| Dataset | MEP.MEP.mega_Pheno.cls #Group1_versus_Group2.MEP.mega_Pheno.cls #Group1_versus_Group2_repos |
| Phenotype | MEP.mega_Pheno.cls#Group1_versus_Group2_repos |
| Upregulated in class | 1 |
| GeneSet | HALLMARK_HYPOXIA |
| Enrichment Score (ES) | -0.2726606 |
| Normalized Enrichment Score (NES) | -1.0829729 |
| Nominal p-value | 0.3486974 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.969 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Bgn | 45 | 0.889 | 0.0222 | No |
| 2 | Ak4 | 144 | 0.745 | 0.0376 | No |
| 3 | Pdgfb | 296 | 0.640 | 0.0474 | No |
| 4 | Ddit4 | 301 | 0.639 | 0.0648 | No |
| 5 | Cxcr4 | 481 | 0.571 | 0.0712 | No |
| 6 | Sdc2 | 935 | 0.474 | 0.0606 | No |
| 7 | Eno3 | 1165 | 0.437 | 0.0607 | No |
| 8 | Adora2b | 1357 | 0.412 | 0.0621 | No |
| 9 | Hmox1 | 1498 | 0.398 | 0.0657 | No |
| 10 | Dtna | 1507 | 0.397 | 0.0763 | No |
| 11 | Fosl2 | 1871 | 0.362 | 0.0673 | No |
| 12 | Gpc1 | 1906 | 0.359 | 0.0754 | No |
| 13 | Cav1 | 1907 | 0.359 | 0.0853 | No |
| 14 | Cdkn1c | 2083 | 0.342 | 0.0856 | No |
| 15 | Noct | 2852 | 0.288 | 0.0534 | No |
| 16 | Tpi1 | 3244 | 0.263 | 0.0402 | No |
| 17 | Rbpj | 3273 | 0.261 | 0.0459 | No |
| 18 | Angptl4 | 3352 | 0.256 | 0.0489 | No |
| 19 | B3galt6 | 3390 | 0.254 | 0.0540 | No |
| 20 | Glrx | 3521 | 0.246 | 0.0540 | No |
| 21 | Ppp1r15a | 3669 | 0.237 | 0.0528 | No |
| 22 | Ldha | 3786 | 0.231 | 0.0532 | No |
| 23 | Xpnpep1 | 3845 | 0.227 | 0.0564 | No |
| 24 | Akap12 | 4087 | 0.215 | 0.0497 | No |
| 25 | Pgm1 | 4140 | 0.212 | 0.0529 | No |
| 26 | Nagk | 4253 | 0.206 | 0.0527 | No |
| 27 | Tpd52 | 4359 | 0.201 | 0.0527 | No |
| 28 | Gcnt2 | 4547 | 0.192 | 0.0483 | No |
| 29 | Pygm | 4720 | 0.184 | 0.0444 | No |
| 30 | Ppfia4 | 4786 | 0.180 | 0.0459 | No |
| 31 | Slc2a5 | 5054 | 0.168 | 0.0366 | No |
| 32 | Hexa | 5078 | 0.167 | 0.0400 | No |
| 33 | Cavin1 | 5101 | 0.166 | 0.0434 | No |
| 34 | Dusp1 | 5219 | 0.160 | 0.0417 | No |
| 35 | Cavin3 | 5330 | 0.155 | 0.0403 | No |
| 36 | Hspa5 | 5397 | 0.152 | 0.0410 | No |
| 37 | Prkca | 5399 | 0.152 | 0.0451 | No |
| 38 | Kif5a | 5429 | 0.151 | 0.0478 | No |
| 39 | Stbd1 | 5450 | 0.150 | 0.0509 | No |
| 40 | Gpc4 | 5490 | 0.148 | 0.0529 | No |
| 41 | Fam162a | 5824 | 0.135 | 0.0392 | No |
| 42 | S100a4 | 5996 | 0.127 | 0.0338 | No |
| 43 | Fos | 6145 | 0.122 | 0.0294 | No |
| 44 | Rragd | 6192 | 0.120 | 0.0303 | No |
| 45 | Grhpr | 6260 | 0.119 | 0.0301 | No |
| 46 | Btg1 | 6285 | 0.117 | 0.0321 | No |
| 47 | Pgk1 | 6351 | 0.114 | 0.0318 | No |
| 48 | Pfkp | 6508 | 0.109 | 0.0267 | No |
| 49 | Bcl2 | 6683 | 0.101 | 0.0204 | No |
| 50 | Pnrc1 | 6731 | 0.100 | 0.0207 | No |
| 51 | Vhl | 6863 | 0.095 | 0.0165 | No |
| 52 | Inha | 6932 | 0.092 | 0.0155 | No |
| 53 | Zfp36 | 7012 | 0.089 | 0.0138 | No |
| 54 | Scarb1 | 7182 | 0.083 | 0.0073 | No |
| 55 | Jun | 7239 | 0.081 | 0.0066 | No |
| 56 | Nr3c1 | 7596 | 0.068 | -0.0101 | No |
| 57 | Pfkfb3 | 7608 | 0.068 | -0.0088 | No |
| 58 | Hk2 | 7613 | 0.068 | -0.0072 | No |
| 59 | Mif | 7844 | 0.060 | -0.0175 | No |
| 60 | Pdk3 | 7991 | 0.054 | -0.0237 | No |
| 61 | Cp | 8106 | 0.050 | -0.0283 | No |
| 62 | Klf7 | 8281 | 0.044 | -0.0361 | No |
| 63 | Cdkn1a | 8434 | 0.040 | -0.0429 | No |
| 64 | Ids | 8465 | 0.039 | -0.0434 | No |
| 65 | Ier3 | 8467 | 0.039 | -0.0424 | No |
| 66 | Sdc3 | 8472 | 0.039 | -0.0416 | No |
| 67 | Klhl24 | 8474 | 0.039 | -0.0405 | No |
| 68 | Nedd4l | 8649 | 0.034 | -0.0487 | No |
| 69 | Pfkl | 9298 | 0.011 | -0.0822 | No |
| 70 | Gpi1 | 9350 | 0.009 | -0.0847 | No |
| 71 | P4ha2 | 9355 | 0.009 | -0.0846 | No |
| 72 | Pdk1 | 9427 | 0.007 | -0.0882 | No |
| 73 | Bnip3l | 9728 | -0.002 | -0.1038 | No |
| 74 | Ets1 | 9765 | -0.003 | -0.1055 | No |
| 75 | Selenbp1 | 10180 | -0.018 | -0.1267 | No |
| 76 | Myh9 | 10197 | -0.019 | -0.1270 | No |
| 77 | Irs2 | 10261 | -0.021 | -0.1297 | No |
| 78 | Zfp292 | 10283 | -0.021 | -0.1302 | No |
| 79 | Gpc3 | 10573 | -0.031 | -0.1445 | No |
| 80 | Slc25a1 | 10604 | -0.032 | -0.1452 | No |
| 81 | Prdx5 | 10729 | -0.036 | -0.1506 | No |
| 82 | Slc6a6 | 10894 | -0.041 | -0.1581 | No |
| 83 | Ankzf1 | 10959 | -0.043 | -0.1602 | No |
| 84 | Cited2 | 10995 | -0.044 | -0.1608 | No |
| 85 | Slc37a4 | 11048 | -0.046 | -0.1623 | No |
| 86 | Tpst2 | 11074 | -0.048 | -0.1622 | No |
| 87 | Foxo3 | 11167 | -0.051 | -0.1657 | No |
| 88 | Lxn | 11305 | -0.055 | -0.1713 | No |
| 89 | Wsb1 | 11548 | -0.065 | -0.1821 | No |
| 90 | Stc2 | 11554 | -0.065 | -0.1806 | No |
| 91 | Pam | 11583 | -0.066 | -0.1803 | No |
| 92 | Ampd3 | 11684 | -0.069 | -0.1836 | No |
| 93 | Gys1 | 11805 | -0.073 | -0.1878 | No |
| 94 | Hdlbp | 12026 | -0.083 | -0.1970 | No |
| 95 | Eno1b | 12067 | -0.085 | -0.1968 | No |
| 96 | Tiparp | 12217 | -0.090 | -0.2021 | No |
| 97 | Eno2 | 12230 | -0.090 | -0.2002 | No |
| 98 | Aldoa | 12356 | -0.094 | -0.2041 | No |
| 99 | Phkg1 | 12385 | -0.095 | -0.2030 | No |
| 100 | Ugp2 | 12423 | -0.097 | -0.2023 | No |
| 101 | Atp7a | 12626 | -0.105 | -0.2099 | No |
| 102 | Rora | 12704 | -0.109 | -0.2109 | No |
| 103 | Gaa | 12757 | -0.110 | -0.2106 | No |
| 104 | Mxi1 | 12822 | -0.112 | -0.2108 | No |
| 105 | Ero1a | 12987 | -0.119 | -0.2161 | No |
| 106 | Atf3 | 12989 | -0.119 | -0.2129 | No |
| 107 | Isg20 | 13329 | -0.131 | -0.2270 | No |
| 108 | Cdkn1b | 13407 | -0.134 | -0.2274 | No |
| 109 | Kdelr3 | 13516 | -0.137 | -0.2292 | No |
| 110 | P4ha1 | 13607 | -0.142 | -0.2300 | No |
| 111 | Slc2a1 | 13859 | -0.152 | -0.2389 | No |
| 112 | Siah2 | 14017 | -0.160 | -0.2427 | No |
| 113 | Nfil3 | 14126 | -0.163 | -0.2438 | No |
| 114 | Hs3st1 | 14227 | -0.169 | -0.2444 | No |
| 115 | Hk1 | 14433 | -0.178 | -0.2502 | No |
| 116 | Tgm2 | 14434 | -0.178 | -0.2453 | No |
| 117 | Ndst1 | 14726 | -0.190 | -0.2553 | No |
| 118 | Map3k1 | 14828 | -0.195 | -0.2552 | No |
| 119 | Gbe1 | 14865 | -0.197 | -0.2516 | No |
| 120 | Mt1 | 15046 | -0.206 | -0.2553 | No |
| 121 | Csrp2 | 15247 | -0.216 | -0.2598 | No |
| 122 | Gapdhs | 15338 | -0.221 | -0.2584 | No |
| 123 | Galk1 | 15612 | -0.236 | -0.2662 | Yes |
| 124 | B4galnt2 | 15673 | -0.240 | -0.2627 | Yes |
| 125 | Tmem45a | 15700 | -0.241 | -0.2574 | Yes |
| 126 | Tgfb3 | 15779 | -0.244 | -0.2547 | Yes |
| 127 | Ndst2 | 15789 | -0.244 | -0.2485 | Yes |
| 128 | Maff | 15859 | -0.248 | -0.2452 | Yes |
| 129 | Ddit3 | 15904 | -0.251 | -0.2406 | Yes |
| 130 | Jmjd6 | 15958 | -0.254 | -0.2363 | Yes |
| 131 | Kdm3a | 15986 | -0.256 | -0.2307 | Yes |
| 132 | Plin2 | 15999 | -0.257 | -0.2242 | Yes |
| 133 | Ext1 | 16063 | -0.262 | -0.2203 | Yes |
| 134 | Vegfa | 16093 | -0.264 | -0.2145 | Yes |
| 135 | Ndrg1 | 16188 | -0.270 | -0.2120 | Yes |
| 136 | Errfi1 | 16306 | -0.278 | -0.2104 | Yes |
| 137 | Bhlhe40 | 16341 | -0.279 | -0.2045 | Yes |
| 138 | Pgm2 | 16413 | -0.284 | -0.2004 | Yes |
| 139 | Slc2a3 | 16419 | -0.284 | -0.1928 | Yes |
| 140 | Large1 | 16634 | -0.299 | -0.1957 | Yes |
| 141 | Pklr | 16683 | -0.303 | -0.1899 | Yes |
| 142 | Anxa2 | 16822 | -0.311 | -0.1885 | Yes |
| 143 | Sult2b1 | 16909 | -0.317 | -0.1843 | Yes |
| 144 | Dcn | 17214 | -0.344 | -0.1906 | Yes |
| 145 | Tes | 17446 | -0.363 | -0.1927 | Yes |
| 146 | Pim1 | 17541 | -0.370 | -0.1874 | Yes |
| 147 | Ccng2 | 17565 | -0.373 | -0.1783 | Yes |
| 148 | Car12 | 17661 | -0.382 | -0.1727 | Yes |
| 149 | Sap30 | 17699 | -0.386 | -0.1640 | Yes |
| 150 | Gck | 17738 | -0.390 | -0.1552 | Yes |
| 151 | Fbp1 | 17777 | -0.395 | -0.1463 | Yes |
| 152 | Tnfaip3 | 18481 | -0.480 | -0.1698 | Yes |
| 153 | Klf6 | 18487 | -0.482 | -0.1567 | Yes |
| 154 | Tgfbi | 18597 | -0.505 | -0.1485 | Yes |
| 155 | Casp6 | 18613 | -0.509 | -0.1353 | Yes |
| 156 | Ilvbl | 18744 | -0.538 | -0.1272 | Yes |
| 157 | Aldoc | 18799 | -0.554 | -0.1148 | Yes |
| 158 | Col5a1 | 18965 | -0.604 | -0.1067 | Yes |
| 159 | Il6 | 19208 | -0.767 | -0.0982 | Yes |
| 160 | Vldlr | 19237 | -0.812 | -0.0773 | Yes |
| 161 | Plac8 | 19250 | -0.837 | -0.0548 | Yes |
| 162 | Ppargc1a | 19259 | -0.865 | -0.0314 | Yes |
| 163 | Plaur | 19303 | -1.228 | 0.0002 | Yes |

