| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group4.MPP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.20830795 |
| Normalized Enrichment Score (NES) | 1.083578 |
| Nominal p-value | 0.3313492 |
| FDR q-value | 0.756154 |
| FWER p-Value | 0.999 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cyp51 | 43 | 0.913 | 0.0195 | Yes |
| 2 | Hk2 | 151 | 0.754 | 0.0319 | Yes |
| 3 | Mcm4 | 379 | 0.628 | 0.0351 | Yes |
| 4 | Cdc25a | 532 | 0.584 | 0.0411 | Yes |
| 5 | Mcm2 | 569 | 0.574 | 0.0529 | Yes |
| 6 | Hspa4 | 655 | 0.553 | 0.0617 | Yes |
| 7 | Fgl2 | 660 | 0.551 | 0.0746 | Yes |
| 8 | Slc37a4 | 709 | 0.543 | 0.0851 | Yes |
| 9 | Insig1 | 767 | 0.532 | 0.0948 | Yes |
| 10 | Stard4 | 852 | 0.514 | 0.1027 | Yes |
| 11 | Hmgcr | 952 | 0.496 | 0.1093 | Yes |
| 12 | Rpa1 | 994 | 0.491 | 0.1189 | Yes |
| 13 | Ak4 | 1088 | 0.479 | 0.1255 | Yes |
| 14 | Acly | 1199 | 0.463 | 0.1308 | Yes |
| 15 | Slc7a5 | 1351 | 0.444 | 0.1336 | Yes |
| 16 | Rrp9 | 1415 | 0.436 | 0.1407 | Yes |
| 17 | Hmgcs1 | 1419 | 0.435 | 0.1509 | Yes |
| 18 | Tm7sf2 | 1570 | 0.419 | 0.1531 | Yes |
| 19 | Stip1 | 1639 | 0.413 | 0.1594 | Yes |
| 20 | Pitpnb | 2065 | 0.372 | 0.1463 | Yes |
| 21 | Fdxr | 2067 | 0.372 | 0.1551 | Yes |
| 22 | Ung | 2072 | 0.372 | 0.1637 | Yes |
| 23 | Hspd1 | 2209 | 0.360 | 0.1652 | Yes |
| 24 | Wars1 | 2240 | 0.358 | 0.1722 | Yes |
| 25 | Ddit4 | 2256 | 0.357 | 0.1799 | Yes |
| 26 | Rpn1 | 2278 | 0.355 | 0.1873 | Yes |
| 27 | Ykt6 | 2280 | 0.355 | 0.1957 | Yes |
| 28 | Hspa9 | 2311 | 0.352 | 0.2025 | Yes |
| 29 | Etf1 | 2360 | 0.348 | 0.2083 | Yes |
| 30 | Plod2 | 2669 | 0.322 | 0.2000 | No |
| 31 | Edem1 | 2756 | 0.317 | 0.2031 | No |
| 32 | Pgk1 | 3290 | 0.286 | 0.1824 | No |
| 33 | Psat1 | 3330 | 0.283 | 0.1871 | No |
| 34 | Actr2 | 3498 | 0.272 | 0.1849 | No |
| 35 | Psmd14 | 3671 | 0.259 | 0.1822 | No |
| 36 | Gpi1 | 3702 | 0.257 | 0.1867 | No |
| 37 | Canx | 3892 | 0.245 | 0.1828 | No |
| 38 | Slc1a5 | 3968 | 0.240 | 0.1846 | No |
| 39 | Txnrd1 | 4162 | 0.231 | 0.1801 | No |
| 40 | Gtf2h1 | 4358 | 0.219 | 0.1752 | No |
| 41 | Add3 | 4368 | 0.219 | 0.1800 | No |
| 42 | Gsk3b | 4461 | 0.214 | 0.1803 | No |
| 43 | Sec11a | 4474 | 0.213 | 0.1847 | No |
| 44 | Qdpr | 4754 | 0.200 | 0.1751 | No |
| 45 | Atp2a2 | 4848 | 0.195 | 0.1749 | No |
| 46 | Nup205 | 4850 | 0.195 | 0.1795 | No |
| 47 | Pdk1 | 4866 | 0.194 | 0.1833 | No |
| 48 | Ssr1 | 5001 | 0.187 | 0.1808 | No |
| 49 | Pno1 | 5151 | 0.181 | 0.1774 | No |
| 50 | Psme3 | 5178 | 0.180 | 0.1804 | No |
| 51 | Tfrc | 5281 | 0.176 | 0.1793 | No |
| 52 | Ufm1 | 5526 | 0.163 | 0.1705 | No |
| 53 | Gla | 5675 | 0.157 | 0.1666 | No |
| 54 | Uso1 | 5751 | 0.152 | 0.1663 | No |
| 55 | Sc5d | 5780 | 0.151 | 0.1685 | No |
| 56 | Acaca | 5846 | 0.148 | 0.1686 | No |
| 57 | Pik3r3 | 5983 | 0.141 | 0.1650 | No |
| 58 | Nufip1 | 6225 | 0.130 | 0.1556 | No |
| 59 | Ddx39a | 6307 | 0.126 | 0.1544 | No |
| 60 | Niban1 | 6370 | 0.122 | 0.1541 | No |
| 61 | Shmt2 | 6390 | 0.121 | 0.1560 | No |
| 62 | Dhfr | 6411 | 0.120 | 0.1578 | No |
| 63 | Ldlr | 6413 | 0.120 | 0.1606 | No |
| 64 | Actr3 | 6420 | 0.120 | 0.1631 | No |
| 65 | Fads1 | 6429 | 0.119 | 0.1655 | No |
| 66 | Lgmn | 6498 | 0.116 | 0.1648 | No |
| 67 | Ube2d3 | 6741 | 0.109 | 0.1549 | No |
| 68 | Immt | 7078 | 0.095 | 0.1397 | No |
| 69 | Serp1 | 7101 | 0.095 | 0.1409 | No |
| 70 | Nfkbib | 7156 | 0.093 | 0.1403 | No |
| 71 | Cyb5b | 7241 | 0.089 | 0.1381 | No |
| 72 | Ccnf | 7257 | 0.089 | 0.1394 | No |
| 73 | M6pr | 7320 | 0.086 | 0.1382 | No |
| 74 | Ppp1r15a | 7423 | 0.082 | 0.1349 | No |
| 75 | Hsp90b1 | 7424 | 0.082 | 0.1368 | No |
| 76 | Pfkl | 7452 | 0.081 | 0.1373 | No |
| 77 | Calr | 7738 | 0.067 | 0.1242 | No |
| 78 | Sdf2l1 | 7927 | 0.059 | 0.1159 | No |
| 79 | Gmps | 8066 | 0.054 | 0.1100 | No |
| 80 | Adipor2 | 8120 | 0.052 | 0.1085 | No |
| 81 | Sqle | 8127 | 0.051 | 0.1094 | No |
| 82 | Tmem97 | 8267 | 0.045 | 0.1033 | No |
| 83 | Slc7a11 | 8333 | 0.043 | 0.1009 | No |
| 84 | Ero1a | 8343 | 0.043 | 0.1015 | No |
| 85 | Rit1 | 8427 | 0.039 | 0.0981 | No |
| 86 | Cct6a | 8433 | 0.039 | 0.0988 | No |
| 87 | Glrx | 8485 | 0.036 | 0.0970 | No |
| 88 | Psmc4 | 8545 | 0.033 | 0.0947 | No |
| 89 | Lta4h | 8582 | 0.032 | 0.0936 | No |
| 90 | Pgm1 | 8792 | 0.024 | 0.0834 | No |
| 91 | Gga2 | 8795 | 0.024 | 0.0838 | No |
| 92 | Egln3 | 8819 | 0.023 | 0.0832 | No |
| 93 | Btg2 | 8903 | 0.019 | 0.0794 | No |
| 94 | Slc2a1 | 9018 | 0.014 | 0.0738 | No |
| 95 | Map2k3 | 9032 | 0.014 | 0.0735 | No |
| 96 | Rab1a | 9271 | 0.004 | 0.0612 | No |
| 97 | Cfp | 9286 | 0.003 | 0.0606 | No |
| 98 | Cops5 | 9290 | 0.003 | 0.0605 | No |
| 99 | Pnp | 9305 | 0.002 | 0.0598 | No |
| 100 | Dhcr24 | 9647 | -0.007 | 0.0423 | No |
| 101 | Hspa5 | 9685 | -0.008 | 0.0406 | No |
| 102 | Ifrd1 | 9852 | -0.015 | 0.0324 | No |
| 103 | Psmd13 | 9930 | -0.018 | 0.0288 | No |
| 104 | Nmt1 | 10045 | -0.023 | 0.0235 | No |
| 105 | Srd5a1 | 10083 | -0.024 | 0.0221 | No |
| 106 | Gsr | 10135 | -0.026 | 0.0201 | No |
| 107 | Psmc6 | 10230 | -0.030 | 0.0160 | No |
| 108 | Hspe1 | 10400 | -0.037 | 0.0081 | No |
| 109 | Ctsc | 10508 | -0.041 | 0.0035 | No |
| 110 | Dhcr7 | 10514 | -0.041 | 0.0043 | No |
| 111 | Nfyc | 10608 | -0.045 | 0.0005 | No |
| 112 | Ifi30 | 10643 | -0.046 | -0.0002 | No |
| 113 | Nampt | 10689 | -0.047 | -0.0014 | No |
| 114 | Cdkn1a | 10760 | -0.050 | -0.0038 | No |
| 115 | Me1 | 10989 | -0.060 | -0.0142 | No |
| 116 | Bhlhe40 | 11048 | -0.062 | -0.0157 | No |
| 117 | Idi1 | 11131 | -0.066 | -0.0184 | No |
| 118 | Skap2 | 11200 | -0.069 | -0.0203 | No |
| 119 | Bcat1 | 11286 | -0.073 | -0.0229 | No |
| 120 | Polr3g | 11493 | -0.081 | -0.0317 | No |
| 121 | Ppia | 11513 | -0.082 | -0.0307 | No |
| 122 | Pdap1 | 11535 | -0.083 | -0.0298 | No |
| 123 | Ddit3 | 11627 | -0.086 | -0.0325 | No |
| 124 | Bub1 | 11691 | -0.089 | -0.0336 | No |
| 125 | Hmbs | 12059 | -0.105 | -0.0501 | No |
| 126 | Slc2a3 | 12159 | -0.109 | -0.0526 | No |
| 127 | Acsl3 | 12170 | -0.110 | -0.0505 | No |
| 128 | Phgdh | 12220 | -0.112 | -0.0504 | No |
| 129 | Ppa1 | 12231 | -0.113 | -0.0482 | No |
| 130 | Cxcr4 | 12295 | -0.116 | -0.0487 | No |
| 131 | Idh1 | 12298 | -0.116 | -0.0461 | No |
| 132 | Psmc2 | 12431 | -0.123 | -0.0500 | No |
| 133 | Psma3 | 12437 | -0.123 | -0.0473 | No |
| 134 | Elovl5 | 12520 | -0.128 | -0.0485 | No |
| 135 | Elovl6 | 12534 | -0.129 | -0.0461 | No |
| 136 | Aldoa | 12538 | -0.129 | -0.0432 | No |
| 137 | Xbp1 | 12642 | -0.133 | -0.0453 | No |
| 138 | G6pdx | 12656 | -0.134 | -0.0428 | No |
| 139 | Trib3 | 12985 | -0.146 | -0.0563 | No |
| 140 | Eno1b | 13057 | -0.150 | -0.0564 | No |
| 141 | Mllt11 | 13226 | -0.158 | -0.0613 | No |
| 142 | Psmd12 | 13284 | -0.162 | -0.0604 | No |
| 143 | Tpi1 | 13288 | -0.162 | -0.0568 | No |
| 144 | Slc1a4 | 13327 | -0.164 | -0.0548 | No |
| 145 | Gbe1 | 13467 | -0.170 | -0.0580 | No |
| 146 | Tbk1 | 13469 | -0.170 | -0.0540 | No |
| 147 | Nupr1 | 13577 | -0.175 | -0.0553 | No |
| 148 | Slc6a6 | 13807 | -0.184 | -0.0628 | No |
| 149 | Tes | 13871 | -0.187 | -0.0616 | No |
| 150 | Mthfd2l | 13977 | -0.192 | -0.0625 | No |
| 151 | Eef1e1 | 14007 | -0.193 | -0.0594 | No |
| 152 | Dapp1 | 14062 | -0.196 | -0.0575 | No |
| 153 | Rdh11 | 14262 | -0.205 | -0.0629 | No |
| 154 | Uchl5 | 14272 | -0.206 | -0.0585 | No |
| 155 | Asns | 14296 | -0.207 | -0.0548 | No |
| 156 | P4ha1 | 14311 | -0.208 | -0.0505 | No |
| 157 | Fkbp2 | 14346 | -0.209 | -0.0473 | No |
| 158 | Psph | 14423 | -0.213 | -0.0462 | No |
| 159 | Tubg1 | 14459 | -0.215 | -0.0429 | No |
| 160 | Sla | 14702 | -0.226 | -0.0500 | No |
| 161 | Abcf2 | 14804 | -0.231 | -0.0498 | No |
| 162 | Vldlr | 14890 | -0.235 | -0.0486 | No |
| 163 | Arpc5l | 15016 | -0.242 | -0.0493 | No |
| 164 | Gclc | 15382 | -0.263 | -0.0619 | No |
| 165 | Eif2s2 | 15478 | -0.269 | -0.0604 | No |
| 166 | Ccng1 | 15575 | -0.275 | -0.0588 | No |
| 167 | Sord | 15593 | -0.277 | -0.0531 | No |
| 168 | Tomm40 | 15607 | -0.278 | -0.0472 | No |
| 169 | Tcea1 | 15717 | -0.285 | -0.0460 | No |
| 170 | Atp6v1d | 15807 | -0.290 | -0.0437 | No |
| 171 | Aurka | 15967 | -0.301 | -0.0448 | No |
| 172 | Itgb2 | 16118 | -0.309 | -0.0452 | No |
| 173 | Plk1 | 16141 | -0.309 | -0.0390 | No |
| 174 | Got1 | 16265 | -0.318 | -0.0378 | No |
| 175 | Serpinh1 | 16546 | -0.336 | -0.0443 | No |
| 176 | Tuba4a | 16721 | -0.349 | -0.0450 | No |
| 177 | Sytl2 | 16878 | -0.361 | -0.0445 | No |
| 178 | Fads2 | 17068 | -0.378 | -0.0452 | No |
| 179 | Ebp | 17080 | -0.379 | -0.0368 | No |
| 180 | Mthfd2 | 17266 | -0.393 | -0.0370 | No |
| 181 | Cacybp | 17583 | -0.421 | -0.0433 | No |
| 182 | Nfil3 | 18073 | -0.472 | -0.0574 | No |
| 183 | Rrm2 | 18292 | -0.503 | -0.0567 | No |
| 184 | Psma4 | 18391 | -0.521 | -0.0494 | No |
| 185 | Prdx1 | 18399 | -0.522 | -0.0373 | No |
| 186 | Cd9 | 18636 | -0.556 | -0.0363 | No |
| 187 | Coro1a | 18973 | -0.631 | -0.0387 | No |
| 188 | Ldha | 18976 | -0.633 | -0.0237 | No |
| 189 | Sqstm1 | 19040 | -0.653 | -0.0115 | No |
| 190 | Psmg1 | 19217 | -0.724 | -0.0033 | No |
| 191 | Psmb5 | 19318 | -0.780 | 0.0100 | No |

