| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group4.MPP_Pheno.cls#Group1_versus_Group4_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_ESTROGEN_RESPONSE_EARLY |
| Enrichment Score (ES) | 0.20689878 |
| Normalized Enrichment Score (NES) | 0.9736604 |
| Nominal p-value | 0.52988046 |
| FDR q-value | 0.9065027 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Akap1 | 21 | 1.004 | 0.0232 | Yes |
| 2 | Fos | 93 | 0.813 | 0.0391 | Yes |
| 3 | Klf4 | 336 | 0.642 | 0.0421 | Yes |
| 4 | Unc119 | 492 | 0.592 | 0.0484 | Yes |
| 5 | Elovl2 | 597 | 0.565 | 0.0567 | Yes |
| 6 | Olfml3 | 682 | 0.547 | 0.0655 | Yes |
| 7 | Slc16a1 | 846 | 0.514 | 0.0695 | Yes |
| 8 | Greb1 | 969 | 0.494 | 0.0751 | Yes |
| 9 | Frk | 975 | 0.493 | 0.0868 | Yes |
| 10 | Rrp12 | 989 | 0.491 | 0.0980 | Yes |
| 11 | Il6st | 1035 | 0.486 | 0.1074 | Yes |
| 12 | Lrig1 | 1078 | 0.480 | 0.1168 | Yes |
| 13 | Tbc1d30 | 1166 | 0.467 | 0.1236 | Yes |
| 14 | Slc7a5 | 1351 | 0.444 | 0.1248 | Yes |
| 15 | Kazn | 1495 | 0.428 | 0.1277 | Yes |
| 16 | Wfs1 | 1688 | 0.407 | 0.1276 | Yes |
| 17 | Rhobtb3 | 1818 | 0.396 | 0.1305 | Yes |
| 18 | Kdm4b | 1967 | 0.382 | 0.1321 | Yes |
| 19 | Inpp5f | 1998 | 0.380 | 0.1397 | Yes |
| 20 | Ar | 2059 | 0.373 | 0.1456 | Yes |
| 21 | Tgif2 | 2060 | 0.373 | 0.1546 | Yes |
| 22 | Papss2 | 2061 | 0.373 | 0.1636 | Yes |
| 23 | Tob1 | 2100 | 0.368 | 0.1705 | Yes |
| 24 | Mybbp1a | 2116 | 0.367 | 0.1786 | Yes |
| 25 | Slc1a1 | 2149 | 0.364 | 0.1858 | Yes |
| 26 | Hspb8 | 2309 | 0.353 | 0.1860 | Yes |
| 27 | Ccnd1 | 2379 | 0.347 | 0.1909 | Yes |
| 28 | Mybl1 | 2546 | 0.331 | 0.1903 | Yes |
| 29 | Dlc1 | 2554 | 0.331 | 0.1979 | Yes |
| 30 | Bcl2 | 2638 | 0.325 | 0.2015 | Yes |
| 31 | Abhd2 | 3023 | 0.304 | 0.1890 | Yes |
| 32 | Gja1 | 3192 | 0.293 | 0.1873 | Yes |
| 33 | Isg20l2 | 3524 | 0.269 | 0.1767 | Yes |
| 34 | Tmprss3 | 3525 | 0.269 | 0.1832 | Yes |
| 35 | Endod1 | 3534 | 0.269 | 0.1893 | Yes |
| 36 | Slc27a2 | 3535 | 0.269 | 0.1958 | Yes |
| 37 | Slc7a2 | 3600 | 0.265 | 0.1989 | Yes |
| 38 | Ncor2 | 3670 | 0.259 | 0.2016 | Yes |
| 39 | Fasn | 3747 | 0.255 | 0.2038 | Yes |
| 40 | Med13l | 3974 | 0.239 | 0.1979 | Yes |
| 41 | Thsd4 | 4078 | 0.234 | 0.1982 | Yes |
| 42 | Adcy9 | 4120 | 0.233 | 0.2017 | Yes |
| 43 | Sfn | 4210 | 0.228 | 0.2026 | Yes |
| 44 | Fkbp5 | 4234 | 0.226 | 0.2069 | Yes |
| 45 | Add3 | 4368 | 0.219 | 0.2053 | No |
| 46 | Car12 | 4537 | 0.210 | 0.2017 | No |
| 47 | Celsr1 | 4760 | 0.200 | 0.1950 | No |
| 48 | Fkbp4 | 4777 | 0.199 | 0.1990 | No |
| 49 | B4galt1 | 5304 | 0.175 | 0.1760 | No |
| 50 | Scarb1 | 5471 | 0.166 | 0.1715 | No |
| 51 | Siah2 | 5539 | 0.163 | 0.1719 | No |
| 52 | Gla | 5675 | 0.157 | 0.1687 | No |
| 53 | Rab17 | 5691 | 0.156 | 0.1717 | No |
| 54 | Tiam1 | 5802 | 0.149 | 0.1696 | No |
| 55 | Zfp185 | 5896 | 0.145 | 0.1684 | No |
| 56 | Fdft1 | 5911 | 0.144 | 0.1711 | No |
| 57 | Elf1 | 6057 | 0.138 | 0.1670 | No |
| 58 | Amfr | 6708 | 0.110 | 0.1360 | No |
| 59 | Jak2 | 7272 | 0.088 | 0.1091 | No |
| 60 | Cd44 | 7361 | 0.084 | 0.1065 | No |
| 61 | Klf10 | 7609 | 0.074 | 0.0955 | No |
| 62 | Tiparp | 7632 | 0.072 | 0.0961 | No |
| 63 | Celsr2 | 7657 | 0.071 | 0.0966 | No |
| 64 | Igf1r | 7672 | 0.070 | 0.0976 | No |
| 65 | Retreg1 | 7678 | 0.070 | 0.0990 | No |
| 66 | Gfra1 | 7745 | 0.066 | 0.0972 | No |
| 67 | Muc1 | 7867 | 0.061 | 0.0924 | No |
| 68 | Chpt1 | 7880 | 0.060 | 0.0933 | No |
| 69 | Snx24 | 8140 | 0.051 | 0.0811 | No |
| 70 | Syngr1 | 8335 | 0.043 | 0.0721 | No |
| 71 | Myof | 8428 | 0.039 | 0.0683 | No |
| 72 | Pex11a | 8681 | 0.028 | 0.0560 | No |
| 73 | Svil | 8724 | 0.026 | 0.0544 | No |
| 74 | Myc | 8957 | 0.017 | 0.0428 | No |
| 75 | Podxl | 8990 | 0.015 | 0.0415 | No |
| 76 | Slc2a1 | 9018 | 0.014 | 0.0405 | No |
| 77 | Mpped2 | 9123 | 0.010 | 0.0354 | No |
| 78 | Stc2 | 9367 | 0.000 | 0.0228 | No |
| 79 | Tpbg | 9377 | 0.000 | 0.0223 | No |
| 80 | Cxcl12 | 9389 | 0.000 | 0.0218 | No |
| 81 | Cldn7 | 9503 | -0.002 | 0.0160 | No |
| 82 | Bag1 | 9734 | -0.010 | 0.0043 | No |
| 83 | Itpk1 | 9872 | -0.016 | -0.0023 | No |
| 84 | Pmaip1 | 10018 | -0.022 | -0.0093 | No |
| 85 | Nrip1 | 10056 | -0.024 | -0.0107 | No |
| 86 | Pgr | 10136 | -0.026 | -0.0141 | No |
| 87 | Asb13 | 10140 | -0.026 | -0.0136 | No |
| 88 | Tpd52l1 | 10291 | -0.033 | -0.0206 | No |
| 89 | Slc26a2 | 10330 | -0.034 | -0.0217 | No |
| 90 | Olfm1 | 10492 | -0.040 | -0.0291 | No |
| 91 | Dhcr7 | 10514 | -0.041 | -0.0292 | No |
| 92 | Slc24a3 | 10877 | -0.055 | -0.0466 | No |
| 93 | Myb | 10942 | -0.058 | -0.0485 | No |
| 94 | Rapgefl1 | 10957 | -0.059 | -0.0478 | No |
| 95 | Bhlhe40 | 11048 | -0.062 | -0.0509 | No |
| 96 | Tmem164 | 11180 | -0.068 | -0.0561 | No |
| 97 | Farp1 | 11302 | -0.073 | -0.0605 | No |
| 98 | Mapt | 11469 | -0.080 | -0.0672 | No |
| 99 | Scnn1a | 11686 | -0.089 | -0.0762 | No |
| 100 | Fhl2 | 11765 | -0.092 | -0.0780 | No |
| 101 | Rara | 11821 | -0.095 | -0.0786 | No |
| 102 | Rab31 | 11848 | -0.096 | -0.0776 | No |
| 103 | Clic3 | 11863 | -0.097 | -0.0760 | No |
| 104 | Cbfa2t3 | 12084 | -0.106 | -0.0848 | No |
| 105 | Ppif | 12086 | -0.106 | -0.0823 | No |
| 106 | Slc39a6 | 12141 | -0.108 | -0.0824 | No |
| 107 | Ptges | 12359 | -0.119 | -0.0908 | No |
| 108 | Nav2 | 12371 | -0.120 | -0.0885 | No |
| 109 | Elovl5 | 12520 | -0.128 | -0.0930 | No |
| 110 | Xbp1 | 12642 | -0.133 | -0.0961 | No |
| 111 | Aff1 | 12676 | -0.135 | -0.0945 | No |
| 112 | Rbbp8 | 13009 | -0.147 | -0.1081 | No |
| 113 | Slc22a5 | 13063 | -0.150 | -0.1072 | No |
| 114 | Dynlt3 | 13245 | -0.159 | -0.1127 | No |
| 115 | P2ry2 | 13317 | -0.163 | -0.1125 | No |
| 116 | Flnb | 13319 | -0.164 | -0.1086 | No |
| 117 | Slc1a4 | 13327 | -0.164 | -0.1050 | No |
| 118 | Hes1 | 13337 | -0.165 | -0.1014 | No |
| 119 | Med24 | 13347 | -0.165 | -0.0979 | No |
| 120 | Nadsyn1 | 13419 | -0.169 | -0.0975 | No |
| 121 | Abat | 13818 | -0.184 | -0.1136 | No |
| 122 | Mreg | 13967 | -0.192 | -0.1167 | No |
| 123 | Cish | 14046 | -0.195 | -0.1160 | No |
| 124 | Ugcg | 14143 | -0.200 | -0.1161 | No |
| 125 | Mast4 | 14742 | -0.228 | -0.1415 | No |
| 126 | Ret | 15158 | -0.250 | -0.1569 | No |
| 127 | Nxt1 | 15189 | -0.252 | -0.1524 | No |
| 128 | Ttc39a | 15215 | -0.253 | -0.1476 | No |
| 129 | Il17rb | 15360 | -0.262 | -0.1487 | No |
| 130 | Blvrb | 15374 | -0.262 | -0.1430 | No |
| 131 | Dhrs3 | 15618 | -0.278 | -0.1489 | No |
| 132 | Slc19a2 | 15769 | -0.289 | -0.1497 | No |
| 133 | Rps6ka2 | 15790 | -0.290 | -0.1437 | No |
| 134 | Tgm2 | 15880 | -0.295 | -0.1412 | No |
| 135 | Opn3 | 15957 | -0.300 | -0.1379 | No |
| 136 | Kcnk5 | 16282 | -0.319 | -0.1469 | No |
| 137 | Pdzk1 | 16340 | -0.322 | -0.1421 | No |
| 138 | Reep1 | 16359 | -0.323 | -0.1352 | No |
| 139 | Mindy1 | 16589 | -0.339 | -0.1389 | No |
| 140 | Cant1 | 16835 | -0.357 | -0.1429 | No |
| 141 | Ablim1 | 17083 | -0.380 | -0.1465 | No |
| 142 | Cyp26b1 | 17134 | -0.384 | -0.1398 | No |
| 143 | Anxa9 | 17184 | -0.386 | -0.1330 | No |
| 144 | Rhod | 17309 | -0.397 | -0.1299 | No |
| 145 | Slc37a1 | 17426 | -0.407 | -0.1260 | No |
| 146 | Abca3 | 17453 | -0.410 | -0.1175 | No |
| 147 | Aldh3b1 | 17463 | -0.411 | -0.1080 | No |
| 148 | Plaat3 | 17574 | -0.420 | -0.1036 | No |
| 149 | Sult2b1 | 17706 | -0.432 | -0.0999 | No |
| 150 | Sybu | 18033 | -0.468 | -0.1055 | No |
| 151 | Prss23 | 18202 | -0.491 | -0.1023 | No |
| 152 | Sh3bp5 | 18278 | -0.501 | -0.0941 | No |
| 153 | Bcl11b | 18405 | -0.522 | -0.0880 | No |
| 154 | Wwc1 | 18588 | -0.547 | -0.0842 | No |
| 155 | Igfbp4 | 18620 | -0.552 | -0.0725 | No |
| 156 | Mlph | 18646 | -0.557 | -0.0603 | No |
| 157 | Gab2 | 18843 | -0.596 | -0.0561 | No |
| 158 | Krt18 | 18897 | -0.611 | -0.0440 | No |
| 159 | Deptor | 18914 | -0.614 | -0.0301 | No |
| 160 | Arl3 | 19193 | -0.709 | -0.0273 | No |
| 161 | Tjp3 | 19361 | -0.820 | -0.0162 | No |
| 162 | Sec14l2 | 19461 | -0.991 | 0.0026 | No |

