| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group4.MPP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_KRAS_SIGNALING_UP |
| Enrichment Score (ES) | -0.26390788 |
| Normalized Enrichment Score (NES) | -1.1312212 |
| Nominal p-value | 0.26760563 |
| FDR q-value | 0.58507794 |
| FWER p-Value | 0.99 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Lif | 131 | 0.771 | 0.0133 | No |
| 2 | Klf4 | 336 | 0.642 | 0.0195 | No |
| 3 | Dusp6 | 375 | 0.629 | 0.0339 | No |
| 4 | Spry2 | 615 | 0.562 | 0.0362 | No |
| 5 | Ptprr | 692 | 0.546 | 0.0465 | No |
| 6 | Tspan7 | 791 | 0.525 | 0.0551 | No |
| 7 | Irf8 | 1298 | 0.449 | 0.0407 | No |
| 8 | Adgra2 | 1343 | 0.444 | 0.0500 | No |
| 9 | Itgbl1 | 1441 | 0.434 | 0.0563 | No |
| 10 | Cxcl10 | 1722 | 0.404 | 0.0524 | No |
| 11 | Tnfaip3 | 1862 | 0.392 | 0.0554 | No |
| 12 | Gabra3 | 1996 | 0.380 | 0.0584 | No |
| 13 | Arg1 | 2014 | 0.378 | 0.0674 | No |
| 14 | Id2 | 2015 | 0.377 | 0.0772 | No |
| 15 | Reln | 2136 | 0.366 | 0.0805 | No |
| 16 | Trib2 | 2168 | 0.363 | 0.0884 | No |
| 17 | Lat2 | 2226 | 0.358 | 0.0948 | No |
| 18 | Map3k1 | 2402 | 0.345 | 0.0947 | No |
| 19 | Mycn | 2513 | 0.335 | 0.0978 | No |
| 20 | H2bc3 | 2818 | 0.315 | 0.0903 | No |
| 21 | Ppbp | 3083 | 0.299 | 0.0844 | No |
| 22 | Tmem100 | 3215 | 0.291 | 0.0852 | No |
| 23 | Ammecr1 | 3369 | 0.280 | 0.0846 | No |
| 24 | Nin | 3445 | 0.276 | 0.0879 | No |
| 25 | Fcer1g | 3700 | 0.257 | 0.0815 | No |
| 26 | Adam17 | 3787 | 0.251 | 0.0836 | No |
| 27 | Fbxo4 | 4117 | 0.233 | 0.0727 | No |
| 28 | Hdac9 | 4128 | 0.233 | 0.0782 | No |
| 29 | Abcb1a | 4280 | 0.223 | 0.0763 | No |
| 30 | Il1rl2 | 4326 | 0.220 | 0.0797 | No |
| 31 | Ptcd2 | 4464 | 0.213 | 0.0782 | No |
| 32 | Plaur | 4597 | 0.207 | 0.0767 | No |
| 33 | Akt2 | 4662 | 0.204 | 0.0787 | No |
| 34 | Yrdc | 4877 | 0.194 | 0.0727 | No |
| 35 | Igf2 | 5041 | 0.185 | 0.0691 | No |
| 36 | Scg3 | 5101 | 0.183 | 0.0708 | No |
| 37 | Ets1 | 5337 | 0.173 | 0.0632 | No |
| 38 | Map7 | 5514 | 0.164 | 0.0584 | No |
| 39 | Fuca1 | 5791 | 0.150 | 0.0480 | No |
| 40 | Cbr4 | 5871 | 0.147 | 0.0478 | No |
| 41 | Btbd3 | 5926 | 0.144 | 0.0487 | No |
| 42 | G0s2 | 6123 | 0.135 | 0.0421 | No |
| 43 | Etv5 | 6636 | 0.114 | 0.0186 | No |
| 44 | Ccnd2 | 6856 | 0.106 | 0.0101 | No |
| 45 | Usp12 | 7092 | 0.095 | 0.0004 | No |
| 46 | Strn | 7208 | 0.091 | -0.0032 | No |
| 47 | Ppp1r15a | 7423 | 0.082 | -0.0121 | No |
| 48 | Gfpt2 | 7487 | 0.079 | -0.0133 | No |
| 49 | Wdr33 | 7629 | 0.072 | -0.0187 | No |
| 50 | Rabgap1l | 7755 | 0.066 | -0.0234 | No |
| 51 | St6gal1 | 7824 | 0.063 | -0.0253 | No |
| 52 | Birc3 | 7933 | 0.059 | -0.0293 | No |
| 53 | Rbm4 | 7984 | 0.057 | -0.0304 | No |
| 54 | Ly96 | 8095 | 0.053 | -0.0347 | No |
| 55 | Ephb2 | 8153 | 0.050 | -0.0364 | No |
| 56 | Ikzf1 | 8186 | 0.049 | -0.0368 | No |
| 57 | Epb41l3 | 8218 | 0.048 | -0.0371 | No |
| 58 | Ero1a | 8343 | 0.043 | -0.0424 | No |
| 59 | Atg10 | 8424 | 0.039 | -0.0455 | No |
| 60 | Glrx | 8485 | 0.036 | -0.0477 | No |
| 61 | Cbl | 8536 | 0.034 | -0.0494 | No |
| 62 | Itga2 | 8543 | 0.033 | -0.0488 | No |
| 63 | Plau | 8691 | 0.027 | -0.0557 | No |
| 64 | Mtmr10 | 8891 | 0.020 | -0.0655 | No |
| 65 | Sdccag8 | 9155 | 0.008 | -0.0788 | No |
| 66 | Crot | 9193 | 0.007 | -0.0806 | No |
| 67 | Dock2 | 9548 | -0.003 | -0.0987 | No |
| 68 | Cab39l | 9630 | -0.006 | -0.1028 | No |
| 69 | Scn1b | 9683 | -0.008 | -0.1052 | No |
| 70 | Zfp277 | 9901 | -0.017 | -0.1160 | No |
| 71 | Kcnn4 | 10071 | -0.024 | -0.1241 | No |
| 72 | Ptbp2 | 10150 | -0.026 | -0.1274 | No |
| 73 | Btc | 10334 | -0.034 | -0.1360 | No |
| 74 | Prelid3b | 10545 | -0.042 | -0.1457 | No |
| 75 | Scg5 | 10995 | -0.060 | -0.1674 | No |
| 76 | Etv4 | 11164 | -0.067 | -0.1743 | No |
| 77 | Flt4 | 11635 | -0.086 | -0.1963 | No |
| 78 | Bpgm | 11647 | -0.086 | -0.1946 | No |
| 79 | Mafb | 11782 | -0.093 | -0.1991 | No |
| 80 | Vwa5a | 12115 | -0.107 | -0.2135 | No |
| 81 | Dnmbp | 12226 | -0.112 | -0.2162 | No |
| 82 | Il7r | 12252 | -0.114 | -0.2145 | No |
| 83 | Laptm5 | 12260 | -0.115 | -0.2119 | No |
| 84 | F13a1 | 12287 | -0.116 | -0.2102 | No |
| 85 | Cxcr4 | 12295 | -0.116 | -0.2076 | No |
| 86 | Wnt7a | 12352 | -0.119 | -0.2074 | No |
| 87 | Avl9 | 12382 | -0.120 | -0.2057 | No |
| 88 | Cbx8 | 12391 | -0.121 | -0.2030 | No |
| 89 | Tor1aip2 | 12393 | -0.121 | -0.1999 | No |
| 90 | Ank | 12535 | -0.129 | -0.2038 | No |
| 91 | Map4k1 | 12808 | -0.139 | -0.2143 | No |
| 92 | Lcp1 | 12971 | -0.145 | -0.2188 | No |
| 93 | Tnfrsf1b | 13083 | -0.151 | -0.2206 | No |
| 94 | Car2 | 13201 | -0.157 | -0.2226 | No |
| 95 | Adam8 | 13231 | -0.159 | -0.2200 | No |
| 96 | Tspan13 | 13680 | -0.180 | -0.2384 | No |
| 97 | Dcbld2 | 13882 | -0.188 | -0.2439 | No |
| 98 | Etv1 | 13946 | -0.191 | -0.2422 | No |
| 99 | Evi5 | 14029 | -0.195 | -0.2413 | No |
| 100 | Ccser2 | 14083 | -0.198 | -0.2389 | No |
| 101 | Tmem176a | 14116 | -0.199 | -0.2354 | No |
| 102 | Mmp11 | 14428 | -0.214 | -0.2459 | No |
| 103 | Adgrl4 | 14453 | -0.215 | -0.2415 | No |
| 104 | Gucy1a1 | 14478 | -0.216 | -0.2371 | No |
| 105 | Hbegf | 14481 | -0.216 | -0.2316 | No |
| 106 | Angptl4 | 14522 | -0.218 | -0.2280 | No |
| 107 | Plvap | 14696 | -0.225 | -0.2310 | No |
| 108 | Gypc | 14933 | -0.237 | -0.2371 | No |
| 109 | Ano1 | 15454 | -0.268 | -0.2569 | Yes |
| 110 | Gadd45g | 15511 | -0.271 | -0.2528 | Yes |
| 111 | Cfb | 15563 | -0.275 | -0.2482 | Yes |
| 112 | Emp1 | 15843 | -0.293 | -0.2550 | Yes |
| 113 | Prdm1 | 15865 | -0.294 | -0.2484 | Yes |
| 114 | Nrp1 | 15898 | -0.296 | -0.2424 | Yes |
| 115 | Pecam1 | 15904 | -0.296 | -0.2349 | Yes |
| 116 | Plek2 | 16022 | -0.303 | -0.2331 | Yes |
| 117 | Itgb2 | 16118 | -0.309 | -0.2299 | Yes |
| 118 | Trib1 | 16189 | -0.313 | -0.2254 | Yes |
| 119 | Cdadc1 | 16194 | -0.313 | -0.2174 | Yes |
| 120 | Mmd | 16319 | -0.321 | -0.2155 | Yes |
| 121 | Fgf9 | 16524 | -0.334 | -0.2173 | Yes |
| 122 | Gprc5b | 16679 | -0.346 | -0.2163 | Yes |
| 123 | Kif5c | 16726 | -0.349 | -0.2095 | Yes |
| 124 | Jup | 16828 | -0.357 | -0.2054 | Yes |
| 125 | Zfp639 | 16873 | -0.361 | -0.1983 | Yes |
| 126 | Nr0b2 | 16965 | -0.368 | -0.1934 | Yes |
| 127 | Satb1 | 17045 | -0.376 | -0.1877 | Yes |
| 128 | Nr1h4 | 17055 | -0.377 | -0.1783 | Yes |
| 129 | Ctss | 17421 | -0.407 | -0.1866 | Yes |
| 130 | Cmklr1 | 17514 | -0.415 | -0.1805 | Yes |
| 131 | Eng | 17627 | -0.426 | -0.1752 | Yes |
| 132 | Cd37 | 17651 | -0.427 | -0.1653 | Yes |
| 133 | Galnt3 | 17682 | -0.429 | -0.1556 | Yes |
| 134 | Tfpi | 17713 | -0.434 | -0.1459 | Yes |
| 135 | Psmb8 | 17865 | -0.451 | -0.1419 | Yes |
| 136 | Slpi | 17879 | -0.453 | -0.1308 | Yes |
| 137 | Gng11 | 18090 | -0.474 | -0.1293 | Yes |
| 138 | Pdcd1lg2 | 18152 | -0.483 | -0.1199 | Yes |
| 139 | Ptgs2 | 18576 | -0.545 | -0.1275 | Yes |
| 140 | Spon1 | 18690 | -0.565 | -0.1186 | Yes |
| 141 | Traf1 | 18693 | -0.565 | -0.1040 | Yes |
| 142 | Csf2ra | 18750 | -0.575 | -0.0919 | Yes |
| 143 | Spp1 | 18880 | -0.606 | -0.0828 | Yes |
| 144 | Akap12 | 18940 | -0.621 | -0.0697 | Yes |
| 145 | Tmem176b | 19015 | -0.643 | -0.0567 | Yes |
| 146 | Il2rg | 19162 | -0.691 | -0.0463 | Yes |
| 147 | Tmem158 | 19222 | -0.726 | -0.0304 | Yes |
| 148 | Hsd11b1 | 19392 | -0.849 | -0.0170 | Yes |
| 149 | Il10ra | 19427 | -0.889 | 0.0044 | Yes |

