| Dataset | MEP.MEP.mega_Pheno.cls #Group6_versus_Group8.MEP.mega_Pheno.cls #Group6_versus_Group8_repos |
| Phenotype | MEP.mega_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 5 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.26164538 |
| Normalized Enrichment Score (NES) | -1.1313788 |
| Nominal p-value | 0.23667377 |
| FDR q-value | 0.43454212 |
| FWER p-Value | 0.968 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Dhrs1 | 139 | 0.773 | 0.0164 | No |
| 2 | Ephx1 | 501 | 0.589 | 0.0156 | No |
| 3 | Maoa | 552 | 0.570 | 0.0305 | No |
| 4 | Pmm1 | 796 | 0.521 | 0.0338 | No |
| 5 | Cndp2 | 923 | 0.501 | 0.0426 | No |
| 6 | Abcd2 | 976 | 0.489 | 0.0549 | No |
| 7 | Nqo1 | 1014 | 0.484 | 0.0678 | No |
| 8 | Ptgr1 | 1063 | 0.475 | 0.0798 | No |
| 9 | Xdh | 1219 | 0.447 | 0.0854 | No |
| 10 | Lcat | 1367 | 0.429 | 0.0909 | No |
| 11 | Kynu | 2000 | 0.369 | 0.0692 | No |
| 12 | Tpst1 | 2030 | 0.364 | 0.0789 | No |
| 13 | Atp2a2 | 2527 | 0.324 | 0.0629 | No |
| 14 | Tkfc | 2823 | 0.299 | 0.0567 | No |
| 15 | Mthfd1 | 2903 | 0.293 | 0.0615 | No |
| 16 | Pycr1 | 3145 | 0.276 | 0.0574 | No |
| 17 | Shmt2 | 3215 | 0.274 | 0.0622 | No |
| 18 | Idh1 | 3318 | 0.267 | 0.0651 | No |
| 19 | Slc6a6 | 3349 | 0.265 | 0.0716 | No |
| 20 | Gcnt2 | 3357 | 0.264 | 0.0793 | No |
| 21 | Gss | 3423 | 0.261 | 0.0839 | No |
| 22 | Cyp26a1 | 3436 | 0.260 | 0.0913 | No |
| 23 | Ccl25 | 3492 | 0.258 | 0.0963 | No |
| 24 | Atoh8 | 3577 | 0.255 | 0.0998 | No |
| 25 | Sar1b | 4158 | 0.220 | 0.0763 | No |
| 26 | Gad1 | 4644 | 0.202 | 0.0571 | No |
| 27 | Gch1 | 4826 | 0.194 | 0.0536 | No |
| 28 | Aqp9 | 4846 | 0.193 | 0.0585 | No |
| 29 | Ttpa | 4859 | 0.192 | 0.0638 | No |
| 30 | Cyp27a1 | 4885 | 0.190 | 0.0683 | No |
| 31 | Man1a | 5389 | 0.168 | 0.0472 | No |
| 32 | Ap4b1 | 5474 | 0.164 | 0.0478 | No |
| 33 | Pcx | 5502 | 0.162 | 0.0514 | No |
| 34 | Elovl5 | 6094 | 0.137 | 0.0248 | No |
| 35 | Hnf4a | 6190 | 0.133 | 0.0239 | No |
| 36 | Ptges | 6340 | 0.126 | 0.0200 | No |
| 37 | Lpin2 | 6369 | 0.126 | 0.0224 | No |
| 38 | Ets2 | 6395 | 0.124 | 0.0249 | No |
| 39 | Gart | 6560 | 0.117 | 0.0199 | No |
| 40 | Arpp19 | 6725 | 0.111 | 0.0148 | No |
| 41 | Etfdh | 6877 | 0.105 | 0.0101 | No |
| 42 | Gabarapl1 | 7051 | 0.099 | 0.0041 | No |
| 43 | Bcat1 | 7125 | 0.096 | 0.0033 | No |
| 44 | Id2 | 7139 | 0.096 | 0.0055 | No |
| 45 | Retsat | 7347 | 0.088 | -0.0026 | No |
| 46 | Smox | 7491 | 0.083 | -0.0075 | No |
| 47 | Aldh2 | 7716 | 0.074 | -0.0169 | No |
| 48 | Gsr | 7749 | 0.072 | -0.0164 | No |
| 49 | Dcxr | 8006 | 0.063 | -0.0278 | No |
| 50 | Abhd6 | 8064 | 0.060 | -0.0290 | No |
| 51 | Pgd | 8090 | 0.059 | -0.0285 | No |
| 52 | Csad | 8341 | 0.049 | -0.0400 | No |
| 53 | Abcc2 | 8480 | 0.044 | -0.0459 | No |
| 54 | Ninj1 | 8627 | 0.038 | -0.0523 | No |
| 55 | Ppard | 8884 | 0.029 | -0.0648 | No |
| 56 | Abcc3 | 8985 | 0.026 | -0.0692 | No |
| 57 | Ugdh | 8991 | 0.025 | -0.0687 | No |
| 58 | Fbp1 | 9140 | 0.020 | -0.0758 | No |
| 59 | Gnmt | 9275 | 0.015 | -0.0824 | No |
| 60 | Nfs1 | 9375 | 0.012 | -0.0872 | No |
| 61 | Cyfip2 | 9465 | 0.009 | -0.0915 | No |
| 62 | Tnfrsf1a | 9564 | 0.005 | -0.0965 | No |
| 63 | Gstt2 | 9572 | 0.005 | -0.0967 | No |
| 64 | Ndrg2 | 9626 | 0.003 | -0.0994 | No |
| 65 | Acp2 | 9960 | -0.002 | -0.1167 | No |
| 66 | Slc35b1 | 10008 | -0.003 | -0.1191 | No |
| 67 | Gclc | 10260 | -0.012 | -0.1318 | No |
| 68 | Mccc2 | 10340 | -0.015 | -0.1355 | No |
| 69 | Acox1 | 10442 | -0.019 | -0.1402 | No |
| 70 | Spint2 | 10607 | -0.025 | -0.1480 | No |
| 71 | Por | 10617 | -0.025 | -0.1477 | No |
| 72 | Apoe | 10667 | -0.027 | -0.1494 | No |
| 73 | Slc46a3 | 10780 | -0.031 | -0.1543 | No |
| 74 | Marchf6 | 10832 | -0.032 | -0.1560 | No |
| 75 | Cyp2j6 | 10853 | -0.033 | -0.1560 | No |
| 76 | Asl | 10967 | -0.037 | -0.1608 | No |
| 77 | Ech1 | 11088 | -0.042 | -0.1657 | No |
| 78 | Nmt1 | 11110 | -0.043 | -0.1655 | No |
| 79 | Sertad1 | 11211 | -0.045 | -0.1693 | No |
| 80 | Pdlim5 | 11462 | -0.055 | -0.1807 | No |
| 81 | Hsd11b1 | 11679 | -0.062 | -0.1901 | No |
| 82 | Igf1 | 11815 | -0.067 | -0.1951 | No |
| 83 | Crot | 11937 | -0.071 | -0.1992 | No |
| 84 | Il1r1 | 12057 | -0.076 | -0.2031 | No |
| 85 | Igfbp4 | 12215 | -0.083 | -0.2087 | No |
| 86 | Acp1 | 12393 | -0.090 | -0.2152 | No |
| 87 | Esr1 | 12394 | -0.090 | -0.2125 | No |
| 88 | Slc12a4 | 12469 | -0.093 | -0.2135 | No |
| 89 | Gstm4 | 12484 | -0.094 | -0.2113 | No |
| 90 | Epha2 | 12512 | -0.095 | -0.2098 | No |
| 91 | Pemt | 12621 | -0.100 | -0.2124 | No |
| 92 | Psmb10 | 12719 | -0.104 | -0.2142 | No |
| 93 | Upp1 | 12830 | -0.109 | -0.2167 | No |
| 94 | Gsto1 | 12922 | -0.113 | -0.2179 | No |
| 95 | Pros1 | 13038 | -0.118 | -0.2203 | No |
| 96 | Tmbim6 | 13200 | -0.124 | -0.2249 | No |
| 97 | Rap1gap | 13270 | -0.127 | -0.2246 | No |
| 98 | Aldh9a1 | 13375 | -0.132 | -0.2260 | No |
| 99 | Hmox1 | 13526 | -0.139 | -0.2296 | No |
| 100 | Irf8 | 13626 | -0.144 | -0.2304 | No |
| 101 | Ssr3 | 13700 | -0.147 | -0.2296 | No |
| 102 | Ddc | 14314 | -0.175 | -0.2563 | Yes |
| 103 | Mpp2 | 14398 | -0.178 | -0.2551 | Yes |
| 104 | Fah | 14399 | -0.179 | -0.2497 | Yes |
| 105 | Tmem176b | 14459 | -0.181 | -0.2472 | Yes |
| 106 | Cda | 14468 | -0.181 | -0.2421 | Yes |
| 107 | Cat | 14537 | -0.185 | -0.2399 | Yes |
| 108 | Adh5 | 14601 | -0.188 | -0.2375 | Yes |
| 109 | Car2 | 14624 | -0.189 | -0.2328 | Yes |
| 110 | Cdo1 | 14702 | -0.193 | -0.2309 | Yes |
| 111 | Crp | 14713 | -0.194 | -0.2255 | Yes |
| 112 | Enpep | 14929 | -0.205 | -0.2305 | Yes |
| 113 | Cyb5a | 15118 | -0.215 | -0.2337 | Yes |
| 114 | Hes6 | 15224 | -0.221 | -0.2324 | Yes |
| 115 | Lonp1 | 15519 | -0.233 | -0.2406 | Yes |
| 116 | Dhrs7 | 15520 | -0.233 | -0.2334 | Yes |
| 117 | Fbln1 | 15563 | -0.235 | -0.2284 | Yes |
| 118 | Slc35d1 | 15585 | -0.237 | -0.2223 | Yes |
| 119 | Pink1 | 15788 | -0.247 | -0.2252 | Yes |
| 120 | Aco2 | 15947 | -0.257 | -0.2256 | Yes |
| 121 | Angptl3 | 16006 | -0.261 | -0.2206 | Yes |
| 122 | Ptges3-ps | 16011 | -0.262 | -0.2128 | Yes |
| 123 | Hgfac | 16208 | -0.274 | -0.2147 | Yes |
| 124 | Fas | 16265 | -0.277 | -0.2091 | Yes |
| 125 | Plg | 16472 | -0.291 | -0.2109 | Yes |
| 126 | Ddt | 16657 | -0.304 | -0.2112 | Yes |
| 127 | Tmem97 | 16699 | -0.305 | -0.2040 | Yes |
| 128 | Pdk4 | 16933 | -0.321 | -0.2063 | Yes |
| 129 | Arg1 | 16971 | -0.324 | -0.1983 | Yes |
| 130 | Cfb | 17083 | -0.331 | -0.1939 | Yes |
| 131 | Papss2 | 17200 | -0.340 | -0.1896 | Yes |
| 132 | Pts | 17236 | -0.343 | -0.1809 | Yes |
| 133 | Pgrmc1 | 17286 | -0.348 | -0.1727 | Yes |
| 134 | F10 | 17370 | -0.356 | -0.1662 | Yes |
| 135 | Slc1a5 | 17468 | -0.364 | -0.1601 | Yes |
| 136 | Npc1 | 17484 | -0.366 | -0.1496 | Yes |
| 137 | Acox3 | 17627 | -0.379 | -0.1454 | Yes |
| 138 | Alas1 | 17631 | -0.380 | -0.1339 | Yes |
| 139 | Casp6 | 17778 | -0.397 | -0.1294 | Yes |
| 140 | Comt | 17789 | -0.399 | -0.1177 | Yes |
| 141 | Hacl1 | 18127 | -0.438 | -0.1218 | Yes |
| 142 | Bphl | 18215 | -0.449 | -0.1126 | Yes |
| 143 | Entpd5 | 18314 | -0.459 | -0.1036 | Yes |
| 144 | Jup | 18320 | -0.460 | -0.0898 | Yes |
| 145 | Tgfb2 | 18438 | -0.479 | -0.0812 | Yes |
| 146 | Dhps | 18491 | -0.490 | -0.0689 | Yes |
| 147 | Tyr | 18492 | -0.490 | -0.0538 | Yes |
| 148 | Ddah2 | 18558 | -0.503 | -0.0418 | Yes |
| 149 | Arg2 | 18651 | -0.521 | -0.0306 | Yes |
| 150 | Cd36 | 18795 | -0.554 | -0.0211 | Yes |
| 151 | Blvrb | 19208 | -0.758 | -0.0194 | Yes |
| 152 | Cbr1 | 19235 | -0.800 | 0.0038 | Yes |

