| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group3.MEP.mega_Pheno.cls #Group1_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | -0.27184987 |
| Normalized Enrichment Score (NES) | -1.1365174 |
| Nominal p-value | 0.27416173 |
| FDR q-value | 0.6488961 |
| FWER p-Value | 0.98 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Pts | 246 | 0.638 | 0.0048 | No |
| 2 | Smox | 606 | 0.518 | 0.0005 | No |
| 3 | Hmox1 | 613 | 0.517 | 0.0145 | No |
| 4 | Gad1 | 718 | 0.495 | 0.0228 | No |
| 5 | Ddc | 755 | 0.490 | 0.0346 | No |
| 6 | Cd36 | 956 | 0.459 | 0.0369 | No |
| 7 | Alas1 | 1164 | 0.429 | 0.0380 | No |
| 8 | Papss2 | 1392 | 0.403 | 0.0373 | No |
| 9 | Csad | 1625 | 0.378 | 0.0357 | No |
| 10 | Igf1 | 1785 | 0.363 | 0.0375 | No |
| 11 | Gsr | 2104 | 0.334 | 0.0301 | No |
| 12 | Pycr1 | 2183 | 0.330 | 0.0352 | No |
| 13 | Pros1 | 2405 | 0.314 | 0.0324 | No |
| 14 | Npc1 | 2417 | 0.312 | 0.0405 | No |
| 15 | Hsd11b1 | 2437 | 0.311 | 0.0481 | No |
| 16 | Hgfac | 2463 | 0.309 | 0.0554 | No |
| 17 | Fbln1 | 2596 | 0.302 | 0.0569 | No |
| 18 | Gart | 2839 | 0.285 | 0.0521 | No |
| 19 | Crot | 3005 | 0.274 | 0.0511 | No |
| 20 | Cfb | 3016 | 0.274 | 0.0582 | No |
| 21 | Id2 | 3249 | 0.259 | 0.0533 | No |
| 22 | Ppard | 3643 | 0.236 | 0.0393 | No |
| 23 | Dhps | 3683 | 0.234 | 0.0438 | No |
| 24 | Marchf6 | 3799 | 0.228 | 0.0441 | No |
| 25 | Cyb5a | 3801 | 0.228 | 0.0504 | No |
| 26 | Hnf4a | 3956 | 0.219 | 0.0484 | No |
| 27 | Fah | 4046 | 0.214 | 0.0497 | No |
| 28 | Entpd5 | 4050 | 0.214 | 0.0555 | No |
| 29 | Cyp26a1 | 4356 | 0.197 | 0.0450 | No |
| 30 | Abcc2 | 4363 | 0.197 | 0.0502 | No |
| 31 | F10 | 4437 | 0.193 | 0.0517 | No |
| 32 | Acp1 | 4466 | 0.192 | 0.0556 | No |
| 33 | Arg2 | 4512 | 0.189 | 0.0585 | No |
| 34 | Apoe | 4672 | 0.182 | 0.0552 | No |
| 35 | Ninj1 | 4681 | 0.182 | 0.0599 | No |
| 36 | Esr1 | 5227 | 0.159 | 0.0358 | No |
| 37 | Lcat | 5512 | 0.148 | 0.0251 | No |
| 38 | Angptl3 | 5549 | 0.146 | 0.0273 | No |
| 39 | Aldh9a1 | 5564 | 0.145 | 0.0306 | No |
| 40 | Epha2 | 5781 | 0.136 | 0.0231 | No |
| 41 | Acox1 | 5885 | 0.132 | 0.0214 | No |
| 42 | Tmem97 | 5896 | 0.131 | 0.0245 | No |
| 43 | Ccl25 | 5904 | 0.131 | 0.0277 | No |
| 44 | Mccc2 | 6046 | 0.126 | 0.0239 | No |
| 45 | Cyfip2 | 6110 | 0.123 | 0.0240 | No |
| 46 | Mthfd1 | 6111 | 0.123 | 0.0274 | No |
| 47 | Ech1 | 6297 | 0.118 | 0.0210 | No |
| 48 | Xdh | 6379 | 0.114 | 0.0200 | No |
| 49 | Pdlim5 | 6482 | 0.111 | 0.0177 | No |
| 50 | Ttpa | 6561 | 0.108 | 0.0166 | No |
| 51 | Aldh2 | 6820 | 0.098 | 0.0059 | No |
| 52 | Idh1 | 6873 | 0.095 | 0.0058 | No |
| 53 | Cda | 6910 | 0.094 | 0.0065 | No |
| 54 | Mpp2 | 6982 | 0.090 | 0.0053 | No |
| 55 | Gnmt | 7166 | 0.084 | -0.0019 | No |
| 56 | Elovl5 | 7225 | 0.082 | -0.0026 | No |
| 57 | Adh5 | 7469 | 0.072 | -0.0133 | No |
| 58 | Comt | 7594 | 0.067 | -0.0179 | No |
| 59 | Ets2 | 7644 | 0.065 | -0.0187 | No |
| 60 | Slc35d1 | 7793 | 0.060 | -0.0247 | No |
| 61 | Acp2 | 7986 | 0.053 | -0.0333 | No |
| 62 | Spint2 | 8032 | 0.051 | -0.0342 | No |
| 63 | Kynu | 8151 | 0.047 | -0.0391 | No |
| 64 | Abcd2 | 8290 | 0.041 | -0.0451 | No |
| 65 | Sertad1 | 8385 | 0.037 | -0.0490 | No |
| 66 | Gclc | 8582 | 0.030 | -0.0584 | No |
| 67 | Lonp1 | 8829 | 0.020 | -0.0707 | No |
| 68 | Aqp9 | 8995 | 0.014 | -0.0789 | No |
| 69 | Tgfb2 | 8999 | 0.014 | -0.0787 | No |
| 70 | Crp | 9054 | 0.012 | -0.0812 | No |
| 71 | Cndp2 | 9153 | 0.009 | -0.0861 | No |
| 72 | Ptges3-ps | 9342 | 0.002 | -0.0958 | No |
| 73 | Enpep | 9681 | -0.008 | -0.1132 | No |
| 74 | Pgd | 9704 | -0.009 | -0.1141 | No |
| 75 | Pgrmc1 | 9793 | -0.013 | -0.1184 | No |
| 76 | Sar1b | 9827 | -0.014 | -0.1197 | No |
| 77 | Bcat1 | 10083 | -0.025 | -0.1323 | No |
| 78 | Acox3 | 10126 | -0.026 | -0.1338 | No |
| 79 | Nfs1 | 10210 | -0.028 | -0.1373 | No |
| 80 | Slc1a5 | 10225 | -0.029 | -0.1373 | No |
| 81 | Aco2 | 10300 | -0.031 | -0.1403 | No |
| 82 | Ephx1 | 10396 | -0.034 | -0.1443 | No |
| 83 | Hacl1 | 10401 | -0.035 | -0.1435 | No |
| 84 | Tkfc | 10635 | -0.044 | -0.1545 | No |
| 85 | Lpin2 | 10755 | -0.048 | -0.1593 | No |
| 86 | Pmm1 | 10811 | -0.051 | -0.1608 | No |
| 87 | Slc6a6 | 11060 | -0.060 | -0.1721 | No |
| 88 | Atp2a2 | 11266 | -0.068 | -0.1809 | No |
| 89 | Pdk4 | 11426 | -0.075 | -0.1871 | No |
| 90 | Tnfrsf1a | 11571 | -0.081 | -0.1924 | No |
| 91 | Man1a | 12041 | -0.100 | -0.2141 | No |
| 92 | Blvrb | 12233 | -0.108 | -0.2211 | No |
| 93 | Cdo1 | 12445 | -0.117 | -0.2288 | No |
| 94 | Tmbim6 | 12675 | -0.127 | -0.2373 | No |
| 95 | Rap1gap | 12694 | -0.128 | -0.2347 | No |
| 96 | Nmt1 | 12876 | -0.136 | -0.2403 | No |
| 97 | Slc35b1 | 13042 | -0.144 | -0.2449 | No |
| 98 | Fas | 13045 | -0.145 | -0.2410 | No |
| 99 | Etfdh | 13128 | -0.148 | -0.2412 | No |
| 100 | Ssr3 | 13149 | -0.149 | -0.2381 | No |
| 101 | Gabarapl1 | 13183 | -0.151 | -0.2356 | No |
| 102 | Cyp2j6 | 13286 | -0.156 | -0.2366 | No |
| 103 | Tpst1 | 13531 | -0.168 | -0.2447 | No |
| 104 | Gcnt2 | 13775 | -0.180 | -0.2524 | No |
| 105 | Dhrs1 | 14052 | -0.194 | -0.2614 | No |
| 106 | Abcc3 | 14164 | -0.199 | -0.2617 | No |
| 107 | Il1r1 | 14261 | -0.204 | -0.2611 | No |
| 108 | Abhd6 | 14350 | -0.208 | -0.2599 | No |
| 109 | Ptgr1 | 14365 | -0.209 | -0.2548 | No |
| 110 | Ugdh | 14624 | -0.222 | -0.2621 | No |
| 111 | Por | 14811 | -0.233 | -0.2654 | Yes |
| 112 | Jup | 14821 | -0.234 | -0.2594 | Yes |
| 113 | Gstt2 | 14845 | -0.234 | -0.2541 | Yes |
| 114 | Retsat | 14882 | -0.236 | -0.2494 | Yes |
| 115 | Dhrs7 | 14930 | -0.239 | -0.2452 | Yes |
| 116 | Arpp19 | 15351 | -0.259 | -0.2600 | Yes |
| 117 | Gsto1 | 15389 | -0.262 | -0.2546 | Yes |
| 118 | Cyp27a1 | 15492 | -0.267 | -0.2526 | Yes |
| 119 | Igfbp4 | 15521 | -0.269 | -0.2466 | Yes |
| 120 | Slc46a3 | 15600 | -0.272 | -0.2431 | Yes |
| 121 | Car2 | 15815 | -0.285 | -0.2464 | Yes |
| 122 | Nqo1 | 15818 | -0.285 | -0.2386 | Yes |
| 123 | Casp6 | 15950 | -0.294 | -0.2372 | Yes |
| 124 | Dcxr | 16033 | -0.302 | -0.2331 | Yes |
| 125 | Gss | 16124 | -0.308 | -0.2293 | Yes |
| 126 | Asl | 16267 | -0.318 | -0.2279 | Yes |
| 127 | Ptges | 16386 | -0.326 | -0.2250 | Yes |
| 128 | Plg | 16482 | -0.334 | -0.2207 | Yes |
| 129 | Slc12a4 | 16495 | -0.335 | -0.2120 | Yes |
| 130 | Pink1 | 16683 | -0.352 | -0.2120 | Yes |
| 131 | Gch1 | 16869 | -0.367 | -0.2115 | Yes |
| 132 | Ap4b1 | 17051 | -0.383 | -0.2103 | Yes |
| 133 | Atoh8 | 17164 | -0.393 | -0.2053 | Yes |
| 134 | Psmb10 | 17195 | -0.397 | -0.1958 | Yes |
| 135 | Shmt2 | 17329 | -0.410 | -0.1914 | Yes |
| 136 | Tyr | 17350 | -0.412 | -0.1810 | Yes |
| 137 | Hes6 | 17489 | -0.427 | -0.1764 | Yes |
| 138 | Arg1 | 17657 | -0.441 | -0.1729 | Yes |
| 139 | Bphl | 17795 | -0.456 | -0.1674 | Yes |
| 140 | Gstm4 | 17907 | -0.469 | -0.1601 | Yes |
| 141 | Fbp1 | 18044 | -0.482 | -0.1539 | Yes |
| 142 | Tmem176b | 18208 | -0.506 | -0.1483 | Yes |
| 143 | Upp1 | 18481 | -0.557 | -0.1471 | Yes |
| 144 | Ddah2 | 18507 | -0.564 | -0.1327 | Yes |
| 145 | Pemt | 18582 | -0.583 | -0.1204 | Yes |
| 146 | Irf8 | 18653 | -0.596 | -0.1075 | Yes |
| 147 | Cat | 18801 | -0.637 | -0.0975 | Yes |
| 148 | Pcx | 18833 | -0.646 | -0.0812 | Yes |
| 149 | Ndrg2 | 18986 | -0.707 | -0.0696 | Yes |
| 150 | Cbr1 | 19242 | -0.952 | -0.0565 | Yes |
| 151 | Maoa | 19272 | -1.070 | -0.0283 | Yes |
| 152 | Ddt | 19275 | -1.084 | 0.0017 | Yes |

