 17909 | -0.433 | -0.0855 | Yes |
| 157 | Btg1 | 18274 | -0.473 | -0.0925 | Yes |
| 158 | Cited2 | 18373 | -0.488 | -0.0853 | Yes |
| 159 | Pgm2 | 18601 | -0.524 | -0.0839 | Yes |
| 160 | Sult2b1 | 18724 | -0.545 | -0.0766 | Yes |
| 161 | Ilvbl | 18857 | -0.573 | -0.0690 | Yes |
| 162 | Cavin3 | 19054 | -0.631 | -0.0633 | Yes |
| 163 | Tpst2 | 19377 | -0.823 | -0.0593 | Yes |
| 164 | Isg20 | 19389 | -0.831 | -0.0391 | Yes |
| 165 | Cdkn1c | 19430 | -0.879 | -0.0191 | Yes |
| 166 | B4galnt2 | 19460 | -0.929 | 0.0027 | Yes |

