| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group3.MEP.mega_Pheno.cls #Group1_versus_Group3_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group3_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_HYPOXIA |
| Enrichment Score (ES) | 0.17747465 |
| Normalized Enrichment Score (NES) | 0.735552 |
| Nominal p-value | 0.93465346 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Dusp1 | 47 | 0.862 | 0.0216 | Yes |
| 2 | Jun | 126 | 0.727 | 0.0378 | Yes |
| 3 | Fos | 169 | 0.692 | 0.0549 | Yes |
| 4 | Ppfia4 | 422 | 0.564 | 0.0575 | Yes |
| 5 | Hmox1 | 613 | 0.517 | 0.0620 | Yes |
| 6 | Myh9 | 807 | 0.483 | 0.0653 | Yes |
| 7 | Sdc2 | 961 | 0.458 | 0.0701 | Yes |
| 8 | Ets1 | 998 | 0.451 | 0.0808 | Yes |
| 9 | P4ha2 | 1251 | 0.420 | 0.0794 | Yes |
| 10 | Gpc1 | 1312 | 0.412 | 0.0878 | Yes |
| 11 | Klf7 | 1336 | 0.409 | 0.0980 | Yes |
| 12 | Sdc3 | 1499 | 0.391 | 0.1004 | Yes |
| 13 | Pgk1 | 1519 | 0.388 | 0.1102 | Yes |
| 14 | Tpd52 | 1576 | 0.384 | 0.1180 | Yes |
| 15 | Cav1 | 1700 | 0.371 | 0.1219 | Yes |
| 16 | Vhl | 1822 | 0.361 | 0.1257 | Yes |
| 17 | Cavin1 | 1840 | 0.359 | 0.1348 | Yes |
| 18 | Cp | 1901 | 0.354 | 0.1416 | Yes |
| 19 | Pfkp | 1907 | 0.353 | 0.1511 | Yes |
| 20 | Cavin3 | 1910 | 0.353 | 0.1609 | Yes |
| 21 | P4ha1 | 2238 | 0.326 | 0.1529 | Yes |
| 22 | Prkca | 2282 | 0.322 | 0.1596 | Yes |
| 23 | Inha | 2561 | 0.305 | 0.1536 | Yes |
| 24 | Gpc4 | 2629 | 0.299 | 0.1585 | Yes |
| 25 | Mxi1 | 2800 | 0.287 | 0.1576 | Yes |
| 26 | Rbpj | 2802 | 0.287 | 0.1655 | Yes |
| 27 | Xpnpep1 | 2963 | 0.276 | 0.1649 | Yes |
| 28 | Dtna | 2997 | 0.275 | 0.1708 | Yes |
| 29 | Zfp36 | 3020 | 0.274 | 0.1773 | Yes |
| 30 | Pfkfb3 | 3204 | 0.262 | 0.1750 | Yes |
| 31 | Vldlr | 3295 | 0.256 | 0.1775 | Yes |
| 32 | Klhl24 | 3653 | 0.235 | 0.1654 | No |
| 33 | Sap30 | 4242 | 0.202 | 0.1403 | No |
| 34 | Atf3 | 4553 | 0.188 | 0.1294 | No |
| 35 | Akap12 | 4571 | 0.187 | 0.1337 | No |
| 36 | Nagk | 4706 | 0.181 | 0.1317 | No |
| 37 | Foxo3 | 4954 | 0.170 | 0.1236 | No |
| 38 | Ddit4 | 5062 | 0.166 | 0.1226 | No |
| 39 | Hk2 | 5221 | 0.160 | 0.1188 | No |
| 40 | Hdlbp | 5240 | 0.159 | 0.1223 | No |
| 41 | Cdkn1b | 5250 | 0.159 | 0.1263 | No |
| 42 | Stc2 | 5280 | 0.157 | 0.1291 | No |
| 43 | Bcl2 | 5728 | 0.138 | 0.1096 | No |
| 44 | Aldoa | 5809 | 0.135 | 0.1092 | No |
| 45 | Rora | 5835 | 0.134 | 0.1116 | No |
| 46 | Ampd3 | 5858 | 0.133 | 0.1142 | No |
| 47 | Btg1 | 5933 | 0.130 | 0.1139 | No |
| 48 | Slc25a1 | 6026 | 0.127 | 0.1127 | No |
| 49 | Pam | 6169 | 0.120 | 0.1086 | No |
| 50 | Ppargc1a | 6202 | 0.120 | 0.1103 | No |
| 51 | Tiparp | 6264 | 0.119 | 0.1104 | No |
| 52 | Gpi1 | 6372 | 0.115 | 0.1080 | No |
| 53 | Pdgfb | 6626 | 0.105 | 0.0977 | No |
| 54 | Slc2a3 | 6797 | 0.098 | 0.0916 | No |
| 55 | B4galnt2 | 7207 | 0.083 | 0.0725 | No |
| 56 | Fosl2 | 7669 | 0.064 | 0.0502 | No |
| 57 | Cdkn1c | 7876 | 0.056 | 0.0411 | No |
| 58 | Pgm2 | 7956 | 0.054 | 0.0384 | No |
| 59 | Wsb1 | 7983 | 0.053 | 0.0386 | No |
| 60 | Hspa5 | 7998 | 0.053 | 0.0393 | No |
| 61 | Slc2a5 | 8122 | 0.048 | 0.0342 | No |
| 62 | Kdm3a | 8164 | 0.046 | 0.0333 | No |
| 63 | Bnip3l | 8197 | 0.045 | 0.0329 | No |
| 64 | Pygm | 8212 | 0.044 | 0.0334 | No |
| 65 | Nedd4l | 8392 | 0.037 | 0.0251 | No |
| 66 | Zfp292 | 8440 | 0.035 | 0.0236 | No |
| 67 | Ugp2 | 8542 | 0.031 | 0.0192 | No |
| 68 | Eno1b | 8564 | 0.030 | 0.0190 | No |
| 69 | Ppp1r15a | 8655 | 0.027 | 0.0150 | No |
| 70 | Prdx5 | 8702 | 0.024 | 0.0133 | No |
| 71 | Kdelr3 | 8912 | 0.017 | 0.0029 | No |
| 72 | Pdk3 | 9038 | 0.013 | -0.0033 | No |
| 73 | Nr3c1 | 9118 | 0.010 | -0.0072 | No |
| 74 | Pgm1 | 9376 | 0.001 | -0.0206 | No |
| 75 | Tmem45a | 9416 | 0.000 | -0.0226 | No |
| 76 | Bgn | 9602 | -0.005 | -0.0321 | No |
| 77 | Ier3 | 9622 | -0.006 | -0.0330 | No |
| 78 | Csrp2 | 9723 | -0.010 | -0.0379 | No |
| 79 | Maff | 9909 | -0.018 | -0.0471 | No |
| 80 | Slc37a4 | 9914 | -0.018 | -0.0468 | No |
| 81 | Ankzf1 | 10066 | -0.024 | -0.0540 | No |
| 82 | Eno3 | 10173 | -0.028 | -0.0588 | No |
| 83 | Pdk1 | 10277 | -0.030 | -0.0633 | No |
| 84 | Kif5a | 10529 | -0.040 | -0.0753 | No |
| 85 | Angptl4 | 10614 | -0.043 | -0.0785 | No |
| 86 | Stbd1 | 10897 | -0.054 | -0.0917 | No |
| 87 | Tnfaip3 | 10936 | -0.056 | -0.0921 | No |
| 88 | Slc6a6 | 11060 | -0.060 | -0.0969 | No |
| 89 | Map3k1 | 11144 | -0.063 | -0.0994 | No |
| 90 | Ccng2 | 11186 | -0.065 | -0.0998 | No |
| 91 | Errfi1 | 11303 | -0.069 | -0.1039 | No |
| 92 | Cxcr4 | 11397 | -0.074 | -0.1067 | No |
| 93 | Gpc3 | 11420 | -0.074 | -0.1058 | No |
| 94 | Pim1 | 11445 | -0.076 | -0.1049 | No |
| 95 | Pnrc1 | 11557 | -0.081 | -0.1084 | No |
| 96 | Ext1 | 11711 | -0.086 | -0.1140 | No |
| 97 | Selenbp1 | 11783 | -0.089 | -0.1152 | No |
| 98 | Noct | 11797 | -0.090 | -0.1134 | No |
| 99 | Tgfbi | 11940 | -0.096 | -0.1182 | No |
| 100 | Hk1 | 11957 | -0.097 | -0.1163 | No |
| 101 | Irs2 | 12138 | -0.104 | -0.1228 | No |
| 102 | Atp7a | 12164 | -0.105 | -0.1212 | No |
| 103 | Tgfb3 | 12401 | -0.115 | -0.1303 | No |
| 104 | Ero1a | 12404 | -0.115 | -0.1272 | No |
| 105 | Gbe1 | 12416 | -0.116 | -0.1245 | No |
| 106 | Glrx | 12469 | -0.118 | -0.1240 | No |
| 107 | Tpi1 | 12566 | -0.122 | -0.1256 | No |
| 108 | Mt1 | 12639 | -0.125 | -0.1258 | No |
| 109 | Tpst2 | 12889 | -0.137 | -0.1350 | No |
| 110 | Ids | 12939 | -0.140 | -0.1337 | No |
| 111 | Grhpr | 12962 | -0.141 | -0.1309 | No |
| 112 | Ndrg1 | 13020 | -0.143 | -0.1299 | No |
| 113 | Gapdhs | 13118 | -0.148 | -0.1308 | No |
| 114 | Plin2 | 13194 | -0.152 | -0.1305 | No |
| 115 | Klf6 | 13253 | -0.155 | -0.1293 | No |
| 116 | Tgm2 | 13266 | -0.155 | -0.1255 | No |
| 117 | Hs3st1 | 13285 | -0.156 | -0.1221 | No |
| 118 | Hexa | 13451 | -0.165 | -0.1262 | No |
| 119 | Isg20 | 13570 | -0.170 | -0.1276 | No |
| 120 | Fam162a | 13574 | -0.170 | -0.1230 | No |
| 121 | Jmjd6 | 13658 | -0.174 | -0.1225 | No |
| 122 | Nfil3 | 13680 | -0.175 | -0.1187 | No |
| 123 | Adora2b | 13705 | -0.176 | -0.1150 | No |
| 124 | Gcnt2 | 13775 | -0.180 | -0.1136 | No |
| 125 | Ak4 | 13974 | -0.189 | -0.1187 | No |
| 126 | Cdkn1a | 13996 | -0.190 | -0.1145 | No |
| 127 | B3galt6 | 14017 | -0.191 | -0.1102 | No |
| 128 | Aldoc | 14210 | -0.201 | -0.1146 | No |
| 129 | Dcn | 14308 | -0.206 | -0.1139 | No |
| 130 | Bhlhe40 | 14416 | -0.211 | -0.1136 | No |
| 131 | Mif | 14424 | -0.212 | -0.1081 | No |
| 132 | Scarb1 | 14595 | -0.220 | -0.1108 | No |
| 133 | Siah2 | 14689 | -0.227 | -0.1093 | No |
| 134 | Phkg1 | 14873 | -0.235 | -0.1123 | No |
| 135 | Ldha | 14926 | -0.238 | -0.1084 | No |
| 136 | Eno2 | 15060 | -0.246 | -0.1085 | No |
| 137 | Gaa | 15127 | -0.247 | -0.1051 | No |
| 138 | Large1 | 15206 | -0.251 | -0.1021 | No |
| 139 | Vegfa | 15380 | -0.261 | -0.1039 | No |
| 140 | Ndst2 | 15709 | -0.279 | -0.1132 | No |
| 141 | Gck | 15780 | -0.282 | -0.1090 | No |
| 142 | Ddit3 | 15811 | -0.284 | -0.1027 | No |
| 143 | Casp6 | 15950 | -0.294 | -0.1017 | No |
| 144 | Pklr | 16164 | -0.310 | -0.1041 | No |
| 145 | Pfkl | 16198 | -0.313 | -0.0971 | No |
| 146 | Sult2b1 | 16289 | -0.319 | -0.0929 | No |
| 147 | Gys1 | 16572 | -0.342 | -0.0981 | No |
| 148 | Plac8 | 16779 | -0.359 | -0.0989 | No |
| 149 | S100a4 | 17528 | -0.430 | -0.1260 | No |
| 150 | Il6 | 17586 | -0.434 | -0.1169 | No |
| 151 | Anxa2 | 17863 | -0.464 | -0.1183 | No |
| 152 | Ndst1 | 17951 | -0.474 | -0.1097 | No |
| 153 | Fbp1 | 18044 | -0.482 | -0.1010 | No |
| 154 | Cited2 | 18072 | -0.485 | -0.0889 | No |
| 155 | Galk1 | 18163 | -0.499 | -0.0797 | No |
| 156 | Rragd | 18299 | -0.520 | -0.0722 | No |
| 157 | Col5a1 | 18557 | -0.578 | -0.0695 | No |
| 158 | Tes | 18628 | -0.591 | -0.0567 | No |
| 159 | Slc2a1 | 18641 | -0.593 | -0.0408 | No |
| 160 | Car12 | 18763 | -0.629 | -0.0296 | No |
| 161 | Ilvbl | 18929 | -0.684 | -0.0191 | No |
| 162 | Lxn | 18935 | -0.689 | -0.0002 | No |
| 163 | Plaur | 18969 | -0.702 | 0.0177 | No |

