| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group3.MEP.mega_Pheno.cls #Group2_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.21725266 |
| Normalized Enrichment Score (NES) | -1.0294324 |
| Nominal p-value | 0.3979798 |
| FDR q-value | 0.76786333 |
| FWER p-Value | 0.988 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Vldlr | 75 | 0.776 | 0.0147 | No |
| 2 | Serpinh1 | 160 | 0.686 | 0.0267 | No |
| 3 | Edem1 | 523 | 0.530 | 0.0204 | No |
| 4 | P4ha1 | 567 | 0.522 | 0.0307 | No |
| 5 | Sord | 729 | 0.487 | 0.0339 | No |
| 6 | Hspa9 | 858 | 0.463 | 0.0383 | No |
| 7 | Pgk1 | 1001 | 0.439 | 0.0414 | No |
| 8 | Ifi30 | 1069 | 0.429 | 0.0481 | No |
| 9 | Slc2a3 | 1169 | 0.416 | 0.0529 | No |
| 10 | Plod2 | 1228 | 0.410 | 0.0597 | No |
| 11 | Rit1 | 1284 | 0.404 | 0.0665 | No |
| 12 | Hspa4 | 1429 | 0.391 | 0.0683 | No |
| 13 | Hspd1 | 1511 | 0.384 | 0.0733 | No |
| 14 | Tfrc | 1649 | 0.369 | 0.0750 | No |
| 15 | Ctsc | 1955 | 0.345 | 0.0673 | No |
| 16 | Canx | 2094 | 0.333 | 0.0680 | No |
| 17 | Psmc4 | 2189 | 0.327 | 0.0709 | No |
| 18 | Aurka | 2385 | 0.312 | 0.0682 | No |
| 19 | Skap2 | 2475 | 0.306 | 0.0709 | No |
| 20 | Nampt | 2500 | 0.304 | 0.0769 | No |
| 21 | Stip1 | 2687 | 0.291 | 0.0741 | No |
| 22 | Slc7a11 | 2703 | 0.290 | 0.0803 | No |
| 23 | Pitpnb | 3037 | 0.268 | 0.0693 | No |
| 24 | Nupr1 | 3103 | 0.264 | 0.0722 | No |
| 25 | Aldoa | 3164 | 0.260 | 0.0753 | No |
| 26 | Fdxr | 3203 | 0.257 | 0.0794 | No |
| 27 | Tm7sf2 | 3275 | 0.253 | 0.0818 | No |
| 28 | Bhlhe40 | 3324 | 0.250 | 0.0853 | No |
| 29 | Uso1 | 3370 | 0.247 | 0.0888 | No |
| 30 | Sytl2 | 3450 | 0.242 | 0.0905 | No |
| 31 | Btg2 | 3485 | 0.241 | 0.0945 | No |
| 32 | Sla | 3487 | 0.241 | 0.1002 | No |
| 33 | Acsl3 | 3853 | 0.220 | 0.0863 | No |
| 34 | Ifrd1 | 3904 | 0.217 | 0.0889 | No |
| 35 | Plk1 | 3981 | 0.214 | 0.0900 | No |
| 36 | Hmbs | 4107 | 0.209 | 0.0885 | No |
| 37 | Gsk3b | 4359 | 0.196 | 0.0801 | No |
| 38 | Lta4h | 4590 | 0.184 | 0.0725 | No |
| 39 | Cdc25a | 4632 | 0.182 | 0.0747 | No |
| 40 | Ppia | 4958 | 0.168 | 0.0617 | No |
| 41 | Nfkbib | 5046 | 0.164 | 0.0611 | No |
| 42 | Txnrd1 | 5249 | 0.157 | 0.0543 | No |
| 43 | Cyb5b | 5373 | 0.151 | 0.0515 | No |
| 44 | Map2k3 | 5383 | 0.151 | 0.0546 | No |
| 45 | Hsp90b1 | 5404 | 0.150 | 0.0571 | No |
| 46 | Abcf2 | 5499 | 0.147 | 0.0557 | No |
| 47 | Fgl2 | 5716 | 0.137 | 0.0477 | No |
| 48 | Rpa1 | 5727 | 0.137 | 0.0505 | No |
| 49 | Gsr | 5825 | 0.132 | 0.0486 | No |
| 50 | Rab1a | 6021 | 0.123 | 0.0413 | No |
| 51 | Eno1b | 6034 | 0.123 | 0.0436 | No |
| 52 | Elovl6 | 6041 | 0.122 | 0.0463 | No |
| 53 | Gga2 | 6118 | 0.119 | 0.0451 | No |
| 54 | Cct6a | 6286 | 0.112 | 0.0391 | No |
| 55 | Gpi1 | 6499 | 0.103 | 0.0304 | No |
| 56 | Asns | 6693 | 0.096 | 0.0226 | No |
| 57 | Etf1 | 6931 | 0.087 | 0.0123 | No |
| 58 | Add3 | 6933 | 0.087 | 0.0143 | No |
| 59 | Tcea1 | 7056 | 0.081 | 0.0099 | No |
| 60 | Prdx1 | 7057 | 0.081 | 0.0118 | No |
| 61 | Gbe1 | 7063 | 0.081 | 0.0135 | No |
| 62 | Ssr1 | 7186 | 0.076 | 0.0090 | No |
| 63 | Lgmn | 7255 | 0.073 | 0.0072 | No |
| 64 | Hk2 | 7327 | 0.071 | 0.0051 | No |
| 65 | Mcm2 | 7373 | 0.069 | 0.0044 | No |
| 66 | Cd9 | 7550 | 0.062 | -0.0033 | No |
| 67 | Mthfd2l | 7695 | 0.058 | -0.0094 | No |
| 68 | Dapp1 | 7890 | 0.050 | -0.0184 | No |
| 69 | Nfyc | 7911 | 0.050 | -0.0182 | No |
| 70 | Elovl5 | 7964 | 0.047 | -0.0198 | No |
| 71 | Ube2d3 | 7987 | 0.046 | -0.0199 | No |
| 72 | Psmc6 | 8060 | 0.043 | -0.0226 | No |
| 73 | Ccnf | 8116 | 0.041 | -0.0245 | No |
| 74 | Actr3 | 8139 | 0.040 | -0.0247 | No |
| 75 | Got1 | 8147 | 0.040 | -0.0241 | No |
| 76 | Nfil3 | 8164 | 0.040 | -0.0240 | No |
| 77 | Gmps | 8174 | 0.039 | -0.0235 | No |
| 78 | Tbk1 | 8188 | 0.038 | -0.0232 | No |
| 79 | Slc37a4 | 8298 | 0.034 | -0.0281 | No |
| 80 | Nup205 | 8830 | 0.015 | -0.0556 | No |
| 81 | Rpn1 | 8833 | 0.015 | -0.0553 | No |
| 82 | Actr2 | 9127 | 0.004 | -0.0705 | No |
| 83 | Ero1a | 9150 | 0.003 | -0.0716 | No |
| 84 | Eef1e1 | 9345 | -0.002 | -0.0817 | No |
| 85 | Stard4 | 9497 | -0.007 | -0.0894 | No |
| 86 | Slc1a5 | 9694 | -0.014 | -0.0994 | No |
| 87 | Fads2 | 9697 | -0.014 | -0.0991 | No |
| 88 | Calr | 9719 | -0.015 | -0.0999 | No |
| 89 | Ufm1 | 9775 | -0.016 | -0.1024 | No |
| 90 | Ebp | 9791 | -0.017 | -0.1027 | No |
| 91 | Psmd14 | 9823 | -0.018 | -0.1039 | No |
| 92 | Pik3r3 | 9838 | -0.019 | -0.1042 | No |
| 93 | Slc6a6 | 9859 | -0.020 | -0.1048 | No |
| 94 | Psmc2 | 9972 | -0.025 | -0.1100 | No |
| 95 | Acaca | 10010 | -0.026 | -0.1114 | No |
| 96 | Gclc | 10186 | -0.032 | -0.1197 | No |
| 97 | Ccng1 | 10200 | -0.032 | -0.1196 | No |
| 98 | Pdk1 | 10277 | -0.036 | -0.1228 | No |
| 99 | Slc7a5 | 10587 | -0.048 | -0.1378 | No |
| 100 | Immt | 10611 | -0.049 | -0.1378 | No |
| 101 | Acly | 10661 | -0.051 | -0.1391 | No |
| 102 | Psmb5 | 10768 | -0.055 | -0.1434 | No |
| 103 | Xbp1 | 10804 | -0.056 | -0.1439 | No |
| 104 | Dhcr24 | 10809 | -0.056 | -0.1427 | No |
| 105 | Sec11a | 10930 | -0.061 | -0.1475 | No |
| 106 | Ddx39a | 10935 | -0.061 | -0.1463 | No |
| 107 | Wars1 | 11062 | -0.066 | -0.1513 | No |
| 108 | Cth | 11162 | -0.070 | -0.1548 | No |
| 109 | Qdpr | 11344 | -0.077 | -0.1624 | No |
| 110 | Nmt1 | 11425 | -0.080 | -0.1647 | No |
| 111 | Gtf2h1 | 11451 | -0.080 | -0.1641 | No |
| 112 | Atp2a2 | 11489 | -0.082 | -0.1640 | No |
| 113 | Dhcr7 | 11530 | -0.084 | -0.1641 | No |
| 114 | Cops5 | 11581 | -0.086 | -0.1647 | No |
| 115 | Idi1 | 11730 | -0.092 | -0.1702 | No |
| 116 | G6pdx | 11802 | -0.095 | -0.1716 | No |
| 117 | Hspa5 | 11927 | -0.101 | -0.1757 | No |
| 118 | Cfp | 12067 | -0.107 | -0.1804 | No |
| 119 | M6pr | 12070 | -0.107 | -0.1779 | No |
| 120 | Ddit3 | 12116 | -0.109 | -0.1777 | No |
| 121 | Psmg1 | 12151 | -0.111 | -0.1768 | No |
| 122 | Ppa1 | 12455 | -0.123 | -0.1897 | No |
| 123 | Atp6v1d | 12546 | -0.127 | -0.1914 | No |
| 124 | Psma4 | 12576 | -0.128 | -0.1898 | No |
| 125 | Hspe1 | 12585 | -0.129 | -0.1872 | No |
| 126 | Mllt11 | 12698 | -0.134 | -0.1898 | No |
| 127 | Nufip1 | 12798 | -0.138 | -0.1917 | No |
| 128 | Fkbp2 | 13287 | -0.159 | -0.2134 | Yes |
| 129 | Fads1 | 13301 | -0.160 | -0.2103 | Yes |
| 130 | Sc5d | 13412 | -0.164 | -0.2121 | Yes |
| 131 | Mcm4 | 13418 | -0.164 | -0.2084 | Yes |
| 132 | Sqstm1 | 13467 | -0.166 | -0.2070 | Yes |
| 133 | Niban1 | 13529 | -0.169 | -0.2061 | Yes |
| 134 | Serp1 | 13606 | -0.173 | -0.2059 | Yes |
| 135 | Igfbp5 | 13622 | -0.174 | -0.2026 | Yes |
| 136 | Bub1 | 13654 | -0.176 | -0.2000 | Yes |
| 137 | Egln3 | 13917 | -0.187 | -0.2092 | Yes |
| 138 | Tomm40 | 13934 | -0.188 | -0.2055 | Yes |
| 139 | Srd5a1 | 14050 | -0.193 | -0.2069 | Yes |
| 140 | Psma3 | 14103 | -0.196 | -0.2049 | Yes |
| 141 | Mthfd2 | 14128 | -0.197 | -0.2015 | Yes |
| 142 | Itgb2 | 14331 | -0.207 | -0.2071 | Yes |
| 143 | Rrm2 | 14486 | -0.216 | -0.2100 | Yes |
| 144 | Pgm1 | 14559 | -0.218 | -0.2085 | Yes |
| 145 | Pno1 | 14568 | -0.219 | -0.2037 | Yes |
| 146 | Cdkn1a | 14702 | -0.226 | -0.2053 | Yes |
| 147 | Tes | 14770 | -0.230 | -0.2033 | Yes |
| 148 | Uchl5 | 14789 | -0.231 | -0.1987 | Yes |
| 149 | Ppp1r15a | 14807 | -0.231 | -0.1940 | Yes |
| 150 | Sqle | 14971 | -0.241 | -0.1968 | Yes |
| 151 | Polr3g | 14984 | -0.241 | -0.1917 | Yes |
| 152 | Shmt2 | 15165 | -0.251 | -0.1951 | Yes |
| 153 | Bcat1 | 15172 | -0.251 | -0.1894 | Yes |
| 154 | Slc1a4 | 15440 | -0.266 | -0.1970 | Yes |
| 155 | Psph | 15469 | -0.268 | -0.1920 | Yes |
| 156 | Psat1 | 15649 | -0.277 | -0.1948 | Yes |
| 157 | Adipor2 | 15845 | -0.289 | -0.1981 | Yes |
| 158 | Sdf2l1 | 16062 | -0.306 | -0.2020 | Yes |
| 159 | Cyp51 | 16143 | -0.311 | -0.1988 | Yes |
| 160 | Coro1a | 16163 | -0.313 | -0.1923 | Yes |
| 161 | Rrp9 | 16417 | -0.329 | -0.1976 | Yes |
| 162 | Hmgcr | 16418 | -0.329 | -0.1898 | Yes |
| 163 | Psmd13 | 16423 | -0.330 | -0.1821 | Yes |
| 164 | Pdap1 | 16450 | -0.331 | -0.1755 | Yes |
| 165 | Tuba4a | 16475 | -0.333 | -0.1688 | Yes |
| 166 | Pfkl | 16486 | -0.334 | -0.1613 | Yes |
| 167 | Cacybp | 16523 | -0.336 | -0.1552 | Yes |
| 168 | Dhfr | 16589 | -0.340 | -0.1504 | Yes |
| 169 | Tpi1 | 16599 | -0.341 | -0.1427 | Yes |
| 170 | Ldlr | 16762 | -0.352 | -0.1428 | Yes |
| 171 | Cxcr4 | 16820 | -0.357 | -0.1372 | Yes |
| 172 | Glrx | 16903 | -0.363 | -0.1328 | Yes |
| 173 | Ddit4 | 16906 | -0.364 | -0.1242 | Yes |
| 174 | Psme3 | 16909 | -0.364 | -0.1156 | Yes |
| 175 | Insig1 | 16941 | -0.367 | -0.1084 | Yes |
| 176 | Me1 | 16951 | -0.367 | -0.1001 | Yes |
| 177 | Eif2s2 | 17159 | -0.386 | -0.1017 | Yes |
| 178 | Gla | 17224 | -0.392 | -0.0957 | Yes |
| 179 | Slc2a1 | 17741 | -0.436 | -0.1122 | Yes |
| 180 | Psmd12 | 17768 | -0.439 | -0.1031 | Yes |
| 181 | Tubg1 | 17964 | -0.460 | -0.1023 | Yes |
| 182 | Tmem97 | 18005 | -0.467 | -0.0932 | Yes |
| 183 | Idh1 | 18028 | -0.470 | -0.0831 | Yes |
| 184 | Ldha | 18254 | -0.504 | -0.0828 | Yes |
| 185 | Pnp | 18273 | -0.506 | -0.0716 | Yes |
| 186 | Ykt6 | 18351 | -0.524 | -0.0631 | Yes |
| 187 | Ung | 18442 | -0.542 | -0.0549 | Yes |
| 188 | Arpc5l | 18637 | -0.583 | -0.0510 | Yes |
| 189 | Trib3 | 18652 | -0.585 | -0.0378 | Yes |
| 190 | Rdh11 | 18856 | -0.636 | -0.0332 | Yes |
| 191 | Phgdh | 19099 | -0.776 | -0.0272 | Yes |
| 192 | Ak4 | 19105 | -0.782 | -0.0088 | Yes |
| 193 | Hmgcs1 | 19137 | -0.806 | 0.0089 | Yes |

