| Dataset | MEP.MEP.mega_Pheno.cls #Group3_versus_Group4.MEP.mega_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_ESTROGEN_RESPONSE_EARLY |
| Enrichment Score (ES) | 0.32124534 |
| Normalized Enrichment Score (NES) | 1.4063773 |
| Nominal p-value | 0.03164557 |
| FDR q-value | 0.827278 |
| FWER p-Value | 0.61 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ccnd1 | 6 | 1.387 | 0.0383 | Yes |
| 2 | Ar | 40 | 1.056 | 0.0660 | Yes |
| 3 | Ablim1 | 82 | 0.895 | 0.0887 | Yes |
| 4 | Rps6ka2 | 84 | 0.892 | 0.1135 | Yes |
| 5 | Xbp1 | 163 | 0.807 | 0.1319 | Yes |
| 6 | Slc7a2 | 228 | 0.737 | 0.1491 | Yes |
| 7 | Sec14l2 | 364 | 0.653 | 0.1602 | Yes |
| 8 | Gfra1 | 378 | 0.648 | 0.1776 | Yes |
| 9 | Mreg | 516 | 0.610 | 0.1874 | Yes |
| 10 | Bhlhe40 | 560 | 0.596 | 0.2018 | Yes |
| 11 | Il17rb | 622 | 0.584 | 0.2148 | Yes |
| 12 | Akap1 | 812 | 0.525 | 0.2196 | Yes |
| 13 | Tiparp | 871 | 0.511 | 0.2308 | Yes |
| 14 | Endod1 | 882 | 0.509 | 0.2444 | Yes |
| 15 | Fdft1 | 1347 | 0.442 | 0.2325 | Yes |
| 16 | Wwc1 | 1456 | 0.431 | 0.2389 | Yes |
| 17 | Il6st | 1503 | 0.428 | 0.2484 | Yes |
| 18 | Scnn1a | 1543 | 0.423 | 0.2581 | Yes |
| 19 | Slc16a1 | 1581 | 0.419 | 0.2678 | Yes |
| 20 | Arl3 | 1651 | 0.410 | 0.2756 | Yes |
| 21 | Sybu | 1945 | 0.379 | 0.2709 | Yes |
| 22 | Opn3 | 2022 | 0.370 | 0.2772 | Yes |
| 23 | Isg20l2 | 2147 | 0.357 | 0.2807 | Yes |
| 24 | Nadsyn1 | 2223 | 0.349 | 0.2865 | Yes |
| 25 | Sfn | 2279 | 0.342 | 0.2931 | Yes |
| 26 | Slc7a5 | 2486 | 0.326 | 0.2915 | Yes |
| 27 | Tmprss3 | 2544 | 0.322 | 0.2974 | Yes |
| 28 | P2ry2 | 2583 | 0.319 | 0.3043 | Yes |
| 29 | Pmaip1 | 2727 | 0.308 | 0.3054 | Yes |
| 30 | Retreg1 | 2729 | 0.308 | 0.3139 | Yes |
| 31 | Bcl11b | 2753 | 0.305 | 0.3212 | Yes |
| 32 | Syngr1 | 3085 | 0.280 | 0.3117 | No |
| 33 | Hes1 | 3390 | 0.261 | 0.3031 | No |
| 34 | Siah2 | 3541 | 0.254 | 0.3024 | No |
| 35 | Flnb | 3976 | 0.234 | 0.2862 | No |
| 36 | Foxc1 | 4295 | 0.216 | 0.2756 | No |
| 37 | Sh3bp5 | 4671 | 0.196 | 0.2615 | No |
| 38 | Amfr | 4674 | 0.195 | 0.2668 | No |
| 39 | Gla | 4704 | 0.194 | 0.2707 | No |
| 40 | Abat | 4854 | 0.184 | 0.2680 | No |
| 41 | Rapgefl1 | 4883 | 0.182 | 0.2716 | No |
| 42 | Slc19a2 | 4935 | 0.180 | 0.2740 | No |
| 43 | Tjp3 | 4943 | 0.179 | 0.2786 | No |
| 44 | Olfml3 | 5100 | 0.170 | 0.2752 | No |
| 45 | Podxl | 5231 | 0.163 | 0.2729 | No |
| 46 | Scarb1 | 5318 | 0.159 | 0.2729 | No |
| 47 | Krt8 | 5420 | 0.153 | 0.2719 | No |
| 48 | Fasn | 5697 | 0.141 | 0.2614 | No |
| 49 | Celsr1 | 5704 | 0.141 | 0.2650 | No |
| 50 | Egr3 | 5961 | 0.129 | 0.2552 | No |
| 51 | Pex11a | 5981 | 0.129 | 0.2578 | No |
| 52 | Kcnk5 | 5991 | 0.129 | 0.2609 | No |
| 53 | Fkbp4 | 6158 | 0.122 | 0.2556 | No |
| 54 | Ttc39a | 6369 | 0.114 | 0.2478 | No |
| 55 | Slc1a4 | 6498 | 0.108 | 0.2442 | No |
| 56 | Rbbp8 | 6553 | 0.106 | 0.2443 | No |
| 57 | Mpped2 | 6595 | 0.104 | 0.2451 | No |
| 58 | Clic3 | 6600 | 0.104 | 0.2477 | No |
| 59 | Plaat3 | 6642 | 0.102 | 0.2484 | No |
| 60 | Aldh3b1 | 6730 | 0.099 | 0.2466 | No |
| 61 | Itpk1 | 7007 | 0.088 | 0.2347 | No |
| 62 | Mybl1 | 7019 | 0.087 | 0.2365 | No |
| 63 | Greb1 | 7197 | 0.081 | 0.2295 | No |
| 64 | Cyp26b1 | 7218 | 0.080 | 0.2307 | No |
| 65 | Ugcg | 7234 | 0.079 | 0.2321 | No |
| 66 | Stc2 | 7248 | 0.079 | 0.2336 | No |
| 67 | Rab31 | 7274 | 0.078 | 0.2345 | No |
| 68 | Igf1r | 7296 | 0.077 | 0.2356 | No |
| 69 | Chpt1 | 7375 | 0.075 | 0.2336 | No |
| 70 | Rrp12 | 7468 | 0.072 | 0.2308 | No |
| 71 | Bag1 | 7498 | 0.071 | 0.2312 | No |
| 72 | Klf4 | 7714 | 0.061 | 0.2217 | No |
| 73 | Fos | 7728 | 0.060 | 0.2227 | No |
| 74 | Hspb8 | 7764 | 0.059 | 0.2225 | No |
| 75 | Myof | 7817 | 0.057 | 0.2214 | No |
| 76 | Deptor | 8273 | 0.040 | 0.1988 | No |
| 77 | Tmem164 | 8383 | 0.037 | 0.1941 | No |
| 78 | Olfm1 | 8544 | 0.030 | 0.1866 | No |
| 79 | Celsr2 | 8809 | 0.021 | 0.1734 | No |
| 80 | Tob1 | 8816 | 0.021 | 0.1737 | No |
| 81 | Add3 | 9204 | 0.009 | 0.1537 | No |
| 82 | Slc1a1 | 9348 | 0.004 | 0.1463 | No |
| 83 | Slc22a5 | 9413 | 0.002 | 0.1430 | No |
| 84 | Cant1 | 9451 | 0.001 | 0.1411 | No |
| 85 | Bcl2 | 9637 | -0.001 | 0.1315 | No |
| 86 | Nxt1 | 9638 | -0.001 | 0.1315 | No |
| 87 | Slc2a1 | 9669 | -0.002 | 0.1300 | No |
| 88 | Rara | 10135 | -0.017 | 0.1062 | No |
| 89 | Slc37a1 | 10248 | -0.021 | 0.1009 | No |
| 90 | Rab17 | 10362 | -0.025 | 0.0957 | No |
| 91 | Fkbp5 | 10389 | -0.027 | 0.0951 | No |
| 92 | Ncor2 | 10391 | -0.027 | 0.0958 | No |
| 93 | Frk | 10529 | -0.031 | 0.0895 | No |
| 94 | Cish | 10643 | -0.035 | 0.0846 | No |
| 95 | Igfbp4 | 10665 | -0.036 | 0.0845 | No |
| 96 | Dhrs3 | 10686 | -0.036 | 0.0844 | No |
| 97 | Mybbp1a | 10755 | -0.039 | 0.0820 | No |
| 98 | Cd44 | 10947 | -0.046 | 0.0733 | No |
| 99 | Blvrb | 10981 | -0.047 | 0.0729 | No |
| 100 | Med24 | 10996 | -0.047 | 0.0734 | No |
| 101 | Myc | 11047 | -0.049 | 0.0722 | No |
| 102 | Sult2b1 | 11048 | -0.049 | 0.0736 | No |
| 103 | Rhod | 11078 | -0.050 | 0.0735 | No |
| 104 | Kdm4b | 11211 | -0.055 | 0.0681 | No |
| 105 | Wfs1 | 11376 | -0.061 | 0.0612 | No |
| 106 | Klf10 | 11553 | -0.068 | 0.0540 | No |
| 107 | Cbfa2t3 | 11705 | -0.074 | 0.0481 | No |
| 108 | Nrip1 | 11749 | -0.076 | 0.0480 | No |
| 109 | Car12 | 11793 | -0.077 | 0.0479 | No |
| 110 | Dlc1 | 11824 | -0.078 | 0.0485 | No |
| 111 | B4galt1 | 11840 | -0.079 | 0.0499 | No |
| 112 | Abhd2 | 11890 | -0.081 | 0.0496 | No |
| 113 | Mapt | 11964 | -0.083 | 0.0481 | No |
| 114 | Ptges | 11972 | -0.083 | 0.0500 | No |
| 115 | Inpp5f | 12062 | -0.086 | 0.0478 | No |
| 116 | Elf1 | 12387 | -0.099 | 0.0336 | No |
| 117 | Myb | 12426 | -0.101 | 0.0344 | No |
| 118 | Lrig1 | 12635 | -0.108 | 0.0266 | No |
| 119 | Rhobtb3 | 12690 | -0.110 | 0.0268 | No |
| 120 | Svil | 12822 | -0.115 | 0.0232 | No |
| 121 | Gja1 | 13100 | -0.125 | 0.0122 | No |
| 122 | Elovl5 | 13169 | -0.127 | 0.0122 | No |
| 123 | Farp1 | 13252 | -0.131 | 0.0115 | No |
| 124 | Adcy9 | 13276 | -0.132 | 0.0140 | No |
| 125 | Tpd52l1 | 13300 | -0.133 | 0.0165 | No |
| 126 | Dynlt3 | 13491 | -0.141 | 0.0105 | No |
| 127 | Med13l | 13696 | -0.149 | 0.0040 | No |
| 128 | Mast4 | 13779 | -0.152 | 0.0039 | No |
| 129 | Jak2 | 13966 | -0.161 | -0.0013 | No |
| 130 | Slc26a2 | 13970 | -0.161 | 0.0030 | No |
| 131 | Aff1 | 13972 | -0.161 | 0.0075 | No |
| 132 | Tgm2 | 14153 | -0.170 | 0.0028 | No |
| 133 | Tiam1 | 14165 | -0.170 | 0.0070 | No |
| 134 | Ret | 14315 | -0.176 | 0.0041 | No |
| 135 | Anxa9 | 14478 | -0.184 | 0.0007 | No |
| 136 | Unc119 | 14630 | -0.192 | -0.0018 | No |
| 137 | Slc39a6 | 14811 | -0.201 | -0.0056 | No |
| 138 | Rasgrp1 | 14900 | -0.206 | -0.0045 | No |
| 139 | Papss2 | 15140 | -0.214 | -0.0110 | No |
| 140 | Ppif | 15338 | -0.223 | -0.0151 | No |
| 141 | Zfp185 | 15625 | -0.238 | -0.0234 | No |
| 142 | Dhcr7 | 15648 | -0.239 | -0.0179 | No |
| 143 | Gab2 | 15755 | -0.243 | -0.0167 | No |
| 144 | Nav2 | 15851 | -0.249 | -0.0147 | No |
| 145 | Krt18 | 15853 | -0.249 | -0.0078 | No |
| 146 | Snx24 | 15872 | -0.251 | -0.0018 | No |
| 147 | Pgr | 16318 | -0.274 | -0.0174 | No |
| 148 | Reep1 | 16574 | -0.289 | -0.0227 | No |
| 149 | Abca3 | 16627 | -0.292 | -0.0173 | No |
| 150 | Slc24a3 | 16799 | -0.303 | -0.0178 | No |
| 151 | Fhl2 | 16856 | -0.306 | -0.0122 | No |
| 152 | Muc1 | 16933 | -0.313 | -0.0074 | No |
| 153 | Tgif2 | 17162 | -0.325 | -0.0103 | No |
| 154 | Kazn | 18017 | -0.403 | -0.0437 | No |
| 155 | Elovl2 | 18499 | -0.464 | -0.0559 | No |
| 156 | Asb13 | 18575 | -0.474 | -0.0466 | No |
| 157 | Mindy1 | 18792 | -0.524 | -0.0433 | No |
| 158 | Thsd4 | 18830 | -0.536 | -0.0303 | No |
| 159 | Pdzk1 | 18981 | -0.591 | -0.0217 | No |
| 160 | Tbc1d30 | 19115 | -0.661 | -0.0102 | No |
| 161 | Mlph | 19190 | -0.725 | 0.0061 | No |

