| Dataset | MPP.MPP_Pheno.cls#Group1_versus_Group2.MPP_Pheno.cls#Group1_versus_Group2_repos |
| Phenotype | MPP_Pheno.cls#Group1_versus_Group2_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | 0.17010944 |
| Normalized Enrichment Score (NES) | 0.75475454 |
| Nominal p-value | 0.9237473 |
| FDR q-value | 0.8406236 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ddit4 | 85 | 0.823 | 0.0146 | Yes |
| 2 | Ctsf | 100 | 0.801 | 0.0323 | Yes |
| 3 | Steap3 | 119 | 0.779 | 0.0493 | Yes |
| 4 | Ccnd2 | 186 | 0.710 | 0.0623 | Yes |
| 5 | Klf4 | 367 | 0.611 | 0.0670 | Yes |
| 6 | St14 | 389 | 0.605 | 0.0799 | Yes |
| 7 | Fam162a | 480 | 0.578 | 0.0886 | Yes |
| 8 | Cdkn2aip | 770 | 0.514 | 0.0854 | Yes |
| 9 | Tprkb | 776 | 0.513 | 0.0970 | Yes |
| 10 | Nudt15 | 940 | 0.486 | 0.0998 | Yes |
| 11 | Tob1 | 1021 | 0.474 | 0.1066 | Yes |
| 12 | Hmox1 | 1253 | 0.439 | 0.1047 | Yes |
| 13 | Trib3 | 1293 | 0.434 | 0.1127 | Yes |
| 14 | Upp1 | 1304 | 0.433 | 0.1222 | Yes |
| 15 | Ephx1 | 1333 | 0.429 | 0.1306 | Yes |
| 16 | Ei24 | 1407 | 0.420 | 0.1365 | Yes |
| 17 | Btg1 | 1505 | 0.410 | 0.1409 | Yes |
| 18 | Tnfsf9 | 1513 | 0.409 | 0.1500 | Yes |
| 19 | Ldhb | 1515 | 0.409 | 0.1594 | Yes |
| 20 | Zbtb16 | 1591 | 0.400 | 0.1647 | Yes |
| 21 | Trafd1 | 1833 | 0.375 | 0.1609 | Yes |
| 22 | Notch1 | 2023 | 0.359 | 0.1594 | Yes |
| 23 | Ptpn14 | 2284 | 0.336 | 0.1537 | Yes |
| 24 | F2r | 2424 | 0.325 | 0.1540 | Yes |
| 25 | Ercc5 | 2472 | 0.321 | 0.1589 | Yes |
| 26 | Pidd1 | 2592 | 0.315 | 0.1600 | Yes |
| 27 | Rchy1 | 2654 | 0.310 | 0.1640 | Yes |
| 28 | Ifi30 | 2808 | 0.301 | 0.1630 | Yes |
| 29 | Cyfip2 | 2842 | 0.299 | 0.1682 | Yes |
| 30 | Dram1 | 3196 | 0.277 | 0.1563 | Yes |
| 31 | Ptpre | 3317 | 0.269 | 0.1563 | Yes |
| 32 | Vdr | 3469 | 0.259 | 0.1545 | Yes |
| 33 | Irag2 | 3586 | 0.252 | 0.1543 | Yes |
| 34 | Tcn2 | 3598 | 0.251 | 0.1595 | Yes |
| 35 | Pdgfa | 3666 | 0.248 | 0.1618 | Yes |
| 36 | Tm7sf3 | 3763 | 0.243 | 0.1624 | Yes |
| 37 | Aen | 3807 | 0.241 | 0.1657 | Yes |
| 38 | Zmat3 | 3924 | 0.235 | 0.1651 | Yes |
| 39 | Cebpa | 3943 | 0.234 | 0.1696 | Yes |
| 40 | Osgin1 | 4138 | 0.223 | 0.1647 | Yes |
| 41 | Ankra2 | 4206 | 0.220 | 0.1663 | Yes |
| 42 | Btg2 | 4231 | 0.219 | 0.1701 | Yes |
| 43 | Bak1 | 4467 | 0.207 | 0.1627 | No |
| 44 | Abcc5 | 4702 | 0.193 | 0.1550 | No |
| 45 | Alox8 | 4753 | 0.191 | 0.1569 | No |
| 46 | Sesn1 | 4816 | 0.189 | 0.1580 | No |
| 47 | Ninj1 | 4850 | 0.188 | 0.1606 | No |
| 48 | Pom121 | 4918 | 0.184 | 0.1614 | No |
| 49 | Tap1 | 5046 | 0.179 | 0.1590 | No |
| 50 | Hdac3 | 5157 | 0.173 | 0.1573 | No |
| 51 | Sdc1 | 5311 | 0.166 | 0.1532 | No |
| 52 | Sat1 | 5401 | 0.162 | 0.1523 | No |
| 53 | Trp53 | 5498 | 0.157 | 0.1509 | No |
| 54 | Ccp110 | 5675 | 0.149 | 0.1453 | No |
| 55 | Tsc22d1 | 5732 | 0.146 | 0.1457 | No |
| 56 | Wwp1 | 5765 | 0.145 | 0.1474 | No |
| 57 | Lif | 5811 | 0.143 | 0.1484 | No |
| 58 | Def6 | 5872 | 0.140 | 0.1485 | No |
| 59 | Mxd4 | 5921 | 0.138 | 0.1492 | No |
| 60 | Zfp365 | 5948 | 0.137 | 0.1510 | No |
| 61 | Ddb2 | 6218 | 0.125 | 0.1400 | No |
| 62 | Coq8a | 6255 | 0.123 | 0.1409 | No |
| 63 | Rab40c | 6260 | 0.123 | 0.1436 | No |
| 64 | Prkab1 | 6296 | 0.122 | 0.1446 | No |
| 65 | Socs1 | 6429 | 0.117 | 0.1404 | No |
| 66 | Pcna | 6543 | 0.114 | 0.1372 | No |
| 67 | Traf4 | 6594 | 0.112 | 0.1372 | No |
| 68 | Fdxr | 6643 | 0.110 | 0.1373 | No |
| 69 | Polh | 6795 | 0.103 | 0.1318 | No |
| 70 | Cdk5r1 | 6808 | 0.103 | 0.1336 | No |
| 71 | Foxo3 | 6814 | 0.103 | 0.1357 | No |
| 72 | Jun | 6818 | 0.103 | 0.1379 | No |
| 73 | Cdkn2a | 6866 | 0.101 | 0.1378 | No |
| 74 | Dgka | 6882 | 0.100 | 0.1393 | No |
| 75 | Ccnk | 6945 | 0.098 | 0.1384 | No |
| 76 | Rnf19b | 6960 | 0.098 | 0.1399 | No |
| 77 | Sec61a1 | 6995 | 0.097 | 0.1404 | No |
| 78 | Tax1bp3 | 7005 | 0.096 | 0.1421 | No |
| 79 | Baiap2 | 7140 | 0.092 | 0.1373 | No |
| 80 | Fos | 7184 | 0.090 | 0.1372 | No |
| 81 | Procr | 7332 | 0.084 | 0.1315 | No |
| 82 | Ralgds | 7370 | 0.083 | 0.1315 | No |
| 83 | Sfn | 7544 | 0.076 | 0.1243 | No |
| 84 | Irak1 | 7703 | 0.070 | 0.1178 | No |
| 85 | Cd81 | 7829 | 0.066 | 0.1128 | No |
| 86 | Txnip | 7842 | 0.065 | 0.1137 | No |
| 87 | H2ac25 | 7891 | 0.063 | 0.1127 | No |
| 88 | Sp1 | 7938 | 0.062 | 0.1117 | No |
| 89 | Slc3a2 | 8006 | 0.060 | 0.1096 | No |
| 90 | Rb1 | 8307 | 0.047 | 0.0952 | No |
| 91 | Rrad | 8569 | 0.038 | 0.0826 | No |
| 92 | Slc35d1 | 8697 | 0.034 | 0.0768 | No |
| 93 | Hspa4l | 8744 | 0.033 | 0.0752 | No |
| 94 | Ppp1r15a | 8860 | 0.029 | 0.0699 | No |
| 95 | Fuca1 | 9145 | 0.018 | 0.0556 | No |
| 96 | Ndrg1 | 9417 | 0.009 | 0.0418 | No |
| 97 | Pmm1 | 9440 | 0.008 | 0.0408 | No |
| 98 | Bax | 9493 | 0.006 | 0.0383 | No |
| 99 | Apaf1 | 9598 | 0.002 | 0.0329 | No |
| 100 | Pvt1 | 9681 | -0.000 | 0.0287 | No |
| 101 | Slc7a11 | 9758 | -0.003 | 0.0248 | No |
| 102 | Rps12 | 9771 | -0.004 | 0.0243 | No |
| 103 | Fas | 10267 | -0.020 | -0.0009 | No |
| 104 | Sphk1 | 10323 | -0.022 | -0.0032 | No |
| 105 | Jag2 | 10682 | -0.034 | -0.0209 | No |
| 106 | Trp63 | 10762 | -0.037 | -0.0242 | No |
| 107 | Prmt2 | 10843 | -0.040 | -0.0274 | No |
| 108 | Mdm2 | 10931 | -0.043 | -0.0309 | No |
| 109 | Epha2 | 11012 | -0.046 | -0.0340 | No |
| 110 | Fbxw7 | 11032 | -0.046 | -0.0339 | No |
| 111 | Mxd1 | 11073 | -0.048 | -0.0349 | No |
| 112 | Sertad3 | 11182 | -0.051 | -0.0393 | No |
| 113 | Tspyl2 | 11241 | -0.053 | -0.0411 | No |
| 114 | Mknk2 | 11260 | -0.054 | -0.0407 | No |
| 115 | Abat | 11334 | -0.057 | -0.0432 | No |
| 116 | Pitpnc1 | 11430 | -0.060 | -0.0468 | No |
| 117 | Zfp36l1 | 11474 | -0.061 | -0.0476 | No |
| 118 | H2aj | 11613 | -0.066 | -0.0532 | No |
| 119 | Blcap | 11776 | -0.073 | -0.0599 | No |
| 120 | Hras | 11787 | -0.073 | -0.0587 | No |
| 121 | Tpd52l1 | 11799 | -0.074 | -0.0576 | No |
| 122 | Rap2b | 12005 | -0.081 | -0.0663 | No |
| 123 | Tgfb1 | 12041 | -0.082 | -0.0662 | No |
| 124 | Cdh13 | 12205 | -0.089 | -0.0726 | No |
| 125 | Rps27l | 12545 | -0.103 | -0.0878 | No |
| 126 | Vwa5a | 12617 | -0.105 | -0.0890 | No |
| 127 | Dnttip2 | 12631 | -0.106 | -0.0873 | No |
| 128 | Plk3 | 12647 | -0.106 | -0.0856 | No |
| 129 | Kif13b | 12728 | -0.110 | -0.0872 | No |
| 130 | Abhd4 | 12929 | -0.118 | -0.0948 | No |
| 131 | Mapkapk3 | 13061 | -0.123 | -0.0988 | No |
| 132 | Hbegf | 13160 | -0.128 | -0.1009 | No |
| 133 | Ccng1 | 13227 | -0.130 | -0.1013 | No |
| 134 | Cgrrf1 | 13315 | -0.134 | -0.1027 | No |
| 135 | Nol8 | 13336 | -0.135 | -0.1006 | No |
| 136 | Casp1 | 13392 | -0.138 | -0.1003 | No |
| 137 | S100a4 | 13400 | -0.139 | -0.0975 | No |
| 138 | Iscu | 13428 | -0.140 | -0.0956 | No |
| 139 | Perp | 13639 | -0.149 | -0.1031 | No |
| 140 | Wrap73 | 14031 | -0.166 | -0.1195 | No |
| 141 | Ada | 14122 | -0.171 | -0.1202 | No |
| 142 | S100a10 | 14254 | -0.177 | -0.1229 | No |
| 143 | Rpl18 | 14264 | -0.177 | -0.1193 | No |
| 144 | Ppm1d | 14335 | -0.180 | -0.1188 | No |
| 145 | Vamp8 | 14376 | -0.182 | -0.1166 | No |
| 146 | Atf3 | 14507 | -0.188 | -0.1190 | No |
| 147 | Ip6k2 | 14548 | -0.190 | -0.1167 | No |
| 148 | Elp1 | 14766 | -0.200 | -0.1233 | No |
| 149 | Ddit3 | 14965 | -0.210 | -0.1287 | No |
| 150 | Rad51c | 15337 | -0.229 | -0.1427 | No |
| 151 | Ctsd | 15499 | -0.238 | -0.1455 | No |
| 152 | Nupr1 | 15540 | -0.240 | -0.1421 | No |
| 153 | Rhbdf2 | 15542 | -0.240 | -0.1366 | No |
| 154 | Itgb4 | 15561 | -0.242 | -0.1319 | No |
| 155 | Xpc | 15668 | -0.249 | -0.1317 | No |
| 156 | Rxra | 15711 | -0.252 | -0.1280 | No |
| 157 | Rad9a | 15814 | -0.258 | -0.1274 | No |
| 158 | Fgf13 | 15855 | -0.261 | -0.1234 | No |
| 159 | Cd82 | 16147 | -0.280 | -0.1320 | No |
| 160 | Dcxr | 16387 | -0.295 | -0.1376 | No |
| 161 | Ccnd3 | 16534 | -0.303 | -0.1382 | No |
| 162 | Rack1 | 16630 | -0.311 | -0.1359 | No |
| 163 | Triap1 | 16648 | -0.312 | -0.1296 | No |
| 164 | Stom | 16654 | -0.312 | -0.1227 | No |
| 165 | Gls2 | 16742 | -0.317 | -0.1199 | No |
| 166 | Gadd45a | 16945 | -0.332 | -0.1227 | No |
| 167 | Retsat | 17058 | -0.340 | -0.1206 | No |
| 168 | Phlda3 | 17118 | -0.345 | -0.1157 | No |
| 169 | Csrnp2 | 17335 | -0.363 | -0.1186 | No |
| 170 | Gm2a | 17442 | -0.373 | -0.1155 | No |
| 171 | Klk8 | 17888 | -0.415 | -0.1289 | No |
| 172 | Hexim1 | 18097 | -0.440 | -0.1295 | No |
| 173 | Tgfa | 18122 | -0.444 | -0.1205 | No |
| 174 | H1f2 | 18320 | -0.467 | -0.1200 | No |
| 175 | Rrp8 | 18347 | -0.472 | -0.1104 | No |
| 176 | Slc19a2 | 18462 | -0.488 | -0.1051 | No |
| 177 | App | 18486 | -0.493 | -0.0949 | No |
| 178 | Ak1 | 18606 | -0.510 | -0.0893 | No |
| 179 | Cdkn1a | 18710 | -0.528 | -0.0825 | No |
| 180 | Acvr1b | 18767 | -0.537 | -0.0730 | No |
| 181 | Rpl36 | 18788 | -0.541 | -0.0616 | No |
| 182 | Plk2 | 19015 | -0.600 | -0.0594 | No |
| 183 | Hint1 | 19079 | -0.624 | -0.0483 | No |
| 184 | Eps8l2 | 19234 | -0.685 | -0.0405 | No |
| 185 | Ier3 | 19335 | -0.747 | -0.0285 | No |
| 186 | Ier5 | 19370 | -0.771 | -0.0125 | No |
| 187 | Plxnb2 | 19426 | -0.858 | 0.0045 | No |

