| Dataset | MEP.MEP.mega_Pheno.cls #Group3_versus_Group4.MEP.mega_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | 0.19457097 |
| Normalized Enrichment Score (NES) | 0.82816046 |
| Nominal p-value | 0.82542694 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Maoa | 5 | 1.407 | 0.0426 | Yes |
| 2 | Hes6 | 65 | 0.934 | 0.0680 | Yes |
| 3 | Slc35b1 | 113 | 0.849 | 0.0915 | Yes |
| 4 | Ap4b1 | 130 | 0.831 | 0.1160 | Yes |
| 5 | Ddt | 330 | 0.671 | 0.1260 | Yes |
| 6 | Dhps | 778 | 0.535 | 0.1190 | Yes |
| 7 | Pemt | 793 | 0.531 | 0.1345 | Yes |
| 8 | Il1r1 | 1205 | 0.456 | 0.1269 | Yes |
| 9 | Cdo1 | 1452 | 0.432 | 0.1273 | Yes |
| 10 | Cfb | 1622 | 0.412 | 0.1310 | Yes |
| 11 | Ugdh | 1653 | 0.410 | 0.1419 | Yes |
| 12 | Ssr3 | 1836 | 0.392 | 0.1444 | Yes |
| 13 | Dhrs1 | 1899 | 0.383 | 0.1528 | Yes |
| 14 | Atp2a2 | 1925 | 0.381 | 0.1632 | Yes |
| 15 | Pcx | 2001 | 0.373 | 0.1706 | Yes |
| 16 | Cyp2j6 | 2078 | 0.363 | 0.1777 | Yes |
| 17 | Irf8 | 2339 | 0.337 | 0.1744 | Yes |
| 18 | Cda | 2499 | 0.325 | 0.1760 | Yes |
| 19 | Bphl | 2655 | 0.313 | 0.1775 | Yes |
| 20 | Upp1 | 2741 | 0.307 | 0.1824 | Yes |
| 21 | Abcc3 | 2892 | 0.294 | 0.1835 | Yes |
| 22 | Plg | 2981 | 0.287 | 0.1877 | Yes |
| 23 | Pmm1 | 3140 | 0.276 | 0.1878 | Yes |
| 24 | Fbln1 | 3172 | 0.274 | 0.1946 | Yes |
| 25 | Cndp2 | 3397 | 0.261 | 0.1908 | No |
| 26 | Pdk4 | 3530 | 0.255 | 0.1917 | No |
| 27 | Pgd | 3939 | 0.236 | 0.1776 | No |
| 28 | Npc1 | 4058 | 0.229 | 0.1784 | No |
| 29 | Hgfac | 4235 | 0.218 | 0.1759 | No |
| 30 | Gcnt2 | 4488 | 0.205 | 0.1690 | No |
| 31 | Tgfb2 | 4554 | 0.201 | 0.1717 | No |
| 32 | Pink1 | 4949 | 0.179 | 0.1566 | No |
| 33 | Enpep | 5017 | 0.175 | 0.1585 | No |
| 34 | Alas1 | 5105 | 0.170 | 0.1591 | No |
| 35 | Atoh8 | 5395 | 0.155 | 0.1487 | No |
| 36 | Gclc | 5557 | 0.148 | 0.1448 | No |
| 37 | Arpp19 | 5610 | 0.145 | 0.1465 | No |
| 38 | Kynu | 6001 | 0.128 | 0.1301 | No |
| 39 | Pdlim5 | 6598 | 0.104 | 0.1022 | No |
| 40 | Gart | 6721 | 0.099 | 0.0988 | No |
| 41 | Tkfc | 6802 | 0.097 | 0.0976 | No |
| 42 | Aco2 | 6917 | 0.091 | 0.0944 | No |
| 43 | Psmb10 | 7144 | 0.082 | 0.0851 | No |
| 44 | Ddah2 | 7209 | 0.080 | 0.0842 | No |
| 45 | Ddc | 7413 | 0.073 | 0.0759 | No |
| 46 | Acp2 | 7509 | 0.070 | 0.0730 | No |
| 47 | Gch1 | 7557 | 0.068 | 0.0727 | No |
| 48 | Marchf6 | 7583 | 0.067 | 0.0734 | No |
| 49 | Dcxr | 7616 | 0.065 | 0.0737 | No |
| 50 | Cbr1 | 7675 | 0.063 | 0.0726 | No |
| 51 | Man1a | 7676 | 0.063 | 0.0745 | No |
| 52 | Nqo1 | 7876 | 0.055 | 0.0658 | No |
| 53 | Gss | 8211 | 0.043 | 0.0497 | No |
| 54 | Arg1 | 8320 | 0.039 | 0.0452 | No |
| 55 | Ndrg2 | 8648 | 0.028 | 0.0290 | No |
| 56 | Bcat1 | 8673 | 0.027 | 0.0286 | No |
| 57 | Tmem97 | 8782 | 0.022 | 0.0236 | No |
| 58 | Acox1 | 8974 | 0.017 | 0.0142 | No |
| 59 | Car2 | 9057 | 0.014 | 0.0103 | No |
| 60 | Sar1b | 9168 | 0.010 | 0.0049 | No |
| 61 | F10 | 9236 | 0.008 | 0.0016 | No |
| 62 | Gabarapl1 | 9241 | 0.008 | 0.0017 | No |
| 63 | Id2 | 9402 | 0.002 | -0.0066 | No |
| 64 | Aldh9a1 | 9411 | 0.002 | -0.0070 | No |
| 65 | Tpst1 | 9644 | -0.001 | -0.0191 | No |
| 66 | Hnf4a | 9798 | -0.006 | -0.0269 | No |
| 67 | Ets2 | 9841 | -0.007 | -0.0288 | No |
| 68 | Slc1a5 | 9925 | -0.010 | -0.0329 | No |
| 69 | Por | 10166 | -0.018 | -0.0448 | No |
| 70 | Spint2 | 10552 | -0.031 | -0.0640 | No |
| 71 | Shmt2 | 10654 | -0.035 | -0.0682 | No |
| 72 | Igfbp4 | 10665 | -0.036 | -0.0676 | No |
| 73 | Gnmt | 10707 | -0.037 | -0.0686 | No |
| 74 | Epha2 | 10941 | -0.045 | -0.0794 | No |
| 75 | Blvrb | 10981 | -0.047 | -0.0800 | No |
| 76 | Gstm4 | 11090 | -0.051 | -0.0841 | No |
| 77 | Lpin2 | 11093 | -0.051 | -0.0826 | No |
| 78 | Gstt2 | 11177 | -0.054 | -0.0853 | No |
| 79 | Retsat | 11201 | -0.055 | -0.0848 | No |
| 80 | Tmbim6 | 11264 | -0.057 | -0.0863 | No |
| 81 | Ccl25 | 11335 | -0.060 | -0.0882 | No |
| 82 | Mthfd1 | 11451 | -0.065 | -0.0922 | No |
| 83 | Dhrs7 | 11534 | -0.067 | -0.0944 | No |
| 84 | Hacl1 | 11737 | -0.075 | -0.1027 | No |
| 85 | Pgrmc1 | 11789 | -0.077 | -0.1030 | No |
| 86 | Ptges | 11972 | -0.083 | -0.1100 | No |
| 87 | Slc35d1 | 12223 | -0.092 | -0.1202 | No |
| 88 | Asl | 12300 | -0.095 | -0.1213 | No |
| 89 | Ninj1 | 12385 | -0.099 | -0.1226 | No |
| 90 | Aldh2 | 12404 | -0.100 | -0.1205 | No |
| 91 | Casp6 | 12446 | -0.101 | -0.1196 | No |
| 92 | Slc12a4 | 12452 | -0.101 | -0.1168 | No |
| 93 | Acp1 | 12633 | -0.108 | -0.1229 | No |
| 94 | Hmox1 | 12732 | -0.112 | -0.1246 | No |
| 95 | Ephx1 | 12795 | -0.115 | -0.1243 | No |
| 96 | Crp | 12840 | -0.116 | -0.1231 | No |
| 97 | Etfdh | 12954 | -0.120 | -0.1253 | No |
| 98 | Sertad1 | 13021 | -0.122 | -0.1250 | No |
| 99 | Mccc2 | 13042 | -0.123 | -0.1223 | No |
| 100 | Smox | 13107 | -0.125 | -0.1218 | No |
| 101 | Elovl5 | 13169 | -0.127 | -0.1211 | No |
| 102 | Cat | 13396 | -0.137 | -0.1287 | No |
| 103 | Angptl3 | 13649 | -0.147 | -0.1374 | No |
| 104 | Ttpa | 13780 | -0.152 | -0.1396 | No |
| 105 | Abcd2 | 13881 | -0.157 | -0.1400 | No |
| 106 | Slc46a3 | 13932 | -0.159 | -0.1377 | No |
| 107 | Fbp1 | 14061 | -0.166 | -0.1394 | No |
| 108 | Lonp1 | 14062 | -0.166 | -0.1343 | No |
| 109 | Lcat | 14106 | -0.168 | -0.1314 | No |
| 110 | Idh1 | 14111 | -0.168 | -0.1265 | No |
| 111 | Comt | 14429 | -0.182 | -0.1375 | No |
| 112 | Aqp9 | 14539 | -0.187 | -0.1375 | No |
| 113 | Arg2 | 14978 | -0.206 | -0.1541 | No |
| 114 | Entpd5 | 15015 | -0.207 | -0.1497 | No |
| 115 | Tnfrsf1a | 15050 | -0.209 | -0.1451 | No |
| 116 | Cyfip2 | 15124 | -0.213 | -0.1424 | No |
| 117 | Papss2 | 15140 | -0.214 | -0.1366 | No |
| 118 | Esr1 | 15171 | -0.215 | -0.1316 | No |
| 119 | Mpp2 | 15581 | -0.236 | -0.1458 | No |
| 120 | Acox3 | 15602 | -0.237 | -0.1396 | No |
| 121 | Ech1 | 15728 | -0.242 | -0.1388 | No |
| 122 | Adh5 | 16061 | -0.259 | -0.1482 | No |
| 123 | Abcc2 | 16096 | -0.262 | -0.1420 | No |
| 124 | Gsto1 | 16099 | -0.262 | -0.1341 | No |
| 125 | Nmt1 | 16108 | -0.263 | -0.1265 | No |
| 126 | Tmem176b | 16135 | -0.265 | -0.1198 | No |
| 127 | Pycr1 | 16232 | -0.270 | -0.1165 | No |
| 128 | Xdh | 16246 | -0.271 | -0.1089 | No |
| 129 | Hsd11b1 | 16403 | -0.279 | -0.1086 | No |
| 130 | Slc6a6 | 16499 | -0.285 | -0.1048 | No |
| 131 | Nfs1 | 16539 | -0.287 | -0.0981 | No |
| 132 | Crot | 16617 | -0.291 | -0.0933 | No |
| 133 | Fas | 16633 | -0.292 | -0.0851 | No |
| 134 | Csad | 16742 | -0.299 | -0.0816 | No |
| 135 | Gsr | 17081 | -0.321 | -0.0895 | No |
| 136 | Pts | 17108 | -0.323 | -0.0810 | No |
| 137 | Pros1 | 17188 | -0.327 | -0.0752 | No |
| 138 | Ptgr1 | 17491 | -0.354 | -0.0801 | No |
| 139 | Jup | 17493 | -0.354 | -0.0694 | No |
| 140 | Ppard | 17537 | -0.358 | -0.0607 | No |
| 141 | Gad1 | 17588 | -0.361 | -0.0523 | No |
| 142 | Apoe | 17663 | -0.367 | -0.0450 | No |
| 143 | Cyb5a | 17670 | -0.368 | -0.0341 | No |
| 144 | Cyp27a1 | 17776 | -0.379 | -0.0280 | No |
| 145 | Tyr | 17814 | -0.383 | -0.0182 | No |
| 146 | Ptges3-ps | 17850 | -0.387 | -0.0082 | No |
| 147 | Rap1gap | 18065 | -0.408 | -0.0070 | No |
| 148 | Fah | 18151 | -0.415 | 0.0013 | No |
| 149 | Abhd6 | 18199 | -0.418 | 0.0115 | No |
| 150 | Cd36 | 18433 | -0.455 | 0.0132 | No |
| 151 | Cyp26a1 | 18807 | -0.528 | 0.0099 | No |
| 152 | Igf1 | 18811 | -0.530 | 0.0259 | No |

