| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group3.MPP_Pheno.cls#Group1_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.20296378 |
| Normalized Enrichment Score (NES) | 0.8995612 |
| Nominal p-value | 0.5971074 |
| FDR q-value | 0.8721949 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Tm7sf2 | 77 | 0.786 | 0.0150 | Yes |
| 2 | Fgl2 | 101 | 0.755 | 0.0321 | Yes |
| 3 | Ppp1r15a | 138 | 0.713 | 0.0474 | Yes |
| 4 | Mcm4 | 445 | 0.566 | 0.0453 | Yes |
| 5 | Wars1 | 617 | 0.522 | 0.0490 | Yes |
| 6 | Acly | 632 | 0.518 | 0.0608 | Yes |
| 7 | Map2k3 | 723 | 0.498 | 0.0682 | Yes |
| 8 | Cyp51 | 737 | 0.496 | 0.0795 | Yes |
| 9 | Hspa4 | 754 | 0.492 | 0.0906 | Yes |
| 10 | Rpa1 | 985 | 0.457 | 0.0897 | Yes |
| 11 | Canx | 1034 | 0.450 | 0.0981 | Yes |
| 12 | Slc7a5 | 1139 | 0.435 | 0.1032 | Yes |
| 13 | Hspa9 | 1170 | 0.431 | 0.1121 | Yes |
| 14 | Ddit4 | 1180 | 0.430 | 0.1220 | Yes |
| 15 | Stard4 | 1229 | 0.425 | 0.1298 | Yes |
| 16 | Cdc25a | 1243 | 0.423 | 0.1393 | Yes |
| 17 | Bhlhe40 | 1406 | 0.401 | 0.1406 | Yes |
| 18 | Fads2 | 1702 | 0.369 | 0.1343 | Yes |
| 19 | Acsl3 | 1999 | 0.344 | 0.1273 | Yes |
| 20 | Hk2 | 2002 | 0.344 | 0.1355 | Yes |
| 21 | Abcf2 | 2034 | 0.341 | 0.1421 | Yes |
| 22 | Pitpnb | 2065 | 0.338 | 0.1487 | Yes |
| 23 | Gpi1 | 2086 | 0.337 | 0.1558 | Yes |
| 24 | Mcm2 | 2089 | 0.336 | 0.1639 | Yes |
| 25 | Gga2 | 2105 | 0.334 | 0.1712 | Yes |
| 26 | Hspd1 | 2332 | 0.318 | 0.1671 | Yes |
| 27 | Bcat1 | 2357 | 0.316 | 0.1735 | Yes |
| 28 | Qdpr | 2407 | 0.314 | 0.1786 | Yes |
| 29 | Pdk1 | 2485 | 0.308 | 0.1820 | Yes |
| 30 | Psmc4 | 2614 | 0.302 | 0.1827 | Yes |
| 31 | Pgk1 | 2764 | 0.292 | 0.1820 | Yes |
| 32 | Serp1 | 2788 | 0.289 | 0.1878 | Yes |
| 33 | Hsp90b1 | 2836 | 0.286 | 0.1923 | Yes |
| 34 | Pno1 | 3061 | 0.271 | 0.1873 | Yes |
| 35 | Idi1 | 3238 | 0.259 | 0.1844 | Yes |
| 36 | Ero1a | 3257 | 0.258 | 0.1897 | Yes |
| 37 | Edem1 | 3274 | 0.256 | 0.1951 | Yes |
| 38 | Ifrd1 | 3453 | 0.247 | 0.1918 | Yes |
| 39 | Ifi30 | 3466 | 0.246 | 0.1972 | Yes |
| 40 | Rab1a | 3470 | 0.246 | 0.2030 | Yes |
| 41 | Nfkbib | 3588 | 0.240 | 0.2027 | No |
| 42 | Hmgcr | 3860 | 0.227 | 0.1942 | No |
| 43 | Fads1 | 4006 | 0.220 | 0.1920 | No |
| 44 | Ssr1 | 4157 | 0.211 | 0.1893 | No |
| 45 | Txnrd1 | 4301 | 0.204 | 0.1868 | No |
| 46 | G6pdx | 4426 | 0.198 | 0.1852 | No |
| 47 | Tfrc | 4633 | 0.189 | 0.1791 | No |
| 48 | Nup205 | 4819 | 0.180 | 0.1739 | No |
| 49 | Cyb5b | 4956 | 0.173 | 0.1710 | No |
| 50 | Add3 | 5008 | 0.171 | 0.1725 | No |
| 51 | Sord | 5060 | 0.168 | 0.1739 | No |
| 52 | Tmem97 | 5252 | 0.162 | 0.1680 | No |
| 53 | Actr2 | 5305 | 0.160 | 0.1691 | No |
| 54 | Sdf2l1 | 5366 | 0.157 | 0.1698 | No |
| 55 | Plod2 | 5851 | 0.134 | 0.1480 | No |
| 56 | Gla | 5883 | 0.132 | 0.1496 | No |
| 57 | Rrp9 | 5898 | 0.132 | 0.1521 | No |
| 58 | Cct6a | 5946 | 0.129 | 0.1528 | No |
| 59 | Insig1 | 6010 | 0.126 | 0.1526 | No |
| 60 | Slc37a4 | 6090 | 0.123 | 0.1514 | No |
| 61 | Glrx | 6102 | 0.123 | 0.1538 | No |
| 62 | Elovl6 | 6147 | 0.121 | 0.1545 | No |
| 63 | Ddit3 | 6471 | 0.111 | 0.1405 | No |
| 64 | Ube2d3 | 6671 | 0.104 | 0.1327 | No |
| 65 | Tbk1 | 6723 | 0.101 | 0.1324 | No |
| 66 | Acaca | 6727 | 0.100 | 0.1347 | No |
| 67 | Psmd14 | 6800 | 0.097 | 0.1333 | No |
| 68 | Hmbs | 6939 | 0.091 | 0.1284 | No |
| 69 | Gmps | 6963 | 0.090 | 0.1294 | No |
| 70 | Ykt6 | 7114 | 0.084 | 0.1237 | No |
| 71 | Pgm1 | 7159 | 0.083 | 0.1234 | No |
| 72 | Rpn1 | 7224 | 0.081 | 0.1220 | No |
| 73 | Ak4 | 7331 | 0.076 | 0.1184 | No |
| 74 | Polr3g | 7372 | 0.073 | 0.1181 | No |
| 75 | Immt | 7518 | 0.068 | 0.1122 | No |
| 76 | Gsk3b | 7574 | 0.065 | 0.1109 | No |
| 77 | Me1 | 7803 | 0.056 | 0.1005 | No |
| 78 | Stip1 | 7824 | 0.055 | 0.1008 | No |
| 79 | Psat1 | 8020 | 0.048 | 0.0919 | No |
| 80 | Dhfr | 8609 | 0.026 | 0.0621 | No |
| 81 | Sec11a | 8668 | 0.024 | 0.0597 | No |
| 82 | Psma3 | 8784 | 0.020 | 0.0542 | No |
| 83 | Btg2 | 8818 | 0.019 | 0.0529 | No |
| 84 | Pfkl | 8847 | 0.017 | 0.0519 | No |
| 85 | Shmt2 | 8849 | 0.017 | 0.0523 | No |
| 86 | Adipor2 | 8852 | 0.017 | 0.0526 | No |
| 87 | Mthfd2l | 8969 | 0.013 | 0.0469 | No |
| 88 | Slc1a5 | 8993 | 0.012 | 0.0460 | No |
| 89 | Psmc2 | 9028 | 0.011 | 0.0445 | No |
| 90 | Slc7a11 | 9110 | 0.008 | 0.0405 | No |
| 91 | Atp2a2 | 9177 | 0.006 | 0.0372 | No |
| 92 | M6pr | 9204 | 0.005 | 0.0360 | No |
| 93 | Sytl2 | 9214 | 0.005 | 0.0356 | No |
| 94 | Ddx39a | 9359 | -0.000 | 0.0282 | No |
| 95 | Hspe1 | 9386 | -0.001 | 0.0269 | No |
| 96 | Got1 | 9500 | -0.006 | 0.0212 | No |
| 97 | Nampt | 9513 | -0.006 | 0.0207 | No |
| 98 | Rit1 | 9518 | -0.006 | 0.0206 | No |
| 99 | Uchl5 | 9583 | -0.008 | 0.0175 | No |
| 100 | Skap2 | 9674 | -0.012 | 0.0132 | No |
| 101 | Lta4h | 9909 | -0.021 | 0.0016 | No |
| 102 | Vldlr | 9977 | -0.023 | -0.0013 | No |
| 103 | Gbe1 | 10073 | -0.027 | -0.0056 | No |
| 104 | Actr3 | 10150 | -0.030 | -0.0088 | No |
| 105 | Nufip1 | 10206 | -0.032 | -0.0109 | No |
| 106 | Uso1 | 10273 | -0.035 | -0.0135 | No |
| 107 | Asns | 10329 | -0.037 | -0.0154 | No |
| 108 | Etf1 | 10360 | -0.038 | -0.0160 | No |
| 109 | Niban1 | 10440 | -0.041 | -0.0191 | No |
| 110 | Ppa1 | 10541 | -0.046 | -0.0232 | No |
| 111 | Cops5 | 10580 | -0.047 | -0.0240 | No |
| 112 | Mllt11 | 10622 | -0.049 | -0.0250 | No |
| 113 | Srd5a1 | 10748 | -0.053 | -0.0302 | No |
| 114 | Ccng1 | 10755 | -0.053 | -0.0292 | No |
| 115 | Psph | 10783 | -0.054 | -0.0293 | No |
| 116 | Gsr | 10843 | -0.057 | -0.0310 | No |
| 117 | Psme3 | 11170 | -0.071 | -0.0461 | No |
| 118 | Nfyc | 11466 | -0.081 | -0.0594 | No |
| 119 | Gclc | 11479 | -0.081 | -0.0581 | No |
| 120 | Rdh11 | 11627 | -0.087 | -0.0636 | No |
| 121 | Hspa5 | 11726 | -0.091 | -0.0665 | No |
| 122 | Hmgcs1 | 11756 | -0.092 | -0.0658 | No |
| 123 | Fkbp2 | 11804 | -0.093 | -0.0659 | No |
| 124 | Tomm40 | 11823 | -0.094 | -0.0646 | No |
| 125 | Ldlr | 11826 | -0.094 | -0.0624 | No |
| 126 | Dapp1 | 11853 | -0.096 | -0.0614 | No |
| 127 | Dhcr24 | 11887 | -0.097 | -0.0608 | No |
| 128 | Fdxr | 11894 | -0.097 | -0.0588 | No |
| 129 | Calr | 11964 | -0.100 | -0.0599 | No |
| 130 | Psmd13 | 12111 | -0.106 | -0.0649 | No |
| 131 | Eif2s2 | 12254 | -0.112 | -0.0696 | No |
| 132 | Tubg1 | 12342 | -0.116 | -0.0713 | No |
| 133 | Pnp | 12357 | -0.116 | -0.0692 | No |
| 134 | Cacybp | 12360 | -0.116 | -0.0665 | No |
| 135 | Gtf2h1 | 12409 | -0.119 | -0.0661 | No |
| 136 | Xbp1 | 12565 | -0.124 | -0.0711 | No |
| 137 | Psmd12 | 12736 | -0.133 | -0.0767 | No |
| 138 | Slc6a6 | 12769 | -0.134 | -0.0751 | No |
| 139 | Aldoa | 12773 | -0.135 | -0.0720 | No |
| 140 | Tcea1 | 12805 | -0.136 | -0.0703 | No |
| 141 | Pdap1 | 13040 | -0.146 | -0.0789 | No |
| 142 | Ufm1 | 13173 | -0.151 | -0.0821 | No |
| 143 | Arpc5l | 13317 | -0.157 | -0.0857 | No |
| 144 | Tes | 13443 | -0.163 | -0.0882 | No |
| 145 | Cdkn1a | 13574 | -0.170 | -0.0909 | No |
| 146 | Slc1a4 | 13748 | -0.179 | -0.0955 | No |
| 147 | Ung | 13865 | -0.184 | -0.0970 | No |
| 148 | Ldha | 14037 | -0.192 | -0.1013 | No |
| 149 | Cxcr4 | 14053 | -0.193 | -0.0974 | No |
| 150 | Coro1a | 14059 | -0.193 | -0.0930 | No |
| 151 | Sla | 14358 | -0.208 | -0.1034 | No |
| 152 | Ebp | 14652 | -0.221 | -0.1132 | No |
| 153 | P4ha1 | 14710 | -0.224 | -0.1107 | No |
| 154 | Psmc6 | 14758 | -0.226 | -0.1077 | No |
| 155 | Nfil3 | 14952 | -0.237 | -0.1120 | No |
| 156 | Atp6v1d | 15008 | -0.240 | -0.1090 | No |
| 157 | Nmt1 | 15038 | -0.242 | -0.1047 | No |
| 158 | Tpi1 | 15469 | -0.266 | -0.1205 | No |
| 159 | Elovl5 | 15524 | -0.268 | -0.1168 | No |
| 160 | Sc5d | 15568 | -0.271 | -0.1125 | No |
| 161 | Ppia | 15570 | -0.271 | -0.1060 | No |
| 162 | Sqle | 15869 | -0.287 | -0.1145 | No |
| 163 | Serpinh1 | 15949 | -0.292 | -0.1115 | No |
| 164 | Lgmn | 16010 | -0.296 | -0.1075 | No |
| 165 | Cfp | 16326 | -0.317 | -0.1161 | No |
| 166 | Cd9 | 16365 | -0.320 | -0.1104 | No |
| 167 | Prdx1 | 16397 | -0.323 | -0.1042 | No |
| 168 | Slc2a3 | 16403 | -0.324 | -0.0966 | No |
| 169 | Slc2a1 | 16411 | -0.324 | -0.0891 | No |
| 170 | Dhcr7 | 16421 | -0.325 | -0.0817 | No |
| 171 | Itgb2 | 16431 | -0.325 | -0.0744 | No |
| 172 | Idh1 | 16484 | -0.327 | -0.0691 | No |
| 173 | Eef1e1 | 16503 | -0.329 | -0.0621 | No |
| 174 | Tuba4a | 16704 | -0.345 | -0.0641 | No |
| 175 | Bub1 | 16799 | -0.351 | -0.0605 | No |
| 176 | Nupr1 | 16834 | -0.353 | -0.0538 | No |
| 177 | Ctsc | 16893 | -0.356 | -0.0482 | No |
| 178 | Trib3 | 16944 | -0.361 | -0.0420 | No |
| 179 | Egln3 | 17134 | -0.375 | -0.0428 | No |
| 180 | Psmb5 | 17171 | -0.377 | -0.0355 | No |
| 181 | Eno1b | 17173 | -0.377 | -0.0265 | No |
| 182 | Aurka | 17331 | -0.388 | -0.0252 | No |
| 183 | Ccnf | 17569 | -0.412 | -0.0275 | No |
| 184 | Psma4 | 17670 | -0.422 | -0.0225 | No |
| 185 | Mthfd2 | 17868 | -0.445 | -0.0220 | No |
| 186 | Sqstm1 | 17987 | -0.456 | -0.0171 | No |
| 187 | Phgdh | 18347 | -0.504 | -0.0235 | No |
| 188 | Rrm2 | 18577 | -0.542 | -0.0222 | No |
| 189 | Psmg1 | 18956 | -0.626 | -0.0267 | No |
| 190 | Pik3r3 | 19452 | -0.965 | -0.0290 | No |
| 191 | Plk1 | 19506 | -1.325 | 0.0003 | No |

