| Dataset | MPP.MPP_Pheno.cls#Group2_versus_Group3.MPP_Pheno.cls#Group2_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_HEME_METABOLISM |
| Enrichment Score (ES) | 0.18341471 |
| Normalized Enrichment Score (NES) | 0.94474155 |
| Nominal p-value | 0.6115538 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Acsl6 | 57 | 0.862 | 0.0203 | Yes |
| 2 | C3 | 124 | 0.744 | 0.0369 | Yes |
| 3 | Sptb | 476 | 0.560 | 0.0338 | Yes |
| 4 | Khnyn | 543 | 0.541 | 0.0450 | Yes |
| 5 | Snca | 603 | 0.527 | 0.0561 | Yes |
| 6 | Uros | 735 | 0.495 | 0.0627 | Yes |
| 7 | Marchf8 | 1125 | 0.435 | 0.0543 | Yes |
| 8 | Fech | 1321 | 0.412 | 0.0553 | Yes |
| 9 | Abcb6 | 1506 | 0.391 | 0.0563 | Yes |
| 10 | Slc30a1 | 1620 | 0.380 | 0.0607 | Yes |
| 11 | Bmp2k | 1725 | 0.370 | 0.0652 | Yes |
| 12 | Lamp2 | 1751 | 0.367 | 0.0738 | Yes |
| 13 | Nudt4 | 1806 | 0.362 | 0.0808 | Yes |
| 14 | Acp5 | 1869 | 0.358 | 0.0872 | Yes |
| 15 | Ccnd3 | 1890 | 0.356 | 0.0958 | Yes |
| 16 | Tyr | 1898 | 0.355 | 0.1050 | Yes |
| 17 | Hmbs | 1947 | 0.353 | 0.1120 | Yes |
| 18 | H1f0 | 2017 | 0.347 | 0.1177 | Yes |
| 19 | Rhd | 2044 | 0.344 | 0.1257 | Yes |
| 20 | Igsf3 | 2139 | 0.338 | 0.1299 | Yes |
| 21 | Tfrc | 2411 | 0.318 | 0.1244 | Yes |
| 22 | Riok3 | 2418 | 0.317 | 0.1327 | Yes |
| 23 | Mboat2 | 2577 | 0.306 | 0.1327 | Yes |
| 24 | Epb42 | 2719 | 0.297 | 0.1334 | Yes |
| 25 | Ctns | 2775 | 0.294 | 0.1385 | Yes |
| 26 | Sdcbp | 2845 | 0.288 | 0.1427 | Yes |
| 27 | Synj1 | 2862 | 0.287 | 0.1496 | Yes |
| 28 | Epb41 | 2875 | 0.286 | 0.1567 | Yes |
| 29 | Ccdc28a | 2917 | 0.284 | 0.1622 | Yes |
| 30 | Rhag | 3028 | 0.277 | 0.1640 | Yes |
| 31 | Top1 | 3189 | 0.266 | 0.1629 | Yes |
| 32 | P4ha2 | 3331 | 0.255 | 0.1624 | Yes |
| 33 | Klf3 | 3403 | 0.251 | 0.1655 | Yes |
| 34 | Picalm | 3413 | 0.250 | 0.1718 | Yes |
| 35 | Lpin2 | 3539 | 0.243 | 0.1719 | Yes |
| 36 | Nr3c1 | 3651 | 0.237 | 0.1725 | Yes |
| 37 | Rap1gap | 3690 | 0.236 | 0.1769 | Yes |
| 38 | Sec14l1 | 3792 | 0.230 | 0.1779 | Yes |
| 39 | Daam1 | 3805 | 0.229 | 0.1834 | Yes |
| 40 | Ank1 | 4155 | 0.212 | 0.1711 | No |
| 41 | Narf | 4161 | 0.212 | 0.1765 | No |
| 42 | Adipor1 | 4181 | 0.211 | 0.1812 | No |
| 43 | Slc4a1 | 4419 | 0.198 | 0.1743 | No |
| 44 | Nfe2l1 | 4708 | 0.184 | 0.1644 | No |
| 45 | Blvra | 4801 | 0.180 | 0.1645 | No |
| 46 | Arhgef12 | 4923 | 0.174 | 0.1629 | No |
| 47 | Aldh1l1 | 4953 | 0.173 | 0.1660 | No |
| 48 | Fn3k | 4961 | 0.172 | 0.1703 | No |
| 49 | Ubac1 | 4973 | 0.172 | 0.1744 | No |
| 50 | Fbxo34 | 4981 | 0.171 | 0.1786 | No |
| 51 | Minpp1 | 5057 | 0.168 | 0.1793 | No |
| 52 | Atg4a | 5158 | 0.163 | 0.1785 | No |
| 53 | Add1 | 5509 | 0.145 | 0.1643 | No |
| 54 | Dcaf11 | 5562 | 0.142 | 0.1654 | No |
| 55 | Myl4 | 5591 | 0.141 | 0.1678 | No |
| 56 | Kdm7a | 5891 | 0.129 | 0.1558 | No |
| 57 | Endod1 | 5984 | 0.124 | 0.1544 | No |
| 58 | Fbxo9 | 6105 | 0.121 | 0.1514 | No |
| 59 | Optn | 6339 | 0.110 | 0.1423 | No |
| 60 | Gapvd1 | 6390 | 0.108 | 0.1426 | No |
| 61 | Eif2ak1 | 6396 | 0.108 | 0.1453 | No |
| 62 | Map2k3 | 6409 | 0.107 | 0.1475 | No |
| 63 | Foxo3 | 6643 | 0.098 | 0.1381 | No |
| 64 | Agpat4 | 6678 | 0.096 | 0.1390 | No |
| 65 | Asns | 6948 | 0.086 | 0.1273 | No |
| 66 | Cpox | 6970 | 0.084 | 0.1285 | No |
| 67 | Ermap | 7173 | 0.078 | 0.1202 | No |
| 68 | Htatip2 | 7179 | 0.078 | 0.1220 | No |
| 69 | Trak2 | 7201 | 0.077 | 0.1230 | No |
| 70 | Ranbp10 | 7370 | 0.071 | 0.1162 | No |
| 71 | Slc6a8 | 7374 | 0.070 | 0.1179 | No |
| 72 | Xpo7 | 7412 | 0.069 | 0.1179 | No |
| 73 | Car1 | 7435 | 0.068 | 0.1186 | No |
| 74 | Ctse | 7518 | 0.065 | 0.1161 | No |
| 75 | Rcl1 | 7690 | 0.059 | 0.1088 | No |
| 76 | Gata1 | 7827 | 0.054 | 0.1032 | No |
| 77 | Ncoa4 | 7856 | 0.053 | 0.1032 | No |
| 78 | Foxj2 | 7959 | 0.049 | 0.0992 | No |
| 79 | Xk | 8033 | 0.046 | 0.0967 | No |
| 80 | Mark3 | 8068 | 0.045 | 0.0961 | No |
| 81 | Ctsb | 8077 | 0.044 | 0.0969 | No |
| 82 | Slc22a4 | 8115 | 0.043 | 0.0961 | No |
| 83 | Mkrn1 | 8138 | 0.042 | 0.0961 | No |
| 84 | Htra2 | 8157 | 0.041 | 0.0963 | No |
| 85 | Rad23a | 8162 | 0.041 | 0.0972 | No |
| 86 | Urod | 8415 | 0.031 | 0.0850 | No |
| 87 | Smox | 8731 | 0.019 | 0.0692 | No |
| 88 | Hdgf | 8779 | 0.017 | 0.0672 | No |
| 89 | Hebp1 | 8855 | 0.015 | 0.0638 | No |
| 90 | Slc7a11 | 8946 | 0.012 | 0.0595 | No |
| 91 | Cast | 9065 | 0.008 | 0.0536 | No |
| 92 | Tnrc6b | 9143 | 0.005 | 0.0497 | No |
| 93 | Pgls | 9249 | 0.001 | 0.0443 | No |
| 94 | Add2 | 9332 | -0.001 | 0.0401 | No |
| 95 | Bsg | 9427 | -0.004 | 0.0353 | No |
| 96 | Mxi1 | 9498 | -0.007 | 0.0319 | No |
| 97 | Tal1 | 9727 | -0.015 | 0.0205 | No |
| 98 | Gclm | 9740 | -0.016 | 0.0203 | No |
| 99 | Rbm5 | 9843 | -0.019 | 0.0156 | No |
| 100 | Slc25a38 | 9999 | -0.025 | 0.0082 | No |
| 101 | Nnt | 10063 | -0.027 | 0.0057 | No |
| 102 | Bnip3l | 10111 | -0.029 | 0.0040 | No |
| 103 | Nek7 | 10129 | -0.029 | 0.0040 | No |
| 104 | Spta1 | 10156 | -0.031 | 0.0034 | No |
| 105 | Gmps | 10291 | -0.036 | -0.0025 | No |
| 106 | Psmd9 | 10510 | -0.044 | -0.0126 | No |
| 107 | Cdr2 | 10691 | -0.050 | -0.0206 | No |
| 108 | Btrc | 10704 | -0.050 | -0.0199 | No |
| 109 | Bach1 | 10756 | -0.052 | -0.0211 | No |
| 110 | Klf1 | 10829 | -0.056 | -0.0233 | No |
| 111 | Ezh1 | 10897 | -0.058 | -0.0252 | No |
| 112 | Tmem9b | 11006 | -0.061 | -0.0291 | No |
| 113 | Tfdp2 | 11016 | -0.062 | -0.0279 | No |
| 114 | Cir1 | 11050 | -0.063 | -0.0279 | No |
| 115 | Usp15 | 11061 | -0.064 | -0.0267 | No |
| 116 | Dcaf10 | 11071 | -0.064 | -0.0255 | No |
| 117 | E2f2 | 11381 | -0.076 | -0.0394 | No |
| 118 | Tns1 | 11459 | -0.079 | -0.0413 | No |
| 119 | Kel | 11469 | -0.079 | -0.0396 | No |
| 120 | Rnf19a | 11671 | -0.086 | -0.0477 | No |
| 121 | Mfhas1 | 11778 | -0.091 | -0.0507 | No |
| 122 | Tspan5 | 11800 | -0.092 | -0.0493 | No |
| 123 | Cdc27 | 11832 | -0.094 | -0.0484 | No |
| 124 | Rnf123 | 11869 | -0.095 | -0.0477 | No |
| 125 | Tent5c | 11897 | -0.095 | -0.0466 | No |
| 126 | Clcn3 | 11953 | -0.097 | -0.0468 | No |
| 127 | Slc2a1 | 11956 | -0.098 | -0.0443 | No |
| 128 | Aldh6a1 | 11968 | -0.099 | -0.0422 | No |
| 129 | Bcam | 12081 | -0.103 | -0.0452 | No |
| 130 | Prdx2 | 12183 | -0.107 | -0.0475 | No |
| 131 | Tcea1 | 12189 | -0.107 | -0.0449 | No |
| 132 | Vezf1 | 12208 | -0.108 | -0.0429 | No |
| 133 | Slc10a3 | 12273 | -0.111 | -0.0433 | No |
| 134 | Pdzk1ip1 | 12300 | -0.112 | -0.0416 | No |
| 135 | Gclc | 12530 | -0.121 | -0.0502 | No |
| 136 | Kat2b | 12564 | -0.123 | -0.0485 | No |
| 137 | Abcg2 | 12823 | -0.134 | -0.0583 | No |
| 138 | Bpgm | 12872 | -0.135 | -0.0571 | No |
| 139 | Sidt2 | 13005 | -0.140 | -0.0602 | No |
| 140 | Mocos | 13007 | -0.141 | -0.0565 | No |
| 141 | Fbxo7 | 13039 | -0.142 | -0.0542 | No |
| 142 | Trim58 | 13074 | -0.143 | -0.0521 | No |
| 143 | Tmcc2 | 13182 | -0.148 | -0.0537 | No |
| 144 | Pigq | 13403 | -0.157 | -0.0608 | No |
| 145 | Mgst3 | 13628 | -0.167 | -0.0679 | No |
| 146 | Slc6a9 | 13681 | -0.169 | -0.0661 | No |
| 147 | Hagh | 13742 | -0.172 | -0.0646 | No |
| 148 | Blvrb | 14636 | -0.212 | -0.1050 | No |
| 149 | Btg2 | 14644 | -0.213 | -0.0997 | No |
| 150 | Rbm38 | 14670 | -0.214 | -0.0952 | No |
| 151 | Arl2bp | 14868 | -0.224 | -0.0994 | No |
| 152 | Slc11a2 | 14927 | -0.226 | -0.0963 | No |
| 153 | Mpp1 | 14965 | -0.228 | -0.0920 | No |
| 154 | Epor | 15117 | -0.236 | -0.0935 | No |
| 155 | Slc66a2 | 15199 | -0.240 | -0.0912 | No |
| 156 | Dmtn | 15225 | -0.242 | -0.0860 | No |
| 157 | Slc30a10 | 15848 | -0.274 | -0.1108 | No |
| 158 | Gde1 | 16271 | -0.301 | -0.1245 | No |
| 159 | Ucp2 | 16316 | -0.304 | -0.1186 | No |
| 160 | Ppp2r5b | 16346 | -0.306 | -0.1119 | No |
| 161 | Gypc | 16379 | -0.308 | -0.1052 | No |
| 162 | Lmo2 | 16981 | -0.349 | -0.1269 | No |
| 163 | Ypel5 | 17291 | -0.371 | -0.1329 | No |
| 164 | Alad | 17335 | -0.375 | -0.1250 | No |
| 165 | Marchf2 | 17378 | -0.378 | -0.1170 | No |
| 166 | Pcx | 17399 | -0.380 | -0.1078 | No |
| 167 | Ell2 | 17460 | -0.386 | -0.1005 | No |
| 168 | Ppox | 17489 | -0.389 | -0.0915 | No |
| 169 | Cat | 17578 | -0.400 | -0.0853 | No |
| 170 | Alas2 | 17584 | -0.400 | -0.0747 | No |
| 171 | Lrp10 | 17634 | -0.405 | -0.0664 | No |
| 172 | Nfe2 | 17847 | -0.426 | -0.0659 | No |
| 173 | Dcun1d1 | 17945 | -0.437 | -0.0591 | No |
| 174 | Icam4 | 18241 | -0.473 | -0.0616 | No |
| 175 | Tspo2 | 18353 | -0.486 | -0.0543 | No |
| 176 | Selenbp1 | 18549 | -0.515 | -0.0505 | No |
| 177 | Trim10 | 18691 | -0.541 | -0.0432 | No |
| 178 | Atp6v0a1 | 18823 | -0.565 | -0.0348 | No |
| 179 | Glrx5 | 19047 | -0.623 | -0.0296 | No |
| 180 | Mospd1 | 19081 | -0.634 | -0.0142 | No |
| 181 | Osbp2 | 19142 | -0.664 | 0.0006 | No |
| 182 | Car2 | 19202 | -0.687 | 0.0160 | No |

