| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group3.MPP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | -0.20882851 |
| Normalized Enrichment Score (NES) | -0.89770365 |
| Nominal p-value | 0.6080508 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Csrnp2 | 87 | 0.788 | 0.0126 | No |
| 2 | Fos | 154 | 0.699 | 0.0243 | No |
| 3 | Ak1 | 165 | 0.688 | 0.0387 | No |
| 4 | Lif | 337 | 0.601 | 0.0429 | No |
| 5 | Acvr1b | 391 | 0.581 | 0.0527 | No |
| 6 | Plxnb2 | 445 | 0.569 | 0.0623 | No |
| 7 | Rab40c | 514 | 0.549 | 0.0707 | No |
| 8 | Zmat3 | 607 | 0.527 | 0.0773 | No |
| 9 | Eps8l2 | 843 | 0.474 | 0.0754 | No |
| 10 | Gls2 | 876 | 0.467 | 0.0839 | No |
| 11 | Jun | 923 | 0.462 | 0.0915 | No |
| 12 | Ada | 1016 | 0.449 | 0.0965 | No |
| 13 | Hexim1 | 1134 | 0.434 | 0.0999 | No |
| 14 | Rad9a | 1186 | 0.428 | 0.1065 | No |
| 15 | Txnip | 1212 | 0.424 | 0.1144 | No |
| 16 | Rrp8 | 1262 | 0.419 | 0.1209 | No |
| 17 | App | 1302 | 0.414 | 0.1279 | No |
| 18 | Ppp1r15a | 1660 | 0.376 | 0.1175 | No |
| 19 | Prmt2 | 1761 | 0.367 | 0.1203 | No |
| 20 | H2ac25 | 1812 | 0.361 | 0.1255 | No |
| 21 | Ccnd3 | 1890 | 0.356 | 0.1293 | No |
| 22 | Pcna | 1921 | 0.355 | 0.1354 | No |
| 23 | Hbegf | 1987 | 0.349 | 0.1396 | No |
| 24 | Vwa5a | 2001 | 0.348 | 0.1465 | No |
| 25 | Baiap2 | 2168 | 0.335 | 0.1451 | No |
| 26 | Ddit3 | 2183 | 0.335 | 0.1517 | No |
| 27 | Perp | 2237 | 0.329 | 0.1561 | No |
| 28 | Elp1 | 2275 | 0.327 | 0.1612 | No |
| 29 | Tspyl2 | 2316 | 0.324 | 0.1662 | No |
| 30 | Ccp110 | 2361 | 0.320 | 0.1709 | No |
| 31 | Sdc1 | 2654 | 0.301 | 0.1623 | No |
| 32 | Coq8a | 2734 | 0.296 | 0.1646 | No |
| 33 | Aen | 2746 | 0.295 | 0.1704 | No |
| 34 | H1f2 | 2852 | 0.288 | 0.1712 | No |
| 35 | Stom | 3185 | 0.266 | 0.1598 | No |
| 36 | Mdm2 | 3238 | 0.262 | 0.1628 | No |
| 37 | Cdkn1a | 4008 | 0.219 | 0.1278 | No |
| 38 | Cd82 | 4053 | 0.217 | 0.1302 | No |
| 39 | Cdk5r1 | 4207 | 0.210 | 0.1268 | No |
| 40 | Kif13b | 4474 | 0.196 | 0.1173 | No |
| 41 | Btg1 | 4483 | 0.195 | 0.1211 | No |
| 42 | Rxra | 4664 | 0.187 | 0.1158 | No |
| 43 | Abcc5 | 4670 | 0.186 | 0.1196 | No |
| 44 | Mapkapk3 | 5100 | 0.165 | 0.1010 | No |
| 45 | Apaf1 | 5141 | 0.164 | 0.1025 | No |
| 46 | Sat1 | 5185 | 0.161 | 0.1037 | No |
| 47 | Slc35d1 | 5239 | 0.158 | 0.1044 | No |
| 48 | Rad51c | 5458 | 0.147 | 0.0963 | No |
| 49 | S100a4 | 5517 | 0.145 | 0.0965 | No |
| 50 | Fbxw7 | 5572 | 0.142 | 0.0968 | No |
| 51 | Slc3a2 | 5706 | 0.136 | 0.0928 | No |
| 52 | Slc19a2 | 5938 | 0.127 | 0.0836 | No |
| 53 | Sec61a1 | 5954 | 0.126 | 0.0856 | No |
| 54 | Rhbdf2 | 6197 | 0.117 | 0.0756 | No |
| 55 | Jag2 | 6427 | 0.107 | 0.0661 | No |
| 56 | Tsc22d1 | 6462 | 0.105 | 0.0666 | No |
| 57 | Polh | 6495 | 0.103 | 0.0672 | No |
| 58 | Foxo3 | 6643 | 0.098 | 0.0617 | No |
| 59 | Atf3 | 6651 | 0.098 | 0.0634 | No |
| 60 | Nol8 | 6874 | 0.088 | 0.0538 | No |
| 61 | Ip6k2 | 6902 | 0.087 | 0.0543 | No |
| 62 | Hmox1 | 7062 | 0.081 | 0.0479 | No |
| 63 | Nupr1 | 7084 | 0.080 | 0.0485 | No |
| 64 | Ier5 | 7109 | 0.080 | 0.0490 | No |
| 65 | Ccng1 | 7196 | 0.077 | 0.0462 | No |
| 66 | Pmm1 | 7337 | 0.072 | 0.0405 | No |
| 67 | Abhd4 | 7462 | 0.067 | 0.0356 | No |
| 68 | Sfn | 7505 | 0.065 | 0.0348 | No |
| 69 | Xpc | 7551 | 0.064 | 0.0339 | No |
| 70 | Blcap | 7635 | 0.061 | 0.0309 | No |
| 71 | Wwp1 | 7862 | 0.052 | 0.0203 | No |
| 72 | S100a10 | 7878 | 0.052 | 0.0207 | No |
| 73 | Ier3 | 7906 | 0.050 | 0.0204 | No |
| 74 | Zfp365 | 8357 | 0.033 | -0.0022 | No |
| 75 | Rb1 | 8412 | 0.031 | -0.0043 | No |
| 76 | Rap2b | 8557 | 0.025 | -0.0112 | No |
| 77 | Ifi30 | 8935 | 0.013 | -0.0304 | No |
| 78 | Ctsd | 8944 | 0.012 | -0.0306 | No |
| 79 | Slc7a11 | 8946 | 0.012 | -0.0304 | No |
| 80 | Sertad3 | 8985 | 0.011 | -0.0321 | No |
| 81 | Ctsf | 9033 | 0.009 | -0.0343 | No |
| 82 | Pdgfa | 9105 | 0.007 | -0.0379 | No |
| 83 | Cdh13 | 9195 | 0.003 | -0.0424 | No |
| 84 | Procr | 9209 | 0.003 | -0.0430 | No |
| 85 | Cgrrf1 | 9336 | -0.001 | -0.0495 | No |
| 86 | Hspa4l | 9492 | -0.007 | -0.0574 | No |
| 87 | Triap1 | 10087 | -0.028 | -0.0875 | No |
| 88 | Plk3 | 10090 | -0.028 | -0.0870 | No |
| 89 | Ddb2 | 10172 | -0.031 | -0.0905 | No |
| 90 | Trafd1 | 10257 | -0.035 | -0.0941 | No |
| 91 | Sp1 | 10573 | -0.047 | -0.1094 | No |
| 92 | Mknk2 | 10606 | -0.048 | -0.1100 | No |
| 93 | Itgb4 | 10921 | -0.059 | -0.1250 | No |
| 94 | Fas | 10999 | -0.061 | -0.1276 | No |
| 95 | Trp53 | 11041 | -0.063 | -0.1284 | No |
| 96 | Tap1 | 11244 | -0.071 | -0.1373 | No |
| 97 | Pidd1 | 11247 | -0.071 | -0.1359 | No |
| 98 | Cdkn2a | 11276 | -0.072 | -0.1358 | No |
| 99 | Dnttip2 | 11380 | -0.076 | -0.1395 | No |
| 100 | Ninj1 | 11438 | -0.078 | -0.1407 | No |
| 101 | Epha2 | 11522 | -0.080 | -0.1433 | No |
| 102 | Plk2 | 11690 | -0.087 | -0.1501 | No |
| 103 | Pom121 | 11762 | -0.091 | -0.1518 | No |
| 104 | Zfp36l1 | 11765 | -0.091 | -0.1499 | No |
| 105 | H2aj | 11904 | -0.095 | -0.1550 | No |
| 106 | Tax1bp3 | 11984 | -0.099 | -0.1569 | No |
| 107 | Pvt1 | 12008 | -0.100 | -0.1559 | No |
| 108 | Cyfip2 | 12027 | -0.101 | -0.1546 | No |
| 109 | Traf4 | 12063 | -0.102 | -0.1542 | No |
| 110 | Phlda3 | 12292 | -0.112 | -0.1636 | No |
| 111 | Zbtb16 | 12324 | -0.113 | -0.1628 | No |
| 112 | Rpl36 | 12382 | -0.116 | -0.1632 | No |
| 113 | Ei24 | 12454 | -0.118 | -0.1643 | No |
| 114 | Hras | 12554 | -0.123 | -0.1668 | No |
| 115 | Ptpn14 | 12857 | -0.135 | -0.1795 | No |
| 116 | Klk8 | 12924 | -0.138 | -0.1799 | No |
| 117 | Bax | 12965 | -0.139 | -0.1790 | No |
| 118 | Wrap73 | 13025 | -0.141 | -0.1790 | No |
| 119 | Casp1 | 13238 | -0.149 | -0.1867 | No |
| 120 | Ddit4 | 13242 | -0.149 | -0.1836 | No |
| 121 | Irak1 | 13290 | -0.152 | -0.1828 | No |
| 122 | Tnfsf9 | 13340 | -0.154 | -0.1820 | No |
| 123 | Ppm1d | 13391 | -0.156 | -0.1812 | No |
| 124 | Hint1 | 13460 | -0.159 | -0.1813 | No |
| 125 | Cebpa | 13523 | -0.162 | -0.1810 | No |
| 126 | Gadd45a | 13667 | -0.169 | -0.1847 | No |
| 127 | Trp63 | 13959 | -0.181 | -0.1958 | No |
| 128 | Rps12 | 13990 | -0.182 | -0.1934 | No |
| 129 | Irag2 | 14106 | -0.187 | -0.1953 | No |
| 130 | Vamp8 | 14351 | -0.198 | -0.2037 | Yes |
| 131 | Fdxr | 14383 | -0.200 | -0.2009 | Yes |
| 132 | Fgf13 | 14442 | -0.203 | -0.1995 | Yes |
| 133 | Dram1 | 14598 | -0.210 | -0.2030 | Yes |
| 134 | Btg2 | 14644 | -0.213 | -0.2007 | Yes |
| 135 | Ralgds | 14659 | -0.214 | -0.1968 | Yes |
| 136 | Prkab1 | 14669 | -0.214 | -0.1926 | Yes |
| 137 | Gm2a | 14729 | -0.217 | -0.1910 | Yes |
| 138 | Rpl18 | 14747 | -0.218 | -0.1871 | Yes |
| 139 | Pitpnc1 | 14895 | -0.225 | -0.1899 | Yes |
| 140 | Rack1 | 15034 | -0.232 | -0.1920 | Yes |
| 141 | Nudt15 | 15124 | -0.236 | -0.1915 | Yes |
| 142 | Iscu | 15178 | -0.238 | -0.1891 | Yes |
| 143 | Hdac3 | 15388 | -0.249 | -0.1945 | Yes |
| 144 | Dgka | 15472 | -0.254 | -0.1933 | Yes |
| 145 | Dcxr | 15541 | -0.258 | -0.1912 | Yes |
| 146 | Rps27l | 15694 | -0.267 | -0.1933 | Yes |
| 147 | Vdr | 15712 | -0.267 | -0.1884 | Yes |
| 148 | Tgfa | 16100 | -0.290 | -0.2021 | Yes |
| 149 | Upp1 | 16231 | -0.298 | -0.2024 | Yes |
| 150 | Tpd52l1 | 16261 | -0.300 | -0.1974 | Yes |
| 151 | Notch1 | 16312 | -0.304 | -0.1934 | Yes |
| 152 | Rrad | 16404 | -0.310 | -0.1913 | Yes |
| 153 | Def6 | 16540 | -0.319 | -0.1914 | Yes |
| 154 | Ccnk | 16726 | -0.332 | -0.1938 | Yes |
| 155 | Retsat | 16801 | -0.337 | -0.1903 | Yes |
| 156 | Socs1 | 16853 | -0.340 | -0.1856 | Yes |
| 157 | Ptpre | 16862 | -0.341 | -0.1786 | Yes |
| 158 | Fuca1 | 16898 | -0.343 | -0.1730 | Yes |
| 159 | Tgfb1 | 16902 | -0.344 | -0.1657 | Yes |
| 160 | Sphk1 | 16923 | -0.346 | -0.1592 | Yes |
| 161 | Ndrg1 | 17084 | -0.356 | -0.1598 | Yes |
| 162 | Sesn1 | 17144 | -0.361 | -0.1550 | Yes |
| 163 | Mxd4 | 17225 | -0.366 | -0.1512 | Yes |
| 164 | F2r | 17405 | -0.380 | -0.1523 | Yes |
| 165 | Mxd1 | 17528 | -0.394 | -0.1500 | Yes |
| 166 | Ercc5 | 17552 | -0.396 | -0.1427 | Yes |
| 167 | Rnf19b | 17572 | -0.399 | -0.1350 | Yes |
| 168 | Bak1 | 17577 | -0.399 | -0.1266 | Yes |
| 169 | Fam162a | 17586 | -0.401 | -0.1183 | Yes |
| 170 | Cd81 | 17728 | -0.413 | -0.1166 | Yes |
| 171 | Klf4 | 17911 | -0.433 | -0.1167 | Yes |
| 172 | Cdkn2aip | 17980 | -0.442 | -0.1106 | Yes |
| 173 | Ephx1 | 17993 | -0.443 | -0.1016 | Yes |
| 174 | Rchy1 | 18087 | -0.455 | -0.0966 | Yes |
| 175 | Osgin1 | 18341 | -0.484 | -0.0992 | Yes |
| 176 | Tprkb | 18451 | -0.500 | -0.0940 | Yes |
| 177 | Abat | 18508 | -0.510 | -0.0858 | Yes |
| 178 | Tcn2 | 18622 | -0.528 | -0.0802 | Yes |
| 179 | Tob1 | 18695 | -0.542 | -0.0722 | Yes |
| 180 | Ankra2 | 18707 | -0.544 | -0.0610 | Yes |
| 181 | Steap3 | 18773 | -0.554 | -0.0524 | Yes |
| 182 | St14 | 18777 | -0.555 | -0.0405 | Yes |
| 183 | Tm7sf3 | 19088 | -0.636 | -0.0428 | Yes |
| 184 | Ldhb | 19149 | -0.667 | -0.0314 | Yes |
| 185 | Alox8 | 19156 | -0.671 | -0.0172 | Yes |
| 186 | Ccnd2 | 19194 | -0.684 | -0.0043 | Yes |
| 187 | Trib3 | 19471 | -0.954 | 0.0021 | Yes |

