| Dataset | MEP.MEP.mega_Pheno.cls #Group3_versus_Group4.MEP.mega_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.23313951 |
| Normalized Enrichment Score (NES) | 1.0078868 |
| Nominal p-value | 0.43960395 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.991 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Xbp1 | 163 | 0.807 | 0.0119 | Yes |
| 2 | Ldlr | 198 | 0.761 | 0.0293 | Yes |
| 3 | Trib3 | 225 | 0.741 | 0.0467 | Yes |
| 4 | Ak4 | 554 | 0.600 | 0.0447 | Yes |
| 5 | Bhlhe40 | 560 | 0.596 | 0.0596 | Yes |
| 6 | Hmgcs1 | 578 | 0.595 | 0.0737 | Yes |
| 7 | Hk2 | 689 | 0.564 | 0.0822 | Yes |
| 8 | Etf1 | 733 | 0.551 | 0.0939 | Yes |
| 9 | Ykt6 | 738 | 0.549 | 0.1076 | Yes |
| 10 | Hmgcr | 759 | 0.541 | 0.1202 | Yes |
| 11 | Ero1a | 981 | 0.489 | 0.1210 | Yes |
| 12 | Igfbp5 | 1215 | 0.454 | 0.1203 | Yes |
| 13 | Bub1 | 1295 | 0.448 | 0.1275 | Yes |
| 14 | Sdf2l1 | 1313 | 0.446 | 0.1379 | Yes |
| 15 | Psat1 | 1409 | 0.437 | 0.1440 | Yes |
| 16 | Nufip1 | 1451 | 0.432 | 0.1528 | Yes |
| 17 | Cyp51 | 1652 | 0.410 | 0.1527 | Yes |
| 18 | Hspa5 | 1897 | 0.383 | 0.1496 | Yes |
| 19 | Ung | 1923 | 0.381 | 0.1579 | Yes |
| 20 | Atp2a2 | 1925 | 0.381 | 0.1675 | Yes |
| 21 | Mcm4 | 2176 | 0.354 | 0.1634 | Yes |
| 22 | Immt | 2241 | 0.347 | 0.1688 | Yes |
| 23 | Plk1 | 2416 | 0.331 | 0.1681 | Yes |
| 24 | Cth | 2444 | 0.329 | 0.1750 | Yes |
| 25 | Slc7a5 | 2486 | 0.326 | 0.1811 | Yes |
| 26 | Psmd14 | 2783 | 0.303 | 0.1733 | Yes |
| 27 | Psmd13 | 2844 | 0.298 | 0.1777 | Yes |
| 28 | Gga2 | 2847 | 0.298 | 0.1851 | Yes |
| 29 | Abcf2 | 2866 | 0.296 | 0.1917 | Yes |
| 30 | Psph | 2886 | 0.294 | 0.1981 | Yes |
| 31 | Cyb5b | 3065 | 0.282 | 0.1959 | Yes |
| 32 | Ddit4 | 3119 | 0.277 | 0.2002 | Yes |
| 33 | Asns | 3186 | 0.273 | 0.2036 | Yes |
| 34 | Tubg1 | 3324 | 0.267 | 0.2032 | Yes |
| 35 | Acly | 3357 | 0.264 | 0.2082 | Yes |
| 36 | Sc5d | 3429 | 0.259 | 0.2110 | Yes |
| 37 | Ccnf | 3455 | 0.256 | 0.2162 | Yes |
| 38 | Sqle | 3528 | 0.255 | 0.2189 | Yes |
| 39 | Ufm1 | 3556 | 0.253 | 0.2238 | Yes |
| 40 | Rpn1 | 3635 | 0.247 | 0.2260 | Yes |
| 41 | Me1 | 4112 | 0.226 | 0.2068 | Yes |
| 42 | Cdkn1a | 4196 | 0.220 | 0.2081 | Yes |
| 43 | Srd5a1 | 4429 | 0.209 | 0.2012 | Yes |
| 44 | Actr3 | 4447 | 0.208 | 0.2056 | Yes |
| 45 | Hspa4 | 4527 | 0.203 | 0.2066 | Yes |
| 46 | Ddx39a | 4577 | 0.200 | 0.2091 | Yes |
| 47 | Gtf2h1 | 4605 | 0.198 | 0.2127 | Yes |
| 48 | Nup205 | 4630 | 0.197 | 0.2164 | Yes |
| 49 | Rrm2 | 4682 | 0.195 | 0.2187 | Yes |
| 50 | Gla | 4704 | 0.194 | 0.2225 | Yes |
| 51 | Nfyc | 4735 | 0.191 | 0.2257 | Yes |
| 52 | Pfkl | 4762 | 0.190 | 0.2292 | Yes |
| 53 | Cct6a | 4855 | 0.184 | 0.2290 | Yes |
| 54 | Actr2 | 4960 | 0.179 | 0.2281 | Yes |
| 55 | Nupr1 | 4991 | 0.177 | 0.2310 | Yes |
| 56 | Aurka | 5035 | 0.174 | 0.2331 | Yes |
| 57 | Hsp90b1 | 5217 | 0.164 | 0.2278 | No |
| 58 | Gmps | 5242 | 0.163 | 0.2307 | No |
| 59 | Nfkbib | 5305 | 0.159 | 0.2315 | No |
| 60 | Rdh11 | 5415 | 0.153 | 0.2296 | No |
| 61 | Gclc | 5557 | 0.148 | 0.2260 | No |
| 62 | Niban1 | 5572 | 0.147 | 0.2290 | No |
| 63 | Psmc6 | 5616 | 0.145 | 0.2304 | No |
| 64 | Sec11a | 5794 | 0.137 | 0.2246 | No |
| 65 | Phgdh | 5927 | 0.130 | 0.2210 | No |
| 66 | Eef1e1 | 6032 | 0.128 | 0.2188 | No |
| 67 | Rrp9 | 6237 | 0.118 | 0.2111 | No |
| 68 | Insig1 | 6264 | 0.117 | 0.2127 | No |
| 69 | Tpi1 | 6315 | 0.116 | 0.2130 | No |
| 70 | Stip1 | 6346 | 0.115 | 0.2143 | No |
| 71 | Nfil3 | 6376 | 0.113 | 0.2157 | No |
| 72 | Ddit3 | 6456 | 0.110 | 0.2143 | No |
| 73 | Hspd1 | 6464 | 0.110 | 0.2167 | No |
| 74 | Slc1a4 | 6498 | 0.108 | 0.2177 | No |
| 75 | Ppia | 6609 | 0.104 | 0.2146 | No |
| 76 | Uso1 | 6616 | 0.103 | 0.2169 | No |
| 77 | Calr | 6634 | 0.103 | 0.2186 | No |
| 78 | Gpi1 | 6669 | 0.101 | 0.2194 | No |
| 79 | Map2k3 | 6676 | 0.101 | 0.2216 | No |
| 80 | Mthfd2 | 6682 | 0.101 | 0.2239 | No |
| 81 | Hspa9 | 6828 | 0.096 | 0.2187 | No |
| 82 | Pdap1 | 6834 | 0.095 | 0.2209 | No |
| 83 | Arpc5l | 6890 | 0.093 | 0.2203 | No |
| 84 | Canx | 6964 | 0.089 | 0.2188 | No |
| 85 | Rpa1 | 7204 | 0.080 | 0.2083 | No |
| 86 | Pik3r3 | 7300 | 0.077 | 0.2053 | No |
| 87 | Hmbs | 7523 | 0.070 | 0.1954 | No |
| 88 | Psme3 | 7571 | 0.068 | 0.1947 | No |
| 89 | Tomm40 | 7642 | 0.065 | 0.1927 | No |
| 90 | Serp1 | 7664 | 0.063 | 0.1932 | No |
| 91 | P4ha1 | 7711 | 0.061 | 0.1923 | No |
| 92 | Uchl5 | 7735 | 0.060 | 0.1926 | No |
| 93 | Stard4 | 7870 | 0.056 | 0.1870 | No |
| 94 | Fads2 | 7903 | 0.054 | 0.1867 | No |
| 95 | Ube2d3 | 7947 | 0.053 | 0.1858 | No |
| 96 | Fgl2 | 7983 | 0.051 | 0.1853 | No |
| 97 | Adipor2 | 8218 | 0.042 | 0.1741 | No |
| 98 | Cxcr4 | 8220 | 0.042 | 0.1751 | No |
| 99 | Ccng1 | 8247 | 0.041 | 0.1748 | No |
| 100 | Acaca | 8255 | 0.041 | 0.1755 | No |
| 101 | Sla | 8295 | 0.040 | 0.1744 | No |
| 102 | Txnrd1 | 8405 | 0.036 | 0.1696 | No |
| 103 | Psmd12 | 8431 | 0.035 | 0.1692 | No |
| 104 | Mcm2 | 8463 | 0.033 | 0.1684 | No |
| 105 | Ctsc | 8653 | 0.027 | 0.1592 | No |
| 106 | Bcat1 | 8673 | 0.027 | 0.1589 | No |
| 107 | M6pr | 8780 | 0.022 | 0.1539 | No |
| 108 | Tmem97 | 8782 | 0.022 | 0.1544 | No |
| 109 | Wars1 | 8791 | 0.022 | 0.1546 | No |
| 110 | Cops5 | 8931 | 0.019 | 0.1478 | No |
| 111 | Tcea1 | 9081 | 0.013 | 0.1403 | No |
| 112 | Sqstm1 | 9115 | 0.012 | 0.1389 | No |
| 113 | Tfrc | 9169 | 0.010 | 0.1364 | No |
| 114 | Add3 | 9204 | 0.009 | 0.1348 | No |
| 115 | G6pdx | 9255 | 0.007 | 0.1324 | No |
| 116 | Slc2a1 | 9669 | -0.002 | 0.1108 | No |
| 117 | Ssr1 | 9748 | -0.004 | 0.1068 | No |
| 118 | Pdk1 | 9790 | -0.006 | 0.1048 | No |
| 119 | Slc1a5 | 9925 | -0.010 | 0.0981 | No |
| 120 | Ppa1 | 10138 | -0.017 | 0.0874 | No |
| 121 | Slc37a4 | 10198 | -0.020 | 0.0848 | No |
| 122 | Shmt2 | 10654 | -0.035 | 0.0619 | No |
| 123 | Hspe1 | 10768 | -0.040 | 0.0570 | No |
| 124 | Fads1 | 10859 | -0.042 | 0.0534 | No |
| 125 | Btg2 | 11007 | -0.048 | 0.0469 | No |
| 126 | Cdc25a | 11151 | -0.053 | 0.0408 | No |
| 127 | Pnp | 11450 | -0.065 | 0.0268 | No |
| 128 | Polr3g | 11470 | -0.065 | 0.0275 | No |
| 129 | Dhcr24 | 11548 | -0.068 | 0.0251 | No |
| 130 | Prdx1 | 11580 | -0.069 | 0.0253 | No |
| 131 | Psma4 | 11610 | -0.070 | 0.0255 | No |
| 132 | Nampt | 11720 | -0.074 | 0.0217 | No |
| 133 | Cacybp | 11777 | -0.076 | 0.0207 | No |
| 134 | Pitpnb | 11810 | -0.077 | 0.0210 | No |
| 135 | Tm7sf2 | 11870 | -0.080 | 0.0199 | No |
| 136 | Ebp | 11924 | -0.082 | 0.0192 | No |
| 137 | Sord | 11930 | -0.082 | 0.0211 | No |
| 138 | Ldha | 12034 | -0.085 | 0.0178 | No |
| 139 | Tbk1 | 12329 | -0.097 | 0.0049 | No |
| 140 | Vldlr | 12390 | -0.099 | 0.0043 | No |
| 141 | Acsl3 | 12473 | -0.102 | 0.0025 | No |
| 142 | Got1 | 12802 | -0.115 | -0.0117 | No |
| 143 | Rit1 | 12830 | -0.115 | -0.0102 | No |
| 144 | Idi1 | 13050 | -0.123 | -0.0185 | No |
| 145 | Gsk3b | 13111 | -0.126 | -0.0185 | No |
| 146 | Elovl5 | 13169 | -0.127 | -0.0183 | No |
| 147 | Mthfd2l | 13278 | -0.132 | -0.0206 | No |
| 148 | Fkbp2 | 13555 | -0.144 | -0.0314 | No |
| 149 | Psma3 | 13654 | -0.147 | -0.0328 | No |
| 150 | Tes | 14002 | -0.162 | -0.0468 | No |
| 151 | Lta4h | 14021 | -0.164 | -0.0436 | No |
| 152 | Eif2s2 | 14026 | -0.164 | -0.0397 | No |
| 153 | Idh1 | 14111 | -0.168 | -0.0398 | No |
| 154 | Psmc4 | 14135 | -0.169 | -0.0368 | No |
| 155 | Pgm1 | 14210 | -0.172 | -0.0363 | No |
| 156 | Edem1 | 14362 | -0.179 | -0.0397 | No |
| 157 | Elovl6 | 14431 | -0.182 | -0.0386 | No |
| 158 | Glrx | 14655 | -0.193 | -0.0454 | No |
| 159 | Pgk1 | 14702 | -0.195 | -0.0429 | No |
| 160 | Pno1 | 14720 | -0.197 | -0.0388 | No |
| 161 | Gbe1 | 14801 | -0.201 | -0.0379 | No |
| 162 | Ppp1r15a | 15153 | -0.214 | -0.0508 | No |
| 163 | Qdpr | 15247 | -0.220 | -0.0501 | No |
| 164 | Tuba4a | 15264 | -0.221 | -0.0454 | No |
| 165 | Aldoa | 15440 | -0.229 | -0.0488 | No |
| 166 | Cd9 | 15531 | -0.233 | -0.0476 | No |
| 167 | Egln3 | 15566 | -0.235 | -0.0434 | No |
| 168 | Itgb2 | 15619 | -0.238 | -0.0401 | No |
| 169 | Dhcr7 | 15648 | -0.239 | -0.0355 | No |
| 170 | Fdxr | 15829 | -0.247 | -0.0387 | No |
| 171 | Skap2 | 15891 | -0.252 | -0.0355 | No |
| 172 | Psmc2 | 15953 | -0.255 | -0.0323 | No |
| 173 | Sytl2 | 15966 | -0.256 | -0.0264 | No |
| 174 | Nmt1 | 16108 | -0.263 | -0.0272 | No |
| 175 | Psmb5 | 16169 | -0.267 | -0.0236 | No |
| 176 | Lgmn | 16289 | -0.274 | -0.0229 | No |
| 177 | Dapp1 | 16387 | -0.279 | -0.0209 | No |
| 178 | Plod2 | 16487 | -0.284 | -0.0189 | No |
| 179 | Slc6a6 | 16499 | -0.285 | -0.0123 | No |
| 180 | Rab1a | 16546 | -0.287 | -0.0074 | No |
| 181 | Eno1b | 16554 | -0.288 | -0.0005 | No |
| 182 | Serpinh1 | 16563 | -0.288 | 0.0064 | No |
| 183 | Dhfr | 17055 | -0.320 | -0.0112 | No |
| 184 | Gsr | 17081 | -0.321 | -0.0044 | No |
| 185 | Ifrd1 | 17346 | -0.341 | -0.0096 | No |
| 186 | Slc2a3 | 17684 | -0.369 | -0.0179 | No |
| 187 | Cfp | 17770 | -0.379 | -0.0128 | No |
| 188 | Psmg1 | 18416 | -0.452 | -0.0351 | No |
| 189 | Coro1a | 18489 | -0.463 | -0.0271 | No |
| 190 | Slc7a11 | 18681 | -0.496 | -0.0246 | No |
| 191 | Atp6v1d | 18888 | -0.550 | -0.0214 | No |
| 192 | Ifi30 | 19249 | -0.818 | -0.0196 | No |
| 193 | Mllt11 | 19278 | -0.893 | 0.0015 | No |

