| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group3.MPP_Pheno.cls#Group1_versus_Group3_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_HEME_METABOLISM |
| Enrichment Score (ES) | 0.18279202 |
| Normalized Enrichment Score (NES) | 0.95183986 |
| Nominal p-value | 0.52838427 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | P4ha2 | 19 | 0.937 | 0.0213 | Yes |
| 2 | Slc4a1 | 24 | 0.914 | 0.0428 | Yes |
| 3 | Marchf8 | 67 | 0.802 | 0.0596 | Yes |
| 4 | Abcb6 | 136 | 0.714 | 0.0731 | Yes |
| 5 | Snca | 178 | 0.683 | 0.0872 | Yes |
| 6 | Acsl6 | 319 | 0.609 | 0.0944 | Yes |
| 7 | Fbxo7 | 455 | 0.562 | 0.1007 | Yes |
| 8 | Arhgef12 | 472 | 0.557 | 0.1131 | Yes |
| 9 | Uros | 540 | 0.544 | 0.1226 | Yes |
| 10 | Epb42 | 651 | 0.514 | 0.1291 | Yes |
| 11 | Map2k3 | 723 | 0.498 | 0.1372 | Yes |
| 12 | Slc66a2 | 1092 | 0.442 | 0.1287 | Yes |
| 13 | Igsf3 | 1217 | 0.427 | 0.1324 | Yes |
| 14 | Mboat2 | 1325 | 0.410 | 0.1366 | Yes |
| 15 | C3 | 1360 | 0.407 | 0.1445 | Yes |
| 16 | Ppp2r5b | 1761 | 0.364 | 0.1325 | Yes |
| 17 | Nudt4 | 1814 | 0.360 | 0.1383 | Yes |
| 18 | Bach1 | 1895 | 0.355 | 0.1426 | Yes |
| 19 | Bpgm | 1967 | 0.347 | 0.1472 | Yes |
| 20 | Fech | 2004 | 0.344 | 0.1535 | Yes |
| 21 | Rnf123 | 2032 | 0.341 | 0.1602 | Yes |
| 22 | Slc22a4 | 2248 | 0.322 | 0.1567 | Yes |
| 23 | Rhag | 2274 | 0.321 | 0.1630 | Yes |
| 24 | Bnip3l | 2278 | 0.321 | 0.1705 | Yes |
| 25 | Tfdp2 | 2934 | 0.279 | 0.1432 | Yes |
| 26 | Ccdc28a | 2970 | 0.276 | 0.1480 | Yes |
| 27 | Klf1 | 3152 | 0.265 | 0.1449 | Yes |
| 28 | Foxj2 | 3179 | 0.263 | 0.1498 | Yes |
| 29 | Slc6a9 | 3232 | 0.260 | 0.1533 | Yes |
| 30 | Epb41 | 3431 | 0.248 | 0.1490 | Yes |
| 31 | Fbxo9 | 3442 | 0.248 | 0.1543 | Yes |
| 32 | Khnyn | 3573 | 0.241 | 0.1533 | Yes |
| 33 | Tyr | 3654 | 0.236 | 0.1548 | Yes |
| 34 | Sptb | 3957 | 0.222 | 0.1444 | Yes |
| 35 | Optn | 3970 | 0.221 | 0.1491 | Yes |
| 36 | Cir1 | 4038 | 0.218 | 0.1508 | Yes |
| 37 | Ranbp10 | 4049 | 0.218 | 0.1554 | Yes |
| 38 | Daam1 | 4083 | 0.216 | 0.1588 | Yes |
| 39 | Mxi1 | 4189 | 0.209 | 0.1584 | Yes |
| 40 | Kdm7a | 4248 | 0.207 | 0.1603 | Yes |
| 41 | Foxo3 | 4380 | 0.200 | 0.1583 | Yes |
| 42 | Btrc | 4457 | 0.197 | 0.1590 | Yes |
| 43 | Rhd | 4469 | 0.197 | 0.1631 | Yes |
| 44 | Trak2 | 4477 | 0.197 | 0.1674 | Yes |
| 45 | Rbm5 | 4507 | 0.195 | 0.1706 | Yes |
| 46 | Slc10a3 | 4561 | 0.192 | 0.1724 | Yes |
| 47 | Spta1 | 4630 | 0.189 | 0.1734 | Yes |
| 48 | Tfrc | 4633 | 0.189 | 0.1777 | Yes |
| 49 | Picalm | 4636 | 0.188 | 0.1821 | Yes |
| 50 | Sdcbp | 4731 | 0.184 | 0.1816 | Yes |
| 51 | Smox | 4792 | 0.181 | 0.1828 | Yes |
| 52 | Bcam | 4898 | 0.176 | 0.1815 | No |
| 53 | Slc30a1 | 4958 | 0.173 | 0.1826 | No |
| 54 | Pgls | 5075 | 0.168 | 0.1806 | No |
| 55 | Mkrn1 | 5296 | 0.160 | 0.1730 | No |
| 56 | Hagh | 5340 | 0.159 | 0.1746 | No |
| 57 | Gapvd1 | 5360 | 0.158 | 0.1773 | No |
| 58 | Tspo2 | 5716 | 0.140 | 0.1623 | No |
| 59 | Sidt2 | 5770 | 0.138 | 0.1628 | No |
| 60 | Gde1 | 5915 | 0.131 | 0.1585 | No |
| 61 | Narf | 5995 | 0.127 | 0.1574 | No |
| 62 | Trim58 | 6064 | 0.124 | 0.1568 | No |
| 63 | Add1 | 6068 | 0.124 | 0.1596 | No |
| 64 | Tal1 | 6076 | 0.124 | 0.1622 | No |
| 65 | Cpox | 6135 | 0.122 | 0.1621 | No |
| 66 | Ank1 | 6255 | 0.117 | 0.1587 | No |
| 67 | Lamp2 | 6271 | 0.117 | 0.1607 | No |
| 68 | Nek7 | 6304 | 0.116 | 0.1618 | No |
| 69 | Xpo7 | 6412 | 0.113 | 0.1590 | No |
| 70 | Pigq | 6418 | 0.113 | 0.1614 | No |
| 71 | Slc11a2 | 6448 | 0.112 | 0.1626 | No |
| 72 | Nnt | 6460 | 0.111 | 0.1646 | No |
| 73 | Eif2ak1 | 6523 | 0.109 | 0.1640 | No |
| 74 | Fbxo34 | 6663 | 0.104 | 0.1593 | No |
| 75 | Ucp2 | 6914 | 0.092 | 0.1486 | No |
| 76 | Hmbs | 6939 | 0.091 | 0.1495 | No |
| 77 | Gmps | 6963 | 0.090 | 0.1504 | No |
| 78 | Xk | 6970 | 0.090 | 0.1523 | No |
| 79 | Synj1 | 7042 | 0.087 | 0.1507 | No |
| 80 | Nfe2l1 | 7324 | 0.076 | 0.1379 | No |
| 81 | Rcl1 | 7494 | 0.069 | 0.1308 | No |
| 82 | Acp5 | 7570 | 0.066 | 0.1285 | No |
| 83 | Ccnd3 | 7737 | 0.059 | 0.1213 | No |
| 84 | Tspan5 | 7787 | 0.057 | 0.1202 | No |
| 85 | Ctse | 8019 | 0.048 | 0.1094 | No |
| 86 | Gata1 | 8112 | 0.046 | 0.1057 | No |
| 87 | Rap1gap | 8168 | 0.043 | 0.1039 | No |
| 88 | Dcaf10 | 8233 | 0.041 | 0.1015 | No |
| 89 | Riok3 | 8457 | 0.032 | 0.0908 | No |
| 90 | Lpin2 | 8711 | 0.023 | 0.0782 | No |
| 91 | Usp15 | 8733 | 0.022 | 0.0776 | No |
| 92 | Btg2 | 8818 | 0.019 | 0.0737 | No |
| 93 | Tnrc6b | 8842 | 0.018 | 0.0730 | No |
| 94 | Myl4 | 8892 | 0.016 | 0.0708 | No |
| 95 | Slc6a8 | 8906 | 0.015 | 0.0705 | No |
| 96 | Slc7a11 | 9110 | 0.008 | 0.0602 | No |
| 97 | Top1 | 9558 | -0.008 | 0.0372 | No |
| 98 | Vezf1 | 9562 | -0.008 | 0.0373 | No |
| 99 | Add2 | 9608 | -0.009 | 0.0352 | No |
| 100 | Tns1 | 9616 | -0.009 | 0.0350 | No |
| 101 | Ezh1 | 9673 | -0.012 | 0.0324 | No |
| 102 | Nr3c1 | 9741 | -0.015 | 0.0293 | No |
| 103 | Agpat4 | 9750 | -0.015 | 0.0292 | No |
| 104 | Htatip2 | 9817 | -0.018 | 0.0262 | No |
| 105 | Bmp2k | 10007 | -0.024 | 0.0170 | No |
| 106 | Cast | 10207 | -0.032 | 0.0075 | No |
| 107 | Slc30a10 | 10265 | -0.035 | 0.0054 | No |
| 108 | Asns | 10329 | -0.037 | 0.0030 | No |
| 109 | Mocos | 10340 | -0.037 | 0.0034 | No |
| 110 | Endod1 | 10533 | -0.045 | -0.0055 | No |
| 111 | Mgst3 | 10565 | -0.046 | -0.0060 | No |
| 112 | Tmem9b | 10719 | -0.052 | -0.0127 | No |
| 113 | Mfhas1 | 10883 | -0.059 | -0.0197 | No |
| 114 | Mpp1 | 10986 | -0.063 | -0.0235 | No |
| 115 | Bsg | 11116 | -0.069 | -0.0285 | No |
| 116 | Car1 | 11147 | -0.070 | -0.0284 | No |
| 117 | Gclc | 11479 | -0.081 | -0.0436 | No |
| 118 | Minpp1 | 11591 | -0.086 | -0.0473 | No |
| 119 | Osbp2 | 11615 | -0.087 | -0.0464 | No |
| 120 | Htra2 | 11698 | -0.090 | -0.0485 | No |
| 121 | Pdzk1ip1 | 12024 | -0.102 | -0.0629 | No |
| 122 | Sec14l1 | 12067 | -0.104 | -0.0626 | No |
| 123 | Blvrb | 12179 | -0.108 | -0.0658 | No |
| 124 | Dcaf11 | 12302 | -0.114 | -0.0694 | No |
| 125 | Atg4a | 12619 | -0.127 | -0.0827 | No |
| 126 | Clcn3 | 12718 | -0.132 | -0.0846 | No |
| 127 | Ncoa4 | 12741 | -0.133 | -0.0826 | No |
| 128 | Ermap | 12778 | -0.135 | -0.0813 | No |
| 129 | Tcea1 | 12805 | -0.136 | -0.0794 | No |
| 130 | Pcx | 13065 | -0.147 | -0.0893 | No |
| 131 | Mark3 | 13140 | -0.149 | -0.0896 | No |
| 132 | Slc25a38 | 13299 | -0.156 | -0.0941 | No |
| 133 | Adipor1 | 13400 | -0.161 | -0.0954 | No |
| 134 | Abcg2 | 13452 | -0.164 | -0.0942 | No |
| 135 | Atp6v0a1 | 13483 | -0.165 | -0.0918 | No |
| 136 | Epor | 14028 | -0.191 | -0.1154 | No |
| 137 | Urod | 14216 | -0.201 | -0.1203 | No |
| 138 | Kat2b | 14318 | -0.206 | -0.1206 | No |
| 139 | Cdc27 | 14351 | -0.207 | -0.1174 | No |
| 140 | Ubac1 | 14452 | -0.211 | -0.1175 | No |
| 141 | E2f2 | 14606 | -0.219 | -0.1203 | No |
| 142 | Alas2 | 14813 | -0.229 | -0.1255 | No |
| 143 | Dcun1d1 | 14891 | -0.233 | -0.1239 | No |
| 144 | Rnf19a | 14921 | -0.235 | -0.1198 | No |
| 145 | Trim10 | 14967 | -0.238 | -0.1165 | No |
| 146 | Kel | 15150 | -0.249 | -0.1200 | No |
| 147 | Klf3 | 15243 | -0.254 | -0.1187 | No |
| 148 | Rad23a | 15323 | -0.258 | -0.1167 | No |
| 149 | Hdgf | 15445 | -0.264 | -0.1167 | No |
| 150 | Gclm | 15532 | -0.269 | -0.1147 | No |
| 151 | Psmd9 | 15720 | -0.279 | -0.1178 | No |
| 152 | Alad | 15852 | -0.286 | -0.1178 | No |
| 153 | Rbm38 | 15964 | -0.293 | -0.1166 | No |
| 154 | Blvra | 16051 | -0.299 | -0.1139 | No |
| 155 | Ypel5 | 16105 | -0.302 | -0.1095 | No |
| 156 | Gypc | 16171 | -0.306 | -0.1056 | No |
| 157 | Tmcc2 | 16336 | -0.317 | -0.1065 | No |
| 158 | Slc2a1 | 16411 | -0.324 | -0.1027 | No |
| 159 | Hebp1 | 16589 | -0.335 | -0.1039 | No |
| 160 | Lrp10 | 16622 | -0.338 | -0.0975 | No |
| 161 | Cat | 16890 | -0.356 | -0.1029 | No |
| 162 | Mospd1 | 16929 | -0.359 | -0.0963 | No |
| 163 | Marchf2 | 16953 | -0.362 | -0.0889 | No |
| 164 | Fn3k | 16967 | -0.363 | -0.0810 | No |
| 165 | Ell2 | 17280 | -0.385 | -0.0880 | No |
| 166 | Lmo2 | 17373 | -0.393 | -0.0834 | No |
| 167 | Ppox | 17374 | -0.393 | -0.0741 | No |
| 168 | Aldh6a1 | 17381 | -0.393 | -0.0650 | No |
| 169 | Ctsb | 17758 | -0.432 | -0.0742 | No |
| 170 | Cdr2 | 17845 | -0.443 | -0.0682 | No |
| 171 | Nfe2 | 17947 | -0.452 | -0.0627 | No |
| 172 | Dmtn | 17981 | -0.456 | -0.0535 | No |
| 173 | Aldh1l1 | 18170 | -0.481 | -0.0518 | No |
| 174 | Arl2bp | 18216 | -0.487 | -0.0426 | No |
| 175 | H1f0 | 18315 | -0.499 | -0.0358 | No |
| 176 | Car2 | 18349 | -0.505 | -0.0256 | No |
| 177 | Selenbp1 | 18501 | -0.528 | -0.0208 | No |
| 178 | Ctns | 18526 | -0.533 | -0.0094 | No |
| 179 | Tent5c | 18773 | -0.577 | -0.0084 | No |
| 180 | Prdx2 | 18869 | -0.602 | 0.0010 | No |
| 181 | Glrx5 | 19071 | -0.666 | 0.0064 | No |
| 182 | Icam4 | 19151 | -0.690 | 0.0187 | No |

