| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group4.MEP.mega_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.30313036 |
| Normalized Enrichment Score (NES) | -1.2950108 |
| Nominal p-value | 0.09306931 |
| FDR q-value | 0.90330243 |
| FWER p-Value | 0.775 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ninj1 | 726 | 0.538 | -0.0241 | No |
| 2 | Cndp2 | 857 | 0.516 | -0.0176 | No |
| 3 | Ddc | 869 | 0.515 | -0.0049 | No |
| 4 | Slc35b1 | 916 | 0.509 | 0.0057 | No |
| 5 | Cdo1 | 1072 | 0.482 | 0.0100 | No |
| 6 | Tgfb2 | 1099 | 0.478 | 0.0210 | No |
| 7 | Kynu | 1148 | 0.473 | 0.0306 | No |
| 8 | Cfb | 1218 | 0.465 | 0.0390 | No |
| 9 | Aco2 | 1852 | 0.395 | 0.0161 | No |
| 10 | Ap4b1 | 1868 | 0.394 | 0.0254 | No |
| 11 | Pgd | 1873 | 0.394 | 0.0353 | No |
| 12 | Cda | 1954 | 0.385 | 0.0410 | No |
| 13 | Atoh8 | 1958 | 0.385 | 0.0508 | No |
| 14 | Il1r1 | 2064 | 0.374 | 0.0549 | No |
| 15 | Npc1 | 2481 | 0.341 | 0.0420 | No |
| 16 | Dhrs1 | 2653 | 0.330 | 0.0415 | No |
| 17 | Atp2a2 | 3076 | 0.299 | 0.0272 | No |
| 18 | Pdlim5 | 3433 | 0.275 | 0.0156 | No |
| 19 | Hgfac | 3485 | 0.272 | 0.0200 | No |
| 20 | Hes6 | 3616 | 0.263 | 0.0199 | No |
| 21 | Pmm1 | 3973 | 0.243 | 0.0076 | No |
| 22 | Slc35d1 | 4259 | 0.228 | -0.0014 | No |
| 23 | Mthfd1 | 4284 | 0.227 | 0.0032 | No |
| 24 | Psmb10 | 4846 | 0.195 | -0.0211 | No |
| 25 | Pink1 | 5096 | 0.182 | -0.0294 | No |
| 26 | Lcat | 5338 | 0.173 | -0.0376 | No |
| 27 | Acox1 | 5355 | 0.172 | -0.0340 | No |
| 28 | Cyp2j6 | 5458 | 0.167 | -0.0350 | No |
| 29 | Maoa | 5485 | 0.165 | -0.0321 | No |
| 30 | Upp1 | 5718 | 0.157 | -0.0402 | No |
| 31 | Pts | 5811 | 0.153 | -0.0411 | No |
| 32 | Ddt | 5856 | 0.151 | -0.0395 | No |
| 33 | Gabarapl1 | 5875 | 0.150 | -0.0366 | No |
| 34 | Id2 | 5900 | 0.149 | -0.0340 | No |
| 35 | Fbln1 | 5952 | 0.145 | -0.0330 | No |
| 36 | F10 | 5959 | 0.145 | -0.0295 | No |
| 37 | Gclc | 6497 | 0.118 | -0.0545 | No |
| 38 | Abcd2 | 6533 | 0.116 | -0.0534 | No |
| 39 | Gart | 6575 | 0.114 | -0.0526 | No |
| 40 | Ets2 | 6659 | 0.110 | -0.0541 | No |
| 41 | Marchf6 | 6686 | 0.109 | -0.0527 | No |
| 42 | Ugdh | 6758 | 0.106 | -0.0537 | No |
| 43 | Csad | 6775 | 0.105 | -0.0518 | No |
| 44 | Enpep | 6919 | 0.098 | -0.0567 | No |
| 45 | Alas1 | 7019 | 0.093 | -0.0595 | No |
| 46 | Man1a | 7319 | 0.081 | -0.0731 | No |
| 47 | Smox | 7817 | 0.059 | -0.0975 | No |
| 48 | Retsat | 7839 | 0.059 | -0.0971 | No |
| 49 | Ccl25 | 8015 | 0.051 | -0.1049 | No |
| 50 | Lpin2 | 8093 | 0.048 | -0.1077 | No |
| 51 | Ech1 | 8158 | 0.045 | -0.1098 | No |
| 52 | Aldh9a1 | 8169 | 0.045 | -0.1092 | No |
| 53 | Gss | 8251 | 0.041 | -0.1124 | No |
| 54 | Ptges | 8416 | 0.033 | -0.1201 | No |
| 55 | Ssr3 | 8826 | 0.015 | -0.1411 | No |
| 56 | Slc1a5 | 9748 | -0.019 | -0.1886 | No |
| 57 | Casp6 | 9901 | -0.026 | -0.1959 | No |
| 58 | Acp2 | 9959 | -0.029 | -0.1981 | No |
| 59 | Hmox1 | 10117 | -0.034 | -0.2054 | No |
| 60 | Esr1 | 10221 | -0.040 | -0.2098 | No |
| 61 | Nfs1 | 10647 | -0.056 | -0.2305 | No |
| 62 | Pdk4 | 10751 | -0.060 | -0.2344 | No |
| 63 | Angptl3 | 10878 | -0.064 | -0.2393 | No |
| 64 | Dhps | 10920 | -0.066 | -0.2398 | No |
| 65 | Apoe | 11105 | -0.074 | -0.2475 | No |
| 66 | Arg1 | 11180 | -0.077 | -0.2493 | No |
| 67 | Elovl5 | 11310 | -0.083 | -0.2540 | No |
| 68 | Crp | 11411 | -0.087 | -0.2569 | No |
| 69 | Ephx1 | 11476 | -0.089 | -0.2580 | No |
| 70 | Sertad1 | 11597 | -0.092 | -0.2619 | No |
| 71 | Dhrs7 | 11931 | -0.108 | -0.2765 | No |
| 72 | Hacl1 | 11987 | -0.110 | -0.2766 | No |
| 73 | Lonp1 | 12067 | -0.113 | -0.2778 | No |
| 74 | Ddah2 | 12192 | -0.118 | -0.2812 | No |
| 75 | Gch1 | 12225 | -0.119 | -0.2798 | No |
| 76 | Entpd5 | 12269 | -0.121 | -0.2790 | No |
| 77 | Spint2 | 12283 | -0.122 | -0.2765 | No |
| 78 | Pros1 | 12401 | -0.127 | -0.2794 | No |
| 79 | Fbp1 | 12527 | -0.133 | -0.2825 | No |
| 80 | Gad1 | 12661 | -0.139 | -0.2858 | No |
| 81 | Bcat1 | 12679 | -0.140 | -0.2831 | No |
| 82 | Pgrmc1 | 12763 | -0.144 | -0.2838 | No |
| 83 | Bphl | 12837 | -0.148 | -0.2838 | No |
| 84 | Arpp19 | 12939 | -0.152 | -0.2851 | No |
| 85 | Abcc2 | 13053 | -0.157 | -0.2870 | No |
| 86 | Gcnt2 | 13183 | -0.163 | -0.2896 | No |
| 87 | Hnf4a | 13444 | -0.175 | -0.2986 | Yes |
| 88 | Gnmt | 13474 | -0.176 | -0.2956 | Yes |
| 89 | Asl | 13614 | -0.182 | -0.2982 | Yes |
| 90 | Blvrb | 13651 | -0.185 | -0.2953 | Yes |
| 91 | Cyp27a1 | 13728 | -0.188 | -0.2945 | Yes |
| 92 | Papss2 | 13789 | -0.191 | -0.2927 | Yes |
| 93 | Ttpa | 13892 | -0.195 | -0.2930 | Yes |
| 94 | Gsr | 13921 | -0.197 | -0.2894 | Yes |
| 95 | Abcc3 | 14008 | -0.202 | -0.2887 | Yes |
| 96 | Plg | 14096 | -0.206 | -0.2880 | Yes |
| 97 | Pemt | 14322 | -0.215 | -0.2942 | Yes |
| 98 | Pcx | 14328 | -0.215 | -0.2889 | Yes |
| 99 | Car2 | 14527 | -0.224 | -0.2935 | Yes |
| 100 | Comt | 14533 | -0.225 | -0.2880 | Yes |
| 101 | Mpp2 | 14682 | -0.233 | -0.2897 | Yes |
| 102 | Gstt2 | 14776 | -0.238 | -0.2885 | Yes |
| 103 | Rap1gap | 14804 | -0.239 | -0.2837 | Yes |
| 104 | Aldh2 | 14904 | -0.245 | -0.2826 | Yes |
| 105 | Ppard | 15076 | -0.255 | -0.2850 | Yes |
| 106 | Tmbim6 | 15085 | -0.256 | -0.2788 | Yes |
| 107 | Slc46a3 | 15306 | -0.267 | -0.2835 | Yes |
| 108 | Tmem97 | 15552 | -0.281 | -0.2890 | Yes |
| 109 | Etfdh | 15610 | -0.285 | -0.2847 | Yes |
| 110 | Mccc2 | 15633 | -0.285 | -0.2785 | Yes |
| 111 | Shmt2 | 15635 | -0.286 | -0.2712 | Yes |
| 112 | Slc12a4 | 15920 | -0.302 | -0.2783 | Yes |
| 113 | Acox3 | 15936 | -0.303 | -0.2713 | Yes |
| 114 | Slc6a6 | 16058 | -0.311 | -0.2696 | Yes |
| 115 | Por | 16176 | -0.318 | -0.2676 | Yes |
| 116 | Abhd6 | 16179 | -0.318 | -0.2595 | Yes |
| 117 | Irf8 | 16221 | -0.322 | -0.2534 | Yes |
| 118 | Epha2 | 16249 | -0.324 | -0.2464 | Yes |
| 119 | Crot | 16484 | -0.340 | -0.2499 | Yes |
| 120 | Nmt1 | 16515 | -0.342 | -0.2427 | Yes |
| 121 | Arg2 | 16615 | -0.349 | -0.2389 | Yes |
| 122 | Cyb5a | 16696 | -0.354 | -0.2340 | Yes |
| 123 | Xdh | 16835 | -0.365 | -0.2318 | Yes |
| 124 | Cyp26a1 | 16856 | -0.366 | -0.2235 | Yes |
| 125 | Cyfip2 | 16918 | -0.371 | -0.2171 | Yes |
| 126 | Cat | 16949 | -0.374 | -0.2091 | Yes |
| 127 | Tkfc | 16968 | -0.375 | -0.2004 | Yes |
| 128 | Ptgr1 | 16993 | -0.377 | -0.1920 | Yes |
| 129 | Adh5 | 17127 | -0.388 | -0.1889 | Yes |
| 130 | Nqo1 | 17315 | -0.401 | -0.1884 | Yes |
| 131 | Ndrg2 | 17397 | -0.409 | -0.1821 | Yes |
| 132 | Ptges3-ps | 17591 | -0.427 | -0.1812 | Yes |
| 133 | Fas | 17610 | -0.428 | -0.1712 | Yes |
| 134 | Hsd11b1 | 17629 | -0.430 | -0.1610 | Yes |
| 135 | Tnfrsf1a | 17655 | -0.433 | -0.1512 | Yes |
| 136 | Acp1 | 17719 | -0.441 | -0.1432 | Yes |
| 137 | Igf1 | 17748 | -0.444 | -0.1332 | Yes |
| 138 | Igfbp4 | 17801 | -0.450 | -0.1244 | Yes |
| 139 | Cd36 | 17852 | -0.455 | -0.1153 | Yes |
| 140 | Sar1b | 17870 | -0.457 | -0.1044 | Yes |
| 141 | Tyr | 17898 | -0.462 | -0.0940 | Yes |
| 142 | Dcxr | 18092 | -0.486 | -0.0916 | Yes |
| 143 | Cbr1 | 18175 | -0.498 | -0.0831 | Yes |
| 144 | Tmem176b | 18275 | -0.514 | -0.0750 | Yes |
| 145 | Aqp9 | 18311 | -0.519 | -0.0635 | Yes |
| 146 | Jup | 18368 | -0.528 | -0.0529 | Yes |
| 147 | Gsto1 | 18389 | -0.532 | -0.0402 | Yes |
| 148 | Idh1 | 18737 | -0.604 | -0.0428 | Yes |
| 149 | Tpst1 | 18798 | -0.622 | -0.0300 | Yes |
| 150 | Pycr1 | 18825 | -0.628 | -0.0152 | Yes |
| 151 | Fah | 19012 | -0.709 | -0.0067 | Yes |
| 152 | Gstm4 | 19194 | -0.858 | 0.0059 | Yes |

