| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group4.MPP_Pheno.cls#Group2_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_APICAL_JUNCTION |
| Enrichment Score (ES) | -0.21226345 |
| Normalized Enrichment Score (NES) | -0.9432285 |
| Nominal p-value | 0.5323887 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cdk8 | 144 | 0.782 | 0.0111 | No |
| 2 | Mpzl1 | 219 | 0.718 | 0.0243 | No |
| 3 | Cdh1 | 222 | 0.716 | 0.0412 | No |
| 4 | Gtf2f1 | 224 | 0.713 | 0.0581 | No |
| 5 | Cd274 | 393 | 0.630 | 0.0644 | No |
| 6 | Myh9 | 394 | 0.630 | 0.0793 | No |
| 7 | Nectin2 | 437 | 0.616 | 0.0918 | No |
| 8 | Amigo2 | 626 | 0.566 | 0.0955 | No |
| 9 | Negr1 | 916 | 0.509 | 0.0927 | No |
| 10 | Dhx16 | 1211 | 0.465 | 0.0885 | No |
| 11 | Ctnna1 | 1558 | 0.422 | 0.0806 | No |
| 12 | Ywhah | 1633 | 0.413 | 0.0866 | No |
| 13 | Itga3 | 1649 | 0.412 | 0.0956 | No |
| 14 | Tjp1 | 1723 | 0.404 | 0.1014 | No |
| 15 | Vcam1 | 1741 | 0.403 | 0.1101 | No |
| 16 | Vav2 | 1804 | 0.397 | 0.1163 | No |
| 17 | Traf1 | 2010 | 0.375 | 0.1146 | No |
| 18 | Adam9 | 2023 | 0.374 | 0.1229 | No |
| 19 | Itgb1 | 2048 | 0.372 | 0.1305 | No |
| 20 | Icam1 | 2452 | 0.337 | 0.1177 | No |
| 21 | Adamts5 | 2490 | 0.334 | 0.1237 | No |
| 22 | Ikbkg | 2524 | 0.332 | 0.1298 | No |
| 23 | Adam23 | 2579 | 0.328 | 0.1348 | No |
| 24 | Epb41l2 | 2777 | 0.313 | 0.1321 | No |
| 25 | Tgfbi | 2804 | 0.311 | 0.1381 | No |
| 26 | Shc1 | 2886 | 0.306 | 0.1412 | No |
| 27 | Plcg1 | 2913 | 0.304 | 0.1471 | No |
| 28 | Adam15 | 3049 | 0.297 | 0.1471 | No |
| 29 | Fscn1 | 3114 | 0.293 | 0.1508 | No |
| 30 | Ptk2 | 3405 | 0.276 | 0.1424 | No |
| 31 | Mapk11 | 3424 | 0.275 | 0.1480 | No |
| 32 | Cadm3 | 3633 | 0.261 | 0.1434 | No |
| 33 | Akt2 | 3762 | 0.253 | 0.1428 | No |
| 34 | B4galt1 | 3803 | 0.251 | 0.1467 | No |
| 35 | Jam3 | 3825 | 0.250 | 0.1516 | No |
| 36 | Mmp2 | 4287 | 0.222 | 0.1330 | No |
| 37 | Pik3cb | 4420 | 0.217 | 0.1313 | No |
| 38 | Nf2 | 4475 | 0.215 | 0.1336 | No |
| 39 | Myh10 | 4477 | 0.215 | 0.1387 | No |
| 40 | Gnai1 | 4690 | 0.204 | 0.1326 | No |
| 41 | Ptprc | 4730 | 0.201 | 0.1353 | No |
| 42 | Skap2 | 4805 | 0.197 | 0.1362 | No |
| 43 | Nectin4 | 4965 | 0.189 | 0.1324 | No |
| 44 | Itgb4 | 5158 | 0.181 | 0.1268 | No |
| 45 | Mapk14 | 5248 | 0.176 | 0.1264 | No |
| 46 | Actn4 | 5687 | 0.154 | 0.1074 | No |
| 47 | Cap1 | 5692 | 0.154 | 0.1108 | No |
| 48 | Thy1 | 6023 | 0.137 | 0.0970 | No |
| 49 | Insig1 | 6201 | 0.129 | 0.0910 | No |
| 50 | Pkd1 | 6219 | 0.129 | 0.0932 | No |
| 51 | Cntn1 | 6380 | 0.122 | 0.0878 | No |
| 52 | Tial1 | 6582 | 0.114 | 0.0801 | No |
| 53 | Pik3r3 | 6589 | 0.114 | 0.0825 | No |
| 54 | Ctnnd1 | 6643 | 0.112 | 0.0824 | No |
| 55 | Nectin1 | 6789 | 0.104 | 0.0774 | No |
| 56 | Rasa1 | 6947 | 0.096 | 0.0716 | No |
| 57 | Mvd | 7023 | 0.093 | 0.0699 | No |
| 58 | Baiap2 | 7222 | 0.085 | 0.0617 | No |
| 59 | Actn2 | 7324 | 0.080 | 0.0583 | No |
| 60 | Cldn4 | 7371 | 0.079 | 0.0579 | No |
| 61 | Msn | 7414 | 0.078 | 0.0575 | No |
| 62 | Nrtn | 7516 | 0.074 | 0.0541 | No |
| 63 | Tspan4 | 7607 | 0.071 | 0.0511 | No |
| 64 | Col16a1 | 7713 | 0.067 | 0.0473 | No |
| 65 | Pecam1 | 7831 | 0.063 | 0.0427 | No |
| 66 | Actb | 7994 | 0.055 | 0.0357 | No |
| 67 | Wasl | 7995 | 0.055 | 0.0370 | No |
| 68 | Nrxn2 | 8008 | 0.055 | 0.0376 | No |
| 69 | Lama3 | 8297 | 0.043 | 0.0238 | No |
| 70 | Arhgef6 | 8431 | 0.038 | 0.0178 | No |
| 71 | Fbn1 | 8607 | 0.030 | 0.0095 | No |
| 72 | Map3k20 | 8712 | 0.026 | 0.0047 | No |
| 73 | Evl | 8834 | 0.021 | -0.0011 | No |
| 74 | Lamb3 | 8865 | 0.019 | -0.0021 | No |
| 75 | Cdh6 | 8905 | 0.018 | -0.0037 | No |
| 76 | Ldlrap1 | 9281 | 0.006 | -0.0230 | No |
| 77 | Pten | 9337 | 0.003 | -0.0257 | No |
| 78 | Nfasc | 9428 | 0.000 | -0.0304 | No |
| 79 | Cdh8 | 9431 | 0.000 | -0.0305 | No |
| 80 | Dsc1 | 9762 | -0.011 | -0.0473 | No |
| 81 | Kcnh2 | 9900 | -0.017 | -0.0540 | No |
| 82 | Myl12b | 9945 | -0.019 | -0.0558 | No |
| 83 | Tmem8b | 10263 | -0.031 | -0.0715 | No |
| 84 | Akt3 | 10523 | -0.042 | -0.0839 | No |
| 85 | Exoc4 | 10542 | -0.042 | -0.0838 | No |
| 86 | Atp1a3 | 10553 | -0.042 | -0.0833 | No |
| 87 | Rras | 10567 | -0.043 | -0.0829 | No |
| 88 | Sgce | 10599 | -0.044 | -0.0835 | No |
| 89 | Taok2 | 10937 | -0.058 | -0.0996 | No |
| 90 | Rsu1 | 11117 | -0.064 | -0.1073 | No |
| 91 | Cadm2 | 11143 | -0.066 | -0.1070 | No |
| 92 | Actg1 | 11247 | -0.069 | -0.1107 | No |
| 93 | Slit2 | 11443 | -0.077 | -0.1189 | No |
| 94 | Hras | 11466 | -0.078 | -0.1182 | No |
| 95 | Vcl | 11563 | -0.082 | -0.1212 | No |
| 96 | Actn1 | 11659 | -0.087 | -0.1241 | No |
| 97 | Tsc1 | 11757 | -0.091 | -0.1270 | No |
| 98 | Mdk | 11851 | -0.096 | -0.1295 | No |
| 99 | Tro | 12044 | -0.104 | -0.1370 | No |
| 100 | Map4k2 | 12145 | -0.108 | -0.1396 | No |
| 101 | Stx4a | 12175 | -0.109 | -0.1385 | No |
| 102 | Speg | 12182 | -0.109 | -0.1362 | No |
| 103 | Gnai2 | 12245 | -0.112 | -0.1367 | No |
| 104 | Amh | 12265 | -0.112 | -0.1350 | No |
| 105 | Nrap | 12324 | -0.115 | -0.1353 | No |
| 106 | Lima1 | 12403 | -0.118 | -0.1365 | No |
| 107 | Cldn7 | 12520 | -0.123 | -0.1396 | No |
| 108 | Pals1 | 12888 | -0.136 | -0.1553 | No |
| 109 | Nlgn3 | 13295 | -0.155 | -0.1726 | No |
| 110 | Pard6g | 13416 | -0.161 | -0.1750 | No |
| 111 | Cd34 | 13515 | -0.166 | -0.1761 | No |
| 112 | Syk | 13760 | -0.176 | -0.1846 | No |
| 113 | Mapk13 | 13990 | -0.186 | -0.1920 | No |
| 114 | Thbs3 | 14058 | -0.190 | -0.1909 | No |
| 115 | Irs1 | 14105 | -0.192 | -0.1887 | No |
| 116 | Nf1 | 14292 | -0.201 | -0.1936 | No |
| 117 | Cx3cl1 | 14390 | -0.205 | -0.1937 | No |
| 118 | Icam2 | 14429 | -0.207 | -0.1908 | No |
| 119 | Tubg1 | 14452 | -0.209 | -0.1869 | No |
| 120 | Dlg1 | 14462 | -0.209 | -0.1825 | No |
| 121 | Bmp1 | 14909 | -0.232 | -0.2000 | No |
| 122 | Vcan | 15051 | -0.240 | -0.2016 | No |
| 123 | Src | 15076 | -0.241 | -0.1971 | No |
| 124 | Crat | 15090 | -0.242 | -0.1921 | No |
| 125 | Hadh | 15175 | -0.245 | -0.1906 | No |
| 126 | Sympk | 15487 | -0.262 | -0.2004 | No |
| 127 | Inppl1 | 15657 | -0.272 | -0.2027 | No |
| 128 | Arpc2 | 15716 | -0.276 | -0.1992 | No |
| 129 | Gamt | 15738 | -0.277 | -0.1937 | No |
| 130 | Itga10 | 15796 | -0.281 | -0.1900 | No |
| 131 | Alox8 | 16178 | -0.301 | -0.2025 | No |
| 132 | Nlgn2 | 16307 | -0.309 | -0.2018 | No |
| 133 | Vasp | 16401 | -0.315 | -0.1991 | No |
| 134 | Zyx | 16616 | -0.328 | -0.2024 | No |
| 135 | Nectin3 | 16808 | -0.341 | -0.2042 | Yes |
| 136 | Amigo1 | 16943 | -0.351 | -0.2028 | Yes |
| 137 | Wnk4 | 17026 | -0.356 | -0.1985 | Yes |
| 138 | Crb3 | 17036 | -0.357 | -0.1905 | Yes |
| 139 | Icam5 | 17090 | -0.361 | -0.1847 | Yes |
| 140 | Vwf | 17268 | -0.374 | -0.1850 | Yes |
| 141 | Icam4 | 17270 | -0.374 | -0.1761 | Yes |
| 142 | Sdc3 | 17424 | -0.386 | -0.1749 | Yes |
| 143 | Actn3 | 17705 | -0.411 | -0.1796 | Yes |
| 144 | Cldn15 | 17768 | -0.417 | -0.1729 | Yes |
| 145 | Cdh4 | 17878 | -0.429 | -0.1683 | Yes |
| 146 | Sorbs3 | 18040 | -0.446 | -0.1661 | Yes |
| 147 | Pbx2 | 18045 | -0.447 | -0.1557 | Yes |
| 148 | Cnn2 | 18068 | -0.449 | -0.1461 | Yes |
| 149 | Cdh11 | 18207 | -0.465 | -0.1422 | Yes |
| 150 | Pfn1 | 18299 | -0.477 | -0.1356 | Yes |
| 151 | Sirpa | 18708 | -0.542 | -0.1438 | Yes |
| 152 | Shroom2 | 18821 | -0.564 | -0.1362 | Yes |
| 153 | Itga2 | 18846 | -0.570 | -0.1239 | Yes |
| 154 | Cd276 | 18886 | -0.580 | -0.1122 | Yes |
| 155 | Cercam | 18889 | -0.582 | -0.0985 | Yes |
| 156 | Rhof | 19139 | -0.664 | -0.0956 | Yes |
| 157 | Rac2 | 19172 | -0.680 | -0.0811 | Yes |
| 158 | Nexn | 19218 | -0.701 | -0.0668 | Yes |
| 159 | Itga9 | 19228 | -0.710 | -0.0504 | Yes |
| 160 | Cd86 | 19275 | -0.741 | -0.0352 | Yes |
| 161 | Layn | 19477 | -0.976 | -0.0224 | Yes |
| 162 | Jup | 19481 | -1.018 | 0.0016 | Yes |

