| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group4.MEP.mega_Pheno.cls #Group1_versus_Group4_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_E2F_TARGETS |
| Enrichment Score (ES) | 0.20679651 |
| Normalized Enrichment Score (NES) | 0.7845476 |
| Nominal p-value | 0.6510204 |
| FDR q-value | 0.98715526 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Xpo1 | 288 | 0.690 | 0.0007 | Yes |
| 2 | Zw10 | 321 | 0.670 | 0.0143 | Yes |
| 3 | Hnrnpd | 380 | 0.643 | 0.0260 | Yes |
| 4 | Cdc25b | 584 | 0.582 | 0.0287 | Yes |
| 5 | Ipo7 | 801 | 0.530 | 0.0295 | Yes |
| 6 | Slbp | 851 | 0.524 | 0.0389 | Yes |
| 7 | Cse1l | 869 | 0.521 | 0.0499 | Yes |
| 8 | Brca1 | 962 | 0.505 | 0.0566 | Yes |
| 9 | Wdr90 | 989 | 0.499 | 0.0666 | Yes |
| 10 | Mcm4 | 1100 | 0.483 | 0.0719 | Yes |
| 11 | Suv39h1 | 1129 | 0.480 | 0.0814 | Yes |
| 12 | Nup107 | 1179 | 0.473 | 0.0897 | Yes |
| 13 | Smc3 | 1218 | 0.465 | 0.0983 | Yes |
| 14 | Nop56 | 1412 | 0.439 | 0.0983 | Yes |
| 15 | Ccp110 | 1478 | 0.432 | 0.1047 | Yes |
| 16 | Chek1 | 1637 | 0.415 | 0.1059 | Yes |
| 17 | Srsf1 | 1638 | 0.414 | 0.1154 | Yes |
| 18 | Dnmt1 | 1701 | 0.404 | 0.1214 | Yes |
| 19 | Lmnb1 | 1716 | 0.403 | 0.1299 | Yes |
| 20 | Mcm6 | 1875 | 0.388 | 0.1304 | Yes |
| 21 | Timeless | 1888 | 0.386 | 0.1386 | Yes |
| 22 | Rad21 | 2177 | 0.363 | 0.1319 | Yes |
| 23 | Atad2 | 2203 | 0.361 | 0.1388 | Yes |
| 24 | Ppp1r8 | 2291 | 0.354 | 0.1423 | Yes |
| 25 | Pnn | 2482 | 0.338 | 0.1401 | Yes |
| 26 | E2f8 | 2559 | 0.334 | 0.1438 | Yes |
| 27 | Rpa1 | 2633 | 0.331 | 0.1475 | Yes |
| 28 | Pole | 2855 | 0.312 | 0.1431 | Yes |
| 29 | Donson | 2880 | 0.309 | 0.1489 | Yes |
| 30 | Nasp | 3068 | 0.299 | 0.1459 | Yes |
| 31 | Msh2 | 3136 | 0.294 | 0.1491 | Yes |
| 32 | Syncrip | 3333 | 0.279 | 0.1452 | Yes |
| 33 | Ncapd2 | 3335 | 0.279 | 0.1515 | Yes |
| 34 | Gins3 | 3541 | 0.269 | 0.1470 | Yes |
| 35 | Lbr | 3586 | 0.265 | 0.1507 | Yes |
| 36 | Nbn | 3599 | 0.264 | 0.1561 | Yes |
| 37 | Rpa2 | 3619 | 0.263 | 0.1611 | Yes |
| 38 | Mre11a | 3669 | 0.259 | 0.1645 | Yes |
| 39 | Dck | 3699 | 0.257 | 0.1688 | Yes |
| 40 | Brms1l | 3770 | 0.253 | 0.1710 | Yes |
| 41 | Cdca8 | 3781 | 0.253 | 0.1762 | Yes |
| 42 | Nap1l1 | 3935 | 0.243 | 0.1737 | Yes |
| 43 | Rbbp7 | 3979 | 0.240 | 0.1770 | Yes |
| 44 | Mcm3 | 3998 | 0.239 | 0.1815 | Yes |
| 45 | Xrcc6 | 4035 | 0.237 | 0.1850 | Yes |
| 46 | Mcm2 | 4189 | 0.231 | 0.1823 | Yes |
| 47 | Espl1 | 4256 | 0.228 | 0.1841 | Yes |
| 48 | Ddx39a | 4350 | 0.224 | 0.1843 | Yes |
| 49 | Ubr7 | 4456 | 0.218 | 0.1838 | Yes |
| 50 | Mybl2 | 4484 | 0.217 | 0.1873 | Yes |
| 51 | Prkdc | 4543 | 0.213 | 0.1892 | Yes |
| 52 | Pold3 | 4556 | 0.211 | 0.1934 | Yes |
| 53 | Phf5a | 4624 | 0.208 | 0.1946 | Yes |
| 54 | Mcm7 | 4790 | 0.200 | 0.1905 | Yes |
| 55 | Wee1 | 4878 | 0.196 | 0.1905 | Yes |
| 56 | Ilf3 | 5009 | 0.190 | 0.1880 | Yes |
| 57 | Ak2 | 5193 | 0.183 | 0.1826 | Yes |
| 58 | Cdk1 | 5277 | 0.178 | 0.1823 | Yes |
| 59 | Tacc3 | 5289 | 0.177 | 0.1858 | Yes |
| 60 | Prim2 | 5299 | 0.177 | 0.1893 | Yes |
| 61 | Ung | 5302 | 0.177 | 0.1933 | Yes |
| 62 | Anp32e | 5318 | 0.175 | 0.1965 | Yes |
| 63 | Srsf2 | 5469 | 0.168 | 0.1925 | Yes |
| 64 | Tcf19 | 5558 | 0.163 | 0.1916 | Yes |
| 65 | Kif2c | 5594 | 0.161 | 0.1935 | Yes |
| 66 | Pcna | 5679 | 0.156 | 0.1926 | Yes |
| 67 | Nup205 | 5701 | 0.155 | 0.1951 | Yes |
| 68 | Tra2b | 5774 | 0.151 | 0.1948 | Yes |
| 69 | Cbx5 | 5777 | 0.151 | 0.1981 | Yes |
| 70 | Exosc8 | 5793 | 0.150 | 0.2008 | Yes |
| 71 | Smc1a | 5805 | 0.149 | 0.2036 | Yes |
| 72 | Kif22 | 5810 | 0.149 | 0.2068 | Yes |
| 73 | Bub1b | 5917 | 0.144 | 0.2045 | No |
| 74 | Trip13 | 5976 | 0.141 | 0.2047 | No |
| 75 | Tbrg4 | 6298 | 0.126 | 0.1908 | No |
| 76 | Rfc1 | 6412 | 0.122 | 0.1877 | No |
| 77 | Brca2 | 6454 | 0.120 | 0.1883 | No |
| 78 | Spag5 | 6634 | 0.118 | 0.1816 | No |
| 79 | Rad1 | 6936 | 0.103 | 0.1682 | No |
| 80 | Plk1 | 6996 | 0.100 | 0.1674 | No |
| 81 | Ssrp1 | 7035 | 0.099 | 0.1677 | No |
| 82 | Pds5b | 7053 | 0.098 | 0.1690 | No |
| 83 | Tmpo | 7159 | 0.093 | 0.1657 | No |
| 84 | Racgap1 | 7249 | 0.089 | 0.1630 | No |
| 85 | Top2a | 7378 | 0.082 | 0.1582 | No |
| 86 | Nolc1 | 7386 | 0.082 | 0.1597 | No |
| 87 | Hells | 7391 | 0.082 | 0.1614 | No |
| 88 | Mcm5 | 7480 | 0.079 | 0.1586 | No |
| 89 | Cdc25a | 7525 | 0.076 | 0.1580 | No |
| 90 | Mlh1 | 7541 | 0.076 | 0.1590 | No |
| 91 | Tfrc | 7690 | 0.069 | 0.1528 | No |
| 92 | Cit | 7737 | 0.067 | 0.1519 | No |
| 93 | Dlgap5 | 7796 | 0.063 | 0.1503 | No |
| 94 | Aurka | 7994 | 0.054 | 0.1412 | No |
| 95 | Mxd3 | 8125 | 0.049 | 0.1355 | No |
| 96 | Cdkn2c | 8177 | 0.047 | 0.1339 | No |
| 97 | Ube2t | 8182 | 0.046 | 0.1348 | No |
| 98 | Aurkb | 8290 | 0.041 | 0.1301 | No |
| 99 | Ing3 | 8334 | 0.040 | 0.1288 | No |
| 100 | Cnot9 | 8463 | 0.035 | 0.1229 | No |
| 101 | Lig1 | 8570 | 0.031 | 0.1181 | No |
| 102 | Eed | 8604 | 0.029 | 0.1170 | No |
| 103 | Usp1 | 8625 | 0.028 | 0.1166 | No |
| 104 | Cdkn1a | 8757 | 0.023 | 0.1103 | No |
| 105 | Depdc1a | 8784 | 0.022 | 0.1094 | No |
| 106 | Hmmr | 8793 | 0.022 | 0.1095 | No |
| 107 | Stmn1 | 8845 | 0.020 | 0.1073 | No |
| 108 | Tipin | 8868 | 0.018 | 0.1065 | No |
| 109 | Orc6 | 8901 | 0.017 | 0.1053 | No |
| 110 | Shmt1 | 8906 | 0.017 | 0.1054 | No |
| 111 | Pan2 | 8943 | 0.015 | 0.1039 | No |
| 112 | Nudt21 | 8972 | 0.014 | 0.1028 | No |
| 113 | Mms22l | 9065 | 0.010 | 0.0982 | No |
| 114 | Ccne1 | 9086 | 0.009 | 0.0973 | No |
| 115 | Spc25 | 9159 | 0.005 | 0.0937 | No |
| 116 | Kif4 | 9280 | 0.000 | 0.0874 | No |
| 117 | Pold1 | 9283 | 0.000 | 0.0873 | No |
| 118 | Rad51ap1 | 9504 | -0.004 | 0.0759 | No |
| 119 | Bard1 | 9550 | -0.005 | 0.0737 | No |
| 120 | Ezh2 | 9552 | -0.006 | 0.0737 | No |
| 121 | Luc7l3 | 9629 | -0.008 | 0.0700 | No |
| 122 | Smc6 | 9742 | -0.014 | 0.0644 | No |
| 123 | Orc2 | 9992 | -0.026 | 0.0520 | No |
| 124 | Tubb5 | 10122 | -0.033 | 0.0460 | No |
| 125 | Nup153 | 10238 | -0.038 | 0.0408 | No |
| 126 | Cdkn1b | 10549 | -0.051 | 0.0258 | No |
| 127 | Cdkn2a | 10583 | -0.052 | 0.0252 | No |
| 128 | Dut | 10594 | -0.053 | 0.0259 | No |
| 129 | Mki67 | 10722 | -0.059 | 0.0206 | No |
| 130 | Nme1 | 10990 | -0.071 | 0.0083 | No |
| 131 | Melk | 10991 | -0.071 | 0.0099 | No |
| 132 | Gins4 | 11491 | -0.094 | -0.0141 | No |
| 133 | Jpt1 | 11540 | -0.095 | -0.0144 | No |
| 134 | Gspt1 | 11571 | -0.097 | -0.0138 | No |
| 135 | Diaph3 | 11792 | -0.107 | -0.0229 | No |
| 136 | Ccnb2 | 11793 | -0.107 | -0.0204 | No |
| 137 | Psmc3ip | 11870 | -0.110 | -0.0219 | No |
| 138 | Stag1 | 12170 | -0.123 | -0.0347 | No |
| 139 | Pttg1 | 12234 | -0.125 | -0.0351 | No |
| 140 | Paics | 12309 | -0.128 | -0.0361 | No |
| 141 | Rad50 | 12343 | -0.130 | -0.0348 | No |
| 142 | Tubg1 | 12372 | -0.131 | -0.0333 | No |
| 143 | Cenpe | 12613 | -0.141 | -0.0426 | No |
| 144 | Spc24 | 12753 | -0.147 | -0.0466 | No |
| 145 | Plk4 | 12926 | -0.155 | -0.0520 | No |
| 146 | Ppm1d | 12961 | -0.156 | -0.0502 | No |
| 147 | Psip1 | 13100 | -0.162 | -0.0537 | No |
| 148 | Kif18b | 13128 | -0.163 | -0.0514 | No |
| 149 | Smc4 | 13201 | -0.167 | -0.0514 | No |
| 150 | Hus1 | 13254 | -0.169 | -0.0502 | No |
| 151 | Pola2 | 13293 | -0.171 | -0.0483 | No |
| 152 | Chek2 | 13390 | -0.173 | -0.0494 | No |
| 153 | Ctcf | 13624 | -0.184 | -0.0574 | No |
| 154 | Eif2s1 | 13701 | -0.187 | -0.0571 | No |
| 155 | Dek | 13779 | -0.191 | -0.0567 | No |
| 156 | Dclre1b | 13833 | -0.193 | -0.0551 | No |
| 157 | Gins1 | 13882 | -0.196 | -0.0531 | No |
| 158 | Dscc1 | 13965 | -0.200 | -0.0529 | No |
| 159 | Lsm8 | 14166 | -0.208 | -0.0586 | No |
| 160 | Asf1b | 14236 | -0.211 | -0.0574 | No |
| 161 | Rpa3 | 14284 | -0.213 | -0.0550 | No |
| 162 | Ranbp1 | 14339 | -0.216 | -0.0529 | No |
| 163 | Rad51c | 14438 | -0.222 | -0.0529 | No |
| 164 | Cenpm | 14508 | -0.225 | -0.0514 | No |
| 165 | Hmgb3 | 14552 | -0.228 | -0.0484 | No |
| 166 | Pa2g4 | 14569 | -0.229 | -0.0440 | No |
| 167 | Lyar | 14727 | -0.237 | -0.0468 | No |
| 168 | Trp53 | 15173 | -0.261 | -0.0641 | No |
| 169 | Cdkn3 | 15560 | -0.282 | -0.0779 | No |
| 170 | Cdca3 | 15645 | -0.288 | -0.0757 | No |
| 171 | Tk1 | 15826 | -0.298 | -0.0783 | No |
| 172 | Mthfd2 | 15846 | -0.299 | -0.0725 | No |
| 173 | Ube2s | 15878 | -0.301 | -0.0672 | No |
| 174 | Rfc2 | 16235 | -0.325 | -0.0784 | No |
| 175 | Pms2 | 16454 | -0.340 | -0.0821 | No |
| 176 | Cdk4 | 16469 | -0.341 | -0.0750 | No |
| 177 | Birc5 | 16545 | -0.347 | -0.0710 | No |
| 178 | Prdx4 | 16673 | -0.356 | -0.0696 | No |
| 179 | Cks1b | 16716 | -0.359 | -0.0635 | No |
| 180 | Hmgb2 | 16737 | -0.360 | -0.0564 | No |
| 181 | Dctpp1 | 16777 | -0.364 | -0.0501 | No |
| 182 | Cks2 | 17001 | -0.381 | -0.0531 | No |
| 183 | H2az1 | 17047 | -0.386 | -0.0466 | No |
| 184 | Rrm2 | 17109 | -0.392 | -0.0408 | No |
| 185 | Asf1a | 17247 | -0.404 | -0.0388 | No |
| 186 | H2ax | 17299 | -0.408 | -0.0321 | No |
| 187 | Snrpb | 17377 | -0.415 | -0.0266 | No |
| 188 | Rnaseh2a | 17404 | -0.417 | -0.0185 | No |
| 189 | Cdc20 | 17537 | -0.428 | -0.0156 | No |
| 190 | Pold2 | 17595 | -0.433 | -0.0087 | No |
| 191 | Mad2l1 | 17659 | -0.438 | -0.0020 | No |
| 192 | Pole4 | 17831 | -0.458 | -0.0005 | No |
| 193 | Ran | 17869 | -0.463 | 0.0082 | No |
| 194 | Pop7 | 18109 | -0.498 | 0.0070 | No |
| 195 | Myc | 18395 | -0.548 | 0.0046 | No |
| 196 | Prps1 | 18545 | -0.575 | 0.0100 | No |
| 197 | Rfc3 | 18768 | -0.633 | 0.0128 | No |
| 198 | Hmga1b | 18893 | -0.671 | 0.0217 | No |

