| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group4.MPP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_HEME_METABOLISM |
| Enrichment Score (ES) | -0.20267114 |
| Normalized Enrichment Score (NES) | -1.0669211 |
| Nominal p-value | 0.31034482 |
| FDR q-value | 0.68996453 |
| FWER p-Value | 0.998 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Marchf8 | 123 | 0.775 | 0.0139 | No |
| 2 | Slc4a1 | 189 | 0.733 | 0.0298 | No |
| 3 | Snca | 400 | 0.620 | 0.0351 | No |
| 4 | Fbxo7 | 628 | 0.558 | 0.0380 | No |
| 5 | Bnip3l | 848 | 0.514 | 0.0402 | No |
| 6 | Slc6a8 | 928 | 0.500 | 0.0492 | No |
| 7 | Bach1 | 1085 | 0.480 | 0.0537 | No |
| 8 | Smox | 1174 | 0.466 | 0.0613 | No |
| 9 | Pcx | 1213 | 0.460 | 0.0714 | No |
| 10 | Uros | 1429 | 0.434 | 0.0717 | No |
| 11 | Ranbp10 | 2432 | 0.342 | 0.0288 | No |
| 12 | Tspo2 | 2715 | 0.320 | 0.0226 | No |
| 13 | Trim58 | 2903 | 0.309 | 0.0210 | No |
| 14 | Sidt2 | 2932 | 0.307 | 0.0276 | No |
| 15 | Gata1 | 3376 | 0.279 | 0.0120 | No |
| 16 | Slc66a2 | 3440 | 0.276 | 0.0160 | No |
| 17 | Mkrn1 | 3500 | 0.271 | 0.0200 | No |
| 18 | Optn | 3531 | 0.269 | 0.0255 | No |
| 19 | Endod1 | 3534 | 0.269 | 0.0325 | No |
| 20 | Tent5c | 3642 | 0.261 | 0.0338 | No |
| 21 | Rnf123 | 3662 | 0.260 | 0.0396 | No |
| 22 | Bmp2k | 3739 | 0.255 | 0.0423 | No |
| 23 | Foxo3 | 3921 | 0.243 | 0.0393 | No |
| 24 | Slc6a9 | 4074 | 0.234 | 0.0376 | No |
| 25 | Foxj2 | 4101 | 0.234 | 0.0424 | No |
| 26 | Trak2 | 4138 | 0.233 | 0.0467 | No |
| 27 | Ccdc28a | 4505 | 0.211 | 0.0333 | No |
| 28 | Gapvd1 | 4659 | 0.204 | 0.0307 | No |
| 29 | Spta1 | 4702 | 0.202 | 0.0338 | No |
| 30 | Slc30a1 | 4975 | 0.188 | 0.0247 | No |
| 31 | Rhd | 4989 | 0.187 | 0.0289 | No |
| 32 | Klf1 | 5226 | 0.179 | 0.0214 | No |
| 33 | Synj1 | 5246 | 0.178 | 0.0251 | No |
| 34 | Tfrc | 5281 | 0.176 | 0.0279 | No |
| 35 | Dcaf10 | 5301 | 0.175 | 0.0315 | No |
| 36 | Ppp2r5b | 5370 | 0.171 | 0.0325 | No |
| 37 | Khnyn | 5401 | 0.170 | 0.0354 | No |
| 38 | Rbm5 | 5473 | 0.166 | 0.0361 | No |
| 39 | Rcl1 | 5626 | 0.159 | 0.0324 | No |
| 40 | Arhgef12 | 5698 | 0.156 | 0.0328 | No |
| 41 | Epb41 | 5703 | 0.155 | 0.0366 | No |
| 42 | C3 | 5706 | 0.155 | 0.0406 | No |
| 43 | Btrc | 5712 | 0.155 | 0.0444 | No |
| 44 | Ucp2 | 5725 | 0.154 | 0.0478 | No |
| 45 | Mxi1 | 5881 | 0.146 | 0.0436 | No |
| 46 | Sptb | 5920 | 0.144 | 0.0454 | No |
| 47 | Nr3c1 | 5988 | 0.141 | 0.0456 | No |
| 48 | Slc10a3 | 6259 | 0.128 | 0.0350 | No |
| 49 | Atp6v0a1 | 6491 | 0.117 | 0.0261 | No |
| 50 | Mfhas1 | 6683 | 0.112 | 0.0192 | No |
| 51 | Tyr | 6747 | 0.109 | 0.0188 | No |
| 52 | Tfdp2 | 6781 | 0.108 | 0.0199 | No |
| 53 | Kdm7a | 6853 | 0.106 | 0.0190 | No |
| 54 | P4ha2 | 6915 | 0.103 | 0.0185 | No |
| 55 | Rap1gap | 7066 | 0.096 | 0.0133 | No |
| 56 | Add1 | 7265 | 0.088 | 0.0053 | No |
| 57 | Xk | 7339 | 0.085 | 0.0038 | No |
| 58 | Tspan5 | 7389 | 0.083 | 0.0034 | No |
| 59 | Picalm | 7402 | 0.082 | 0.0050 | No |
| 60 | Aldh1l1 | 7579 | 0.075 | -0.0022 | No |
| 61 | Nnt | 7671 | 0.070 | -0.0050 | No |
| 62 | Sdcbp | 7858 | 0.061 | -0.0131 | No |
| 63 | Agpat4 | 8039 | 0.054 | -0.0209 | No |
| 64 | Slc11a2 | 8057 | 0.054 | -0.0204 | No |
| 65 | Gmps | 8066 | 0.054 | -0.0194 | No |
| 66 | E2f2 | 8131 | 0.051 | -0.0214 | No |
| 67 | Lamp2 | 8258 | 0.046 | -0.0267 | No |
| 68 | Slc7a11 | 8333 | 0.043 | -0.0294 | No |
| 69 | Usp15 | 8435 | 0.039 | -0.0336 | No |
| 70 | Abcb6 | 8490 | 0.036 | -0.0355 | No |
| 71 | Ezh1 | 8514 | 0.035 | -0.0358 | No |
| 72 | Mpp1 | 8551 | 0.033 | -0.0368 | No |
| 73 | Minpp1 | 8842 | 0.022 | -0.0512 | No |
| 74 | Btg2 | 8903 | 0.019 | -0.0538 | No |
| 75 | Slc2a1 | 9018 | 0.014 | -0.0593 | No |
| 76 | Map2k3 | 9032 | 0.014 | -0.0596 | No |
| 77 | Hagh | 9245 | 0.005 | -0.0704 | No |
| 78 | Nudt4 | 9287 | 0.003 | -0.0725 | No |
| 79 | Cpox | 9294 | 0.003 | -0.0727 | No |
| 80 | Ncoa4 | 9333 | 0.002 | -0.0747 | No |
| 81 | Dcaf11 | 9434 | -0.000 | -0.0798 | No |
| 82 | Mboat2 | 9583 | -0.005 | -0.0874 | No |
| 83 | Tmcc2 | 9764 | -0.011 | -0.0964 | No |
| 84 | Adipor1 | 9913 | -0.018 | -0.1036 | No |
| 85 | Cast | 10081 | -0.024 | -0.1116 | No |
| 86 | Epb42 | 10214 | -0.029 | -0.1176 | No |
| 87 | Riok3 | 10342 | -0.034 | -0.1233 | No |
| 88 | Htra2 | 10374 | -0.036 | -0.1240 | No |
| 89 | Cir1 | 10397 | -0.037 | -0.1241 | No |
| 90 | Daam1 | 10550 | -0.043 | -0.1309 | No |
| 91 | Mgst3 | 10645 | -0.046 | -0.1346 | No |
| 92 | Fbxo34 | 10692 | -0.048 | -0.1357 | No |
| 93 | Fn3k | 10795 | -0.052 | -0.1396 | No |
| 94 | Cat | 10815 | -0.053 | -0.1392 | No |
| 95 | Alas2 | 10816 | -0.053 | -0.1378 | No |
| 96 | Nek7 | 10855 | -0.054 | -0.1384 | No |
| 97 | Nfe2l1 | 10926 | -0.057 | -0.1405 | No |
| 98 | Clcn3 | 11114 | -0.065 | -0.1485 | No |
| 99 | Cdr2 | 11209 | -0.069 | -0.1515 | No |
| 100 | Sec14l1 | 11467 | -0.080 | -0.1627 | No |
| 101 | Alad | 11492 | -0.081 | -0.1618 | No |
| 102 | Slc25a38 | 11572 | -0.084 | -0.1637 | No |
| 103 | Tns1 | 11588 | -0.085 | -0.1623 | No |
| 104 | Bpgm | 11647 | -0.086 | -0.1630 | No |
| 105 | Atg4a | 11695 | -0.089 | -0.1631 | No |
| 106 | Pigq | 11719 | -0.091 | -0.1619 | No |
| 107 | Acsl6 | 11743 | -0.092 | -0.1607 | No |
| 108 | Dcun1d1 | 11776 | -0.093 | -0.1599 | No |
| 109 | Slc22a4 | 11879 | -0.098 | -0.1626 | No |
| 110 | Bsg | 11919 | -0.099 | -0.1621 | No |
| 111 | Hmbs | 12059 | -0.105 | -0.1665 | No |
| 112 | Acp5 | 12229 | -0.113 | -0.1723 | No |
| 113 | Top1 | 12441 | -0.124 | -0.1800 | No |
| 114 | Xpo7 | 12689 | -0.136 | -0.1892 | No |
| 115 | Kel | 12883 | -0.142 | -0.1954 | No |
| 116 | Lpin2 | 12944 | -0.144 | -0.1948 | No |
| 117 | Rad23a | 12975 | -0.145 | -0.1925 | No |
| 118 | Tnrc6b | 13157 | -0.155 | -0.1978 | No |
| 119 | Car2 | 13201 | -0.157 | -0.1959 | No |
| 120 | Osbp2 | 13251 | -0.160 | -0.1943 | No |
| 121 | Ypel5 | 13275 | -0.161 | -0.1912 | No |
| 122 | Add2 | 13285 | -0.162 | -0.1875 | No |
| 123 | Mospd1 | 13580 | -0.175 | -0.1981 | Yes |
| 124 | Tmem9b | 13585 | -0.175 | -0.1937 | Yes |
| 125 | Cdc27 | 13748 | -0.181 | -0.1973 | Yes |
| 126 | Mocos | 13841 | -0.186 | -0.1972 | Yes |
| 127 | Epor | 13935 | -0.190 | -0.1971 | Yes |
| 128 | Igsf3 | 13948 | -0.191 | -0.1927 | Yes |
| 129 | Aldh6a1 | 13968 | -0.192 | -0.1886 | Yes |
| 130 | Vezf1 | 13995 | -0.193 | -0.1849 | Yes |
| 131 | Eif2ak1 | 14048 | -0.196 | -0.1825 | Yes |
| 132 | Abcg2 | 14064 | -0.196 | -0.1781 | Yes |
| 133 | Rnf19a | 14065 | -0.196 | -0.1730 | Yes |
| 134 | Asns | 14296 | -0.207 | -0.1795 | Yes |
| 135 | Gclm | 14381 | -0.211 | -0.1783 | Yes |
| 136 | Pdzk1ip1 | 14391 | -0.212 | -0.1732 | Yes |
| 137 | Lmo2 | 14454 | -0.215 | -0.1708 | Yes |
| 138 | Ermap | 14518 | -0.218 | -0.1683 | Yes |
| 139 | Ppox | 14768 | -0.229 | -0.1752 | Yes |
| 140 | Kat2b | 14837 | -0.232 | -0.1726 | Yes |
| 141 | Pgls | 14915 | -0.236 | -0.1704 | Yes |
| 142 | Gypc | 14933 | -0.237 | -0.1651 | Yes |
| 143 | Fech | 14949 | -0.238 | -0.1596 | Yes |
| 144 | Htatip2 | 14951 | -0.238 | -0.1534 | Yes |
| 145 | Trim10 | 15074 | -0.245 | -0.1533 | Yes |
| 146 | Ank1 | 15151 | -0.250 | -0.1507 | Yes |
| 147 | Blvrb | 15374 | -0.262 | -0.1553 | Yes |
| 148 | Gclc | 15382 | -0.263 | -0.1488 | Yes |
| 149 | Lrp10 | 15459 | -0.268 | -0.1457 | Yes |
| 150 | Mark3 | 15693 | -0.284 | -0.1503 | Yes |
| 151 | Tcea1 | 15717 | -0.285 | -0.1440 | Yes |
| 152 | Ctse | 15746 | -0.287 | -0.1380 | Yes |
| 153 | Bcam | 15759 | -0.288 | -0.1310 | Yes |
| 154 | Blvra | 15844 | -0.293 | -0.1277 | Yes |
| 155 | Fbxo9 | 15975 | -0.301 | -0.1266 | Yes |
| 156 | Tal1 | 16234 | -0.316 | -0.1316 | Yes |
| 157 | Gde1 | 16249 | -0.317 | -0.1241 | Yes |
| 158 | Hdgf | 16358 | -0.323 | -0.1212 | Yes |
| 159 | Psmd9 | 16480 | -0.331 | -0.1188 | Yes |
| 160 | Ubac1 | 16509 | -0.333 | -0.1115 | Yes |
| 161 | Car1 | 16517 | -0.334 | -0.1031 | Yes |
| 162 | Selenbp1 | 16533 | -0.335 | -0.0951 | Yes |
| 163 | Rbm38 | 16643 | -0.343 | -0.0918 | Yes |
| 164 | Urod | 16857 | -0.359 | -0.0934 | Yes |
| 165 | Rhag | 16994 | -0.372 | -0.0907 | Yes |
| 166 | Hebp1 | 17035 | -0.376 | -0.0829 | Yes |
| 167 | Narf | 17051 | -0.377 | -0.0738 | Yes |
| 168 | Klf3 | 17056 | -0.377 | -0.0642 | Yes |
| 169 | Slc30a10 | 17381 | -0.404 | -0.0703 | Yes |
| 170 | Myl4 | 17796 | -0.443 | -0.0802 | Yes |
| 171 | Nfe2 | 17952 | -0.459 | -0.0762 | Yes |
| 172 | Ctsb | 17990 | -0.464 | -0.0659 | Yes |
| 173 | H1f0 | 18066 | -0.471 | -0.0575 | Yes |
| 174 | Ctns | 18097 | -0.475 | -0.0466 | Yes |
| 175 | Dmtn | 18245 | -0.496 | -0.0412 | Yes |
| 176 | Arl2bp | 18253 | -0.497 | -0.0285 | Yes |
| 177 | Marchf2 | 18345 | -0.512 | -0.0198 | Yes |
| 178 | Ccnd3 | 18468 | -0.531 | -0.0122 | Yes |
| 179 | Ell2 | 18670 | -0.562 | -0.0079 | Yes |
| 180 | Icam4 | 18776 | -0.581 | 0.0019 | Yes |
| 181 | Glrx5 | 18908 | -0.613 | 0.0112 | Yes |
| 182 | Prdx2 | 19287 | -0.764 | 0.0116 | Yes |

