| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group3.MEP.mega_Pheno.cls #Group2_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.31123888 |
| Normalized Enrichment Score (NES) | -1.2670598 |
| Nominal p-value | 0.087576374 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.882 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Ninj1 | 235 | 0.631 | 0.0053 | No |
| 2 | Pts | 547 | 0.525 | 0.0037 | No |
| 3 | Ddc | 786 | 0.476 | 0.0046 | No |
| 4 | Apoe | 924 | 0.452 | 0.0100 | No |
| 5 | Csad | 991 | 0.440 | 0.0189 | No |
| 6 | Abcd2 | 1218 | 0.411 | 0.0185 | No |
| 7 | Atoh8 | 1645 | 0.370 | 0.0066 | No |
| 8 | Slc35d1 | 1687 | 0.366 | 0.0147 | No |
| 9 | Kynu | 1725 | 0.362 | 0.0228 | No |
| 10 | Gad1 | 2243 | 0.323 | 0.0048 | No |
| 11 | Aco2 | 2503 | 0.304 | -0.0002 | No |
| 12 | Mthfd1 | 2689 | 0.291 | -0.0017 | No |
| 13 | Pros1 | 2720 | 0.289 | 0.0047 | No |
| 14 | Lcat | 2818 | 0.282 | 0.0075 | No |
| 15 | Smox | 2889 | 0.277 | 0.0116 | No |
| 16 | Tgfb2 | 2892 | 0.276 | 0.0192 | No |
| 17 | Ech1 | 2987 | 0.271 | 0.0218 | No |
| 18 | Nfs1 | 3133 | 0.262 | 0.0216 | No |
| 19 | Cndp2 | 3399 | 0.245 | 0.0146 | No |
| 20 | Esr1 | 3556 | 0.236 | 0.0130 | No |
| 21 | Cyp27a1 | 3788 | 0.224 | 0.0072 | No |
| 22 | Igf1 | 3991 | 0.213 | 0.0026 | No |
| 23 | Cyp26a1 | 4373 | 0.196 | -0.0118 | No |
| 24 | Id2 | 4642 | 0.182 | -0.0208 | No |
| 25 | Pdlim5 | 4892 | 0.172 | -0.0290 | No |
| 26 | F10 | 5015 | 0.166 | -0.0307 | No |
| 27 | Npc1 | 5048 | 0.164 | -0.0278 | No |
| 28 | Casp6 | 5149 | 0.161 | -0.0286 | No |
| 29 | Pgd | 5213 | 0.158 | -0.0274 | No |
| 30 | Acox1 | 5326 | 0.154 | -0.0290 | No |
| 31 | Abcc2 | 5451 | 0.148 | -0.0313 | No |
| 32 | Psmb10 | 5534 | 0.145 | -0.0316 | No |
| 33 | Gabarapl1 | 5601 | 0.142 | -0.0311 | No |
| 34 | Ptges | 5759 | 0.135 | -0.0355 | No |
| 35 | Gsr | 5825 | 0.132 | -0.0352 | No |
| 36 | Ets2 | 5872 | 0.130 | -0.0340 | No |
| 37 | Abhd6 | 5915 | 0.128 | -0.0326 | No |
| 38 | Cfb | 6023 | 0.123 | -0.0347 | No |
| 39 | Hmox1 | 6069 | 0.121 | -0.0337 | No |
| 40 | Retsat | 6076 | 0.120 | -0.0307 | No |
| 41 | Ccl25 | 6304 | 0.111 | -0.0394 | No |
| 42 | Ppard | 6488 | 0.104 | -0.0461 | No |
| 43 | Cdo1 | 6512 | 0.103 | -0.0444 | No |
| 44 | Lpin2 | 6686 | 0.096 | -0.0508 | No |
| 45 | Entpd5 | 7086 | 0.080 | -0.0694 | No |
| 46 | Rap1gap | 7382 | 0.069 | -0.0829 | No |
| 47 | Hgfac | 7450 | 0.067 | -0.0845 | No |
| 48 | Sertad1 | 7680 | 0.058 | -0.0948 | No |
| 49 | Lonp1 | 7710 | 0.057 | -0.0948 | No |
| 50 | Angptl3 | 7877 | 0.051 | -0.1020 | No |
| 51 | Ephx1 | 7918 | 0.049 | -0.1027 | No |
| 52 | Elovl5 | 7964 | 0.047 | -0.1037 | No |
| 53 | Aldh9a1 | 8058 | 0.043 | -0.1074 | No |
| 54 | Papss2 | 8087 | 0.042 | -0.1077 | No |
| 55 | Marchf6 | 8103 | 0.042 | -0.1073 | No |
| 56 | Crp | 8390 | 0.031 | -0.1214 | No |
| 57 | Cyb5a | 8550 | 0.026 | -0.1290 | No |
| 58 | Ptgr1 | 8576 | 0.024 | -0.1296 | No |
| 59 | Man1a | 8692 | 0.020 | -0.1350 | No |
| 60 | Fbp1 | 8732 | 0.019 | -0.1366 | No |
| 61 | Gart | 8818 | 0.015 | -0.1406 | No |
| 62 | Cd36 | 9162 | 0.003 | -0.1584 | No |
| 63 | Gss | 9352 | -0.002 | -0.1682 | No |
| 64 | Mpp2 | 9690 | -0.014 | -0.1854 | No |
| 65 | Slc1a5 | 9694 | -0.014 | -0.1852 | No |
| 66 | Acox3 | 9795 | -0.017 | -0.1899 | No |
| 67 | Slc6a6 | 9859 | -0.020 | -0.1927 | No |
| 68 | Gclc | 10186 | -0.032 | -0.2088 | No |
| 69 | Cda | 10253 | -0.035 | -0.2113 | No |
| 70 | Ptges3-ps | 10263 | -0.035 | -0.2108 | No |
| 71 | Pink1 | 10306 | -0.037 | -0.2119 | No |
| 72 | Comt | 10456 | -0.043 | -0.2185 | No |
| 73 | Dhrs7 | 10508 | -0.046 | -0.2199 | No |
| 74 | Hacl1 | 10669 | -0.051 | -0.2268 | No |
| 75 | Crot | 10893 | -0.060 | -0.2368 | No |
| 76 | Ttpa | 11036 | -0.065 | -0.2424 | No |
| 77 | Pmm1 | 11064 | -0.067 | -0.2419 | No |
| 78 | Pgrmc1 | 11152 | -0.070 | -0.2445 | No |
| 79 | Tyr | 11252 | -0.073 | -0.2476 | No |
| 80 | Alas1 | 11328 | -0.077 | -0.2494 | No |
| 81 | Nmt1 | 11425 | -0.080 | -0.2522 | No |
| 82 | Atp2a2 | 11489 | -0.082 | -0.2532 | No |
| 83 | Spint2 | 11529 | -0.084 | -0.2529 | No |
| 84 | Asl | 11588 | -0.086 | -0.2535 | No |
| 85 | Acp2 | 11878 | -0.099 | -0.2659 | No |
| 86 | Upp1 | 11932 | -0.101 | -0.2658 | No |
| 87 | Blvrb | 12180 | -0.112 | -0.2756 | No |
| 88 | Arg1 | 12242 | -0.114 | -0.2756 | No |
| 89 | Dhrs1 | 12298 | -0.116 | -0.2753 | No |
| 90 | Enpep | 12473 | -0.124 | -0.2809 | No |
| 91 | Slc46a3 | 12548 | -0.127 | -0.2812 | No |
| 92 | Xdh | 12567 | -0.128 | -0.2786 | No |
| 93 | Fah | 12824 | -0.139 | -0.2881 | No |
| 94 | Il1r1 | 13052 | -0.150 | -0.2957 | No |
| 95 | Hsd11b1 | 13053 | -0.150 | -0.2916 | No |
| 96 | Hnf4a | 13098 | -0.152 | -0.2896 | No |
| 97 | Cyfip2 | 13267 | -0.158 | -0.2940 | No |
| 98 | Mccc2 | 13369 | -0.163 | -0.2947 | No |
| 99 | Slc35b1 | 13420 | -0.164 | -0.2927 | No |
| 100 | Gnmt | 13448 | -0.165 | -0.2895 | No |
| 101 | Tnfrsf1a | 13458 | -0.166 | -0.2854 | No |
| 102 | Adh5 | 13628 | -0.174 | -0.2894 | No |
| 103 | Fbln1 | 13647 | -0.175 | -0.2854 | No |
| 104 | Aldh2 | 13915 | -0.187 | -0.2941 | No |
| 105 | Etfdh | 14058 | -0.194 | -0.2961 | No |
| 106 | Tmbim6 | 14177 | -0.200 | -0.2967 | No |
| 107 | Car2 | 14241 | -0.203 | -0.2944 | No |
| 108 | Fas | 14366 | -0.209 | -0.2950 | No |
| 109 | Cyp2j6 | 14465 | -0.214 | -0.2941 | No |
| 110 | Gch1 | 14730 | -0.227 | -0.3016 | No |
| 111 | Tmem176b | 14784 | -0.230 | -0.2979 | No |
| 112 | Cat | 15040 | -0.244 | -0.3044 | Yes |
| 113 | Shmt2 | 15165 | -0.251 | -0.3039 | Yes |
| 114 | Bcat1 | 15172 | -0.251 | -0.2972 | Yes |
| 115 | Ddah2 | 15239 | -0.256 | -0.2935 | Yes |
| 116 | Arg2 | 15500 | -0.270 | -0.2996 | Yes |
| 117 | Gsto1 | 15545 | -0.271 | -0.2943 | Yes |
| 118 | Pycr1 | 15585 | -0.273 | -0.2888 | Yes |
| 119 | Jup | 15599 | -0.274 | -0.2818 | Yes |
| 120 | Gstt2 | 15761 | -0.283 | -0.2823 | Yes |
| 121 | Acp1 | 15776 | -0.285 | -0.2751 | Yes |
| 122 | Slc12a4 | 15795 | -0.286 | -0.2681 | Yes |
| 123 | Arpp19 | 15808 | -0.287 | -0.2607 | Yes |
| 124 | Pdk4 | 15825 | -0.288 | -0.2535 | Yes |
| 125 | Gcnt2 | 16616 | -0.342 | -0.2852 | Yes |
| 126 | Ugdh | 16877 | -0.361 | -0.2887 | Yes |
| 127 | Por | 17037 | -0.376 | -0.2865 | Yes |
| 128 | Ssr3 | 17077 | -0.379 | -0.2780 | Yes |
| 129 | Plg | 17660 | -0.428 | -0.2964 | Yes |
| 130 | Epha2 | 17690 | -0.431 | -0.2859 | Yes |
| 131 | Hes6 | 17706 | -0.433 | -0.2746 | Yes |
| 132 | Aqp9 | 17736 | -0.436 | -0.2640 | Yes |
| 133 | Nqo1 | 17752 | -0.437 | -0.2526 | Yes |
| 134 | Igfbp4 | 17972 | -0.461 | -0.2512 | Yes |
| 135 | Tmem97 | 18005 | -0.467 | -0.2398 | Yes |
| 136 | Idh1 | 18028 | -0.470 | -0.2279 | Yes |
| 137 | Ddt | 18244 | -0.503 | -0.2251 | Yes |
| 138 | Abcc3 | 18320 | -0.518 | -0.2145 | Yes |
| 139 | Sar1b | 18411 | -0.535 | -0.2043 | Yes |
| 140 | Tpst1 | 18437 | -0.541 | -0.1905 | Yes |
| 141 | Cbr1 | 18444 | -0.542 | -0.1758 | Yes |
| 142 | Tkfc | 18597 | -0.575 | -0.1677 | Yes |
| 143 | Dcxr | 18664 | -0.588 | -0.1547 | Yes |
| 144 | Bphl | 18674 | -0.590 | -0.1387 | Yes |
| 145 | Ap4b1 | 18702 | -0.596 | -0.1235 | Yes |
| 146 | Irf8 | 19016 | -0.716 | -0.1199 | Yes |
| 147 | Ndrg2 | 19030 | -0.729 | -0.1002 | Yes |
| 148 | Maoa | 19096 | -0.774 | -0.0821 | Yes |
| 149 | Gstm4 | 19118 | -0.791 | -0.0611 | Yes |
| 150 | Dhps | 19133 | -0.804 | -0.0394 | Yes |
| 151 | Pcx | 19144 | -0.820 | -0.0171 | Yes |
| 152 | Pemt | 19232 | -0.916 | 0.0039 | Yes |

