| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group4.MEP.mega_Pheno.cls #Group2_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group4_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.24600887 |
| Normalized Enrichment Score (NES) | 0.8393113 |
| Nominal p-value | 0.61054766 |
| FDR q-value | 0.9035008 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Zw10 | 114 | 0.794 | 0.0121 | Yes |
| 2 | Srsf1 | 209 | 0.714 | 0.0234 | Yes |
| 3 | Ncapd2 | 456 | 0.603 | 0.0242 | Yes |
| 4 | Lmnb1 | 478 | 0.598 | 0.0367 | Yes |
| 5 | Ipo7 | 502 | 0.592 | 0.0489 | Yes |
| 6 | Xpo1 | 539 | 0.582 | 0.0602 | Yes |
| 7 | Bub1b | 891 | 0.512 | 0.0535 | Yes |
| 8 | Aurka | 972 | 0.498 | 0.0606 | Yes |
| 9 | Plk1 | 994 | 0.494 | 0.0707 | Yes |
| 10 | Slbp | 1055 | 0.485 | 0.0786 | Yes |
| 11 | Wdr90 | 1056 | 0.484 | 0.0896 | Yes |
| 12 | Dlgap5 | 1211 | 0.467 | 0.0921 | Yes |
| 13 | Kif2c | 1217 | 0.465 | 0.1024 | Yes |
| 14 | Brca1 | 1235 | 0.463 | 0.1121 | Yes |
| 15 | Rad21 | 1273 | 0.457 | 0.1205 | Yes |
| 16 | Cdkn2c | 1327 | 0.450 | 0.1280 | Yes |
| 17 | Nup107 | 1501 | 0.429 | 0.1287 | Yes |
| 18 | Hnrnpd | 1638 | 0.416 | 0.1310 | Yes |
| 19 | Ppp1r8 | 1720 | 0.408 | 0.1360 | Yes |
| 20 | Dnmt1 | 1752 | 0.405 | 0.1436 | Yes |
| 21 | Cdk1 | 1792 | 0.400 | 0.1506 | Yes |
| 22 | Depdc1a | 1824 | 0.397 | 0.1580 | Yes |
| 23 | Racgap1 | 1920 | 0.389 | 0.1619 | Yes |
| 24 | Hmmr | 1928 | 0.388 | 0.1703 | Yes |
| 25 | Cdc25b | 2006 | 0.379 | 0.1749 | Yes |
| 26 | Smc3 | 2092 | 0.370 | 0.1788 | Yes |
| 27 | Tfrc | 2264 | 0.354 | 0.1780 | Yes |
| 28 | Ccp110 | 2543 | 0.337 | 0.1710 | Yes |
| 29 | Espl1 | 2558 | 0.335 | 0.1779 | Yes |
| 30 | Cse1l | 2565 | 0.335 | 0.1852 | Yes |
| 31 | Cenpe | 2852 | 0.312 | 0.1773 | Yes |
| 32 | Ak2 | 2969 | 0.304 | 0.1782 | Yes |
| 33 | Nop56 | 3192 | 0.291 | 0.1732 | Yes |
| 34 | Ubr7 | 3199 | 0.291 | 0.1794 | Yes |
| 35 | Tacc3 | 3255 | 0.287 | 0.1831 | Yes |
| 36 | Top2a | 3260 | 0.287 | 0.1894 | Yes |
| 37 | Pcna | 3297 | 0.284 | 0.1940 | Yes |
| 38 | Donson | 3356 | 0.280 | 0.1973 | Yes |
| 39 | Msh2 | 3364 | 0.280 | 0.2033 | Yes |
| 40 | Spag5 | 3448 | 0.274 | 0.2052 | Yes |
| 41 | Ssrp1 | 3482 | 0.272 | 0.2096 | Yes |
| 42 | Mcm6 | 3486 | 0.271 | 0.2156 | Yes |
| 43 | Lsm8 | 3549 | 0.268 | 0.2185 | Yes |
| 44 | Cdca8 | 3646 | 0.262 | 0.2194 | Yes |
| 45 | Exosc8 | 3672 | 0.261 | 0.2240 | Yes |
| 46 | Dck | 3802 | 0.252 | 0.2230 | Yes |
| 47 | Nap1l1 | 3844 | 0.249 | 0.2265 | Yes |
| 48 | Xrcc6 | 4098 | 0.238 | 0.2186 | Yes |
| 49 | Kif4 | 4199 | 0.231 | 0.2186 | Yes |
| 50 | Lbr | 4267 | 0.228 | 0.2203 | Yes |
| 51 | Kif22 | 4278 | 0.227 | 0.2249 | Yes |
| 52 | Aurkb | 4310 | 0.225 | 0.2284 | Yes |
| 53 | Gins3 | 4352 | 0.222 | 0.2313 | Yes |
| 54 | Atad2 | 4360 | 0.221 | 0.2360 | Yes |
| 55 | Ilf3 | 4463 | 0.216 | 0.2355 | Yes |
| 56 | Nup205 | 4554 | 0.212 | 0.2356 | Yes |
| 57 | Rpa1 | 4665 | 0.205 | 0.2345 | Yes |
| 58 | Prps1 | 4810 | 0.196 | 0.2315 | Yes |
| 59 | Syncrip | 4832 | 0.195 | 0.2348 | Yes |
| 60 | Phf5a | 4861 | 0.194 | 0.2377 | Yes |
| 61 | Spc25 | 4913 | 0.192 | 0.2394 | Yes |
| 62 | Suv39h1 | 4920 | 0.191 | 0.2434 | Yes |
| 63 | Mcm4 | 4954 | 0.189 | 0.2460 | Yes |
| 64 | Smc1a | 5296 | 0.176 | 0.2322 | No |
| 65 | Tmpo | 5408 | 0.169 | 0.2302 | No |
| 66 | Rbbp7 | 5880 | 0.149 | 0.2089 | No |
| 67 | Melk | 5922 | 0.147 | 0.2101 | No |
| 68 | Brms1l | 5925 | 0.147 | 0.2134 | No |
| 69 | Mki67 | 5972 | 0.144 | 0.2142 | No |
| 70 | Prkdc | 5974 | 0.144 | 0.2174 | No |
| 71 | Chek2 | 6002 | 0.142 | 0.2193 | No |
| 72 | E2f8 | 6017 | 0.141 | 0.2217 | No |
| 73 | Pnn | 6176 | 0.133 | 0.2165 | No |
| 74 | Birc5 | 6280 | 0.129 | 0.2140 | No |
| 75 | Cdc25a | 6321 | 0.127 | 0.2148 | No |
| 76 | Pole | 6461 | 0.120 | 0.2103 | No |
| 77 | Kif18b | 6465 | 0.119 | 0.2128 | No |
| 78 | Chek1 | 6469 | 0.119 | 0.2154 | No |
| 79 | Plk4 | 6517 | 0.117 | 0.2156 | No |
| 80 | Bard1 | 6605 | 0.112 | 0.2136 | No |
| 81 | Mms22l | 6616 | 0.112 | 0.2156 | No |
| 82 | Ddx39a | 6719 | 0.107 | 0.2127 | No |
| 83 | Prim2 | 6746 | 0.106 | 0.2137 | No |
| 84 | Mcm2 | 6820 | 0.103 | 0.2122 | No |
| 85 | Trip13 | 6909 | 0.098 | 0.2099 | No |
| 86 | Cit | 6987 | 0.095 | 0.2080 | No |
| 87 | Tra2b | 6993 | 0.094 | 0.2099 | No |
| 88 | Psmc3ip | 7069 | 0.091 | 0.2080 | No |
| 89 | Nasp | 7097 | 0.090 | 0.2086 | No |
| 90 | Lyar | 7129 | 0.088 | 0.2090 | No |
| 91 | Nbn | 7242 | 0.083 | 0.2050 | No |
| 92 | Cbx5 | 7306 | 0.082 | 0.2036 | No |
| 93 | Cdkn1b | 7415 | 0.076 | 0.1997 | No |
| 94 | Ube2t | 7780 | 0.060 | 0.1820 | No |
| 95 | Diaph3 | 7838 | 0.059 | 0.1804 | No |
| 96 | Mre11a | 7848 | 0.058 | 0.1812 | No |
| 97 | Pds5b | 8154 | 0.045 | 0.1663 | No |
| 98 | Tbrg4 | 8314 | 0.038 | 0.1588 | No |
| 99 | Timeless | 8432 | 0.032 | 0.1534 | No |
| 100 | Wee1 | 8538 | 0.027 | 0.1486 | No |
| 101 | Mybl2 | 8615 | 0.023 | 0.1451 | No |
| 102 | Paics | 8691 | 0.020 | 0.1416 | No |
| 103 | Anp32e | 8720 | 0.019 | 0.1406 | No |
| 104 | Ccnb2 | 8729 | 0.019 | 0.1406 | No |
| 105 | Shmt1 | 8788 | 0.016 | 0.1380 | No |
| 106 | Tubb5 | 8864 | 0.014 | 0.1344 | No |
| 107 | Pan2 | 8884 | 0.014 | 0.1337 | No |
| 108 | Cenpm | 8915 | 0.013 | 0.1324 | No |
| 109 | Pold3 | 8970 | 0.010 | 0.1298 | No |
| 110 | Ccne1 | 8995 | 0.009 | 0.1287 | No |
| 111 | Orc2 | 9130 | 0.004 | 0.1218 | No |
| 112 | Tcf19 | 9187 | 0.001 | 0.1189 | No |
| 113 | Mcm3 | 9355 | -0.002 | 0.1102 | No |
| 114 | Luc7l3 | 9574 | -0.012 | 0.0991 | No |
| 115 | Cdkn1a | 9757 | -0.020 | 0.0900 | No |
| 116 | Smc4 | 9774 | -0.020 | 0.0896 | No |
| 117 | Cdkn2a | 9948 | -0.028 | 0.0812 | No |
| 118 | Cdc20 | 10115 | -0.034 | 0.0733 | No |
| 119 | Pa2g4 | 10205 | -0.039 | 0.0696 | No |
| 120 | Hus1 | 10208 | -0.039 | 0.0703 | No |
| 121 | Nup153 | 10214 | -0.039 | 0.0710 | No |
| 122 | Ube2s | 10403 | -0.047 | 0.0622 | No |
| 123 | Ezh2 | 10482 | -0.050 | 0.0592 | No |
| 124 | Mlh1 | 10628 | -0.056 | 0.0529 | No |
| 125 | Lig1 | 10635 | -0.056 | 0.0539 | No |
| 126 | Mcm5 | 10802 | -0.061 | 0.0466 | No |
| 127 | Rrm2 | 10853 | -0.063 | 0.0454 | No |
| 128 | Brca2 | 10909 | -0.066 | 0.0440 | No |
| 129 | Nudt21 | 11054 | -0.072 | 0.0381 | No |
| 130 | Asf1b | 11072 | -0.073 | 0.0389 | No |
| 131 | Jpt1 | 11075 | -0.073 | 0.0404 | No |
| 132 | Stmn1 | 11077 | -0.073 | 0.0420 | No |
| 133 | Rad51c | 11144 | -0.076 | 0.0403 | No |
| 134 | Stag1 | 11183 | -0.077 | 0.0401 | No |
| 135 | Cks1b | 11202 | -0.078 | 0.0409 | No |
| 136 | Eed | 11379 | -0.085 | 0.0336 | No |
| 137 | Tubg1 | 11511 | -0.090 | 0.0288 | No |
| 138 | Dut | 11553 | -0.090 | 0.0287 | No |
| 139 | Rad50 | 11590 | -0.092 | 0.0289 | No |
| 140 | Eif2s1 | 11592 | -0.092 | 0.0310 | No |
| 141 | Hmgb2 | 11895 | -0.106 | 0.0176 | No |
| 142 | Hmgb3 | 11902 | -0.106 | 0.0197 | No |
| 143 | Cks2 | 11980 | -0.109 | 0.0181 | No |
| 144 | Ran | 12264 | -0.121 | 0.0061 | No |
| 145 | Rad1 | 12352 | -0.125 | 0.0043 | No |
| 146 | Srsf2 | 12437 | -0.128 | 0.0029 | No |
| 147 | Rfc1 | 12493 | -0.132 | 0.0030 | No |
| 148 | Psip1 | 12507 | -0.132 | 0.0053 | No |
| 149 | Pold1 | 12671 | -0.139 | -0.0001 | No |
| 150 | Nolc1 | 12691 | -0.140 | 0.0021 | No |
| 151 | Tipin | 12783 | -0.145 | 0.0007 | No |
| 152 | Usp1 | 12800 | -0.146 | 0.0031 | No |
| 153 | Gspt1 | 12855 | -0.148 | 0.0037 | No |
| 154 | Mthfd2 | 13153 | -0.161 | -0.0082 | No |
| 155 | Rpa2 | 13154 | -0.161 | -0.0045 | No |
| 156 | Mcm7 | 13371 | -0.171 | -0.0120 | No |
| 157 | Ctcf | 13426 | -0.174 | -0.0108 | No |
| 158 | Trp53 | 13548 | -0.179 | -0.0131 | No |
| 159 | Mxd3 | 13687 | -0.186 | -0.0161 | No |
| 160 | Orc6 | 13793 | -0.191 | -0.0172 | No |
| 161 | Pms2 | 13846 | -0.194 | -0.0156 | No |
| 162 | Hells | 13853 | -0.194 | -0.0115 | No |
| 163 | Gins4 | 13963 | -0.199 | -0.0126 | No |
| 164 | Ung | 14298 | -0.214 | -0.0253 | No |
| 165 | H2az1 | 14508 | -0.223 | -0.0311 | No |
| 166 | Pttg1 | 14537 | -0.225 | -0.0275 | No |
| 167 | Asf1a | 14635 | -0.230 | -0.0273 | No |
| 168 | Dek | 14698 | -0.233 | -0.0253 | No |
| 169 | Cnot9 | 14873 | -0.243 | -0.0289 | No |
| 170 | Snrpb | 15011 | -0.251 | -0.0303 | No |
| 171 | Hmga1b | 15030 | -0.253 | -0.0255 | No |
| 172 | Myc | 15146 | -0.258 | -0.0257 | No |
| 173 | Mad2l1 | 15148 | -0.258 | -0.0199 | No |
| 174 | Cdk4 | 15202 | -0.261 | -0.0167 | No |
| 175 | Smc6 | 15220 | -0.262 | -0.0117 | No |
| 176 | Spc24 | 15230 | -0.262 | -0.0062 | No |
| 177 | Cdkn3 | 15261 | -0.264 | -0.0018 | No |
| 178 | Ranbp1 | 15361 | -0.270 | -0.0008 | No |
| 179 | Dclre1b | 15501 | -0.278 | -0.0018 | No |
| 180 | Nme1 | 15813 | -0.295 | -0.0113 | No |
| 181 | H2ax | 15892 | -0.301 | -0.0086 | No |
| 182 | Gins1 | 15967 | -0.305 | -0.0056 | No |
| 183 | Tk1 | 16124 | -0.316 | -0.0065 | No |
| 184 | Ppm1d | 16169 | -0.318 | -0.0016 | No |
| 185 | Rpa3 | 16276 | -0.325 | 0.0002 | No |
| 186 | Ing3 | 16417 | -0.334 | 0.0005 | No |
| 187 | Rad51ap1 | 16498 | -0.341 | 0.0040 | No |
| 188 | Pola2 | 16600 | -0.348 | 0.0066 | No |
| 189 | Dctpp1 | 16611 | -0.349 | 0.0140 | No |
| 190 | Prdx4 | 17252 | -0.397 | -0.0104 | No |
| 191 | Cdca3 | 17561 | -0.424 | -0.0169 | No |
| 192 | Rfc2 | 18134 | -0.492 | -0.0357 | No |
| 193 | Dscc1 | 18631 | -0.578 | -0.0485 | No |
| 194 | Rnaseh2a | 18686 | -0.593 | -0.0379 | No |
| 195 | Pop7 | 19000 | -0.703 | -0.0383 | No |
| 196 | Rfc3 | 19024 | -0.716 | -0.0233 | No |
| 197 | Pold2 | 19172 | -0.833 | -0.0120 | No |
| 198 | Pole4 | 19178 | -0.839 | 0.0068 | No |

