| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group3.MEP.mega_Pheno.cls #Group1_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.26103136 |
| Normalized Enrichment Score (NES) | -1.1936736 |
| Nominal p-value | 0.23135756 |
| FDR q-value | 0.85839933 |
| FWER p-Value | 0.925 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Gga2 | 393 | 0.572 | -0.0061 | No |
| 2 | Plod2 | 826 | 0.480 | -0.0166 | No |
| 3 | Slc7a11 | 866 | 0.474 | -0.0067 | No |
| 4 | Edem1 | 969 | 0.457 | -0.0005 | No |
| 5 | Tm7sf2 | 1393 | 0.403 | -0.0125 | No |
| 6 | Canx | 1418 | 0.400 | -0.0036 | No |
| 7 | Pgk1 | 1519 | 0.388 | 0.0009 | No |
| 8 | Fdxr | 1522 | 0.388 | 0.0106 | No |
| 9 | Ifrd1 | 1599 | 0.381 | 0.0163 | No |
| 10 | Gsr | 2104 | 0.334 | -0.0017 | No |
| 11 | Hspa9 | 2225 | 0.327 | 0.0003 | No |
| 12 | P4ha1 | 2238 | 0.326 | 0.0079 | No |
| 13 | Hspa4 | 2279 | 0.323 | 0.0139 | No |
| 14 | Atp6v1d | 2356 | 0.316 | 0.0180 | No |
| 15 | Serpinh1 | 2544 | 0.306 | 0.0159 | No |
| 16 | Elovl6 | 2822 | 0.286 | 0.0086 | No |
| 17 | Gmps | 2915 | 0.280 | 0.0109 | No |
| 18 | Abcf2 | 2985 | 0.276 | 0.0142 | No |
| 19 | Rpa1 | 3011 | 0.274 | 0.0198 | No |
| 20 | Sla | 3042 | 0.272 | 0.0251 | No |
| 21 | Hsp90b1 | 3257 | 0.258 | 0.0204 | No |
| 22 | Vldlr | 3295 | 0.256 | 0.0249 | No |
| 23 | Skap2 | 3427 | 0.248 | 0.0243 | No |
| 24 | Rit1 | 3516 | 0.244 | 0.0259 | No |
| 25 | Me1 | 3812 | 0.228 | 0.0162 | No |
| 26 | Hspd1 | 3976 | 0.218 | 0.0132 | No |
| 27 | Psmb5 | 4372 | 0.196 | -0.0025 | No |
| 28 | Mcm2 | 4381 | 0.196 | 0.0020 | No |
| 29 | Pitpnb | 4531 | 0.188 | -0.0011 | No |
| 30 | Dhcr7 | 4724 | 0.180 | -0.0066 | No |
| 31 | Cd9 | 4732 | 0.180 | -0.0024 | No |
| 32 | Sqle | 4759 | 0.179 | 0.0008 | No |
| 33 | Nampt | 4769 | 0.178 | 0.0048 | No |
| 34 | Mthfd2l | 4930 | 0.171 | 0.0007 | No |
| 35 | Stip1 | 5032 | 0.167 | -0.0003 | No |
| 36 | Ddit4 | 5062 | 0.166 | 0.0023 | No |
| 37 | Lta4h | 5178 | 0.161 | 0.0004 | No |
| 38 | Hk2 | 5221 | 0.160 | 0.0022 | No |
| 39 | Dhcr24 | 5457 | 0.150 | -0.0063 | No |
| 40 | Fads1 | 5758 | 0.137 | -0.0186 | No |
| 41 | Aldoa | 5809 | 0.135 | -0.0178 | No |
| 42 | Sytl2 | 5891 | 0.131 | -0.0187 | No |
| 43 | Tmem97 | 5896 | 0.131 | -0.0156 | No |
| 44 | Cdc25a | 5902 | 0.131 | -0.0125 | No |
| 45 | Mcm4 | 5925 | 0.130 | -0.0104 | No |
| 46 | Nfkbib | 6021 | 0.127 | -0.0122 | No |
| 47 | Txnrd1 | 6102 | 0.124 | -0.0132 | No |
| 48 | Calr | 6337 | 0.117 | -0.0225 | No |
| 49 | Gpi1 | 6372 | 0.115 | -0.0214 | No |
| 50 | Gsk3b | 6426 | 0.113 | -0.0213 | No |
| 51 | Phgdh | 6519 | 0.109 | -0.0234 | No |
| 52 | Add3 | 6758 | 0.100 | -0.0333 | No |
| 53 | Slc2a3 | 6797 | 0.098 | -0.0328 | No |
| 54 | Idh1 | 6873 | 0.095 | -0.0343 | No |
| 55 | Uso1 | 6921 | 0.093 | -0.0345 | No |
| 56 | Ssr1 | 7046 | 0.088 | -0.0387 | No |
| 57 | Elovl5 | 7225 | 0.082 | -0.0460 | No |
| 58 | Wars1 | 7310 | 0.079 | -0.0484 | No |
| 59 | Rab1a | 7331 | 0.078 | -0.0475 | No |
| 60 | Actr2 | 7451 | 0.073 | -0.0518 | No |
| 61 | Acly | 7581 | 0.068 | -0.0569 | No |
| 62 | Tfrc | 7686 | 0.063 | -0.0607 | No |
| 63 | Map2k3 | 7737 | 0.062 | -0.0618 | No |
| 64 | Trib3 | 7987 | 0.053 | -0.0735 | No |
| 65 | Hspa5 | 7998 | 0.053 | -0.0727 | No |
| 66 | Dapp1 | 8134 | 0.047 | -0.0785 | No |
| 67 | Tbk1 | 8203 | 0.045 | -0.0810 | No |
| 68 | Ube2d3 | 8347 | 0.039 | -0.0875 | No |
| 69 | Actr3 | 8409 | 0.036 | -0.0898 | No |
| 70 | Itgb2 | 8420 | 0.036 | -0.0894 | No |
| 71 | Eno1b | 8564 | 0.030 | -0.0961 | No |
| 72 | Gclc | 8582 | 0.030 | -0.0962 | No |
| 73 | Stard4 | 8626 | 0.028 | -0.0978 | No |
| 74 | Ppp1r15a | 8655 | 0.027 | -0.0986 | No |
| 75 | Btg2 | 8710 | 0.024 | -0.1008 | No |
| 76 | Ddx39a | 8826 | 0.020 | -0.1063 | No |
| 77 | Ppia | 8951 | 0.016 | -0.1124 | No |
| 78 | Fads2 | 9228 | 0.006 | -0.1267 | No |
| 79 | Pgm1 | 9376 | 0.001 | -0.1343 | No |
| 80 | Immt | 9472 | -0.000 | -0.1393 | No |
| 81 | Psmc4 | 9474 | -0.000 | -0.1393 | No |
| 82 | Fgl2 | 9550 | -0.003 | -0.1432 | No |
| 83 | Rpn1 | 9778 | -0.012 | -0.1547 | No |
| 84 | Psma3 | 9810 | -0.013 | -0.1560 | No |
| 85 | Tuba4a | 9842 | -0.015 | -0.1573 | No |
| 86 | Slc37a4 | 9914 | -0.018 | -0.1605 | No |
| 87 | Acaca | 10022 | -0.022 | -0.1656 | No |
| 88 | Bcat1 | 10083 | -0.025 | -0.1681 | No |
| 89 | Qdpr | 10181 | -0.028 | -0.1725 | No |
| 90 | Slc1a5 | 10225 | -0.029 | -0.1740 | No |
| 91 | Pik3r3 | 10233 | -0.029 | -0.1736 | No |
| 92 | Pdk1 | 10277 | -0.030 | -0.1751 | No |
| 93 | Cth | 10292 | -0.031 | -0.1751 | No |
| 94 | Hmbs | 10408 | -0.035 | -0.1802 | No |
| 95 | Etf1 | 10538 | -0.041 | -0.1859 | No |
| 96 | Nup205 | 10589 | -0.042 | -0.1875 | No |
| 97 | Psmg1 | 10674 | -0.046 | -0.1907 | No |
| 98 | Sord | 10950 | -0.056 | -0.2037 | No |
| 99 | Slc6a6 | 11060 | -0.060 | -0.2079 | No |
| 100 | Acsl3 | 11063 | -0.060 | -0.2065 | No |
| 101 | Psmc6 | 11255 | -0.068 | -0.2147 | No |
| 102 | Atp2a2 | 11266 | -0.068 | -0.2136 | No |
| 103 | Ccng1 | 11384 | -0.073 | -0.2178 | No |
| 104 | Cxcr4 | 11397 | -0.074 | -0.2166 | No |
| 105 | Got1 | 11598 | -0.082 | -0.2250 | No |
| 106 | Serp1 | 11663 | -0.085 | -0.2262 | No |
| 107 | Cct6a | 11670 | -0.085 | -0.2244 | No |
| 108 | Ccnf | 11716 | -0.087 | -0.2245 | No |
| 109 | Psme3 | 12338 | -0.113 | -0.2542 | No |
| 110 | Cyp51 | 12339 | -0.113 | -0.2514 | No |
| 111 | Sec11a | 12402 | -0.115 | -0.2517 | No |
| 112 | Ero1a | 12404 | -0.115 | -0.2488 | No |
| 113 | Gbe1 | 12416 | -0.116 | -0.2465 | No |
| 114 | Aurka | 12437 | -0.117 | -0.2446 | No |
| 115 | Ung | 12468 | -0.118 | -0.2432 | No |
| 116 | Glrx | 12469 | -0.118 | -0.2402 | No |
| 117 | Egln3 | 12552 | -0.122 | -0.2414 | No |
| 118 | Cyb5b | 12555 | -0.122 | -0.2384 | No |
| 119 | Tpi1 | 12566 | -0.122 | -0.2359 | No |
| 120 | Nfyc | 12713 | -0.128 | -0.2403 | No |
| 121 | Adipor2 | 12769 | -0.131 | -0.2398 | No |
| 122 | Pno1 | 12783 | -0.132 | -0.2372 | No |
| 123 | Hmgcr | 12827 | -0.134 | -0.2361 | No |
| 124 | Nmt1 | 12876 | -0.136 | -0.2351 | No |
| 125 | Bub1 | 13372 | -0.161 | -0.2570 | Yes |
| 126 | Slc7a5 | 13375 | -0.161 | -0.2530 | Yes |
| 127 | Psmd13 | 13378 | -0.161 | -0.2491 | Yes |
| 128 | Ppa1 | 13449 | -0.164 | -0.2486 | Yes |
| 129 | Hmgcs1 | 13476 | -0.165 | -0.2458 | Yes |
| 130 | Tcea1 | 13588 | -0.171 | -0.2473 | Yes |
| 131 | Nfil3 | 13680 | -0.175 | -0.2476 | Yes |
| 132 | Psma4 | 13690 | -0.176 | -0.2436 | Yes |
| 133 | Ebp | 13883 | -0.186 | -0.2490 | Yes |
| 134 | Dhfr | 13961 | -0.188 | -0.2483 | Yes |
| 135 | Psmd14 | 13963 | -0.189 | -0.2436 | Yes |
| 136 | Ak4 | 13974 | -0.189 | -0.2393 | Yes |
| 137 | Cdkn1a | 13996 | -0.190 | -0.2356 | Yes |
| 138 | Eef1e1 | 14105 | -0.196 | -0.2363 | Yes |
| 139 | Lgmn | 14173 | -0.199 | -0.2348 | Yes |
| 140 | Polr3g | 14227 | -0.202 | -0.2325 | Yes |
| 141 | Idi1 | 14240 | -0.203 | -0.2280 | Yes |
| 142 | Prdx1 | 14329 | -0.207 | -0.2274 | Yes |
| 143 | Bhlhe40 | 14416 | -0.211 | -0.2265 | Yes |
| 144 | Tomm40 | 14493 | -0.215 | -0.2251 | Yes |
| 145 | Asns | 14558 | -0.217 | -0.2229 | Yes |
| 146 | Plk1 | 14576 | -0.219 | -0.2183 | Yes |
| 147 | Ctsc | 14583 | -0.219 | -0.2131 | Yes |
| 148 | Rrp9 | 14755 | -0.229 | -0.2163 | Yes |
| 149 | Ldha | 14926 | -0.238 | -0.2191 | Yes |
| 150 | Coro1a | 15043 | -0.245 | -0.2190 | Yes |
| 151 | Gla | 15353 | -0.259 | -0.2287 | Yes |
| 152 | Arpc5l | 15483 | -0.266 | -0.2287 | Yes |
| 153 | Uchl5 | 15623 | -0.273 | -0.2291 | Yes |
| 154 | Psmc2 | 15641 | -0.274 | -0.2230 | Yes |
| 155 | Mllt11 | 15679 | -0.277 | -0.2180 | Yes |
| 156 | Igfbp5 | 15683 | -0.277 | -0.2112 | Yes |
| 157 | Psat1 | 15725 | -0.280 | -0.2062 | Yes |
| 158 | Ddit3 | 15811 | -0.284 | -0.2035 | Yes |
| 159 | Eif2s2 | 15864 | -0.288 | -0.1990 | Yes |
| 160 | Cfp | 15865 | -0.288 | -0.1917 | Yes |
| 161 | Mthfd2 | 15875 | -0.289 | -0.1849 | Yes |
| 162 | G6pdx | 16005 | -0.298 | -0.1841 | Yes |
| 163 | Gtf2h1 | 16024 | -0.300 | -0.1775 | Yes |
| 164 | Niban1 | 16026 | -0.301 | -0.1699 | Yes |
| 165 | M6pr | 16186 | -0.312 | -0.1704 | Yes |
| 166 | Pfkl | 16198 | -0.313 | -0.1630 | Yes |
| 167 | Cops5 | 16200 | -0.313 | -0.1552 | Yes |
| 168 | Hspe1 | 16218 | -0.314 | -0.1482 | Yes |
| 169 | Pdap1 | 16368 | -0.324 | -0.1478 | Yes |
| 170 | Psph | 16460 | -0.331 | -0.1442 | Yes |
| 171 | Sdf2l1 | 16691 | -0.353 | -0.1473 | Yes |
| 172 | Ufm1 | 16711 | -0.354 | -0.1394 | Yes |
| 173 | Psmd12 | 16983 | -0.377 | -0.1440 | Yes |
| 174 | Xbp1 | 16995 | -0.379 | -0.1350 | Yes |
| 175 | Nupr1 | 17198 | -0.397 | -0.1356 | Yes |
| 176 | Nufip1 | 17327 | -0.409 | -0.1319 | Yes |
| 177 | Shmt2 | 17329 | -0.410 | -0.1217 | Yes |
| 178 | Insig1 | 17405 | -0.417 | -0.1151 | Yes |
| 179 | Ldlr | 17744 | -0.449 | -0.1214 | Yes |
| 180 | Ifi30 | 17836 | -0.462 | -0.1145 | Yes |
| 181 | Cacybp | 17913 | -0.470 | -0.1066 | Yes |
| 182 | Sc5d | 18002 | -0.478 | -0.0992 | Yes |
| 183 | Ykt6 | 18036 | -0.482 | -0.0888 | Yes |
| 184 | Rrm2 | 18153 | -0.498 | -0.0823 | Yes |
| 185 | Tubg1 | 18339 | -0.527 | -0.0787 | Yes |
| 186 | Slc1a4 | 18518 | -0.567 | -0.0737 | Yes |
| 187 | Pnp | 18520 | -0.567 | -0.0594 | Yes |
| 188 | Fkbp2 | 18544 | -0.574 | -0.0461 | Yes |
| 189 | Srd5a1 | 18580 | -0.582 | -0.0332 | Yes |
| 190 | Tes | 18628 | -0.591 | -0.0208 | Yes |
| 191 | Slc2a1 | 18641 | -0.593 | -0.0065 | Yes |
| 192 | Sqstm1 | 19078 | -0.761 | -0.0101 | Yes |
| 193 | Rdh11 | 19180 | -0.871 | 0.0066 | Yes |

