| Dataset | MEP.MEP.ery_Pheno.cls #Group6_versus_Group8.MEP.ery_Pheno.cls #Group6_versus_Group8_repos |
| Phenotype | MEP.ery_Pheno.cls#Group6_versus_Group8_repos |
| Upregulated in class | 5 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.15956052 |
| Normalized Enrichment Score (NES) | -0.7160211 |
| Nominal p-value | 0.75445545 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.999 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Vldlr | 730 | 0.592 | -0.0009 | No |
| 2 | Fgl2 | 1113 | 0.520 | 0.0078 | No |
| 3 | Me1 | 1408 | 0.486 | 0.0182 | No |
| 4 | Stc1 | 1785 | 0.442 | 0.0237 | No |
| 5 | Egln3 | 2045 | 0.418 | 0.0324 | No |
| 6 | Idh1 | 3260 | 0.325 | 0.0022 | No |
| 7 | Rit1 | 3309 | 0.321 | 0.0144 | No |
| 8 | Pgk1 | 3650 | 0.299 | 0.0150 | No |
| 9 | Abcf2 | 3931 | 0.283 | 0.0171 | No |
| 10 | Gla | 3936 | 0.283 | 0.0293 | No |
| 11 | Ppp1r15a | 4167 | 0.270 | 0.0327 | No |
| 12 | Btg2 | 4231 | 0.267 | 0.0420 | No |
| 13 | Cfp | 5316 | 0.216 | 0.0118 | No |
| 14 | Mthfd2l | 5506 | 0.209 | 0.0140 | No |
| 15 | Bhlhe40 | 6186 | 0.184 | -0.0028 | No |
| 16 | Slc7a11 | 6198 | 0.184 | 0.0048 | No |
| 17 | Sla | 6223 | 0.183 | 0.0119 | No |
| 18 | Stard4 | 6307 | 0.180 | 0.0167 | No |
| 19 | Aurka | 6423 | 0.175 | 0.0201 | No |
| 20 | Slc1a5 | 7053 | 0.155 | 0.0039 | No |
| 21 | Dhcr24 | 7101 | 0.154 | 0.0089 | No |
| 22 | Pitpnb | 7129 | 0.153 | 0.0145 | No |
| 23 | Wars1 | 7356 | 0.145 | 0.0126 | No |
| 24 | Slc7a5 | 7469 | 0.142 | 0.0146 | No |
| 25 | Pik3r3 | 7539 | 0.140 | 0.0182 | No |
| 26 | Cyb5b | 7612 | 0.137 | 0.0215 | No |
| 27 | Slc1a4 | 7617 | 0.137 | 0.0273 | No |
| 28 | Txnrd1 | 7668 | 0.136 | 0.0314 | No |
| 29 | Cth | 7977 | 0.127 | 0.0257 | No |
| 30 | Sc5d | 8058 | 0.125 | 0.0282 | No |
| 31 | Plod2 | 8582 | 0.112 | 0.0140 | No |
| 32 | Atp2a2 | 8741 | 0.108 | 0.0129 | No |
| 33 | G6pdx | 8903 | 0.104 | 0.0116 | No |
| 34 | Psmd14 | 8979 | 0.102 | 0.0133 | No |
| 35 | Slc37a4 | 9352 | 0.093 | 0.0037 | No |
| 36 | Tfrc | 9473 | 0.091 | 0.0033 | No |
| 37 | Acaca | 9476 | 0.090 | 0.0071 | No |
| 38 | Igfbp5 | 9578 | 0.089 | 0.0073 | No |
| 39 | Ufm1 | 9629 | 0.087 | 0.0093 | No |
| 40 | Ifi30 | 9656 | 0.086 | 0.0121 | No |
| 41 | Phgdh | 9971 | 0.079 | 0.0041 | No |
| 42 | Sdf2l1 | 10102 | 0.077 | 0.0027 | No |
| 43 | Bcat1 | 10184 | 0.075 | 0.0030 | No |
| 44 | Slc6a6 | 10219 | 0.074 | 0.0050 | No |
| 45 | Hspd1 | 10297 | 0.073 | 0.0053 | No |
| 46 | Slc2a3 | 10472 | 0.069 | 0.0020 | No |
| 47 | Gclc | 10544 | 0.068 | 0.0023 | No |
| 48 | Nfyc | 10661 | 0.065 | 0.0009 | No |
| 49 | Sqle | 10669 | 0.065 | 0.0035 | No |
| 50 | Psma3 | 10926 | 0.061 | -0.0032 | No |
| 51 | Hspa9 | 10927 | 0.061 | -0.0006 | No |
| 52 | Rrp9 | 11146 | 0.056 | -0.0061 | No |
| 53 | Tes | 11266 | 0.054 | -0.0081 | No |
| 54 | Psme3 | 11462 | 0.050 | -0.0130 | No |
| 55 | Cxcr4 | 11471 | 0.049 | -0.0112 | No |
| 56 | Hmgcr | 11644 | 0.047 | -0.0154 | No |
| 57 | Cacybp | 11695 | 0.046 | -0.0153 | No |
| 58 | Pgm1 | 11751 | 0.044 | -0.0153 | No |
| 59 | Nampt | 11832 | 0.043 | -0.0164 | No |
| 60 | Ppia | 12035 | 0.039 | -0.0221 | No |
| 61 | Etf1 | 12077 | 0.038 | -0.0219 | No |
| 62 | Nup205 | 12082 | 0.038 | -0.0204 | No |
| 63 | Elovl6 | 12094 | 0.038 | -0.0191 | No |
| 64 | Skap2 | 12317 | 0.034 | -0.0258 | No |
| 65 | Dapp1 | 12407 | 0.032 | -0.0276 | No |
| 66 | Tbk1 | 12477 | 0.030 | -0.0288 | No |
| 67 | Ssr1 | 12568 | 0.029 | -0.0309 | No |
| 68 | Hspa4 | 12719 | 0.026 | -0.0352 | No |
| 69 | Ero1a | 12729 | 0.026 | -0.0344 | No |
| 70 | Cops5 | 12936 | 0.023 | -0.0410 | No |
| 71 | Uso1 | 12938 | 0.023 | -0.0400 | No |
| 72 | Plk1 | 13038 | 0.021 | -0.0427 | No |
| 73 | Pdk1 | 13066 | 0.020 | -0.0428 | No |
| 74 | Mcm4 | 13150 | 0.019 | -0.0450 | No |
| 75 | Hsp90b1 | 13162 | 0.018 | -0.0446 | No |
| 76 | Gtf2h1 | 13363 | 0.015 | -0.0513 | No |
| 77 | Atp6v1d | 13403 | 0.014 | -0.0521 | No |
| 78 | Ifrd1 | 13469 | 0.013 | -0.0539 | No |
| 79 | Sqstm1 | 13487 | 0.013 | -0.0540 | No |
| 80 | Hk2 | 13579 | 0.011 | -0.0569 | No |
| 81 | Add3 | 13635 | 0.010 | -0.0584 | No |
| 82 | Polr3g | 13830 | 0.006 | -0.0652 | No |
| 83 | Edem1 | 13867 | 0.005 | -0.0663 | No |
| 84 | Asns | 13931 | 0.004 | -0.0684 | No |
| 85 | Actr2 | 13942 | 0.004 | -0.0686 | No |
| 86 | Got1 | 14037 | 0.003 | -0.0719 | No |
| 87 | Dhfr | 14528 | -0.004 | -0.0896 | No |
| 88 | Acsl3 | 14576 | -0.005 | -0.0911 | No |
| 89 | Gmps | 14752 | -0.008 | -0.0971 | No |
| 90 | Adipor2 | 14757 | -0.008 | -0.0969 | No |
| 91 | Uchl5 | 14981 | -0.012 | -0.1046 | No |
| 92 | Cdkn1a | 15145 | -0.015 | -0.1098 | No |
| 93 | Gsk3b | 15152 | -0.015 | -0.1094 | No |
| 94 | Map2k3 | 15190 | -0.016 | -0.1100 | No |
| 95 | Arpc5l | 15308 | -0.018 | -0.1135 | No |
| 96 | Cdc25a | 15558 | -0.023 | -0.1216 | No |
| 97 | Actr3 | 15714 | -0.026 | -0.1261 | No |
| 98 | Mthfd2 | 15730 | -0.026 | -0.1256 | No |
| 99 | Psma4 | 15855 | -0.028 | -0.1289 | No |
| 100 | Ldlr | 15892 | -0.029 | -0.1289 | No |
| 101 | Acly | 16059 | -0.032 | -0.1336 | No |
| 102 | Ube2d3 | 16079 | -0.033 | -0.1328 | No |
| 103 | Psmg1 | 16093 | -0.033 | -0.1319 | No |
| 104 | Tcea1 | 16139 | -0.034 | -0.1320 | No |
| 105 | Canx | 16145 | -0.034 | -0.1307 | No |
| 106 | Pfkl | 16161 | -0.034 | -0.1298 | No |
| 107 | Psmc2 | 16191 | -0.035 | -0.1293 | No |
| 108 | Sord | 16236 | -0.035 | -0.1294 | No |
| 109 | Srd5a1 | 16534 | -0.041 | -0.1384 | No |
| 110 | Aldoa | 16545 | -0.042 | -0.1370 | No |
| 111 | Mllt11 | 16567 | -0.042 | -0.1359 | No |
| 112 | Psmd12 | 16571 | -0.042 | -0.1342 | No |
| 113 | Cct6a | 16674 | -0.044 | -0.1360 | No |
| 114 | Lta4h | 16786 | -0.046 | -0.1380 | No |
| 115 | Eef1e1 | 16826 | -0.047 | -0.1374 | No |
| 116 | Ppa1 | 16886 | -0.048 | -0.1375 | No |
| 117 | Gsr | 16918 | -0.049 | -0.1365 | No |
| 118 | Nfil3 | 16951 | -0.050 | -0.1355 | No |
| 119 | Mcm2 | 16961 | -0.050 | -0.1337 | No |
| 120 | Ak4 | 17301 | -0.057 | -0.1436 | No |
| 121 | Ddx39a | 17442 | -0.059 | -0.1461 | No |
| 122 | Nufip1 | 17567 | -0.062 | -0.1479 | No |
| 123 | Pnp | 17627 | -0.063 | -0.1473 | No |
| 124 | Immt | 17817 | -0.068 | -0.1513 | No |
| 125 | Ctsc | 18045 | -0.073 | -0.1564 | Yes |
| 126 | Serp1 | 18070 | -0.073 | -0.1541 | Yes |
| 127 | Serpinh1 | 18094 | -0.074 | -0.1517 | Yes |
| 128 | Niban1 | 18147 | -0.075 | -0.1504 | Yes |
| 129 | Hmgcs1 | 18258 | -0.077 | -0.1511 | Yes |
| 130 | Slc2a1 | 18289 | -0.078 | -0.1488 | Yes |
| 131 | Idi1 | 18334 | -0.079 | -0.1469 | Yes |
| 132 | Fdxr | 18340 | -0.079 | -0.1437 | Yes |
| 133 | Pno1 | 18363 | -0.080 | -0.1410 | Yes |
| 134 | Rpn1 | 18369 | -0.080 | -0.1377 | Yes |
| 135 | Calr | 18563 | -0.085 | -0.1411 | Yes |
| 136 | M6pr | 18637 | -0.086 | -0.1400 | Yes |
| 137 | Rpa1 | 18640 | -0.086 | -0.1363 | Yes |
| 138 | Gga2 | 18646 | -0.087 | -0.1327 | Yes |
| 139 | Fads1 | 18709 | -0.087 | -0.1312 | Yes |
| 140 | Sec11a | 18761 | -0.089 | -0.1292 | Yes |
| 141 | Hspe1 | 18952 | -0.093 | -0.1321 | Yes |
| 142 | Ldha | 18986 | -0.094 | -0.1292 | Yes |
| 143 | Ccnf | 19399 | -0.104 | -0.1397 | Yes |
| 144 | Rrm2 | 19583 | -0.109 | -0.1416 | Yes |
| 145 | Hmbs | 19605 | -0.109 | -0.1377 | Yes |
| 146 | Dhcr7 | 19693 | -0.112 | -0.1360 | Yes |
| 147 | Nmt1 | 19723 | -0.112 | -0.1322 | Yes |
| 148 | Elovl5 | 19960 | -0.117 | -0.1357 | Yes |
| 149 | P4ha1 | 20030 | -0.119 | -0.1330 | Yes |
| 150 | Psmc4 | 20067 | -0.119 | -0.1292 | Yes |
| 151 | Gpi1 | 20094 | -0.120 | -0.1249 | Yes |
| 152 | Eif2s2 | 20112 | -0.120 | -0.1203 | Yes |
| 153 | Hspa5 | 20259 | -0.124 | -0.1202 | Yes |
| 154 | Itgb2 | 20681 | -0.136 | -0.1297 | Yes |
| 155 | Rab1a | 20707 | -0.137 | -0.1247 | Yes |
| 156 | Tubg1 | 20875 | -0.141 | -0.1246 | Yes |
| 157 | Bub1 | 20878 | -0.141 | -0.1185 | Yes |
| 158 | Trib3 | 20974 | -0.144 | -0.1158 | Yes |
| 159 | Psmd13 | 21044 | -0.146 | -0.1120 | Yes |
| 160 | Ddit3 | 21069 | -0.146 | -0.1065 | Yes |
| 161 | Ccng1 | 21086 | -0.147 | -0.1007 | Yes |
| 162 | Stip1 | 21123 | -0.148 | -0.0955 | Yes |
| 163 | Psmc6 | 21130 | -0.149 | -0.0893 | Yes |
| 164 | Cd9 | 21161 | -0.150 | -0.0839 | Yes |
| 165 | Shmt2 | 21348 | -0.155 | -0.0839 | Yes |
| 166 | Ung | 21470 | -0.159 | -0.0814 | Yes |
| 167 | Gbe1 | 21471 | -0.159 | -0.0745 | Yes |
| 168 | Prdx1 | 21613 | -0.163 | -0.0726 | Yes |
| 169 | Psat1 | 21630 | -0.164 | -0.0660 | Yes |
| 170 | Ykt6 | 21860 | -0.172 | -0.0669 | Yes |
| 171 | Tuba4a | 21943 | -0.175 | -0.0623 | Yes |
| 172 | Pdap1 | 22497 | -0.194 | -0.0740 | Yes |
| 173 | Ebp | 22547 | -0.196 | -0.0673 | Yes |
| 174 | Fkbp2 | 22642 | -0.199 | -0.0621 | Yes |
| 175 | Tpi1 | 22669 | -0.200 | -0.0543 | Yes |
| 176 | Tomm40 | 22709 | -0.202 | -0.0470 | Yes |
| 177 | Sytl2 | 22791 | -0.205 | -0.0410 | Yes |
| 178 | Rdh11 | 23021 | -0.213 | -0.0401 | Yes |
| 179 | Nfkbib | 23104 | -0.216 | -0.0337 | Yes |
| 180 | Cyp51 | 23226 | -0.221 | -0.0285 | Yes |
| 181 | Fads2 | 23290 | -0.224 | -0.0210 | Yes |
| 182 | Psph | 23596 | -0.238 | -0.0218 | Yes |
| 183 | Coro1a | 23619 | -0.239 | -0.0123 | Yes |
| 184 | Tmem97 | 23638 | -0.240 | -0.0025 | Yes |
| 185 | Tm7sf2 | 23826 | -0.248 | 0.0015 | Yes |
| 186 | Glrx | 23868 | -0.250 | 0.0108 | Yes |
| 187 | Lgmn | 24074 | -0.259 | 0.0146 | Yes |
| 188 | Psmb5 | 24443 | -0.277 | 0.0132 | Yes |
| 189 | Nupr1 | 24452 | -0.278 | 0.0250 | Yes |
| 190 | Qdpr | 25117 | -0.313 | 0.0144 | Yes |
| 191 | Eno1b | 25695 | -0.354 | 0.0087 | Yes |
| 192 | Xbp1 | 25748 | -0.358 | 0.0224 | Yes |
| 193 | Insig1 | 26791 | -0.479 | 0.0052 | Yes |
| 194 | Ddit4 | 27163 | -0.560 | 0.0160 | Yes |

