| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group3.MPP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.2519415 |
| Normalized Enrichment Score (NES) | -1.1189927 |
| Nominal p-value | 0.23045267 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.972 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cdo1 | 51 | 0.885 | 0.0223 | No |
| 2 | Gnmt | 210 | 0.658 | 0.0327 | No |
| 3 | Arg1 | 218 | 0.653 | 0.0507 | No |
| 4 | Tmem97 | 375 | 0.588 | 0.0592 | No |
| 5 | Pros1 | 611 | 0.526 | 0.0619 | No |
| 6 | Maoa | 1196 | 0.426 | 0.0438 | No |
| 7 | Abcc3 | 1224 | 0.423 | 0.0543 | No |
| 8 | Ahcyl | 1226 | 0.422 | 0.0662 | No |
| 9 | Cda | 1255 | 0.420 | 0.0765 | No |
| 10 | Aox1 | 1618 | 0.380 | 0.0686 | No |
| 11 | Lonp1 | 1767 | 0.366 | 0.0712 | No |
| 12 | Pts | 1801 | 0.362 | 0.0797 | No |
| 13 | Tyr | 1898 | 0.355 | 0.0848 | No |
| 14 | Lcat | 1999 | 0.348 | 0.0894 | No |
| 15 | Cndp2 | 2133 | 0.338 | 0.0921 | No |
| 16 | Gart | 2453 | 0.315 | 0.0845 | No |
| 17 | Etfdh | 2454 | 0.315 | 0.0933 | No |
| 18 | Igf1 | 2566 | 0.307 | 0.0963 | No |
| 19 | Nqo1 | 2833 | 0.289 | 0.0907 | No |
| 20 | Mthfd1 | 2948 | 0.282 | 0.0927 | No |
| 21 | Ptges3-ps | 3048 | 0.276 | 0.0954 | No |
| 22 | Ugdh | 3434 | 0.249 | 0.0825 | No |
| 23 | Il1r1 | 3511 | 0.245 | 0.0855 | No |
| 24 | Lpin2 | 3539 | 0.243 | 0.0910 | No |
| 25 | Rap1gap | 3690 | 0.236 | 0.0899 | No |
| 26 | Acp2 | 3931 | 0.222 | 0.0837 | No |
| 27 | Dhrs1 | 4042 | 0.217 | 0.0842 | No |
| 28 | Marchf6 | 4193 | 0.210 | 0.0824 | No |
| 29 | Gabarapl1 | 4354 | 0.202 | 0.0798 | No |
| 30 | Crp | 4460 | 0.197 | 0.0799 | No |
| 31 | Por | 4580 | 0.190 | 0.0791 | No |
| 32 | Pgd | 4622 | 0.188 | 0.0823 | No |
| 33 | Acox1 | 4757 | 0.182 | 0.0805 | No |
| 34 | Entpd5 | 4957 | 0.172 | 0.0751 | No |
| 35 | Acox3 | 4963 | 0.172 | 0.0797 | No |
| 36 | Gstm4 | 5040 | 0.169 | 0.0806 | No |
| 37 | Slc35d1 | 5239 | 0.158 | 0.0748 | No |
| 38 | Hgfac | 5254 | 0.158 | 0.0785 | No |
| 39 | Cfb | 5341 | 0.153 | 0.0784 | No |
| 40 | Ssr3 | 5477 | 0.147 | 0.0755 | No |
| 41 | Bcat1 | 5645 | 0.139 | 0.0708 | No |
| 42 | Kynu | 5769 | 0.134 | 0.0683 | No |
| 43 | Cd36 | 5777 | 0.134 | 0.0717 | No |
| 44 | Ech1 | 5889 | 0.130 | 0.0696 | No |
| 45 | Apoe | 5914 | 0.128 | 0.0720 | No |
| 46 | Id2 | 6593 | 0.100 | 0.0397 | No |
| 47 | Crot | 6653 | 0.097 | 0.0394 | No |
| 48 | Tgfb2 | 6656 | 0.097 | 0.0421 | No |
| 49 | Ddc | 6732 | 0.094 | 0.0409 | No |
| 50 | Slc35b1 | 6930 | 0.086 | 0.0331 | No |
| 51 | Shmt2 | 7025 | 0.082 | 0.0306 | No |
| 52 | Hmox1 | 7062 | 0.081 | 0.0310 | No |
| 53 | Pmm1 | 7337 | 0.072 | 0.0189 | No |
| 54 | Slc12a4 | 8078 | 0.044 | -0.0181 | No |
| 55 | Npc1 | 8273 | 0.036 | -0.0271 | No |
| 56 | Ap4b1 | 8287 | 0.036 | -0.0268 | No |
| 57 | Tkfc | 8337 | 0.034 | -0.0284 | No |
| 58 | Spint2 | 8436 | 0.030 | -0.0326 | No |
| 59 | Casp6 | 8510 | 0.027 | -0.0356 | No |
| 60 | Man1a | 8595 | 0.024 | -0.0392 | No |
| 61 | Smox | 8731 | 0.019 | -0.0457 | No |
| 62 | Aldh9a1 | 8884 | 0.014 | -0.0531 | No |
| 63 | Hsd11b1 | 8947 | 0.012 | -0.0560 | No |
| 64 | Csad | 8971 | 0.011 | -0.0568 | No |
| 65 | Aqp9 | 9039 | 0.009 | -0.0601 | No |
| 66 | Alas1 | 9049 | 0.008 | -0.0603 | No |
| 67 | Psmb10 | 9064 | 0.008 | -0.0608 | No |
| 68 | Tmem176b | 9086 | 0.007 | -0.0617 | No |
| 69 | Tmbim6 | 9098 | 0.007 | -0.0621 | No |
| 70 | Nmt1 | 9218 | 0.002 | -0.0681 | No |
| 71 | Gsr | 9547 | -0.009 | -0.0848 | No |
| 72 | Papss2 | 9623 | -0.012 | -0.0884 | No |
| 73 | Pdlim5 | 9633 | -0.012 | -0.0885 | No |
| 74 | Ptges | 10011 | -0.025 | -0.1073 | No |
| 75 | Atp2a2 | 10237 | -0.034 | -0.1180 | No |
| 76 | Gss | 10261 | -0.035 | -0.1182 | No |
| 77 | Fbln1 | 10310 | -0.037 | -0.1196 | No |
| 78 | Ptgr1 | 10317 | -0.037 | -0.1189 | No |
| 79 | Aco2 | 10390 | -0.040 | -0.1215 | No |
| 80 | Sar1b | 10393 | -0.040 | -0.1204 | No |
| 81 | Abcc2 | 10502 | -0.044 | -0.1248 | No |
| 82 | Igfbp4 | 10508 | -0.044 | -0.1238 | No |
| 83 | Slc6a6 | 10629 | -0.048 | -0.1286 | No |
| 84 | Hes6 | 10862 | -0.057 | -0.1390 | No |
| 85 | Fas | 10999 | -0.061 | -0.1443 | No |
| 86 | Fmo1 | 11099 | -0.065 | -0.1476 | No |
| 87 | Ddt | 11103 | -0.065 | -0.1459 | No |
| 88 | Ninj1 | 11438 | -0.078 | -0.1610 | No |
| 89 | Epha2 | 11522 | -0.080 | -0.1630 | No |
| 90 | Elovl5 | 11624 | -0.084 | -0.1658 | No |
| 91 | Arpp19 | 11900 | -0.095 | -0.1774 | No |
| 92 | Aldh2 | 12023 | -0.101 | -0.1808 | No |
| 93 | Cyfip2 | 12027 | -0.101 | -0.1781 | No |
| 94 | Tnfrsf1a | 12089 | -0.103 | -0.1784 | No |
| 95 | Pgrmc1 | 12248 | -0.110 | -0.1834 | No |
| 96 | Fah | 12279 | -0.111 | -0.1818 | No |
| 97 | Ccl25 | 12304 | -0.112 | -0.1799 | No |
| 98 | Gclc | 12530 | -0.121 | -0.1881 | No |
| 99 | Ptgds | 12544 | -0.122 | -0.1853 | No |
| 100 | Dhrs7 | 12632 | -0.126 | -0.1863 | No |
| 101 | F10 | 12699 | -0.128 | -0.1861 | No |
| 102 | Idh1 | 12701 | -0.128 | -0.1825 | No |
| 103 | Ndrg2 | 12866 | -0.135 | -0.1872 | No |
| 104 | Abhd6 | 12877 | -0.135 | -0.1839 | No |
| 105 | Ttpa | 12998 | -0.140 | -0.1861 | No |
| 106 | Ddah2 | 13095 | -0.144 | -0.1870 | No |
| 107 | Asl | 13148 | -0.146 | -0.1856 | No |
| 108 | Pdk4 | 13710 | -0.171 | -0.2098 | No |
| 109 | Nfs1 | 13890 | -0.178 | -0.2140 | No |
| 110 | Acp1 | 13931 | -0.180 | -0.2110 | No |
| 111 | Gcnt2 | 14131 | -0.189 | -0.2159 | No |
| 112 | Tdo2 | 14252 | -0.194 | -0.2167 | No |
| 113 | Blvrb | 14636 | -0.212 | -0.2305 | No |
| 114 | Ets2 | 14653 | -0.213 | -0.2253 | No |
| 115 | Mpp2 | 15170 | -0.238 | -0.2452 | Yes |
| 116 | Ppard | 15176 | -0.238 | -0.2388 | Yes |
| 117 | Hnf4a | 15224 | -0.241 | -0.2344 | Yes |
| 118 | Comt | 15301 | -0.246 | -0.2314 | Yes |
| 119 | Dcxr | 15541 | -0.258 | -0.2365 | Yes |
| 120 | Pemt | 15835 | -0.273 | -0.2439 | Yes |
| 121 | Vnn1 | 15935 | -0.280 | -0.2411 | Yes |
| 122 | Cyb5a | 15979 | -0.282 | -0.2354 | Yes |
| 123 | Esr1 | 16180 | -0.295 | -0.2374 | Yes |
| 124 | Upp1 | 16231 | -0.298 | -0.2316 | Yes |
| 125 | Mccc2 | 16299 | -0.303 | -0.2265 | Yes |
| 126 | Dhps | 16309 | -0.304 | -0.2184 | Yes |
| 127 | Irf8 | 16366 | -0.308 | -0.2126 | Yes |
| 128 | Upb1 | 16503 | -0.316 | -0.2107 | Yes |
| 129 | Cyp27a1 | 16661 | -0.326 | -0.2097 | Yes |
| 130 | Retsat | 16801 | -0.337 | -0.2073 | Yes |
| 131 | Gstt2 | 17362 | -0.377 | -0.2256 | Yes |
| 132 | Pcx | 17399 | -0.380 | -0.2168 | Yes |
| 133 | Hacl1 | 17408 | -0.381 | -0.2065 | Yes |
| 134 | Slc1a5 | 17438 | -0.384 | -0.1971 | Yes |
| 135 | Xdh | 17520 | -0.393 | -0.1902 | Yes |
| 136 | Cyp2j6 | 17550 | -0.395 | -0.1806 | Yes |
| 137 | Cat | 17578 | -0.400 | -0.1707 | Yes |
| 138 | Pycr1 | 17676 | -0.409 | -0.1642 | Yes |
| 139 | Ephx1 | 17993 | -0.443 | -0.1680 | Yes |
| 140 | Cbr1 | 18009 | -0.445 | -0.1563 | Yes |
| 141 | Pink1 | 18135 | -0.460 | -0.1497 | Yes |
| 142 | Angptl3 | 18217 | -0.470 | -0.1407 | Yes |
| 143 | Gch1 | 18248 | -0.474 | -0.1289 | Yes |
| 144 | Adh5 | 18378 | -0.489 | -0.1217 | Yes |
| 145 | Tpst1 | 18528 | -0.512 | -0.1150 | Yes |
| 146 | Fbp1 | 18585 | -0.521 | -0.1032 | Yes |
| 147 | Bphl | 18833 | -0.568 | -0.1000 | Yes |
| 148 | Slc46a3 | 18966 | -0.600 | -0.0899 | Yes |
| 149 | Abcd2 | 19007 | -0.610 | -0.0747 | Yes |
| 150 | Jup | 19160 | -0.673 | -0.0636 | Yes |
| 151 | Gsto1 | 19192 | -0.684 | -0.0459 | Yes |
| 152 | Car2 | 19202 | -0.687 | -0.0270 | Yes |
| 153 | Arg2 | 19326 | -0.762 | -0.0119 | Yes |
| 154 | Sertad1 | 19328 | -0.762 | 0.0095 | Yes |

