| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group3.MPP_Pheno.cls#Group1_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_KRAS_SIGNALING_UP |
| Enrichment Score (ES) | -0.22749372 |
| Normalized Enrichment Score (NES) | -0.991391 |
| Nominal p-value | 0.44656488 |
| FDR q-value | 0.83657485 |
| FWER p-Value | 0.998 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Arg1 | 32 | 0.870 | 0.0218 | No |
| 2 | Lif | 83 | 0.771 | 0.0401 | No |
| 3 | Ppp1r15a | 138 | 0.713 | 0.0565 | No |
| 4 | Gabra3 | 150 | 0.702 | 0.0749 | No |
| 5 | Tspan7 | 254 | 0.641 | 0.0869 | No |
| 6 | Btc | 442 | 0.567 | 0.0926 | No |
| 7 | St6gal1 | 1022 | 0.451 | 0.0748 | No |
| 8 | Adam17 | 1196 | 0.429 | 0.0775 | No |
| 9 | Itgbl1 | 1210 | 0.427 | 0.0884 | No |
| 10 | Il1rl2 | 1223 | 0.426 | 0.0992 | No |
| 11 | Strn | 1231 | 0.424 | 0.1103 | No |
| 12 | Trib1 | 1265 | 0.419 | 0.1199 | No |
| 13 | Ank | 1328 | 0.409 | 0.1278 | No |
| 14 | Adam8 | 1403 | 0.402 | 0.1348 | No |
| 15 | Map3k1 | 1544 | 0.386 | 0.1380 | No |
| 16 | Gfpt2 | 1652 | 0.375 | 0.1426 | No |
| 17 | Irf8 | 1876 | 0.356 | 0.1407 | No |
| 18 | Bpgm | 1967 | 0.347 | 0.1454 | No |
| 19 | Akt2 | 2334 | 0.317 | 0.1351 | No |
| 20 | Dcbld2 | 2413 | 0.313 | 0.1395 | No |
| 21 | Mycn | 2482 | 0.309 | 0.1444 | No |
| 22 | Itga2 | 2487 | 0.308 | 0.1525 | No |
| 23 | Nr1h4 | 2519 | 0.306 | 0.1591 | No |
| 24 | Yrdc | 2797 | 0.289 | 0.1526 | No |
| 25 | Hbegf | 3105 | 0.268 | 0.1440 | No |
| 26 | Trib2 | 3151 | 0.265 | 0.1489 | No |
| 27 | Tor1aip2 | 3206 | 0.261 | 0.1531 | No |
| 28 | Ero1a | 3257 | 0.258 | 0.1575 | No |
| 29 | Tfpi | 3467 | 0.246 | 0.1534 | No |
| 30 | Vwa5a | 3534 | 0.243 | 0.1565 | No |
| 31 | Fbxo4 | 4528 | 0.194 | 0.1105 | No |
| 32 | Usp12 | 4690 | 0.186 | 0.1072 | No |
| 33 | Sdccag8 | 4740 | 0.183 | 0.1096 | No |
| 34 | Klf4 | 4885 | 0.177 | 0.1069 | No |
| 35 | F13a1 | 4929 | 0.175 | 0.1094 | No |
| 36 | Cbx8 | 4964 | 0.173 | 0.1123 | No |
| 37 | Ly96 | 5048 | 0.169 | 0.1126 | No |
| 38 | Cxcl10 | 5568 | 0.148 | 0.0898 | No |
| 39 | Id2 | 6000 | 0.127 | 0.0710 | No |
| 40 | Glrx | 6102 | 0.123 | 0.0691 | No |
| 41 | Scg5 | 6324 | 0.115 | 0.0608 | No |
| 42 | Etv5 | 6407 | 0.114 | 0.0596 | No |
| 43 | Il7r | 6478 | 0.111 | 0.0590 | No |
| 44 | Ppbp | 6578 | 0.107 | 0.0568 | No |
| 45 | Tmem100 | 6607 | 0.106 | 0.0582 | No |
| 46 | Birc3 | 6651 | 0.104 | 0.0588 | No |
| 47 | Igf2 | 7076 | 0.086 | 0.0392 | No |
| 48 | Abcb1a | 7104 | 0.085 | 0.0401 | No |
| 49 | Ptcd2 | 7183 | 0.082 | 0.0383 | No |
| 50 | Crot | 7210 | 0.081 | 0.0391 | No |
| 51 | Rbm4 | 7228 | 0.080 | 0.0404 | No |
| 52 | Ammecr1 | 7298 | 0.077 | 0.0389 | No |
| 53 | Wdr33 | 7314 | 0.076 | 0.0402 | No |
| 54 | Nin | 7601 | 0.064 | 0.0272 | No |
| 55 | Flt4 | 7624 | 0.064 | 0.0278 | No |
| 56 | Epb41l3 | 7736 | 0.059 | 0.0236 | No |
| 57 | Rabgap1l | 7772 | 0.058 | 0.0234 | No |
| 58 | Zfp277 | 7851 | 0.054 | 0.0208 | No |
| 59 | Reln | 7898 | 0.052 | 0.0198 | No |
| 60 | Spry2 | 7962 | 0.051 | 0.0180 | No |
| 61 | Map4k1 | 8033 | 0.048 | 0.0156 | No |
| 62 | Plaur | 8109 | 0.046 | 0.0130 | No |
| 63 | Map7 | 8309 | 0.038 | 0.0037 | No |
| 64 | Ccser2 | 8434 | 0.033 | -0.0018 | No |
| 65 | Dock2 | 8506 | 0.029 | -0.0046 | No |
| 66 | Ptbp2 | 8522 | 0.029 | -0.0046 | No |
| 67 | Ccnd2 | 8574 | 0.027 | -0.0066 | No |
| 68 | Ikzf1 | 8628 | 0.025 | -0.0086 | No |
| 69 | Dnmbp | 8684 | 0.024 | -0.0108 | No |
| 70 | Laptm5 | 8771 | 0.020 | -0.0147 | No |
| 71 | Atg10 | 9118 | 0.008 | -0.0324 | No |
| 72 | Gucy1a1 | 9232 | 0.004 | -0.0381 | No |
| 73 | Avl9 | 9287 | 0.001 | -0.0408 | No |
| 74 | Ets1 | 9971 | -0.023 | -0.0755 | No |
| 75 | Btbd3 | 9974 | -0.023 | -0.0750 | No |
| 76 | Evi5 | 9999 | -0.024 | -0.0756 | No |
| 77 | Cdadc1 | 10378 | -0.039 | -0.0940 | No |
| 78 | Wnt7a | 10567 | -0.046 | -0.1025 | No |
| 79 | Cbl | 10664 | -0.050 | -0.1061 | No |
| 80 | Mafb | 10770 | -0.054 | -0.1101 | No |
| 81 | Tspan13 | 10996 | -0.063 | -0.1200 | No |
| 82 | Ephb2 | 11230 | -0.074 | -0.1300 | No |
| 83 | Slpi | 11308 | -0.076 | -0.1319 | No |
| 84 | Scn1b | 11383 | -0.078 | -0.1337 | No |
| 85 | Gprc5b | 11538 | -0.084 | -0.1393 | No |
| 86 | Tnfrsf1b | 11602 | -0.086 | -0.1403 | No |
| 87 | H2bc3 | 11984 | -0.101 | -0.1572 | No |
| 88 | G0s2 | 12167 | -0.108 | -0.1637 | No |
| 89 | Ctss | 12206 | -0.110 | -0.1627 | No |
| 90 | Mmp11 | 12270 | -0.113 | -0.1629 | No |
| 91 | Cfb | 12323 | -0.115 | -0.1625 | No |
| 92 | Prdm1 | 12678 | -0.130 | -0.1773 | No |
| 93 | Cbr4 | 12934 | -0.142 | -0.1866 | No |
| 94 | Gng11 | 12988 | -0.144 | -0.1854 | No |
| 95 | Etv4 | 13044 | -0.147 | -0.1843 | No |
| 96 | Cab39l | 13128 | -0.148 | -0.1846 | No |
| 97 | Prelid3b | 13349 | -0.158 | -0.1917 | No |
| 98 | Ptprr | 13357 | -0.159 | -0.1878 | No |
| 99 | Akap12 | 13425 | -0.162 | -0.1869 | No |
| 100 | Kcnn4 | 13621 | -0.172 | -0.1923 | No |
| 101 | Ano1 | 13677 | -0.175 | -0.1904 | No |
| 102 | Jup | 13797 | -0.181 | -0.1916 | No |
| 103 | Pecam1 | 13842 | -0.183 | -0.1890 | No |
| 104 | Dusp6 | 13971 | -0.189 | -0.1905 | No |
| 105 | Cxcr4 | 14053 | -0.193 | -0.1895 | No |
| 106 | Adgrl4 | 14094 | -0.195 | -0.1863 | No |
| 107 | Lcp1 | 14715 | -0.224 | -0.2122 | No |
| 108 | Mmd | 14910 | -0.234 | -0.2159 | No |
| 109 | Spon1 | 14940 | -0.236 | -0.2110 | No |
| 110 | Mtmr10 | 15141 | -0.248 | -0.2147 | No |
| 111 | Eng | 15167 | -0.250 | -0.2092 | No |
| 112 | Fcer1g | 15443 | -0.264 | -0.2163 | No |
| 113 | Cmklr1 | 15475 | -0.267 | -0.2107 | No |
| 114 | Plek2 | 15801 | -0.283 | -0.2198 | Yes |
| 115 | Nrp1 | 15841 | -0.285 | -0.2141 | Yes |
| 116 | Adgra2 | 15845 | -0.286 | -0.2066 | Yes |
| 117 | Tmem176a | 15930 | -0.292 | -0.2030 | Yes |
| 118 | Nr0b2 | 15959 | -0.293 | -0.1966 | Yes |
| 119 | Scg3 | 16011 | -0.296 | -0.1912 | Yes |
| 120 | Ptgs2 | 16086 | -0.301 | -0.1869 | Yes |
| 121 | Gadd45g | 16161 | -0.305 | -0.1825 | Yes |
| 122 | Gypc | 16171 | -0.306 | -0.1747 | Yes |
| 123 | Kif5c | 16246 | -0.312 | -0.1701 | Yes |
| 124 | Itgb2 | 16431 | -0.325 | -0.1708 | Yes |
| 125 | Fuca1 | 16433 | -0.326 | -0.1620 | Yes |
| 126 | Plvap | 16496 | -0.328 | -0.1564 | Yes |
| 127 | Pdcd1lg2 | 16577 | -0.334 | -0.1515 | Yes |
| 128 | Etv1 | 16766 | -0.349 | -0.1518 | Yes |
| 129 | Psmb8 | 17018 | -0.366 | -0.1548 | Yes |
| 130 | Il2rg | 17155 | -0.376 | -0.1517 | Yes |
| 131 | Lat2 | 17165 | -0.376 | -0.1420 | Yes |
| 132 | Plau | 17172 | -0.377 | -0.1322 | Yes |
| 133 | Angptl4 | 17243 | -0.381 | -0.1255 | Yes |
| 134 | Emp1 | 17365 | -0.391 | -0.1212 | Yes |
| 135 | Tnfaip3 | 17582 | -0.413 | -0.1212 | Yes |
| 136 | Tmem176b | 17617 | -0.416 | -0.1117 | Yes |
| 137 | Hdac9 | 18147 | -0.478 | -0.1261 | Yes |
| 138 | Satb1 | 18306 | -0.498 | -0.1208 | Yes |
| 139 | Car2 | 18349 | -0.505 | -0.1093 | Yes |
| 140 | Il10ra | 18362 | -0.507 | -0.0963 | Yes |
| 141 | Hsd11b1 | 18603 | -0.547 | -0.0939 | Yes |
| 142 | Cd37 | 18622 | -0.550 | -0.0800 | Yes |
| 143 | Traf1 | 18628 | -0.551 | -0.0654 | Yes |
| 144 | Fgf9 | 18780 | -0.579 | -0.0575 | Yes |
| 145 | Zfp639 | 18897 | -0.608 | -0.0471 | Yes |
| 146 | Spp1 | 19162 | -0.695 | -0.0420 | Yes |
| 147 | Tmem158 | 19178 | -0.704 | -0.0237 | Yes |
| 148 | Csf2ra | 19251 | -0.748 | -0.0073 | Yes |
| 149 | Galnt3 | 19284 | -0.766 | 0.0118 | Yes |

