| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group4.MEP.mega_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.17453489 |
| Normalized Enrichment Score (NES) | 0.7463544 |
| Nominal p-value | 0.8275154 |
| FDR q-value | 0.96704215 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Vldlr | 206 | 0.715 | 0.0044 | Yes |
| 2 | Etf1 | 365 | 0.636 | 0.0096 | Yes |
| 3 | Hspa4 | 498 | 0.592 | 0.0152 | Yes |
| 4 | Xbp1 | 588 | 0.570 | 0.0227 | Yes |
| 5 | Nupr1 | 593 | 0.569 | 0.0345 | Yes |
| 6 | Hk2 | 678 | 0.550 | 0.0418 | Yes |
| 7 | P4ha1 | 893 | 0.512 | 0.0414 | Yes |
| 8 | Bhlhe40 | 964 | 0.500 | 0.0484 | Yes |
| 9 | Aurka | 972 | 0.498 | 0.0585 | Yes |
| 10 | Plk1 | 994 | 0.494 | 0.0679 | Yes |
| 11 | Ero1a | 1006 | 0.492 | 0.0777 | Yes |
| 12 | Hspa9 | 1053 | 0.485 | 0.0856 | Yes |
| 13 | Cyb5b | 1468 | 0.433 | 0.0731 | Yes |
| 14 | Abcf2 | 1564 | 0.422 | 0.0771 | Yes |
| 15 | Canx | 1565 | 0.422 | 0.0860 | Yes |
| 16 | Gga2 | 1581 | 0.421 | 0.0941 | Yes |
| 17 | Hspd1 | 1606 | 0.420 | 0.1018 | Yes |
| 18 | Stip1 | 1749 | 0.405 | 0.1029 | Yes |
| 19 | Cth | 1805 | 0.399 | 0.1085 | Yes |
| 20 | Asns | 2014 | 0.378 | 0.1056 | Yes |
| 21 | Bub1 | 2098 | 0.370 | 0.1091 | Yes |
| 22 | Ctsc | 2106 | 0.369 | 0.1166 | Yes |
| 23 | Igfbp5 | 2193 | 0.361 | 0.1197 | Yes |
| 24 | Tfrc | 2264 | 0.354 | 0.1236 | Yes |
| 25 | Uso1 | 2321 | 0.350 | 0.1280 | Yes |
| 26 | Ccnf | 2794 | 0.317 | 0.1101 | Yes |
| 27 | Hsp90b1 | 2834 | 0.313 | 0.1147 | Yes |
| 28 | Sord | 2929 | 0.307 | 0.1162 | Yes |
| 29 | Nufip1 | 3053 | 0.301 | 0.1162 | Yes |
| 30 | Atp2a2 | 3076 | 0.299 | 0.1214 | Yes |
| 31 | Immt | 3103 | 0.297 | 0.1263 | Yes |
| 32 | Nfkbib | 3134 | 0.296 | 0.1310 | Yes |
| 33 | Cct6a | 3135 | 0.295 | 0.1373 | Yes |
| 34 | Psmd14 | 3285 | 0.285 | 0.1355 | Yes |
| 35 | Sla | 3457 | 0.273 | 0.1324 | Yes |
| 36 | Ppia | 3539 | 0.269 | 0.1338 | Yes |
| 37 | Rpn1 | 3637 | 0.262 | 0.1343 | Yes |
| 38 | Hspa5 | 3676 | 0.260 | 0.1378 | Yes |
| 39 | Serpinh1 | 3703 | 0.258 | 0.1419 | Yes |
| 40 | Ldlr | 3842 | 0.250 | 0.1400 | Yes |
| 41 | Actr3 | 3854 | 0.249 | 0.1447 | Yes |
| 42 | Hmbs | 3891 | 0.246 | 0.1480 | Yes |
| 43 | Nfyc | 4038 | 0.241 | 0.1455 | Yes |
| 44 | Ufm1 | 4041 | 0.241 | 0.1505 | Yes |
| 45 | Fgl2 | 4048 | 0.241 | 0.1552 | Yes |
| 46 | Trib3 | 4204 | 0.231 | 0.1520 | Yes |
| 47 | Nampt | 4222 | 0.230 | 0.1560 | Yes |
| 48 | Hmgcr | 4357 | 0.221 | 0.1537 | Yes |
| 49 | Acly | 4534 | 0.213 | 0.1490 | Yes |
| 50 | Nup205 | 4554 | 0.212 | 0.1525 | Yes |
| 51 | Slc7a5 | 4571 | 0.212 | 0.1561 | Yes |
| 52 | Rpa1 | 4665 | 0.205 | 0.1556 | Yes |
| 53 | Gmps | 4714 | 0.202 | 0.1574 | Yes |
| 54 | Pgk1 | 4725 | 0.201 | 0.1611 | Yes |
| 55 | Map2k3 | 4812 | 0.196 | 0.1608 | Yes |
| 56 | Txnrd1 | 4896 | 0.192 | 0.1605 | Yes |
| 57 | Gpi1 | 4905 | 0.192 | 0.1642 | Yes |
| 58 | Mcm4 | 4954 | 0.189 | 0.1656 | Yes |
| 59 | Pitpnb | 4963 | 0.189 | 0.1692 | Yes |
| 60 | Psmc6 | 4973 | 0.188 | 0.1727 | Yes |
| 61 | Btg2 | 5069 | 0.184 | 0.1717 | Yes |
| 62 | Actr2 | 5089 | 0.183 | 0.1745 | Yes |
| 63 | Psat1 | 5300 | 0.175 | 0.1673 | No |
| 64 | Tm7sf2 | 5365 | 0.172 | 0.1676 | No |
| 65 | Plod2 | 5445 | 0.168 | 0.1670 | No |
| 66 | Cdc25a | 6321 | 0.127 | 0.1239 | No |
| 67 | Eef1e1 | 6334 | 0.126 | 0.1259 | No |
| 68 | Acsl3 | 6495 | 0.118 | 0.1201 | No |
| 69 | Gclc | 6497 | 0.118 | 0.1225 | No |
| 70 | Gtf2h1 | 6501 | 0.118 | 0.1248 | No |
| 71 | Nfil3 | 6504 | 0.118 | 0.1272 | No |
| 72 | Sdf2l1 | 6600 | 0.113 | 0.1247 | No |
| 73 | Ddx39a | 6719 | 0.107 | 0.1208 | No |
| 74 | Rit1 | 6740 | 0.106 | 0.1220 | No |
| 75 | Cyp51 | 6793 | 0.104 | 0.1214 | No |
| 76 | Mcm2 | 6820 | 0.103 | 0.1223 | No |
| 77 | Ube2d3 | 6896 | 0.099 | 0.1204 | No |
| 78 | Add3 | 6980 | 0.095 | 0.1181 | No |
| 79 | Tcea1 | 6985 | 0.095 | 0.1199 | No |
| 80 | Calr | 7079 | 0.090 | 0.1169 | No |
| 81 | Sec11a | 7419 | 0.076 | 0.1008 | No |
| 82 | Psph | 7436 | 0.075 | 0.1016 | No |
| 83 | Ssr1 | 7495 | 0.072 | 0.1000 | No |
| 84 | Gsk3b | 7525 | 0.071 | 0.1000 | No |
| 85 | Edem1 | 7658 | 0.066 | 0.0945 | No |
| 86 | Psmc4 | 7777 | 0.061 | 0.0896 | No |
| 87 | Pik3r3 | 7804 | 0.060 | 0.0895 | No |
| 88 | Sc5d | 7832 | 0.059 | 0.0894 | No |
| 89 | Skap2 | 7918 | 0.055 | 0.0861 | No |
| 90 | Ykt6 | 8036 | 0.050 | 0.0810 | No |
| 91 | Stard4 | 8097 | 0.048 | 0.0789 | No |
| 92 | Fads2 | 8261 | 0.041 | 0.0712 | No |
| 93 | Srd5a1 | 8441 | 0.032 | 0.0626 | No |
| 94 | Ddit4 | 8590 | 0.025 | 0.0553 | No |
| 95 | Ddit3 | 8600 | 0.024 | 0.0554 | No |
| 96 | Lta4h | 8677 | 0.020 | 0.0518 | No |
| 97 | Ccng1 | 8775 | 0.017 | 0.0471 | No |
| 98 | Acaca | 8823 | 0.015 | 0.0450 | No |
| 99 | Prdx1 | 8898 | 0.013 | 0.0414 | No |
| 100 | Slc37a4 | 9163 | 0.002 | 0.0276 | No |
| 101 | Fdxr | 9416 | -0.005 | 0.0146 | No |
| 102 | Psmd13 | 9450 | -0.007 | 0.0130 | No |
| 103 | Niban1 | 9517 | -0.010 | 0.0097 | No |
| 104 | Slc1a5 | 9748 | -0.019 | -0.0019 | No |
| 105 | Cdkn1a | 9757 | -0.020 | -0.0019 | No |
| 106 | Slc2a3 | 10108 | -0.034 | -0.0195 | No |
| 107 | Aldoa | 10113 | -0.034 | -0.0190 | No |
| 108 | Sqle | 10126 | -0.035 | -0.0189 | No |
| 109 | Pdk1 | 10264 | -0.041 | -0.0252 | No |
| 110 | Wars1 | 10332 | -0.044 | -0.0277 | No |
| 111 | Mthfd2l | 10499 | -0.051 | -0.0353 | No |
| 112 | Tbk1 | 10712 | -0.059 | -0.0452 | No |
| 113 | Elovl6 | 10731 | -0.060 | -0.0449 | No |
| 114 | Rrm2 | 10853 | -0.063 | -0.0498 | No |
| 115 | Gla | 10876 | -0.064 | -0.0496 | No |
| 116 | Cops5 | 10947 | -0.067 | -0.0519 | No |
| 117 | Sytl2 | 10968 | -0.068 | -0.0515 | No |
| 118 | Ak4 | 11111 | -0.074 | -0.0573 | No |
| 119 | Got1 | 11119 | -0.075 | -0.0561 | No |
| 120 | G6pdx | 11265 | -0.081 | -0.0620 | No |
| 121 | Elovl5 | 11310 | -0.083 | -0.0625 | No |
| 122 | Slc1a4 | 11351 | -0.084 | -0.0628 | No |
| 123 | Tubg1 | 11511 | -0.090 | -0.0693 | No |
| 124 | M6pr | 11566 | -0.091 | -0.0702 | No |
| 125 | Ebp | 11687 | -0.096 | -0.0744 | No |
| 126 | Rrp9 | 11804 | -0.102 | -0.0783 | No |
| 127 | Dhcr24 | 11878 | -0.105 | -0.0799 | No |
| 128 | Serp1 | 11990 | -0.110 | -0.0834 | No |
| 129 | Gbe1 | 12234 | -0.120 | -0.0936 | No |
| 130 | Tomm40 | 12332 | -0.124 | -0.0960 | No |
| 131 | Me1 | 12508 | -0.132 | -0.1024 | No |
| 132 | Bcat1 | 12679 | -0.140 | -0.1083 | No |
| 133 | Ppa1 | 12764 | -0.144 | -0.1096 | No |
| 134 | Pfkl | 12769 | -0.144 | -0.1068 | No |
| 135 | Sqstm1 | 12976 | -0.154 | -0.1143 | No |
| 136 | Mthfd2 | 13153 | -0.161 | -0.1201 | No |
| 137 | Hmgcs1 | 13223 | -0.164 | -0.1202 | No |
| 138 | Rab1a | 13226 | -0.164 | -0.1168 | No |
| 139 | Eno1b | 13310 | -0.169 | -0.1176 | No |
| 140 | Uchl5 | 13327 | -0.169 | -0.1148 | No |
| 141 | Hspe1 | 13360 | -0.171 | -0.1129 | No |
| 142 | Cd9 | 13823 | -0.193 | -0.1330 | No |
| 143 | Gsr | 13921 | -0.197 | -0.1339 | No |
| 144 | Ifrd1 | 14056 | -0.204 | -0.1366 | No |
| 145 | Ung | 14298 | -0.214 | -0.1447 | No |
| 146 | Psma4 | 14362 | -0.217 | -0.1434 | No |
| 147 | Idi1 | 14372 | -0.217 | -0.1392 | No |
| 148 | Dapp1 | 14604 | -0.228 | -0.1465 | No |
| 149 | Fads1 | 14777 | -0.238 | -0.1504 | No |
| 150 | Slc7a11 | 14894 | -0.244 | -0.1513 | No |
| 151 | Adipor2 | 14939 | -0.247 | -0.1484 | No |
| 152 | Lgmn | 14970 | -0.249 | -0.1447 | No |
| 153 | Pdap1 | 15034 | -0.253 | -0.1426 | No |
| 154 | Fkbp2 | 15316 | -0.267 | -0.1517 | No |
| 155 | Tpi1 | 15332 | -0.268 | -0.1468 | No |
| 156 | Psme3 | 15335 | -0.268 | -0.1412 | No |
| 157 | Psmc2 | 15460 | -0.276 | -0.1418 | No |
| 158 | Insig1 | 15496 | -0.278 | -0.1378 | No |
| 159 | Tmem97 | 15552 | -0.281 | -0.1347 | No |
| 160 | Shmt2 | 15635 | -0.286 | -0.1330 | No |
| 161 | Qdpr | 15864 | -0.299 | -0.1386 | No |
| 162 | Tuba4a | 15927 | -0.302 | -0.1354 | No |
| 163 | Polr3g | 15985 | -0.306 | -0.1319 | No |
| 164 | Slc6a6 | 16058 | -0.311 | -0.1291 | No |
| 165 | Itgb2 | 16391 | -0.332 | -0.1394 | No |
| 166 | Psma3 | 16399 | -0.332 | -0.1327 | No |
| 167 | Nmt1 | 16515 | -0.342 | -0.1315 | No |
| 168 | Psmb5 | 16586 | -0.347 | -0.1278 | No |
| 169 | Ppp1r15a | 16684 | -0.353 | -0.1254 | No |
| 170 | Egln3 | 16815 | -0.363 | -0.1245 | No |
| 171 | Pgm1 | 16995 | -0.377 | -0.1259 | No |
| 172 | Arpc5l | 17009 | -0.378 | -0.1186 | No |
| 173 | Tes | 17182 | -0.391 | -0.1193 | No |
| 174 | Rdh11 | 17187 | -0.392 | -0.1112 | No |
| 175 | Cacybp | 17344 | -0.403 | -0.1108 | No |
| 176 | Psmd12 | 17351 | -0.404 | -0.1026 | No |
| 177 | Ifi30 | 17409 | -0.410 | -0.0969 | No |
| 178 | Cfp | 17792 | -0.450 | -0.1073 | No |
| 179 | Psmg1 | 17881 | -0.458 | -0.1022 | No |
| 180 | Dhcr7 | 18087 | -0.486 | -0.1026 | No |
| 181 | Cxcr4 | 18109 | -0.489 | -0.0934 | No |
| 182 | Slc2a1 | 18124 | -0.491 | -0.0837 | No |
| 183 | Pnp | 18312 | -0.520 | -0.0825 | No |
| 184 | Ldha | 18390 | -0.532 | -0.0753 | No |
| 185 | Phgdh | 18486 | -0.548 | -0.0686 | No |
| 186 | Eif2s2 | 18487 | -0.548 | -0.0570 | No |
| 187 | Pno1 | 18656 | -0.585 | -0.0534 | No |
| 188 | Glrx | 18704 | -0.597 | -0.0432 | No |
| 189 | Idh1 | 18737 | -0.604 | -0.0321 | No |
| 190 | Atp6v1d | 18866 | -0.644 | -0.0251 | No |
| 191 | Dhfr | 18887 | -0.651 | -0.0124 | No |
| 192 | Coro1a | 19141 | -0.804 | -0.0086 | No |
| 193 | Mllt11 | 19151 | -0.814 | 0.0082 | No |

