| Dataset | MEP.MEP.mega_Pheno.cls #Group2_versus_Group3.MEP.mega_Pheno.cls #Group2_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group2_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_ESTROGEN_RESPONSE_LATE |
| Enrichment Score (ES) | -0.29512215 |
| Normalized Enrichment Score (NES) | -1.2848597 |
| Nominal p-value | 0.061507937 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.87 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Dlg5 | 296 | 0.607 | 0.0019 | No |
| 2 | Sord | 729 | 0.487 | -0.0067 | No |
| 3 | Hmgcs2 | 896 | 0.455 | -0.0024 | No |
| 4 | Chpt1 | 985 | 0.441 | 0.0056 | No |
| 5 | Mest | 1082 | 0.426 | 0.0128 | No |
| 6 | Cyp26b1 | 1185 | 0.414 | 0.0193 | No |
| 7 | Slc24a3 | 1293 | 0.403 | 0.0252 | No |
| 8 | Mettl3 | 1629 | 0.372 | 0.0184 | No |
| 9 | Kcnk5 | 1685 | 0.366 | 0.0259 | No |
| 10 | Tnnc1 | 1808 | 0.355 | 0.0297 | No |
| 11 | Llgl2 | 1853 | 0.351 | 0.0374 | No |
| 12 | Chst8 | 1868 | 0.350 | 0.0467 | No |
| 13 | Fos | 2111 | 0.332 | 0.0436 | No |
| 14 | Unc13b | 2194 | 0.326 | 0.0486 | No |
| 15 | Jak2 | 2590 | 0.299 | 0.0365 | No |
| 16 | Aff1 | 2624 | 0.297 | 0.0433 | No |
| 17 | Pgr | 2679 | 0.292 | 0.0488 | No |
| 18 | Lsr | 2694 | 0.291 | 0.0564 | No |
| 19 | Rab31 | 2864 | 0.278 | 0.0555 | No |
| 20 | Pdzk1 | 3156 | 0.260 | 0.0477 | No |
| 21 | Gper1 | 3219 | 0.256 | 0.0518 | No |
| 22 | Prkar2b | 3223 | 0.256 | 0.0590 | No |
| 23 | Plac1 | 3520 | 0.239 | 0.0504 | No |
| 24 | Cox6c | 4079 | 0.210 | 0.0272 | No |
| 25 | Homer2 | 4151 | 0.207 | 0.0294 | No |
| 26 | Jak1 | 4177 | 0.206 | 0.0340 | No |
| 27 | Anxa9 | 4249 | 0.202 | 0.0361 | No |
| 28 | Il6st | 4406 | 0.194 | 0.0335 | No |
| 29 | Id2 | 4642 | 0.182 | 0.0264 | No |
| 30 | Sult2b1 | 4980 | 0.167 | 0.0136 | No |
| 31 | Prlr | 5310 | 0.154 | 0.0008 | No |
| 32 | Mapt | 5407 | 0.150 | 0.0001 | No |
| 33 | Btg3 | 5625 | 0.141 | -0.0072 | No |
| 34 | Ptges | 5759 | 0.135 | -0.0103 | No |
| 35 | Zfp36 | 5932 | 0.128 | -0.0156 | No |
| 36 | Batf | 6144 | 0.118 | -0.0233 | No |
| 37 | Kif20a | 6195 | 0.115 | -0.0226 | No |
| 38 | Idh2 | 6282 | 0.112 | -0.0239 | No |
| 39 | Cav1 | 6643 | 0.098 | -0.0399 | No |
| 40 | Pdcd4 | 6916 | 0.087 | -0.0516 | No |
| 41 | Add3 | 6933 | 0.087 | -0.0499 | No |
| 42 | Sgk1 | 6960 | 0.085 | -0.0489 | No |
| 43 | Hspa4l | 7040 | 0.082 | -0.0507 | No |
| 44 | Abca3 | 7080 | 0.081 | -0.0504 | No |
| 45 | Top2a | 7161 | 0.077 | -0.0524 | No |
| 46 | Ret | 7203 | 0.075 | -0.0523 | No |
| 47 | Farp1 | 7278 | 0.073 | -0.0541 | No |
| 48 | Plxnb1 | 7349 | 0.070 | -0.0558 | No |
| 49 | Dynlt3 | 7470 | 0.066 | -0.0602 | No |
| 50 | Cd9 | 7550 | 0.062 | -0.0625 | No |
| 51 | S100a9 | 7594 | 0.061 | -0.0630 | No |
| 52 | Large1 | 7768 | 0.055 | -0.0705 | No |
| 53 | Dnajc1 | 7838 | 0.053 | -0.0726 | No |
| 54 | Rabep1 | 7849 | 0.052 | -0.0716 | No |
| 55 | Plk4 | 7901 | 0.050 | -0.0729 | No |
| 56 | Elovl5 | 7964 | 0.047 | -0.0747 | No |
| 57 | Abhd2 | 8018 | 0.045 | -0.0762 | No |
| 58 | Papss2 | 8087 | 0.042 | -0.0786 | No |
| 59 | Bag1 | 8206 | 0.038 | -0.0837 | No |
| 60 | Bcl2 | 8238 | 0.036 | -0.0842 | No |
| 61 | Slc16a1 | 8241 | 0.036 | -0.0833 | No |
| 62 | Slc26a2 | 8277 | 0.035 | -0.0841 | No |
| 63 | Amfr | 8303 | 0.034 | -0.0845 | No |
| 64 | Impa2 | 8364 | 0.032 | -0.0867 | No |
| 65 | Aldh3a2 | 8536 | 0.026 | -0.0949 | No |
| 66 | Cdh1 | 8756 | 0.018 | -0.1058 | No |
| 67 | Slc29a1 | 8783 | 0.017 | -0.1066 | No |
| 68 | Siah2 | 8991 | 0.009 | -0.1172 | No |
| 69 | Mdk | 9054 | 0.007 | -0.1202 | No |
| 70 | Celsr2 | 9217 | 0.001 | -0.1287 | No |
| 71 | Ltf | 9236 | 0.000 | -0.1296 | No |
| 72 | Pkp3 | 9398 | -0.004 | -0.1379 | No |
| 73 | Il17rb | 9597 | -0.011 | -0.1479 | No |
| 74 | Olfm1 | 9799 | -0.017 | -0.1579 | No |
| 75 | Ckb | 9863 | -0.020 | -0.1606 | No |
| 76 | Snx10 | 9899 | -0.021 | -0.1619 | No |
| 77 | Aldh3b1 | 10399 | -0.041 | -0.1867 | No |
| 78 | Slc7a5 | 10587 | -0.048 | -0.1951 | No |
| 79 | Fkbp5 | 10629 | -0.050 | -0.1958 | No |
| 80 | Xbp1 | 10804 | -0.056 | -0.2033 | No |
| 81 | Isg20 | 11043 | -0.066 | -0.2139 | No |
| 82 | Myof | 11085 | -0.067 | -0.2141 | No |
| 83 | Itpk1 | 11215 | -0.072 | -0.2187 | No |
| 84 | Dhcr7 | 11530 | -0.084 | -0.2327 | No |
| 85 | Cd44 | 11765 | -0.094 | -0.2423 | No |
| 86 | Nrip1 | 11769 | -0.094 | -0.2397 | No |
| 87 | Tiam1 | 11791 | -0.095 | -0.2381 | No |
| 88 | Fkbp4 | 12014 | -0.105 | -0.2467 | No |
| 89 | Klf4 | 12023 | -0.105 | -0.2441 | No |
| 90 | Slc22a5 | 12050 | -0.106 | -0.2425 | No |
| 91 | Myb | 12125 | -0.109 | -0.2432 | No |
| 92 | Blvrb | 12180 | -0.112 | -0.2428 | No |
| 93 | Cish | 12613 | -0.130 | -0.2617 | No |
| 94 | Sfn | 12671 | -0.132 | -0.2609 | No |
| 95 | Ptpn6 | 12916 | -0.144 | -0.2695 | No |
| 96 | Rbbp8 | 13090 | -0.151 | -0.2742 | No |
| 97 | Slc2a8 | 13456 | -0.166 | -0.2885 | No |
| 98 | Mocs2 | 13457 | -0.166 | -0.2838 | No |
| 99 | Rapgefl1 | 13478 | -0.167 | -0.2801 | No |
| 100 | Gins2 | 13643 | -0.175 | -0.2836 | No |
| 101 | Hspb8 | 13655 | -0.176 | -0.2792 | No |
| 102 | Stil | 13788 | -0.180 | -0.2809 | No |
| 103 | Atp2b4 | 13836 | -0.183 | -0.2782 | No |
| 104 | Ptger3 | 14019 | -0.192 | -0.2822 | No |
| 105 | Car2 | 14241 | -0.203 | -0.2879 | No |
| 106 | Egr3 | 14293 | -0.205 | -0.2847 | No |
| 107 | Foxc1 | 14493 | -0.216 | -0.2890 | Yes |
| 108 | Plaat3 | 14576 | -0.219 | -0.2870 | Yes |
| 109 | Etfb | 14723 | -0.227 | -0.2881 | Yes |
| 110 | Rnaseh2a | 14806 | -0.231 | -0.2858 | Yes |
| 111 | Wfs1 | 14832 | -0.233 | -0.2804 | Yes |
| 112 | St14 | 14885 | -0.236 | -0.2764 | Yes |
| 113 | Opn3 | 14916 | -0.237 | -0.2712 | Yes |
| 114 | Rps6ka2 | 14954 | -0.240 | -0.2663 | Yes |
| 115 | Arl3 | 15248 | -0.256 | -0.2743 | Yes |
| 116 | Scnn1a | 15254 | -0.256 | -0.2672 | Yes |
| 117 | Tmprss3 | 15280 | -0.258 | -0.2611 | Yes |
| 118 | Gfus | 15415 | -0.265 | -0.2606 | Yes |
| 119 | Slc1a4 | 15440 | -0.266 | -0.2542 | Yes |
| 120 | Ncor2 | 15607 | -0.275 | -0.2551 | Yes |
| 121 | St6galnac2 | 15796 | -0.286 | -0.2567 | Yes |
| 122 | Fdft1 | 15826 | -0.288 | -0.2500 | Yes |
| 123 | Perp | 15966 | -0.299 | -0.2487 | Yes |
| 124 | Tjp3 | 16001 | -0.302 | -0.2418 | Yes |
| 125 | Car12 | 16124 | -0.310 | -0.2394 | Yes |
| 126 | Tfpi2 | 16193 | -0.314 | -0.2339 | Yes |
| 127 | Frk | 16326 | -0.324 | -0.2316 | Yes |
| 128 | Cdc6 | 16403 | -0.329 | -0.2262 | Yes |
| 129 | Tspan13 | 16419 | -0.329 | -0.2175 | Yes |
| 130 | Scarb1 | 16534 | -0.337 | -0.2139 | Yes |
| 131 | Tob1 | 16708 | -0.348 | -0.2130 | Yes |
| 132 | Ugdh | 16877 | -0.361 | -0.2114 | Yes |
| 133 | Fgfr3 | 17118 | -0.382 | -0.2130 | Yes |
| 134 | Gla | 17224 | -0.392 | -0.2073 | Yes |
| 135 | Ppif | 17479 | -0.412 | -0.2088 | Yes |
| 136 | Clic3 | 17480 | -0.412 | -0.1970 | Yes |
| 137 | Cdc20 | 17529 | -0.416 | -0.1877 | Yes |
| 138 | Flnb | 17933 | -0.456 | -0.1957 | Yes |
| 139 | Igfbp4 | 17972 | -0.461 | -0.1845 | Yes |
| 140 | Nab2 | 18089 | -0.479 | -0.1769 | Yes |
| 141 | Dnajc12 | 18145 | -0.488 | -0.1658 | Yes |
| 142 | Tpd52l1 | 18259 | -0.504 | -0.1573 | Yes |
| 143 | Ass1 | 18408 | -0.535 | -0.1497 | Yes |
| 144 | Dcxr | 18664 | -0.588 | -0.1462 | Yes |
| 145 | Nxt1 | 18712 | -0.602 | -0.1315 | Yes |
| 146 | Xrcc3 | 18767 | -0.613 | -0.1168 | Yes |
| 147 | Cacna2d2 | 18810 | -0.623 | -0.1012 | Yes |
| 148 | Gale | 18903 | -0.654 | -0.0873 | Yes |
| 149 | Tst | 18973 | -0.688 | -0.0712 | Yes |
| 150 | Fabp5 | 19176 | -0.839 | -0.0578 | Yes |
| 151 | Ccnd1 | 19270 | -1.031 | -0.0332 | Yes |
| 152 | Dusp2 | 19297 | -1.227 | 0.0005 | Yes |

