| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group4.MEP.mega_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Enrichment Score (ES) | 0.16738692 |
| Normalized Enrichment Score (NES) | 0.60343415 |
| Nominal p-value | 0.98136646 |
| FDR q-value | 0.9539095 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Fosb | 88 | 0.828 | 0.0156 | Yes |
| 2 | Tnip2 | 133 | 0.772 | 0.0322 | Yes |
| 3 | Fut4 | 204 | 0.717 | 0.0460 | Yes |
| 4 | Tiparp | 360 | 0.639 | 0.0535 | Yes |
| 5 | Atf3 | 374 | 0.633 | 0.0683 | Yes |
| 6 | Trip10 | 381 | 0.630 | 0.0834 | Yes |
| 7 | Traf1 | 584 | 0.571 | 0.0868 | Yes |
| 8 | Ninj1 | 726 | 0.538 | 0.0926 | Yes |
| 9 | Plk2 | 782 | 0.528 | 0.1026 | Yes |
| 10 | Il6st | 917 | 0.509 | 0.1080 | Yes |
| 11 | Il1b | 942 | 0.505 | 0.1191 | Yes |
| 12 | Bhlhe40 | 964 | 0.500 | 0.1302 | Yes |
| 13 | Kynu | 1148 | 0.473 | 0.1322 | Yes |
| 14 | Cd69 | 1224 | 0.465 | 0.1396 | Yes |
| 15 | Il7r | 1285 | 0.456 | 0.1476 | Yes |
| 16 | Jun | 1406 | 0.441 | 0.1521 | Yes |
| 17 | Bcl3 | 1605 | 0.420 | 0.1520 | Yes |
| 18 | Nr4a3 | 1934 | 0.387 | 0.1443 | Yes |
| 19 | Rhob | 1961 | 0.384 | 0.1523 | Yes |
| 20 | Dusp1 | 2118 | 0.369 | 0.1532 | Yes |
| 21 | Mcl1 | 2148 | 0.366 | 0.1606 | Yes |
| 22 | Irs2 | 2233 | 0.357 | 0.1649 | Yes |
| 23 | Fos | 2390 | 0.346 | 0.1652 | Yes |
| 24 | Trib1 | 2508 | 0.339 | 0.1674 | Yes |
| 25 | Serpinb8 | 2688 | 0.327 | 0.1660 | No |
| 26 | Ier5 | 3100 | 0.298 | 0.1518 | No |
| 27 | Il6 | 3265 | 0.286 | 0.1502 | No |
| 28 | Pdlim5 | 3433 | 0.275 | 0.1482 | No |
| 29 | Hes1 | 3447 | 0.274 | 0.1543 | No |
| 30 | Zc3h12a | 3626 | 0.263 | 0.1514 | No |
| 31 | Btg3 | 3821 | 0.251 | 0.1473 | No |
| 32 | Ldlr | 3842 | 0.250 | 0.1524 | No |
| 33 | Sgk1 | 4085 | 0.238 | 0.1456 | No |
| 34 | Nampt | 4222 | 0.230 | 0.1441 | No |
| 35 | Smad3 | 4271 | 0.227 | 0.1471 | No |
| 36 | Rel | 4323 | 0.224 | 0.1499 | No |
| 37 | Atp2b1 | 4454 | 0.216 | 0.1484 | No |
| 38 | Plpp3 | 4690 | 0.204 | 0.1411 | No |
| 39 | Map2k3 | 4812 | 0.196 | 0.1396 | No |
| 40 | Maff | 4840 | 0.195 | 0.1429 | No |
| 41 | Ccnl1 | 4906 | 0.192 | 0.1442 | No |
| 42 | Tank | 4972 | 0.188 | 0.1454 | No |
| 43 | Hbegf | 4974 | 0.188 | 0.1500 | No |
| 44 | Pmepa1 | 5047 | 0.184 | 0.1507 | No |
| 45 | Btg2 | 5069 | 0.184 | 0.1541 | No |
| 46 | Tnfaip3 | 5472 | 0.166 | 0.1371 | No |
| 47 | Plau | 5581 | 0.161 | 0.1354 | No |
| 48 | Id2 | 5900 | 0.149 | 0.1224 | No |
| 49 | Cd80 | 6015 | 0.142 | 0.1199 | No |
| 50 | Ifit2 | 6037 | 0.140 | 0.1223 | No |
| 51 | Yrdc | 6166 | 0.134 | 0.1189 | No |
| 52 | Socs3 | 6230 | 0.131 | 0.1188 | No |
| 53 | Jag1 | 6338 | 0.126 | 0.1162 | No |
| 54 | Nfkb2 | 6344 | 0.125 | 0.1190 | No |
| 55 | Klf2 | 6372 | 0.124 | 0.1207 | No |
| 56 | Csf1 | 6439 | 0.121 | 0.1202 | No |
| 57 | Relb | 6443 | 0.121 | 0.1230 | No |
| 58 | Nfil3 | 6504 | 0.118 | 0.1227 | No |
| 59 | Birc2 | 6535 | 0.116 | 0.1240 | No |
| 60 | Vegfa | 6551 | 0.116 | 0.1260 | No |
| 61 | Ets2 | 6659 | 0.110 | 0.1231 | No |
| 62 | Lamb3 | 6672 | 0.110 | 0.1251 | No |
| 63 | Bmp2 | 6704 | 0.108 | 0.1262 | No |
| 64 | Tnip1 | 6868 | 0.100 | 0.1201 | No |
| 65 | Slc16a6 | 6925 | 0.097 | 0.1195 | No |
| 66 | Per1 | 6927 | 0.097 | 0.1219 | No |
| 67 | Klf6 | 7029 | 0.092 | 0.1189 | No |
| 68 | Klf10 | 7102 | 0.089 | 0.1173 | No |
| 69 | Dennd5a | 7191 | 0.086 | 0.1148 | No |
| 70 | Plek | 7336 | 0.080 | 0.1092 | No |
| 71 | Dram1 | 7392 | 0.077 | 0.1082 | No |
| 72 | B4galt1 | 7469 | 0.073 | 0.1060 | No |
| 73 | Irf1 | 7585 | 0.069 | 0.1017 | No |
| 74 | Ccnd1 | 7774 | 0.061 | 0.0934 | No |
| 75 | Gfpt2 | 7891 | 0.056 | 0.0887 | No |
| 76 | Nfe2l2 | 7919 | 0.055 | 0.0886 | No |
| 77 | Olr1 | 8332 | 0.037 | 0.0680 | No |
| 78 | Zbtb10 | 8404 | 0.034 | 0.0651 | No |
| 79 | Il15ra | 8820 | 0.015 | 0.0438 | No |
| 80 | Ifih1 | 9007 | 0.009 | 0.0343 | No |
| 81 | Ifngr2 | 9173 | 0.002 | 0.0257 | No |
| 82 | Litaf | 9632 | -0.015 | 0.0021 | No |
| 83 | Plaur | 9698 | -0.017 | -0.0008 | No |
| 84 | Klf9 | 9706 | -0.018 | -0.0008 | No |
| 85 | Cdkn1a | 9757 | -0.020 | -0.0029 | No |
| 86 | Rigi | 9761 | -0.020 | -0.0026 | No |
| 87 | Slc2a6 | 9783 | -0.021 | -0.0031 | No |
| 88 | Nr4a2 | 9784 | -0.021 | -0.0026 | No |
| 89 | Klf4 | 9839 | -0.023 | -0.0049 | No |
| 90 | Nfkbie | 9909 | -0.026 | -0.0078 | No |
| 91 | Birc3 | 9990 | -0.030 | -0.0113 | No |
| 92 | Slc2a3 | 10108 | -0.034 | -0.0166 | No |
| 93 | Nfkbia | 10309 | -0.043 | -0.0260 | No |
| 94 | Cxcl5 | 10318 | -0.044 | -0.0253 | No |
| 95 | Tnfrsf9 | 10359 | -0.045 | -0.0263 | No |
| 96 | Ripk2 | 10384 | -0.046 | -0.0264 | No |
| 97 | Junb | 10401 | -0.047 | -0.0261 | No |
| 98 | Cebpd | 10450 | -0.049 | -0.0274 | No |
| 99 | Ier2 | 10748 | -0.060 | -0.0415 | No |
| 100 | Rnf19b | 11071 | -0.073 | -0.0565 | No |
| 101 | Ehd1 | 11086 | -0.073 | -0.0555 | No |
| 102 | Nr4a1 | 11318 | -0.083 | -0.0655 | No |
| 103 | Egr3 | 11520 | -0.090 | -0.0738 | No |
| 104 | Sat1 | 11774 | -0.100 | -0.0846 | No |
| 105 | Btg1 | 11874 | -0.105 | -0.0872 | No |
| 106 | Nfkb1 | 11979 | -0.109 | -0.0900 | No |
| 107 | Rcan1 | 12013 | -0.111 | -0.0890 | No |
| 108 | Il1a | 12028 | -0.111 | -0.0870 | No |
| 109 | Stat5a | 12093 | -0.114 | -0.0875 | No |
| 110 | Gpr183 | 12107 | -0.115 | -0.0854 | No |
| 111 | Gch1 | 12225 | -0.119 | -0.0886 | No |
| 112 | Rela | 12297 | -0.122 | -0.0893 | No |
| 113 | Pfkfb3 | 12503 | -0.132 | -0.0968 | No |
| 114 | Cd44 | 12511 | -0.133 | -0.0939 | No |
| 115 | Dnajb4 | 12627 | -0.138 | -0.0966 | No |
| 116 | Tgif1 | 12719 | -0.142 | -0.0979 | No |
| 117 | Sqstm1 | 12976 | -0.154 | -0.1075 | No |
| 118 | Cflar | 12990 | -0.155 | -0.1044 | No |
| 119 | Phlda1 | 13289 | -0.168 | -0.1159 | No |
| 120 | Mxd1 | 13354 | -0.170 | -0.1151 | No |
| 121 | Icam1 | 13653 | -0.185 | -0.1261 | No |
| 122 | Tnfaip8 | 13673 | -0.186 | -0.1226 | No |
| 123 | Pde4b | 13696 | -0.187 | -0.1192 | No |
| 124 | Kdm6b | 13749 | -0.189 | -0.1173 | No |
| 125 | Serpinb2 | 13751 | -0.190 | -0.1127 | No |
| 126 | Fosl1 | 13862 | -0.194 | -0.1137 | No |
| 127 | Tlr2 | 13927 | -0.198 | -0.1122 | No |
| 128 | Fjx1 | 13934 | -0.198 | -0.1077 | No |
| 129 | Tubb2a | 14010 | -0.202 | -0.1067 | No |
| 130 | Phlda2 | 14406 | -0.219 | -0.1220 | No |
| 131 | Il18 | 14456 | -0.221 | -0.1191 | No |
| 132 | Bcl6 | 14528 | -0.224 | -0.1174 | No |
| 133 | Tsc22d1 | 14788 | -0.238 | -0.1251 | No |
| 134 | Dusp4 | 14877 | -0.243 | -0.1237 | No |
| 135 | Ptger4 | 14900 | -0.245 | -0.1189 | No |
| 136 | Myc | 15146 | -0.258 | -0.1254 | No |
| 137 | Zfp36 | 15204 | -0.261 | -0.1220 | No |
| 138 | Panx1 | 15214 | -0.261 | -0.1161 | No |
| 139 | Gadd45b | 15284 | -0.265 | -0.1132 | No |
| 140 | Tnfsf9 | 15562 | -0.281 | -0.1208 | No |
| 141 | Fosl2 | 15568 | -0.282 | -0.1142 | No |
| 142 | Nfat5 | 15570 | -0.282 | -0.1074 | No |
| 143 | Sphk1 | 15707 | -0.289 | -0.1074 | No |
| 144 | Cxcl10 | 15733 | -0.290 | -0.1017 | No |
| 145 | Map3k8 | 15829 | -0.296 | -0.0994 | No |
| 146 | Tnfaip2 | 15945 | -0.303 | -0.0980 | No |
| 147 | Tnf | 16117 | -0.315 | -0.0992 | No |
| 148 | Marcks | 16206 | -0.320 | -0.0960 | No |
| 149 | Snn | 16358 | -0.330 | -0.0958 | No |
| 150 | Ier3 | 16477 | -0.339 | -0.0937 | No |
| 151 | Dusp5 | 16626 | -0.349 | -0.0929 | No |
| 152 | Ppp1r15a | 16684 | -0.353 | -0.0873 | No |
| 153 | Abca1 | 16782 | -0.361 | -0.0835 | No |
| 154 | B4galt5 | 16977 | -0.375 | -0.0845 | No |
| 155 | Cebpb | 17006 | -0.378 | -0.0767 | No |
| 156 | Tap1 | 17367 | -0.406 | -0.0856 | No |
| 157 | Ptpre | 17447 | -0.414 | -0.0796 | No |
| 158 | Ccl5 | 17492 | -0.416 | -0.0718 | No |
| 159 | Sod2 | 17786 | -0.449 | -0.0761 | No |
| 160 | Icosl | 17966 | -0.467 | -0.0741 | No |
| 161 | Gem | 18073 | -0.483 | -0.0678 | No |
| 162 | Spsb1 | 18141 | -0.493 | -0.0593 | No |
| 163 | Pnrc1 | 18216 | -0.504 | -0.0508 | No |
| 164 | Ccrl2 | 18217 | -0.504 | -0.0385 | No |
| 165 | Gadd45a | 18603 | -0.572 | -0.0447 | No |
| 166 | Clcf1 | 18708 | -0.598 | -0.0355 | No |
| 167 | Eif1 | 18754 | -0.609 | -0.0230 | No |
| 168 | Egr1 | 19071 | -0.744 | -0.0213 | No |
| 169 | Dusp2 | 19305 | -1.375 | 0.0001 | No |

