| Dataset | MEP.MEP.mega_Pheno.cls #Group3_versus_Group4.MEP.mega_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_G2M_CHECKPOINT |
| Enrichment Score (ES) | 0.42313778 |
| Normalized Enrichment Score (NES) | 1.4470828 |
| Nominal p-value | 0.14619882 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.526 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ccnd1 | 6 | 1.387 | 0.0394 | Yes |
| 2 | Cdc25b | 716 | 0.555 | 0.0182 | Yes |
| 3 | Dbf4 | 802 | 0.529 | 0.0288 | Yes |
| 4 | Upf1 | 1072 | 0.474 | 0.0283 | Yes |
| 5 | Bub1 | 1295 | 0.448 | 0.0295 | Yes |
| 6 | Dmd | 1315 | 0.446 | 0.0413 | Yes |
| 7 | Bcl3 | 1368 | 0.441 | 0.0512 | Yes |
| 8 | Kif23 | 1474 | 0.431 | 0.0580 | Yes |
| 9 | Meis2 | 1537 | 0.424 | 0.0669 | Yes |
| 10 | Nek2 | 1672 | 0.407 | 0.0715 | Yes |
| 11 | Kif2c | 1739 | 0.400 | 0.0795 | Yes |
| 12 | Espl1 | 1868 | 0.388 | 0.0839 | Yes |
| 13 | Xpo1 | 1876 | 0.387 | 0.0946 | Yes |
| 14 | Exo1 | 1889 | 0.385 | 0.1050 | Yes |
| 15 | Ube2c | 1960 | 0.378 | 0.1121 | Yes |
| 16 | Ccna2 | 1986 | 0.375 | 0.1215 | Yes |
| 17 | Cdc20 | 2161 | 0.356 | 0.1226 | Yes |
| 18 | Ttk | 2210 | 0.350 | 0.1301 | Yes |
| 19 | Tacc3 | 2276 | 0.342 | 0.1365 | Yes |
| 20 | Chaf1a | 2286 | 0.342 | 0.1458 | Yes |
| 21 | Ccnb2 | 2296 | 0.341 | 0.1551 | Yes |
| 22 | Plk1 | 2416 | 0.331 | 0.1584 | Yes |
| 23 | Cdk1 | 2456 | 0.329 | 0.1657 | Yes |
| 24 | Traip | 2460 | 0.328 | 0.1750 | Yes |
| 25 | Slc7a5 | 2486 | 0.326 | 0.1830 | Yes |
| 26 | Cks1b | 2603 | 0.318 | 0.1860 | Yes |
| 27 | Smad3 | 2626 | 0.315 | 0.1938 | Yes |
| 28 | Hmmr | 2671 | 0.312 | 0.2005 | Yes |
| 29 | Incenp | 2731 | 0.307 | 0.2062 | Yes |
| 30 | Mki67 | 2767 | 0.305 | 0.2130 | Yes |
| 31 | Prc1 | 2784 | 0.303 | 0.2209 | Yes |
| 32 | Suv39h1 | 2858 | 0.297 | 0.2256 | Yes |
| 33 | Kif11 | 2869 | 0.296 | 0.2335 | Yes |
| 34 | Fbxo5 | 2882 | 0.295 | 0.2413 | Yes |
| 35 | Rpa2 | 3014 | 0.285 | 0.2426 | Yes |
| 36 | Cdkn2c | 3041 | 0.283 | 0.2493 | Yes |
| 37 | Tent4a | 3203 | 0.272 | 0.2487 | Yes |
| 38 | Map3k20 | 3311 | 0.268 | 0.2508 | Yes |
| 39 | Cenpe | 3319 | 0.267 | 0.2580 | Yes |
| 40 | Stmn1 | 3332 | 0.266 | 0.2650 | Yes |
| 41 | Nsd2 | 3337 | 0.266 | 0.2724 | Yes |
| 42 | Pole | 3372 | 0.263 | 0.2782 | Yes |
| 43 | Chek1 | 3420 | 0.259 | 0.2831 | Yes |
| 44 | Lmnb1 | 3433 | 0.258 | 0.2899 | Yes |
| 45 | Srsf1 | 3451 | 0.256 | 0.2963 | Yes |
| 46 | Ccnf | 3455 | 0.256 | 0.3035 | Yes |
| 47 | Racgap1 | 3464 | 0.255 | 0.3104 | Yes |
| 48 | Sqle | 3528 | 0.255 | 0.3144 | Yes |
| 49 | Srsf2 | 3624 | 0.248 | 0.3165 | Yes |
| 50 | Hspa8 | 3715 | 0.246 | 0.3188 | Yes |
| 51 | Bard1 | 3839 | 0.242 | 0.3193 | Yes |
| 52 | Knl1 | 3850 | 0.241 | 0.3257 | Yes |
| 53 | Kif15 | 3913 | 0.237 | 0.3292 | Yes |
| 54 | Cdc6 | 3974 | 0.234 | 0.3328 | Yes |
| 55 | Odf2 | 3983 | 0.234 | 0.3391 | Yes |
| 56 | Cenpa | 4002 | 0.233 | 0.3448 | Yes |
| 57 | Sfpq | 4010 | 0.232 | 0.3511 | Yes |
| 58 | Tpx2 | 4078 | 0.228 | 0.3541 | Yes |
| 59 | Polq | 4135 | 0.225 | 0.3576 | Yes |
| 60 | Cenpf | 4198 | 0.220 | 0.3606 | Yes |
| 61 | Kif4 | 4397 | 0.211 | 0.3563 | Yes |
| 62 | Nusap1 | 4410 | 0.211 | 0.3617 | Yes |
| 63 | Kif20b | 4442 | 0.209 | 0.3661 | Yes |
| 64 | Rad21 | 4466 | 0.207 | 0.3708 | Yes |
| 65 | Mcm6 | 4563 | 0.201 | 0.3715 | Yes |
| 66 | Ewsr1 | 4569 | 0.201 | 0.3770 | Yes |
| 67 | Ddx39a | 4577 | 0.200 | 0.3823 | Yes |
| 68 | Egf | 4695 | 0.194 | 0.3817 | Yes |
| 69 | Hnrnpu | 4718 | 0.192 | 0.3861 | Yes |
| 70 | Uck2 | 4758 | 0.190 | 0.3895 | Yes |
| 71 | Tfdp1 | 4779 | 0.188 | 0.3938 | Yes |
| 72 | Kif22 | 4887 | 0.182 | 0.3934 | Yes |
| 73 | Aurkb | 4923 | 0.181 | 0.3968 | Yes |
| 74 | Aurka | 5035 | 0.174 | 0.3959 | Yes |
| 75 | Kpnb1 | 5103 | 0.170 | 0.3973 | Yes |
| 76 | Nup98 | 5274 | 0.161 | 0.3930 | Yes |
| 77 | Tnpo2 | 5339 | 0.158 | 0.3941 | Yes |
| 78 | Cul4a | 5450 | 0.152 | 0.3927 | Yes |
| 79 | Tra2b | 5510 | 0.149 | 0.3939 | Yes |
| 80 | Top2a | 5514 | 0.149 | 0.3980 | Yes |
| 81 | Tmpo | 5533 | 0.149 | 0.4013 | Yes |
| 82 | Ube2s | 5603 | 0.146 | 0.4019 | Yes |
| 83 | Amd1 | 5644 | 0.144 | 0.4039 | Yes |
| 84 | Rad23b | 5733 | 0.139 | 0.4033 | Yes |
| 85 | Cdc27 | 5761 | 0.138 | 0.4058 | Yes |
| 86 | Pttg1 | 5812 | 0.136 | 0.4071 | Yes |
| 87 | H2bc12 | 5829 | 0.135 | 0.4101 | Yes |
| 88 | H2ax | 5900 | 0.132 | 0.4102 | Yes |
| 89 | Hif1a | 5915 | 0.131 | 0.4132 | Yes |
| 90 | Srsf10 | 5931 | 0.130 | 0.4162 | Yes |
| 91 | Hnrnpd | 6045 | 0.127 | 0.4139 | Yes |
| 92 | E2f2 | 6086 | 0.125 | 0.4154 | Yes |
| 93 | Stil | 6148 | 0.122 | 0.4157 | Yes |
| 94 | Kmt5a | 6163 | 0.122 | 0.4184 | Yes |
| 95 | Dr1 | 6211 | 0.120 | 0.4194 | Yes |
| 96 | Cdkn3 | 6226 | 0.119 | 0.4221 | Yes |
| 97 | Mybl2 | 6370 | 0.114 | 0.4179 | Yes |
| 98 | Numa1 | 6428 | 0.111 | 0.4181 | Yes |
| 99 | Ccnt1 | 6451 | 0.110 | 0.4200 | Yes |
| 100 | Troap | 6522 | 0.107 | 0.4195 | Yes |
| 101 | Fancc | 6549 | 0.106 | 0.4211 | Yes |
| 102 | Rad54l | 6569 | 0.105 | 0.4231 | Yes |
| 103 | Mapk14 | 6811 | 0.096 | 0.4133 | No |
| 104 | Smc4 | 7194 | 0.081 | 0.3956 | No |
| 105 | Smc1a | 7267 | 0.078 | 0.3941 | No |
| 106 | Slc12a2 | 7362 | 0.075 | 0.3913 | No |
| 107 | Mcm3 | 7481 | 0.072 | 0.3872 | No |
| 108 | G3bp1 | 7508 | 0.070 | 0.3878 | No |
| 109 | Lbr | 7577 | 0.068 | 0.3862 | No |
| 110 | Syncrip | 7662 | 0.063 | 0.3836 | No |
| 111 | Ctcf | 7805 | 0.057 | 0.3778 | No |
| 112 | Wrn | 7806 | 0.057 | 0.3795 | No |
| 113 | Cul3 | 7816 | 0.057 | 0.3807 | No |
| 114 | Mcm5 | 7821 | 0.057 | 0.3821 | No |
| 115 | Cdc45 | 7842 | 0.056 | 0.3826 | No |
| 116 | Plk4 | 7900 | 0.054 | 0.3812 | No |
| 117 | Katna1 | 7991 | 0.051 | 0.3780 | No |
| 118 | Dtymk | 8062 | 0.048 | 0.3757 | No |
| 119 | Gins2 | 8094 | 0.047 | 0.3754 | No |
| 120 | Birc5 | 8110 | 0.046 | 0.3759 | No |
| 121 | Smarcc1 | 8116 | 0.046 | 0.3770 | No |
| 122 | Pds5b | 8222 | 0.042 | 0.3727 | No |
| 123 | Casp8ap2 | 8333 | 0.038 | 0.3680 | No |
| 124 | Prim2 | 8334 | 0.038 | 0.3691 | No |
| 125 | Cul5 | 8360 | 0.037 | 0.3689 | No |
| 126 | Mcm2 | 8463 | 0.033 | 0.3645 | No |
| 127 | Ythdc1 | 8527 | 0.031 | 0.3621 | No |
| 128 | Snrpd1 | 8751 | 0.024 | 0.3511 | No |
| 129 | Smc2 | 8838 | 0.021 | 0.3472 | No |
| 130 | Prpf4b | 8852 | 0.020 | 0.3471 | No |
| 131 | Dkc1 | 8948 | 0.018 | 0.3426 | No |
| 132 | Abl1 | 8988 | 0.017 | 0.3411 | No |
| 133 | Mtf2 | 9094 | 0.013 | 0.3360 | No |
| 134 | Ndc80 | 9347 | 0.004 | 0.3229 | No |
| 135 | Cbx1 | 9741 | -0.004 | 0.3024 | No |
| 136 | Slc38a1 | 9812 | -0.006 | 0.2990 | No |
| 137 | Cdc7 | 9856 | -0.008 | 0.2969 | No |
| 138 | Pml | 10022 | -0.013 | 0.2887 | No |
| 139 | Pbk | 10126 | -0.017 | 0.2838 | No |
| 140 | Mnat1 | 10224 | -0.020 | 0.2793 | No |
| 141 | Cul1 | 10280 | -0.022 | 0.2770 | No |
| 142 | Lig3 | 10405 | -0.027 | 0.2713 | No |
| 143 | Cdk4 | 10426 | -0.028 | 0.2711 | No |
| 144 | Gspt1 | 10444 | -0.028 | 0.2710 | No |
| 145 | Ezh2 | 10565 | -0.032 | 0.2656 | No |
| 146 | Rbl1 | 10595 | -0.033 | 0.2651 | No |
| 147 | Brca2 | 10693 | -0.037 | 0.2610 | No |
| 148 | Pafah1b1 | 10992 | -0.047 | 0.2468 | No |
| 149 | Myc | 11047 | -0.049 | 0.2454 | No |
| 150 | Cks2 | 11119 | -0.052 | 0.2431 | No |
| 151 | Cdc25a | 11151 | -0.053 | 0.2430 | No |
| 152 | Ilf3 | 11168 | -0.054 | 0.2438 | No |
| 153 | Slc7a1 | 11260 | -0.057 | 0.2406 | No |
| 154 | Chmp1a | 11312 | -0.059 | 0.2397 | No |
| 155 | Nup50 | 11314 | -0.059 | 0.2413 | No |
| 156 | Atrx | 11342 | -0.060 | 0.2416 | No |
| 157 | Meis1 | 11387 | -0.062 | 0.2411 | No |
| 158 | Jpt1 | 11436 | -0.064 | 0.2404 | No |
| 159 | Nasp | 11627 | -0.071 | 0.2325 | No |
| 160 | Rasal2 | 11649 | -0.072 | 0.2334 | No |
| 161 | Top1 | 11884 | -0.081 | 0.2235 | No |
| 162 | E2f1 | 11889 | -0.081 | 0.2256 | No |
| 163 | Foxn3 | 11926 | -0.082 | 0.2261 | No |
| 164 | Kif5b | 12105 | -0.087 | 0.2193 | No |
| 165 | Orc6 | 12231 | -0.092 | 0.2154 | No |
| 166 | Hira | 12249 | -0.093 | 0.2171 | No |
| 167 | Mad2l1 | 12465 | -0.102 | 0.2088 | No |
| 168 | Rps6ka5 | 12590 | -0.107 | 0.2054 | No |
| 169 | Bub3 | 12649 | -0.109 | 0.2054 | No |
| 170 | Notch2 | 12744 | -0.113 | 0.2037 | No |
| 171 | Hmgb3 | 12851 | -0.116 | 0.2015 | No |
| 172 | Stag1 | 13273 | -0.132 | 0.1833 | No |
| 173 | Pura | 13405 | -0.137 | 0.1803 | No |
| 174 | H2az2 | 13414 | -0.137 | 0.1838 | No |
| 175 | E2f3 | 13428 | -0.138 | 0.1871 | No |
| 176 | Arid4a | 13493 | -0.141 | 0.1878 | No |
| 177 | Pola2 | 13527 | -0.143 | 0.1901 | No |
| 178 | Prmt5 | 13669 | -0.148 | 0.1870 | No |
| 179 | Ss18 | 13758 | -0.152 | 0.1867 | No |
| 180 | Ncl | 13854 | -0.156 | 0.1862 | No |
| 181 | Tgfb1 | 13896 | -0.158 | 0.1886 | No |
| 182 | H2az1 | 14237 | -0.173 | 0.1757 | No |
| 183 | Cdkn1b | 14634 | -0.192 | 0.1605 | No |
| 184 | E2f4 | 14862 | -0.204 | 0.1545 | No |
| 185 | Tle3 | 15103 | -0.212 | 0.1480 | No |
| 186 | Nolc1 | 15340 | -0.223 | 0.1420 | No |
| 187 | Orc5 | 15364 | -0.225 | 0.1472 | No |
| 188 | Hus1 | 15466 | -0.230 | 0.1485 | No |
| 189 | Efna5 | 15751 | -0.243 | 0.1406 | No |
| 190 | Hmga1b | 16352 | -0.276 | 0.1171 | No |
| 191 | Odc1 | 16398 | -0.279 | 0.1228 | No |
| 192 | Atf5 | 16481 | -0.284 | 0.1266 | No |
| 193 | Marcks | 17622 | -0.364 | 0.0774 | No |
| 194 | Sap30 | 17739 | -0.375 | 0.0820 | No |

