| Dataset | MEP.MEP.mega_Pheno.cls #Group3_versus_Group4.MEP.mega_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.40114647 |
| Normalized Enrichment Score (NES) | 1.346109 |
| Nominal p-value | 0.23062016 |
| FDR q-value | 0.577292 |
| FWER p-Value | 0.7 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cdc25b | 716 | 0.555 | -0.0211 | Yes |
| 2 | Cdkn2a | 743 | 0.548 | -0.0062 | Yes |
| 3 | Nop56 | 829 | 0.521 | 0.0048 | Yes |
| 4 | Ppp1r8 | 866 | 0.512 | 0.0180 | Yes |
| 5 | Kif18b | 1079 | 0.473 | 0.0209 | Yes |
| 6 | Ncapd2 | 1671 | 0.407 | 0.0020 | Yes |
| 7 | Slbp | 1718 | 0.403 | 0.0115 | Yes |
| 8 | Kif2c | 1739 | 0.400 | 0.0223 | Yes |
| 9 | Timeless | 1772 | 0.399 | 0.0324 | Yes |
| 10 | Mxd3 | 1835 | 0.392 | 0.0408 | Yes |
| 11 | Espl1 | 1868 | 0.388 | 0.0506 | Yes |
| 12 | Xpo1 | 1876 | 0.387 | 0.0616 | Yes |
| 13 | Zw10 | 1881 | 0.387 | 0.0728 | Yes |
| 14 | Ung | 1923 | 0.381 | 0.0820 | Yes |
| 15 | Exosc8 | 2068 | 0.364 | 0.0852 | Yes |
| 16 | Spag5 | 2097 | 0.361 | 0.0944 | Yes |
| 17 | Rad1 | 2109 | 0.360 | 0.1045 | Yes |
| 18 | Cdc20 | 2161 | 0.356 | 0.1123 | Yes |
| 19 | Mcm4 | 2176 | 0.354 | 0.1220 | Yes |
| 20 | Nup107 | 2190 | 0.353 | 0.1318 | Yes |
| 21 | Cenpm | 2236 | 0.347 | 0.1397 | Yes |
| 22 | Tubb5 | 2269 | 0.344 | 0.1482 | Yes |
| 23 | Tacc3 | 2276 | 0.342 | 0.1580 | Yes |
| 24 | Ccnb2 | 2296 | 0.341 | 0.1671 | Yes |
| 25 | Trip13 | 2337 | 0.337 | 0.1750 | Yes |
| 26 | Plk1 | 2416 | 0.331 | 0.1807 | Yes |
| 27 | Cdk1 | 2456 | 0.329 | 0.1884 | Yes |
| 28 | Cks1b | 2603 | 0.318 | 0.1901 | Yes |
| 29 | Cdca3 | 2669 | 0.312 | 0.1959 | Yes |
| 30 | Hmmr | 2671 | 0.312 | 0.2051 | Yes |
| 31 | Wdr90 | 2679 | 0.311 | 0.2139 | Yes |
| 32 | Brca1 | 2749 | 0.306 | 0.2193 | Yes |
| 33 | Mki67 | 2767 | 0.305 | 0.2275 | Yes |
| 34 | Cdca8 | 2841 | 0.298 | 0.2325 | Yes |
| 35 | Suv39h1 | 2858 | 0.297 | 0.2404 | Yes |
| 36 | Cse1l | 2877 | 0.295 | 0.2482 | Yes |
| 37 | Rpa2 | 3014 | 0.285 | 0.2495 | Yes |
| 38 | Cdkn2c | 3041 | 0.283 | 0.2565 | Yes |
| 39 | Ak2 | 3199 | 0.272 | 0.2563 | Yes |
| 40 | E2f8 | 3308 | 0.268 | 0.2586 | Yes |
| 41 | Cenpe | 3319 | 0.267 | 0.2660 | Yes |
| 42 | Tubg1 | 3324 | 0.267 | 0.2737 | Yes |
| 43 | Stmn1 | 3332 | 0.266 | 0.2812 | Yes |
| 44 | Pole | 3372 | 0.263 | 0.2869 | Yes |
| 45 | Chek1 | 3420 | 0.259 | 0.2921 | Yes |
| 46 | Lmnb1 | 3433 | 0.258 | 0.2991 | Yes |
| 47 | Srsf1 | 3451 | 0.256 | 0.3058 | Yes |
| 48 | Racgap1 | 3464 | 0.255 | 0.3127 | Yes |
| 49 | Asf1b | 3558 | 0.252 | 0.3153 | Yes |
| 50 | Srsf2 | 3624 | 0.248 | 0.3193 | Yes |
| 51 | Gins1 | 3732 | 0.244 | 0.3209 | Yes |
| 52 | Ubr7 | 3768 | 0.243 | 0.3263 | Yes |
| 53 | Bard1 | 3839 | 0.242 | 0.3298 | Yes |
| 54 | Spc25 | 3898 | 0.238 | 0.3338 | Yes |
| 55 | Ipo7 | 3902 | 0.238 | 0.3407 | Yes |
| 56 | Ssrp1 | 3935 | 0.236 | 0.3460 | Yes |
| 57 | Rbbp7 | 4172 | 0.222 | 0.3402 | Yes |
| 58 | Cdkn1a | 4196 | 0.220 | 0.3455 | Yes |
| 59 | Ing3 | 4257 | 0.217 | 0.3488 | Yes |
| 60 | Kif4 | 4397 | 0.211 | 0.3477 | Yes |
| 61 | Tcf19 | 4461 | 0.207 | 0.3506 | Yes |
| 62 | Rad21 | 4466 | 0.207 | 0.3565 | Yes |
| 63 | Mcm6 | 4563 | 0.201 | 0.3574 | Yes |
| 64 | Ddx39a | 4577 | 0.200 | 0.3626 | Yes |
| 65 | Nup205 | 4630 | 0.197 | 0.3657 | Yes |
| 66 | Rrm2 | 4682 | 0.195 | 0.3688 | Yes |
| 67 | Tipin | 4698 | 0.194 | 0.3738 | Yes |
| 68 | Ccne1 | 4776 | 0.189 | 0.3753 | Yes |
| 69 | Kif22 | 4887 | 0.182 | 0.3749 | Yes |
| 70 | Aurkb | 4923 | 0.181 | 0.3784 | Yes |
| 71 | Hells | 4942 | 0.179 | 0.3828 | Yes |
| 72 | Aurka | 5035 | 0.174 | 0.3831 | Yes |
| 73 | Cbx5 | 5061 | 0.172 | 0.3869 | Yes |
| 74 | Nap1l1 | 5129 | 0.169 | 0.3884 | Yes |
| 75 | Bub1b | 5174 | 0.166 | 0.3910 | Yes |
| 76 | Depdc1a | 5233 | 0.163 | 0.3928 | Yes |
| 77 | Tra2b | 5510 | 0.149 | 0.3827 | Yes |
| 78 | Top2a | 5514 | 0.149 | 0.3870 | Yes |
| 79 | Tmpo | 5533 | 0.149 | 0.3904 | Yes |
| 80 | Ube2s | 5603 | 0.146 | 0.3911 | Yes |
| 81 | Ccp110 | 5705 | 0.141 | 0.3900 | Yes |
| 82 | Tbrg4 | 5800 | 0.136 | 0.3891 | Yes |
| 83 | Pttg1 | 5812 | 0.136 | 0.3925 | Yes |
| 84 | Gins3 | 5861 | 0.133 | 0.3940 | Yes |
| 85 | H2ax | 5900 | 0.132 | 0.3959 | Yes |
| 86 | Dnmt1 | 5943 | 0.130 | 0.3975 | Yes |
| 87 | Msh2 | 5948 | 0.130 | 0.4011 | Yes |
| 88 | Hnrnpd | 6045 | 0.127 | 0.3999 | No |
| 89 | Gins4 | 6105 | 0.124 | 0.4005 | No |
| 90 | Cdkn3 | 6226 | 0.119 | 0.3977 | No |
| 91 | Mybl2 | 6370 | 0.114 | 0.3936 | No |
| 92 | Ube2t | 6386 | 0.113 | 0.3961 | No |
| 93 | Nbn | 6493 | 0.109 | 0.3938 | No |
| 94 | Cit | 6567 | 0.105 | 0.3931 | No |
| 95 | Mms22l | 6635 | 0.103 | 0.3926 | No |
| 96 | Mthfd2 | 6682 | 0.101 | 0.3932 | No |
| 97 | Xrcc6 | 6848 | 0.095 | 0.3873 | No |
| 98 | Dctpp1 | 6913 | 0.091 | 0.3867 | No |
| 99 | Spc24 | 6986 | 0.088 | 0.3855 | No |
| 100 | Pold1 | 6996 | 0.088 | 0.3877 | No |
| 101 | Wee1 | 7018 | 0.087 | 0.3892 | No |
| 102 | Smc3 | 7035 | 0.086 | 0.3909 | No |
| 103 | Rfc1 | 7146 | 0.082 | 0.3875 | No |
| 104 | Smc4 | 7194 | 0.081 | 0.3875 | No |
| 105 | Rpa1 | 7204 | 0.080 | 0.3894 | No |
| 106 | Smc1a | 7267 | 0.078 | 0.3884 | No |
| 107 | Mcm3 | 7481 | 0.072 | 0.3794 | No |
| 108 | Cnot9 | 7491 | 0.071 | 0.3810 | No |
| 109 | Rad51c | 7550 | 0.069 | 0.3800 | No |
| 110 | Lbr | 7577 | 0.068 | 0.3807 | No |
| 111 | Syncrip | 7662 | 0.063 | 0.3782 | No |
| 112 | Atad2 | 7700 | 0.062 | 0.3780 | No |
| 113 | Paics | 7706 | 0.061 | 0.3796 | No |
| 114 | Melk | 7724 | 0.061 | 0.3805 | No |
| 115 | Ctcf | 7805 | 0.057 | 0.3780 | No |
| 116 | Mcm5 | 7821 | 0.057 | 0.3789 | No |
| 117 | Plk4 | 7900 | 0.054 | 0.3764 | No |
| 118 | Prkdc | 7941 | 0.053 | 0.3759 | No |
| 119 | Phf5a | 8028 | 0.049 | 0.3729 | No |
| 120 | Birc5 | 8110 | 0.046 | 0.3700 | No |
| 121 | Pa2g4 | 8113 | 0.046 | 0.3712 | No |
| 122 | Orc2 | 8171 | 0.044 | 0.3695 | No |
| 123 | Pan2 | 8184 | 0.044 | 0.3702 | No |
| 124 | Pds5b | 8222 | 0.042 | 0.3695 | No |
| 125 | Rpa3 | 8325 | 0.039 | 0.3653 | No |
| 126 | Prim2 | 8334 | 0.038 | 0.3660 | No |
| 127 | Dlgap5 | 8376 | 0.037 | 0.3650 | No |
| 128 | Mcm2 | 8463 | 0.033 | 0.3615 | No |
| 129 | Asf1a | 8473 | 0.033 | 0.3620 | No |
| 130 | Diaph3 | 8533 | 0.031 | 0.3598 | No |
| 131 | Usp1 | 8647 | 0.028 | 0.3547 | No |
| 132 | Dek | 8904 | 0.020 | 0.3419 | No |
| 133 | Pold3 | 8993 | 0.016 | 0.3378 | No |
| 134 | Lyar | 9007 | 0.016 | 0.3376 | No |
| 135 | Pcna | 9042 | 0.015 | 0.3362 | No |
| 136 | Prdx4 | 9123 | 0.012 | 0.3324 | No |
| 137 | Pms2 | 9156 | 0.011 | 0.3310 | No |
| 138 | Tfrc | 9169 | 0.010 | 0.3307 | No |
| 139 | Rad51ap1 | 9213 | 0.009 | 0.3287 | No |
| 140 | Rad50 | 9247 | 0.008 | 0.3272 | No |
| 141 | Hmgb2 | 9678 | -0.002 | 0.3048 | No |
| 142 | Rfc2 | 9913 | -0.010 | 0.2928 | No |
| 143 | Prps1 | 10194 | -0.019 | 0.2787 | No |
| 144 | Lsm8 | 10200 | -0.020 | 0.2790 | No |
| 145 | Eed | 10232 | -0.021 | 0.2780 | No |
| 146 | Cdk4 | 10426 | -0.028 | 0.2688 | No |
| 147 | Nme1 | 10430 | -0.028 | 0.2694 | No |
| 148 | Gspt1 | 10444 | -0.028 | 0.2696 | No |
| 149 | Ezh2 | 10565 | -0.032 | 0.2642 | No |
| 150 | Ranbp1 | 10569 | -0.032 | 0.2650 | No |
| 151 | Dut | 10671 | -0.036 | 0.2608 | No |
| 152 | Brca2 | 10693 | -0.037 | 0.2608 | No |
| 153 | Mcm7 | 10702 | -0.037 | 0.2614 | No |
| 154 | Brms1l | 10715 | -0.037 | 0.2619 | No |
| 155 | Pnn | 10801 | -0.041 | 0.2587 | No |
| 156 | Psip1 | 10967 | -0.046 | 0.2514 | No |
| 157 | Myc | 11047 | -0.049 | 0.2487 | No |
| 158 | Cks2 | 11119 | -0.052 | 0.2466 | No |
| 159 | Cdc25a | 11151 | -0.053 | 0.2465 | No |
| 160 | Ilf3 | 11168 | -0.054 | 0.2473 | No |
| 161 | Psmc3ip | 11294 | -0.058 | 0.2425 | No |
| 162 | Jpt1 | 11436 | -0.064 | 0.2370 | No |
| 163 | Shmt1 | 11502 | -0.066 | 0.2355 | No |
| 164 | Luc7l3 | 11536 | -0.067 | 0.2358 | No |
| 165 | Nasp | 11627 | -0.071 | 0.2332 | No |
| 166 | Dclre1b | 11852 | -0.079 | 0.2238 | No |
| 167 | Nup153 | 12057 | -0.086 | 0.2157 | No |
| 168 | Chek2 | 12091 | -0.087 | 0.2165 | No |
| 169 | Orc6 | 12231 | -0.092 | 0.2120 | No |
| 170 | Pole4 | 12309 | -0.096 | 0.2108 | No |
| 171 | Mad2l1 | 12465 | -0.102 | 0.2057 | No |
| 172 | Mre11a | 12620 | -0.108 | 0.2008 | No |
| 173 | Lig1 | 12641 | -0.108 | 0.2030 | No |
| 174 | Hmgb3 | 12851 | -0.116 | 0.1955 | No |
| 175 | Trp53 | 12855 | -0.116 | 0.1987 | No |
| 176 | Rfc3 | 12987 | -0.121 | 0.1955 | No |
| 177 | Stag1 | 13273 | -0.132 | 0.1845 | No |
| 178 | Ran | 13297 | -0.132 | 0.1872 | No |
| 179 | Donson | 13339 | -0.134 | 0.1890 | No |
| 180 | Anp32e | 13351 | -0.135 | 0.1924 | No |
| 181 | Smc6 | 13502 | -0.141 | 0.1887 | No |
| 182 | Pola2 | 13527 | -0.143 | 0.1917 | No |
| 183 | Nudt21 | 13859 | -0.156 | 0.1790 | No |
| 184 | Tk1 | 14216 | -0.172 | 0.1654 | No |
| 185 | H2az1 | 14237 | -0.173 | 0.1695 | No |
| 186 | Dck | 14311 | -0.176 | 0.1709 | No |
| 187 | Dscc1 | 14368 | -0.179 | 0.1733 | No |
| 188 | Snrpb | 14445 | -0.182 | 0.1747 | No |
| 189 | Cdkn1b | 14634 | -0.192 | 0.1705 | No |
| 190 | Eif2s1 | 14703 | -0.195 | 0.1728 | No |
| 191 | Ppm1d | 14785 | -0.200 | 0.1744 | No |
| 192 | Nolc1 | 15340 | -0.223 | 0.1520 | No |
| 193 | Hus1 | 15466 | -0.230 | 0.1523 | No |
| 194 | Hmga1b | 16352 | -0.276 | 0.1142 | No |
| 195 | Mlh1 | 16602 | -0.290 | 0.1097 | No |
| 196 | Pop7 | 17059 | -0.320 | 0.0953 | No |
| 197 | Rnaseh2a | 17615 | -0.363 | 0.0770 | No |
| 198 | Pold2 | 17861 | -0.388 | 0.0757 | No |

