| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group4.MPP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.28189054 |
| Normalized Enrichment Score (NES) | -1.3051577 |
| Nominal p-value | 0.060311284 |
| FDR q-value | 0.53322476 |
| FWER p-Value | 0.834 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Abcc3 | 143 | 0.759 | 0.0115 | No |
| 2 | Hmox1 | 230 | 0.701 | 0.0246 | No |
| 3 | Entpd5 | 238 | 0.697 | 0.0416 | No |
| 4 | Lonp1 | 537 | 0.583 | 0.0408 | No |
| 5 | Smox | 1174 | 0.466 | 0.0196 | No |
| 6 | Pcx | 1213 | 0.460 | 0.0291 | No |
| 7 | Irf8 | 1298 | 0.449 | 0.0360 | No |
| 8 | Ssr3 | 1559 | 0.422 | 0.0331 | No |
| 9 | Cndp2 | 1749 | 0.401 | 0.0333 | No |
| 10 | Xdh | 1942 | 0.385 | 0.0330 | No |
| 11 | Arg1 | 2014 | 0.378 | 0.0388 | No |
| 12 | Id2 | 2015 | 0.377 | 0.0482 | No |
| 13 | Slc35d1 | 2032 | 0.375 | 0.0567 | No |
| 14 | Papss2 | 2061 | 0.373 | 0.0646 | No |
| 15 | Gart | 2295 | 0.353 | 0.0614 | No |
| 16 | Ap4b1 | 2619 | 0.327 | 0.0528 | No |
| 17 | Por | 2678 | 0.322 | 0.0579 | No |
| 18 | Ptges3-ps | 2697 | 0.321 | 0.0649 | No |
| 19 | F10 | 2826 | 0.314 | 0.0662 | No |
| 20 | Fbln1 | 2924 | 0.307 | 0.0688 | No |
| 21 | Slc46a3 | 2945 | 0.306 | 0.0754 | No |
| 22 | Npc1 | 3017 | 0.304 | 0.0793 | No |
| 23 | Cdo1 | 3453 | 0.275 | 0.0637 | No |
| 24 | Gss | 3683 | 0.258 | 0.0584 | No |
| 25 | Cda | 3849 | 0.247 | 0.0560 | No |
| 26 | Pgd | 3885 | 0.246 | 0.0603 | No |
| 27 | Slc1a5 | 3968 | 0.240 | 0.0621 | No |
| 28 | Marchf6 | 4140 | 0.233 | 0.0591 | No |
| 29 | Apoe | 4181 | 0.229 | 0.0627 | No |
| 30 | Ptgds | 4224 | 0.227 | 0.0662 | No |
| 31 | Alas1 | 4624 | 0.206 | 0.0507 | No |
| 32 | Atp2a2 | 4848 | 0.195 | 0.0441 | No |
| 33 | Fas | 5015 | 0.186 | 0.0401 | No |
| 34 | Arg2 | 5332 | 0.173 | 0.0281 | No |
| 35 | Kynu | 5374 | 0.171 | 0.0303 | No |
| 36 | Tgfb2 | 5510 | 0.164 | 0.0274 | No |
| 37 | Hnf4a | 5872 | 0.146 | 0.0124 | No |
| 38 | Ugdh | 5995 | 0.141 | 0.0096 | No |
| 39 | Vnn1 | 6014 | 0.140 | 0.0122 | No |
| 40 | Bphl | 6038 | 0.139 | 0.0145 | No |
| 41 | Tmbim6 | 6114 | 0.135 | 0.0140 | No |
| 42 | Ets2 | 6142 | 0.134 | 0.0159 | No |
| 43 | Aldh9a1 | 6282 | 0.127 | 0.0119 | No |
| 44 | Aqp9 | 6376 | 0.122 | 0.0102 | No |
| 45 | Shmt2 | 6390 | 0.121 | 0.0125 | No |
| 46 | Pycr1 | 6529 | 0.115 | 0.0083 | No |
| 47 | Acox3 | 6652 | 0.113 | 0.0048 | No |
| 48 | Tyr | 6747 | 0.109 | 0.0026 | No |
| 49 | Ephx1 | 6892 | 0.104 | -0.0022 | No |
| 50 | Pemt | 7044 | 0.097 | -0.0076 | No |
| 51 | Rap1gap | 7066 | 0.096 | -0.0063 | No |
| 52 | Pmm1 | 7113 | 0.094 | -0.0063 | No |
| 53 | Cyfip2 | 7352 | 0.084 | -0.0165 | No |
| 54 | Angptl3 | 7366 | 0.084 | -0.0151 | No |
| 55 | Sar1b | 7493 | 0.079 | -0.0196 | No |
| 56 | Ppard | 7670 | 0.070 | -0.0269 | No |
| 57 | Tmem97 | 8267 | 0.045 | -0.0566 | No |
| 58 | Dhrs1 | 8356 | 0.042 | -0.0601 | No |
| 59 | Ninj1 | 8492 | 0.036 | -0.0662 | No |
| 60 | Ttpa | 8725 | 0.026 | -0.0775 | No |
| 61 | Pts | 9010 | 0.015 | -0.0918 | No |
| 62 | Pdlim5 | 9167 | 0.008 | -0.0997 | No |
| 63 | Crot | 9193 | 0.007 | -0.1008 | No |
| 64 | Fah | 9239 | 0.005 | -0.1030 | No |
| 65 | Nfs1 | 9596 | -0.005 | -0.1212 | No |
| 66 | Acp1 | 9680 | -0.008 | -0.1253 | No |
| 67 | Tpst1 | 9839 | -0.014 | -0.1331 | No |
| 68 | Aco2 | 10004 | -0.022 | -0.1411 | No |
| 69 | Nmt1 | 10045 | -0.023 | -0.1425 | No |
| 70 | Cyb5a | 10047 | -0.023 | -0.1420 | No |
| 71 | Gsr | 10135 | -0.026 | -0.1459 | No |
| 72 | Gcnt2 | 10274 | -0.032 | -0.1522 | No |
| 73 | Aldh2 | 10433 | -0.038 | -0.1594 | No |
| 74 | Ccl25 | 10517 | -0.041 | -0.1627 | No |
| 75 | Slc35b1 | 10606 | -0.045 | -0.1661 | No |
| 76 | Abcc2 | 10656 | -0.046 | -0.1675 | No |
| 77 | Pgrmc1 | 10709 | -0.048 | -0.1689 | No |
| 78 | Cat | 10815 | -0.053 | -0.1731 | No |
| 79 | Cyp2j6 | 10990 | -0.060 | -0.1806 | No |
| 80 | Acp2 | 10998 | -0.060 | -0.1794 | No |
| 81 | Fbp1 | 11100 | -0.064 | -0.1830 | No |
| 82 | Ndrg2 | 11151 | -0.067 | -0.1839 | No |
| 83 | Cd36 | 11241 | -0.071 | -0.1868 | No |
| 84 | Bcat1 | 11286 | -0.073 | -0.1872 | No |
| 85 | Retsat | 11388 | -0.077 | -0.1905 | No |
| 86 | Spint2 | 11623 | -0.086 | -0.2005 | No |
| 87 | Man1a | 11876 | -0.097 | -0.2111 | No |
| 88 | Il1r1 | 11917 | -0.099 | -0.2107 | No |
| 89 | Ech1 | 12036 | -0.104 | -0.2142 | No |
| 90 | Mthfd1 | 12056 | -0.105 | -0.2125 | No |
| 91 | Hacl1 | 12179 | -0.110 | -0.2161 | No |
| 92 | Maoa | 12213 | -0.112 | -0.2150 | No |
| 93 | Idh1 | 12298 | -0.116 | -0.2164 | No |
| 94 | Ptges | 12359 | -0.119 | -0.2166 | No |
| 95 | Elovl5 | 12520 | -0.128 | -0.2216 | No |
| 96 | Tkfc | 12549 | -0.130 | -0.2198 | No |
| 97 | Pros1 | 12699 | -0.137 | -0.2241 | No |
| 98 | Lpin2 | 12944 | -0.144 | -0.2331 | No |
| 99 | Hgfac | 13011 | -0.147 | -0.2329 | No |
| 100 | Tdo2 | 13086 | -0.151 | -0.2329 | No |
| 101 | Car2 | 13201 | -0.157 | -0.2349 | No |
| 102 | Asl | 13274 | -0.161 | -0.2346 | No |
| 103 | Ptgr1 | 13311 | -0.163 | -0.2324 | No |
| 104 | Mpp2 | 13322 | -0.164 | -0.2288 | No |
| 105 | Gabarapl1 | 13487 | -0.171 | -0.2330 | No |
| 106 | Fmo1 | 13491 | -0.171 | -0.2289 | No |
| 107 | Slc6a6 | 13807 | -0.184 | -0.2406 | No |
| 108 | Dcxr | 13834 | -0.185 | -0.2373 | No |
| 109 | Abcd2 | 14114 | -0.199 | -0.2467 | No |
| 110 | Etfdh | 14118 | -0.199 | -0.2419 | No |
| 111 | Crp | 14226 | -0.205 | -0.2423 | No |
| 112 | Csad | 14690 | -0.225 | -0.2606 | No |
| 113 | Acox1 | 14831 | -0.232 | -0.2621 | No |
| 114 | Gch1 | 15032 | -0.243 | -0.2663 | No |
| 115 | Mccc2 | 15334 | -0.260 | -0.2754 | Yes |
| 116 | Blvrb | 15374 | -0.262 | -0.2709 | Yes |
| 117 | Gclc | 15382 | -0.263 | -0.2647 | Yes |
| 118 | Cfb | 15563 | -0.275 | -0.2671 | Yes |
| 119 | Esr1 | 15682 | -0.283 | -0.2662 | Yes |
| 120 | Pdk4 | 15695 | -0.284 | -0.2597 | Yes |
| 121 | Aox1 | 15986 | -0.301 | -0.2671 | Yes |
| 122 | Cbr1 | 16151 | -0.310 | -0.2679 | Yes |
| 123 | Upb1 | 16342 | -0.323 | -0.2696 | Yes |
| 124 | Gstm4 | 16432 | -0.327 | -0.2661 | Yes |
| 125 | Adh5 | 16477 | -0.331 | -0.2601 | Yes |
| 126 | Hes6 | 16683 | -0.346 | -0.2621 | Yes |
| 127 | Upp1 | 16729 | -0.350 | -0.2556 | Yes |
| 128 | Jup | 16828 | -0.357 | -0.2518 | Yes |
| 129 | Arpp19 | 17046 | -0.376 | -0.2536 | Yes |
| 130 | Epha2 | 17047 | -0.376 | -0.2442 | Yes |
| 131 | Slc12a4 | 17135 | -0.384 | -0.2391 | Yes |
| 132 | Dhps | 17182 | -0.386 | -0.2319 | Yes |
| 133 | Tnfrsf1a | 17244 | -0.392 | -0.2252 | Yes |
| 134 | Ddc | 17393 | -0.405 | -0.2228 | Yes |
| 135 | Comt | 17448 | -0.409 | -0.2154 | Yes |
| 136 | Igf1 | 17531 | -0.416 | -0.2092 | Yes |
| 137 | Psmb10 | 17573 | -0.420 | -0.2009 | Yes |
| 138 | Nqo1 | 17693 | -0.431 | -0.1962 | Yes |
| 139 | Ddt | 17848 | -0.449 | -0.1930 | Yes |
| 140 | Lcat | 18175 | -0.486 | -0.1977 | Yes |
| 141 | Ddah2 | 18377 | -0.518 | -0.1952 | Yes |
| 142 | Igfbp4 | 18620 | -0.552 | -0.1939 | Yes |
| 143 | Casp6 | 18929 | -0.617 | -0.1944 | Yes |
| 144 | Gnmt | 18977 | -0.634 | -0.1810 | Yes |
| 145 | Dhrs7 | 18989 | -0.635 | -0.1657 | Yes |
| 146 | Tmem176b | 19015 | -0.643 | -0.1510 | Yes |
| 147 | Pink1 | 19044 | -0.655 | -0.1361 | Yes |
| 148 | Cyp27a1 | 19161 | -0.691 | -0.1248 | Yes |
| 149 | Gstt2 | 19276 | -0.755 | -0.1119 | Yes |
| 150 | Ahcyl | 19371 | -0.827 | -0.0961 | Yes |
| 151 | Gsto1 | 19376 | -0.830 | -0.0756 | Yes |
| 152 | Hsd11b1 | 19392 | -0.849 | -0.0552 | Yes |
| 153 | Sertad1 | 19492 | -1.078 | -0.0334 | Yes |
| 154 | Abhd6 | 19510 | -1.377 | 0.0001 | Yes |

