| Dataset | MEP.MEP.mega_Pheno.cls #Group6_versus_Group8.MEP.mega_Pheno.cls #Group6_versus_Group8_repos |
| Phenotype | MEP.mega_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 5 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.24694243 |
| Normalized Enrichment Score (NES) | -1.1513482 |
| Nominal p-value | 0.27234927 |
| FDR q-value | 0.41528654 |
| FWER p-Value | 0.963 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Serpinh1 | 15 | 1.083 | 0.0292 | No |
| 2 | Cth | 398 | 0.623 | 0.0264 | No |
| 3 | Ak4 | 1226 | 0.446 | -0.0045 | No |
| 4 | Phgdh | 1562 | 0.401 | -0.0109 | No |
| 5 | Slc7a11 | 1600 | 0.398 | -0.0018 | No |
| 6 | Pdk1 | 1813 | 0.383 | -0.0023 | No |
| 7 | Slc2a3 | 2129 | 0.358 | -0.0089 | No |
| 8 | Dhcr24 | 2363 | 0.336 | -0.0118 | No |
| 9 | Hspd1 | 2509 | 0.325 | -0.0104 | No |
| 10 | Atp2a2 | 2527 | 0.324 | -0.0024 | No |
| 11 | Wars1 | 2613 | 0.317 | 0.0020 | No |
| 12 | Pgm1 | 2782 | 0.302 | 0.0015 | No |
| 13 | Cdkn1a | 2943 | 0.290 | 0.0012 | No |
| 14 | Rit1 | 2976 | 0.288 | 0.0075 | No |
| 15 | Cyb5b | 3040 | 0.283 | 0.0120 | No |
| 16 | Aurka | 3047 | 0.283 | 0.0195 | No |
| 17 | Shmt2 | 3215 | 0.274 | 0.0183 | No |
| 18 | Idh1 | 3318 | 0.267 | 0.0204 | No |
| 19 | Tm7sf2 | 3333 | 0.266 | 0.0270 | No |
| 20 | Slc6a6 | 3349 | 0.265 | 0.0336 | No |
| 21 | Fkbp2 | 3547 | 0.257 | 0.0304 | No |
| 22 | Me1 | 3630 | 0.251 | 0.0330 | No |
| 23 | Etf1 | 3641 | 0.251 | 0.0394 | No |
| 24 | Itgb2 | 3822 | 0.242 | 0.0367 | No |
| 25 | Vldlr | 4120 | 0.223 | 0.0273 | No |
| 26 | Hspa9 | 4229 | 0.217 | 0.0277 | No |
| 27 | Ppp1r15a | 4260 | 0.215 | 0.0321 | No |
| 28 | Nufip1 | 4396 | 0.211 | 0.0308 | No |
| 29 | Uchl5 | 4507 | 0.208 | 0.0308 | No |
| 30 | Arpc5l | 4545 | 0.206 | 0.0346 | No |
| 31 | Cfp | 4571 | 0.204 | 0.0389 | No |
| 32 | Acaca | 4699 | 0.201 | 0.0378 | No |
| 33 | Hmgcs1 | 4902 | 0.190 | 0.0325 | No |
| 34 | Gla | 4945 | 0.187 | 0.0355 | No |
| 35 | Fads1 | 5153 | 0.178 | 0.0296 | No |
| 36 | Trib3 | 5224 | 0.175 | 0.0307 | No |
| 37 | Asns | 5248 | 0.173 | 0.0343 | No |
| 38 | Gmps | 5348 | 0.169 | 0.0338 | No |
| 39 | Pnp | 5460 | 0.164 | 0.0326 | No |
| 40 | Abcf2 | 5603 | 0.158 | 0.0295 | No |
| 41 | Nup205 | 5711 | 0.153 | 0.0281 | No |
| 42 | Ung | 5855 | 0.146 | 0.0247 | No |
| 43 | Gga2 | 5920 | 0.144 | 0.0253 | No |
| 44 | Mllt11 | 6034 | 0.140 | 0.0233 | No |
| 45 | Idi1 | 6086 | 0.138 | 0.0244 | No |
| 46 | Elovl5 | 6094 | 0.137 | 0.0279 | No |
| 47 | Fads2 | 6275 | 0.130 | 0.0220 | No |
| 48 | Immt | 6377 | 0.125 | 0.0202 | No |
| 49 | Calr | 6494 | 0.120 | 0.0175 | No |
| 50 | Actr2 | 6706 | 0.112 | 0.0095 | No |
| 51 | Cxcr4 | 6803 | 0.107 | 0.0075 | No |
| 52 | Niban1 | 6806 | 0.107 | 0.0103 | No |
| 53 | Btg2 | 6912 | 0.104 | 0.0077 | No |
| 54 | Bcat1 | 7125 | 0.096 | -0.0007 | No |
| 55 | Pik3r3 | 7145 | 0.096 | 0.0009 | No |
| 56 | Cyp51 | 7261 | 0.091 | -0.0026 | No |
| 57 | Uso1 | 7323 | 0.089 | -0.0033 | No |
| 58 | Nfyc | 7652 | 0.077 | -0.0183 | No |
| 59 | Gsr | 7749 | 0.072 | -0.0214 | No |
| 60 | Ssr1 | 7878 | 0.068 | -0.0262 | No |
| 61 | Hmbs | 7931 | 0.065 | -0.0271 | No |
| 62 | Nfil3 | 8062 | 0.060 | -0.0322 | No |
| 63 | Mcm4 | 8208 | 0.054 | -0.0383 | No |
| 64 | Psmg1 | 8356 | 0.048 | -0.0447 | No |
| 65 | Plk1 | 8562 | 0.041 | -0.0543 | No |
| 66 | Canx | 8744 | 0.034 | -0.0628 | No |
| 67 | Bhlhe40 | 8754 | 0.034 | -0.0624 | No |
| 68 | Edem1 | 8876 | 0.029 | -0.0679 | No |
| 69 | Sqle | 8914 | 0.028 | -0.0690 | No |
| 70 | Psmd13 | 8921 | 0.028 | -0.0686 | No |
| 71 | Actr3 | 9160 | 0.019 | -0.0805 | No |
| 72 | Psmc2 | 9206 | 0.018 | -0.0824 | No |
| 73 | Srd5a1 | 9274 | 0.015 | -0.0854 | No |
| 74 | Ifrd1 | 9322 | 0.014 | -0.0875 | No |
| 75 | Ero1a | 9377 | 0.011 | -0.0900 | No |
| 76 | Tfrc | 9383 | 0.011 | -0.0900 | No |
| 77 | Psma3 | 9430 | 0.010 | -0.0921 | No |
| 78 | Hsp90b1 | 9435 | 0.010 | -0.0921 | No |
| 79 | Slc37a4 | 9576 | 0.004 | -0.0993 | No |
| 80 | Psmd14 | 9587 | 0.004 | -0.0997 | No |
| 81 | Ccnf | 9650 | 0.002 | -0.1029 | No |
| 82 | Hspa4 | 9660 | 0.002 | -0.1033 | No |
| 83 | G6pdx | 10049 | -0.005 | -0.1234 | No |
| 84 | Gtf2h1 | 10058 | -0.005 | -0.1237 | No |
| 85 | Pitpnb | 10175 | -0.009 | -0.1295 | No |
| 86 | Gclc | 10260 | -0.012 | -0.1336 | No |
| 87 | Ddx39a | 10349 | -0.016 | -0.1378 | No |
| 88 | Acly | 10479 | -0.021 | -0.1440 | No |
| 89 | Elovl6 | 10480 | -0.021 | -0.1434 | No |
| 90 | P4ha1 | 10495 | -0.021 | -0.1435 | No |
| 91 | Add3 | 10517 | -0.022 | -0.1440 | No |
| 92 | Fdxr | 10529 | -0.022 | -0.1440 | No |
| 93 | Skap2 | 10592 | -0.025 | -0.1466 | No |
| 94 | Got1 | 10659 | -0.026 | -0.1493 | No |
| 95 | Ebp | 10714 | -0.028 | -0.1513 | No |
| 96 | Rpa1 | 10737 | -0.029 | -0.1517 | No |
| 97 | Gsk3b | 10899 | -0.035 | -0.1591 | No |
| 98 | Nampt | 10976 | -0.038 | -0.1620 | No |
| 99 | Slc2a1 | 11030 | -0.040 | -0.1637 | No |
| 100 | Nmt1 | 11110 | -0.043 | -0.1666 | No |
| 101 | Mcm2 | 11273 | -0.048 | -0.1738 | No |
| 102 | Psma4 | 11399 | -0.052 | -0.1789 | No |
| 103 | Tbk1 | 11445 | -0.054 | -0.1797 | No |
| 104 | Psme3 | 11544 | -0.058 | -0.1833 | No |
| 105 | Bub1 | 11611 | -0.060 | -0.1851 | No |
| 106 | Ccng1 | 11612 | -0.060 | -0.1834 | No |
| 107 | Psph | 11665 | -0.061 | -0.1844 | No |
| 108 | Plod2 | 11684 | -0.062 | -0.1836 | No |
| 109 | Stard4 | 11703 | -0.063 | -0.1828 | No |
| 110 | Rpn1 | 11796 | -0.066 | -0.1858 | No |
| 111 | Rdh11 | 11831 | -0.068 | -0.1857 | No |
| 112 | Txnrd1 | 12037 | -0.075 | -0.1944 | No |
| 113 | Aldoa | 12208 | -0.082 | -0.2010 | No |
| 114 | Cdc25a | 12528 | -0.096 | -0.2150 | No |
| 115 | Mthfd2l | 12548 | -0.097 | -0.2134 | No |
| 116 | Rrp9 | 12558 | -0.097 | -0.2112 | No |
| 117 | Acsl3 | 12590 | -0.098 | -0.2101 | No |
| 118 | Dhfr | 12646 | -0.101 | -0.2101 | No |
| 119 | Mthfd2 | 13078 | -0.120 | -0.2294 | No |
| 120 | Gpi1 | 13146 | -0.122 | -0.2295 | No |
| 121 | Psmc6 | 13215 | -0.125 | -0.2296 | No |
| 122 | Adipor2 | 13247 | -0.126 | -0.2277 | No |
| 123 | Ube2d3 | 13583 | -0.141 | -0.2413 | No |
| 124 | Eno1b | 13618 | -0.143 | -0.2392 | No |
| 125 | Sytl2 | 13638 | -0.144 | -0.2362 | No |
| 126 | Ykt6 | 13782 | -0.152 | -0.2395 | No |
| 127 | Dapp1 | 13926 | -0.158 | -0.2426 | Yes |
| 128 | Sord | 13949 | -0.159 | -0.2393 | Yes |
| 129 | Rrm2 | 13958 | -0.159 | -0.2353 | Yes |
| 130 | Tubg1 | 13996 | -0.161 | -0.2328 | Yes |
| 131 | Ctsc | 14032 | -0.163 | -0.2301 | Yes |
| 132 | Hk2 | 14084 | -0.165 | -0.2282 | Yes |
| 133 | Tomm40 | 14152 | -0.168 | -0.2271 | Yes |
| 134 | Ldha | 14246 | -0.172 | -0.2272 | Yes |
| 135 | Hspa5 | 14319 | -0.175 | -0.2261 | Yes |
| 136 | Lta4h | 14354 | -0.177 | -0.2230 | Yes |
| 137 | Ldlr | 14489 | -0.182 | -0.2250 | Yes |
| 138 | Slc7a5 | 14490 | -0.182 | -0.2199 | Yes |
| 139 | Cacybp | 14519 | -0.184 | -0.2163 | Yes |
| 140 | Pdap1 | 14522 | -0.184 | -0.2113 | Yes |
| 141 | Glrx | 14574 | -0.186 | -0.2089 | Yes |
| 142 | Polr3g | 14611 | -0.188 | -0.2055 | Yes |
| 143 | Ppa1 | 14750 | -0.195 | -0.2073 | Yes |
| 144 | Igfbp5 | 14805 | -0.198 | -0.2047 | Yes |
| 145 | Dhcr7 | 14862 | -0.202 | -0.2021 | Yes |
| 146 | Ifi30 | 14901 | -0.203 | -0.1984 | Yes |
| 147 | Sqstm1 | 14954 | -0.206 | -0.1954 | Yes |
| 148 | Sla | 15187 | -0.219 | -0.2015 | Yes |
| 149 | Sec11a | 15206 | -0.220 | -0.1964 | Yes |
| 150 | Psat1 | 15391 | -0.230 | -0.1996 | Yes |
| 151 | Sc5d | 15628 | -0.240 | -0.2054 | Yes |
| 152 | Stip1 | 15637 | -0.240 | -0.1991 | Yes |
| 153 | Qdpr | 15655 | -0.242 | -0.1933 | Yes |
| 154 | Atp6v1d | 15722 | -0.246 | -0.1900 | Yes |
| 155 | Egln3 | 15785 | -0.247 | -0.1864 | Yes |
| 156 | Serp1 | 15793 | -0.247 | -0.1799 | Yes |
| 157 | M6pr | 15914 | -0.255 | -0.1792 | Yes |
| 158 | Tuba4a | 15926 | -0.256 | -0.1727 | Yes |
| 159 | Ufm1 | 15943 | -0.257 | -0.1664 | Yes |
| 160 | Tcea1 | 16112 | -0.268 | -0.1678 | Yes |
| 161 | Psmd12 | 16156 | -0.271 | -0.1626 | Yes |
| 162 | Tpi1 | 16178 | -0.272 | -0.1561 | Yes |
| 163 | Map2k3 | 16191 | -0.273 | -0.1492 | Yes |
| 164 | Hmgcr | 16227 | -0.275 | -0.1434 | Yes |
| 165 | Cct6a | 16235 | -0.275 | -0.1362 | Yes |
| 166 | Ppia | 16272 | -0.277 | -0.1304 | Yes |
| 167 | Gbe1 | 16298 | -0.279 | -0.1240 | Yes |
| 168 | Sdf2l1 | 16379 | -0.285 | -0.1203 | Yes |
| 169 | Cd9 | 16387 | -0.286 | -0.1128 | Yes |
| 170 | Prdx1 | 16389 | -0.286 | -0.1049 | Yes |
| 171 | Psmc4 | 16445 | -0.290 | -0.0998 | Yes |
| 172 | Eif2s2 | 16507 | -0.294 | -0.0948 | Yes |
| 173 | Pfkl | 16582 | -0.298 | -0.0905 | Yes |
| 174 | Pgk1 | 16635 | -0.302 | -0.0849 | Yes |
| 175 | Tmem97 | 16699 | -0.305 | -0.0797 | Yes |
| 176 | Nupr1 | 16797 | -0.311 | -0.0762 | Yes |
| 177 | Xbp1 | 16850 | -0.316 | -0.0702 | Yes |
| 178 | Cops5 | 16899 | -0.319 | -0.0639 | Yes |
| 179 | Tes | 17227 | -0.343 | -0.0715 | Yes |
| 180 | Nfkbib | 17393 | -0.358 | -0.0702 | Yes |
| 181 | Fgl2 | 17452 | -0.363 | -0.0632 | Yes |
| 182 | Ddit4 | 17456 | -0.363 | -0.0533 | Yes |
| 183 | Slc1a5 | 17468 | -0.364 | -0.0438 | Yes |
| 184 | Eef1e1 | 17806 | -0.400 | -0.0504 | Yes |
| 185 | Pno1 | 17894 | -0.411 | -0.0436 | Yes |
| 186 | Rab1a | 17915 | -0.414 | -0.0332 | Yes |
| 187 | Hspe1 | 17961 | -0.417 | -0.0240 | Yes |
| 188 | Insig1 | 18536 | -0.499 | -0.0402 | Yes |
| 189 | Psmb5 | 18540 | -0.499 | -0.0266 | Yes |
| 190 | Coro1a | 18565 | -0.504 | -0.0139 | Yes |
| 191 | Slc1a4 | 18788 | -0.552 | -0.0102 | Yes |
| 192 | Lgmn | 19022 | -0.628 | -0.0051 | Yes |
| 193 | Ddit3 | 19174 | -0.720 | 0.0070 | Yes |

