| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group3.MPP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.27856746 |
| Normalized Enrichment Score (NES) | 1.1634173 |
| Nominal p-value | 0.2510204 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.96 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Nfkbib | 204 | 0.663 | 0.0060 | Yes |
| 2 | Bhlhe40 | 304 | 0.614 | 0.0162 | Yes |
| 3 | Tmem97 | 375 | 0.588 | 0.0273 | Yes |
| 4 | Psmc4 | 457 | 0.565 | 0.0372 | Yes |
| 5 | Canx | 469 | 0.563 | 0.0507 | Yes |
| 6 | Mcm4 | 487 | 0.558 | 0.0637 | Yes |
| 7 | Hspa9 | 497 | 0.554 | 0.0771 | Yes |
| 8 | Hspa4 | 531 | 0.545 | 0.0890 | Yes |
| 9 | Vldlr | 572 | 0.535 | 0.1003 | Yes |
| 10 | Pgk1 | 794 | 0.481 | 0.1009 | Yes |
| 11 | Edem1 | 915 | 0.464 | 0.1062 | Yes |
| 12 | Mcm2 | 1156 | 0.431 | 0.1046 | Yes |
| 13 | Hsp90b1 | 1178 | 0.429 | 0.1142 | Yes |
| 14 | Fads2 | 1187 | 0.428 | 0.1245 | Yes |
| 15 | Abcf2 | 1402 | 0.401 | 0.1234 | Yes |
| 16 | Gpi1 | 1475 | 0.393 | 0.1295 | Yes |
| 17 | Hspd1 | 1550 | 0.387 | 0.1353 | Yes |
| 18 | Rab1a | 1632 | 0.379 | 0.1406 | Yes |
| 19 | Ppp1r15a | 1660 | 0.376 | 0.1486 | Yes |
| 20 | Nampt | 1664 | 0.375 | 0.1578 | Yes |
| 21 | Psph | 1677 | 0.374 | 0.1666 | Yes |
| 22 | Ssr1 | 1696 | 0.372 | 0.1749 | Yes |
| 23 | Acsl3 | 1875 | 0.357 | 0.1746 | Yes |
| 24 | Cct6a | 1880 | 0.357 | 0.1833 | Yes |
| 25 | Stard4 | 1932 | 0.354 | 0.1895 | Yes |
| 26 | Hmbs | 1947 | 0.353 | 0.1976 | Yes |
| 27 | Hmgcr | 1986 | 0.349 | 0.2044 | Yes |
| 28 | Fgl2 | 2027 | 0.346 | 0.2109 | Yes |
| 29 | Cacybp | 2045 | 0.344 | 0.2186 | Yes |
| 30 | Tm7sf2 | 2086 | 0.342 | 0.2251 | Yes |
| 31 | Serp1 | 2105 | 0.340 | 0.2327 | Yes |
| 32 | Cyp51 | 2110 | 0.340 | 0.2410 | Yes |
| 33 | Ddit3 | 2183 | 0.335 | 0.2456 | Yes |
| 34 | Txnrd1 | 2215 | 0.331 | 0.2523 | Yes |
| 35 | Gga2 | 2232 | 0.330 | 0.2597 | Yes |
| 36 | Tfrc | 2411 | 0.318 | 0.2584 | Yes |
| 37 | Ube2d3 | 2545 | 0.309 | 0.2592 | Yes |
| 38 | Wars1 | 2835 | 0.289 | 0.2515 | Yes |
| 39 | Gla | 2978 | 0.279 | 0.2511 | Yes |
| 40 | Sord | 3098 | 0.272 | 0.2518 | Yes |
| 41 | Rpa1 | 3133 | 0.269 | 0.2567 | Yes |
| 42 | Cdc25a | 3159 | 0.268 | 0.2621 | Yes |
| 43 | Cops5 | 3220 | 0.264 | 0.2656 | Yes |
| 44 | Got1 | 3319 | 0.256 | 0.2669 | Yes |
| 45 | Skap2 | 3351 | 0.254 | 0.2717 | Yes |
| 46 | Ebp | 3390 | 0.252 | 0.2760 | Yes |
| 47 | Actr2 | 3515 | 0.245 | 0.2757 | Yes |
| 48 | Lgmn | 3745 | 0.232 | 0.2697 | Yes |
| 49 | Hspa5 | 3784 | 0.230 | 0.2734 | Yes |
| 50 | Rpn1 | 3935 | 0.222 | 0.2712 | Yes |
| 51 | Pitpnb | 3936 | 0.222 | 0.2768 | Yes |
| 52 | Cdkn1a | 4008 | 0.219 | 0.2786 | Yes |
| 53 | Acly | 4158 | 0.212 | 0.2762 | No |
| 54 | Slc1a4 | 4270 | 0.206 | 0.2756 | No |
| 55 | Pno1 | 4520 | 0.193 | 0.2675 | No |
| 56 | Elovl6 | 4614 | 0.189 | 0.2674 | No |
| 57 | Nup205 | 4750 | 0.183 | 0.2650 | No |
| 58 | Nfyc | 4818 | 0.179 | 0.2660 | No |
| 59 | Aurka | 4841 | 0.177 | 0.2693 | No |
| 60 | Ddx39a | 4877 | 0.175 | 0.2718 | No |
| 61 | Hk2 | 5062 | 0.167 | 0.2665 | No |
| 62 | Stip1 | 5167 | 0.162 | 0.2651 | No |
| 63 | Calr | 5186 | 0.161 | 0.2682 | No |
| 64 | Me1 | 5208 | 0.160 | 0.2711 | No |
| 65 | Actr3 | 5386 | 0.151 | 0.2657 | No |
| 66 | Etf1 | 5628 | 0.140 | 0.2568 | No |
| 67 | Bcat1 | 5645 | 0.139 | 0.2594 | No |
| 68 | Ifrd1 | 5678 | 0.138 | 0.2612 | No |
| 69 | Immt | 5834 | 0.132 | 0.2565 | No |
| 70 | Pfkl | 5890 | 0.129 | 0.2569 | No |
| 71 | Ero1a | 6013 | 0.123 | 0.2536 | No |
| 72 | Pnp | 6035 | 0.123 | 0.2556 | No |
| 73 | Bub1 | 6345 | 0.110 | 0.2424 | No |
| 74 | Plod2 | 6407 | 0.107 | 0.2419 | No |
| 75 | Map2k3 | 6409 | 0.107 | 0.2445 | No |
| 76 | Uso1 | 6441 | 0.106 | 0.2456 | No |
| 77 | Ppa1 | 6477 | 0.104 | 0.2464 | No |
| 78 | Rdh11 | 6509 | 0.103 | 0.2473 | No |
| 79 | Sc5d | 6682 | 0.096 | 0.2408 | No |
| 80 | Sytl2 | 6743 | 0.093 | 0.2400 | No |
| 81 | Rrm2 | 6792 | 0.091 | 0.2398 | No |
| 82 | Srd5a1 | 6841 | 0.089 | 0.2396 | No |
| 83 | Tbk1 | 6923 | 0.086 | 0.2376 | No |
| 84 | Asns | 6948 | 0.086 | 0.2384 | No |
| 85 | Shmt2 | 7025 | 0.082 | 0.2366 | No |
| 86 | Psmd14 | 7067 | 0.081 | 0.2365 | No |
| 87 | Nupr1 | 7084 | 0.080 | 0.2376 | No |
| 88 | Psma4 | 7172 | 0.078 | 0.2351 | No |
| 89 | Ccng1 | 7196 | 0.077 | 0.2358 | No |
| 90 | Cyb5b | 7223 | 0.076 | 0.2364 | No |
| 91 | G6pdx | 7311 | 0.073 | 0.2337 | No |
| 92 | Pdk1 | 7328 | 0.072 | 0.2347 | No |
| 93 | Psmb5 | 7360 | 0.071 | 0.2348 | No |
| 94 | Psmd12 | 7431 | 0.068 | 0.2329 | No |
| 95 | Hspe1 | 7598 | 0.062 | 0.2259 | No |
| 96 | Hmgcs1 | 7921 | 0.050 | 0.2104 | No |
| 97 | Pgm1 | 7988 | 0.047 | 0.2082 | No |
| 98 | Psmc2 | 8090 | 0.044 | 0.2041 | No |
| 99 | Fads1 | 8131 | 0.042 | 0.2031 | No |
| 100 | Gsk3b | 8170 | 0.040 | 0.2021 | No |
| 101 | Uchl5 | 8268 | 0.036 | 0.1980 | No |
| 102 | Idi1 | 8351 | 0.033 | 0.1946 | No |
| 103 | Ppia | 8368 | 0.033 | 0.1946 | No |
| 104 | Ldha | 8434 | 0.030 | 0.1920 | No |
| 105 | Xbp1 | 8648 | 0.022 | 0.1815 | No |
| 106 | Tes | 8720 | 0.019 | 0.1783 | No |
| 107 | M6pr | 8810 | 0.017 | 0.1741 | No |
| 108 | Ifi30 | 8935 | 0.013 | 0.1680 | No |
| 109 | Slc7a11 | 8946 | 0.012 | 0.1678 | No |
| 110 | Add3 | 9082 | 0.007 | 0.1610 | No |
| 111 | Nmt1 | 9218 | 0.002 | 0.1540 | No |
| 112 | Lta4h | 9319 | -0.001 | 0.1489 | No |
| 113 | Prdx1 | 9422 | -0.004 | 0.1437 | No |
| 114 | Ykt6 | 9463 | -0.006 | 0.1418 | No |
| 115 | Gsr | 9547 | -0.009 | 0.1377 | No |
| 116 | Sqstm1 | 9579 | -0.010 | 0.1364 | No |
| 117 | Sqle | 9701 | -0.014 | 0.1304 | No |
| 118 | Tomm40 | 9855 | -0.020 | 0.1230 | No |
| 119 | Acaca | 10137 | -0.030 | 0.1092 | No |
| 120 | Niban1 | 10170 | -0.031 | 0.1083 | No |
| 121 | Atp2a2 | 10237 | -0.034 | 0.1058 | No |
| 122 | Gbe1 | 10264 | -0.035 | 0.1053 | No |
| 123 | Gmps | 10291 | -0.036 | 0.1048 | No |
| 124 | Aldoa | 10628 | -0.048 | 0.0887 | No |
| 125 | Slc6a6 | 10629 | -0.048 | 0.0899 | No |
| 126 | Psat1 | 10661 | -0.049 | 0.0895 | No |
| 127 | Ldlr | 10801 | -0.054 | 0.0836 | No |
| 128 | Fkbp2 | 10828 | -0.056 | 0.0837 | No |
| 129 | Pdap1 | 11034 | -0.062 | 0.0746 | No |
| 130 | Gtf2h1 | 11174 | -0.068 | 0.0691 | No |
| 131 | Psmg1 | 11439 | -0.078 | 0.0574 | No |
| 132 | Elovl5 | 11624 | -0.084 | 0.0500 | No |
| 133 | Eif2s2 | 11661 | -0.086 | 0.0503 | No |
| 134 | Tpi1 | 11843 | -0.094 | 0.0433 | No |
| 135 | Dhcr24 | 11851 | -0.094 | 0.0453 | No |
| 136 | Insig1 | 11895 | -0.095 | 0.0454 | No |
| 137 | Slc2a1 | 11956 | -0.098 | 0.0448 | No |
| 138 | Ung | 12071 | -0.103 | 0.0414 | No |
| 139 | Sec11a | 12091 | -0.103 | 0.0430 | No |
| 140 | Tcea1 | 12189 | -0.107 | 0.0407 | No |
| 141 | Cxcr4 | 12238 | -0.109 | 0.0409 | No |
| 142 | Egln3 | 12362 | -0.115 | 0.0374 | No |
| 143 | Sla | 12363 | -0.115 | 0.0403 | No |
| 144 | Glrx | 12473 | -0.119 | 0.0376 | No |
| 145 | Gclc | 12530 | -0.121 | 0.0378 | No |
| 146 | Qdpr | 12596 | -0.124 | 0.0375 | No |
| 147 | Idh1 | 12701 | -0.128 | 0.0353 | No |
| 148 | Ctsc | 12710 | -0.129 | 0.0381 | No |
| 149 | Tubg1 | 12798 | -0.132 | 0.0369 | No |
| 150 | Coro1a | 13001 | -0.140 | 0.0300 | No |
| 151 | Adipor2 | 13111 | -0.145 | 0.0280 | No |
| 152 | Slc7a5 | 13136 | -0.146 | 0.0304 | No |
| 153 | Slc37a4 | 13181 | -0.148 | 0.0318 | No |
| 154 | Nufip1 | 13185 | -0.148 | 0.0353 | No |
| 155 | Itgb2 | 13228 | -0.149 | 0.0368 | No |
| 156 | Ddit4 | 13242 | -0.149 | 0.0399 | No |
| 157 | Nfil3 | 13328 | -0.154 | 0.0393 | No |
| 158 | Serpinh1 | 13386 | -0.156 | 0.0403 | No |
| 159 | Rit1 | 13527 | -0.162 | 0.0371 | No |
| 160 | Psmc6 | 13622 | -0.167 | 0.0364 | No |
| 161 | Psmd13 | 13740 | -0.172 | 0.0346 | No |
| 162 | Psma3 | 13758 | -0.172 | 0.0381 | No |
| 163 | Sdf2l1 | 13798 | -0.174 | 0.0404 | No |
| 164 | Psme3 | 14236 | -0.193 | 0.0226 | No |
| 165 | Eef1e1 | 14246 | -0.194 | 0.0270 | No |
| 166 | Atp6v1d | 14313 | -0.197 | 0.0285 | No |
| 167 | Fdxr | 14383 | -0.200 | 0.0299 | No |
| 168 | Btg2 | 14644 | -0.213 | 0.0218 | No |
| 169 | Dhfr | 15079 | -0.234 | 0.0052 | No |
| 170 | Cd9 | 15280 | -0.245 | 0.0009 | No |
| 171 | Mthfd2l | 15299 | -0.246 | 0.0061 | No |
| 172 | Mllt11 | 15617 | -0.262 | -0.0037 | No |
| 173 | Ccnf | 15970 | -0.281 | -0.0149 | No |
| 174 | Dapp1 | 16018 | -0.284 | -0.0103 | No |
| 175 | Ak4 | 16060 | -0.286 | -0.0052 | No |
| 176 | Rrp9 | 16266 | -0.301 | -0.0083 | No |
| 177 | Tuba4a | 16353 | -0.307 | -0.0051 | No |
| 178 | Ufm1 | 16357 | -0.307 | 0.0024 | No |
| 179 | Mthfd2 | 16542 | -0.319 | 0.0008 | No |
| 180 | Arpc5l | 17227 | -0.366 | -0.0254 | No |
| 181 | Dhcr7 | 17269 | -0.369 | -0.0183 | No |
| 182 | Polr3g | 17409 | -0.381 | -0.0160 | No |
| 183 | Slc1a5 | 17438 | -0.384 | -0.0079 | No |
| 184 | Slc2a3 | 17789 | -0.419 | -0.0155 | No |
| 185 | Phgdh | 17808 | -0.421 | -0.0059 | No |
| 186 | P4ha1 | 17866 | -0.429 | 0.0019 | No |
| 187 | Plk1 | 18063 | -0.451 | 0.0030 | No |
| 188 | Eno1b | 18152 | -0.462 | 0.0100 | No |
| 189 | Cfp | 18497 | -0.508 | 0.0049 | No |
| 190 | Pik3r3 | 19469 | -0.950 | -0.0217 | No |
| 191 | Trib3 | 19471 | -0.954 | 0.0021 | No |

