| Dataset | MEP.MEP.ery_Pheno.cls #Group3_versus_Group4.MEP.ery_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.ery_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 3 |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | -0.18194896 |
| Normalized Enrichment Score (NES) | -0.78414214 |
| Nominal p-value | 0.790927 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Slc19a2 | 336 | 0.745 | 0.0056 | No |
| 2 | Plk3 | 400 | 0.722 | 0.0206 | No |
| 3 | Upp1 | 518 | 0.676 | 0.0326 | No |
| 4 | Tgfa | 533 | 0.674 | 0.0482 | No |
| 5 | S100a4 | 624 | 0.644 | 0.0604 | No |
| 6 | Epha2 | 1170 | 0.538 | 0.0534 | No |
| 7 | Zfp365 | 1313 | 0.515 | 0.0606 | No |
| 8 | Osgin1 | 1615 | 0.485 | 0.0612 | No |
| 9 | Notch1 | 1643 | 0.481 | 0.0718 | No |
| 10 | Phlda3 | 1648 | 0.481 | 0.0832 | No |
| 11 | Tnni1 | 1678 | 0.477 | 0.0936 | No |
| 12 | Perp | 2252 | 0.424 | 0.0829 | No |
| 13 | Fgf13 | 2298 | 0.423 | 0.0914 | No |
| 14 | Slc7a11 | 2746 | 0.398 | 0.0846 | No |
| 15 | Pdgfa | 2812 | 0.393 | 0.0917 | No |
| 16 | Cd81 | 2836 | 0.390 | 0.1002 | No |
| 17 | Ctsd | 3099 | 0.372 | 0.0996 | No |
| 18 | Vdr | 3105 | 0.371 | 0.1083 | No |
| 19 | Cdh13 | 3291 | 0.357 | 0.1101 | No |
| 20 | Zmat3 | 3396 | 0.348 | 0.1147 | No |
| 21 | Rap2b | 3555 | 0.337 | 0.1170 | No |
| 22 | Ada | 3664 | 0.334 | 0.1211 | No |
| 23 | Cdkn2a | 3692 | 0.332 | 0.1280 | No |
| 24 | Retsat | 4062 | 0.306 | 0.1219 | No |
| 25 | Tob1 | 4073 | 0.305 | 0.1289 | No |
| 26 | Cd82 | 4106 | 0.302 | 0.1349 | No |
| 27 | Slc35d1 | 4114 | 0.301 | 0.1419 | No |
| 28 | Ldhb | 4559 | 0.290 | 0.1327 | No |
| 29 | Ak1 | 4733 | 0.280 | 0.1331 | No |
| 30 | Stom | 5029 | 0.266 | 0.1287 | No |
| 31 | Sfn | 5035 | 0.266 | 0.1349 | No |
| 32 | Pvt1 | 5411 | 0.252 | 0.1272 | No |
| 33 | Sphk1 | 5639 | 0.241 | 0.1247 | No |
| 34 | Gls2 | 5922 | 0.229 | 0.1199 | No |
| 35 | Il1a | 6163 | 0.226 | 0.1166 | No |
| 36 | Cdkn2b | 6230 | 0.222 | 0.1195 | No |
| 37 | Tm4sf1 | 6390 | 0.216 | 0.1189 | No |
| 38 | Aen | 6753 | 0.209 | 0.1107 | No |
| 39 | Rxra | 6834 | 0.205 | 0.1127 | No |
| 40 | Itgb4 | 6966 | 0.200 | 0.1127 | No |
| 41 | Rad9a | 6971 | 0.200 | 0.1174 | No |
| 42 | Pidd1 | 7054 | 0.197 | 0.1191 | No |
| 43 | Ephx1 | 7275 | 0.189 | 0.1156 | No |
| 44 | Ifi30 | 7336 | 0.186 | 0.1179 | No |
| 45 | Baiap2 | 7403 | 0.184 | 0.1199 | No |
| 46 | Traf4 | 7499 | 0.181 | 0.1208 | No |
| 47 | Fuca1 | 7567 | 0.179 | 0.1226 | No |
| 48 | Plk2 | 7843 | 0.168 | 0.1166 | No |
| 49 | Tsc22d1 | 7891 | 0.165 | 0.1189 | No |
| 50 | Tspyl2 | 8120 | 0.158 | 0.1143 | No |
| 51 | Mknk2 | 8230 | 0.154 | 0.1141 | No |
| 52 | Rhbdf2 | 8340 | 0.150 | 0.1137 | No |
| 53 | Steap3 | 8822 | 0.135 | 0.0994 | No |
| 54 | Hras | 8903 | 0.132 | 0.0996 | No |
| 55 | Csrnp2 | 8920 | 0.132 | 0.1022 | No |
| 56 | Cdkn1a | 9146 | 0.125 | 0.0970 | No |
| 57 | H1f2 | 9244 | 0.122 | 0.0964 | No |
| 58 | Tm7sf3 | 9402 | 0.117 | 0.0935 | No |
| 59 | Triap1 | 9461 | 0.115 | 0.0941 | No |
| 60 | Elp1 | 9509 | 0.113 | 0.0951 | No |
| 61 | Klf4 | 9570 | 0.112 | 0.0956 | No |
| 62 | Irag2 | 9735 | 0.107 | 0.0922 | No |
| 63 | Sp1 | 9809 | 0.105 | 0.0920 | No |
| 64 | Ccp110 | 9842 | 0.104 | 0.0934 | No |
| 65 | Xpc | 9966 | 0.101 | 0.0913 | No |
| 66 | Bax | 9979 | 0.100 | 0.0932 | No |
| 67 | Acvr1b | 10066 | 0.098 | 0.0925 | No |
| 68 | Slc3a2 | 10089 | 0.097 | 0.0940 | No |
| 69 | Trib3 | 10235 | 0.093 | 0.0909 | No |
| 70 | Wwp1 | 10335 | 0.091 | 0.0895 | No |
| 71 | Hspa4l | 10516 | 0.087 | 0.0850 | No |
| 72 | Ddb2 | 10682 | 0.083 | 0.0810 | No |
| 73 | Rad51c | 10830 | 0.079 | 0.0775 | No |
| 74 | Cebpa | 10872 | 0.078 | 0.0779 | No |
| 75 | Ei24 | 11122 | 0.072 | 0.0705 | No |
| 76 | Foxo3 | 11137 | 0.071 | 0.0717 | No |
| 77 | Tprkb | 11153 | 0.071 | 0.0729 | No |
| 78 | Ercc5 | 11190 | 0.070 | 0.0733 | No |
| 79 | Pom121 | 11240 | 0.069 | 0.0731 | No |
| 80 | Fbxw7 | 11254 | 0.069 | 0.0743 | No |
| 81 | Hmox1 | 11370 | 0.065 | 0.0717 | No |
| 82 | Ralgds | 11388 | 0.065 | 0.0726 | No |
| 83 | Hexim1 | 11401 | 0.064 | 0.0737 | No |
| 84 | Casp1 | 11761 | 0.054 | 0.0619 | No |
| 85 | Dram1 | 11856 | 0.052 | 0.0597 | No |
| 86 | Ccng1 | 11999 | 0.048 | 0.0557 | No |
| 87 | Blcap | 12067 | 0.046 | 0.0544 | No |
| 88 | Sesn1 | 12143 | 0.044 | 0.0527 | No |
| 89 | Cyfip2 | 12485 | 0.035 | 0.0411 | No |
| 90 | Def6 | 12675 | 0.030 | 0.0349 | No |
| 91 | Abcc5 | 12854 | 0.026 | 0.0291 | No |
| 92 | Dgka | 12995 | 0.023 | 0.0245 | No |
| 93 | Plxnb2 | 13000 | 0.023 | 0.0249 | No |
| 94 | Dcxr | 13018 | 0.022 | 0.0248 | No |
| 95 | Rab40c | 13255 | 0.017 | 0.0166 | No |
| 96 | Bmp2 | 13435 | 0.013 | 0.0104 | No |
| 97 | Mapkapk3 | 13517 | 0.013 | 0.0077 | No |
| 98 | Rps27l | 13579 | 0.012 | 0.0058 | No |
| 99 | App | 13799 | 0.007 | -0.0020 | No |
| 100 | Alox8 | 13928 | 0.004 | -0.0066 | No |
| 101 | Clca2 | 14218 | 0.000 | -0.0171 | No |
| 102 | Tchh | 14275 | 0.000 | -0.0192 | No |
| 103 | Fam162a | 14825 | -0.000 | -0.0392 | No |
| 104 | Lif | 15156 | -0.008 | -0.0511 | No |
| 105 | Nol8 | 15446 | -0.014 | -0.0613 | No |
| 106 | Nudt15 | 15464 | -0.014 | -0.0616 | No |
| 107 | Mxd1 | 15810 | -0.022 | -0.0736 | No |
| 108 | Jun | 16413 | -0.038 | -0.0947 | No |
| 109 | Rpl18 | 16422 | -0.038 | -0.0941 | No |
| 110 | Fas | 16681 | -0.045 | -0.1024 | No |
| 111 | Pcna | 16700 | -0.045 | -0.1020 | No |
| 112 | Bak1 | 16794 | -0.048 | -0.1042 | No |
| 113 | Kif13b | 16901 | -0.050 | -0.1069 | No |
| 114 | Rb1 | 17269 | -0.060 | -0.1189 | No |
| 115 | Ppm1d | 17460 | -0.065 | -0.1242 | No |
| 116 | Rack1 | 17606 | -0.067 | -0.1279 | No |
| 117 | Ptpn14 | 17679 | -0.069 | -0.1289 | No |
| 118 | Tap1 | 17898 | -0.074 | -0.1351 | No |
| 119 | Hint1 | 17939 | -0.075 | -0.1347 | No |
| 120 | Klk8 | 18121 | -0.080 | -0.1394 | No |
| 121 | Rrp8 | 18153 | -0.081 | -0.1386 | No |
| 122 | Tgfb1 | 18170 | -0.082 | -0.1372 | No |
| 123 | H2aj | 18255 | -0.083 | -0.1383 | No |
| 124 | Sec61a1 | 18257 | -0.083 | -0.1363 | No |
| 125 | Mdm2 | 18273 | -0.084 | -0.1349 | No |
| 126 | Apaf1 | 18275 | -0.084 | -0.1329 | No |
| 127 | Wrap73 | 18336 | -0.085 | -0.1330 | No |
| 128 | Rnf19b | 18904 | -0.100 | -0.1513 | No |
| 129 | Ddit3 | 19010 | -0.103 | -0.1527 | No |
| 130 | Hbegf | 19399 | -0.115 | -0.1641 | No |
| 131 | Irak1 | 19438 | -0.116 | -0.1627 | No |
| 132 | Abhd4 | 19552 | -0.118 | -0.1640 | No |
| 133 | Eps8l2 | 19570 | -0.119 | -0.1617 | No |
| 134 | Rgs16 | 19827 | -0.126 | -0.1680 | No |
| 135 | Sertad3 | 19868 | -0.127 | -0.1664 | No |
| 136 | Vwa5a | 19896 | -0.128 | -0.1644 | No |
| 137 | Zfp36l1 | 20004 | -0.132 | -0.1651 | No |
| 138 | Pitpnc1 | 20098 | -0.136 | -0.1652 | No |
| 139 | Polh | 20243 | -0.140 | -0.1671 | No |
| 140 | Rchy1 | 20300 | -0.142 | -0.1658 | No |
| 141 | Rpl36 | 20380 | -0.145 | -0.1652 | No |
| 142 | Cdkn2aip | 20406 | -0.146 | -0.1626 | No |
| 143 | Ccnk | 20432 | -0.146 | -0.1600 | No |
| 144 | St14 | 20498 | -0.148 | -0.1588 | No |
| 145 | Pmm1 | 20581 | -0.151 | -0.1582 | No |
| 146 | Trafd1 | 20590 | -0.151 | -0.1548 | No |
| 147 | Gm2a | 20837 | -0.159 | -0.1600 | No |
| 148 | Trp53 | 20985 | -0.163 | -0.1615 | No |
| 149 | Prkab1 | 21468 | -0.180 | -0.1747 | Yes |
| 150 | Ccnd2 | 21480 | -0.181 | -0.1708 | Yes |
| 151 | Vamp8 | 21702 | -0.189 | -0.1743 | Yes |
| 152 | Sdc1 | 21827 | -0.194 | -0.1742 | Yes |
| 153 | F2r | 21855 | -0.195 | -0.1705 | Yes |
| 154 | Procr | 21972 | -0.200 | -0.1699 | Yes |
| 155 | Sat1 | 22074 | -0.203 | -0.1688 | Yes |
| 156 | Iscu | 22164 | -0.206 | -0.1670 | Yes |
| 157 | Ninj1 | 22192 | -0.207 | -0.1631 | Yes |
| 158 | Ip6k2 | 22290 | -0.211 | -0.1615 | Yes |
| 159 | Serpinb5 | 22638 | -0.221 | -0.1689 | Yes |
| 160 | Btg2 | 22860 | -0.224 | -0.1716 | Yes |
| 161 | Fdxr | 22868 | -0.225 | -0.1665 | Yes |
| 162 | S100a10 | 22954 | -0.228 | -0.1641 | Yes |
| 163 | Ptpre | 23007 | -0.231 | -0.1604 | Yes |
| 164 | Cdk5r1 | 23100 | -0.235 | -0.1581 | Yes |
| 165 | Ankra2 | 23232 | -0.241 | -0.1571 | Yes |
| 166 | Dnttip2 | 23530 | -0.254 | -0.1619 | Yes |
| 167 | Hdac3 | 23542 | -0.255 | -0.1562 | Yes |
| 168 | Coq8a | 23828 | -0.262 | -0.1603 | Yes |
| 169 | Ddit4 | 23845 | -0.262 | -0.1546 | Yes |
| 170 | Zbtb16 | 23861 | -0.263 | -0.1488 | Yes |
| 171 | Rps12 | 23883 | -0.264 | -0.1432 | Yes |
| 172 | Gadd45a | 23991 | -0.270 | -0.1407 | Yes |
| 173 | Tpd52l1 | 24216 | -0.282 | -0.1421 | Yes |
| 174 | Btg1 | 25310 | -0.338 | -0.1738 | Yes |
| 175 | Nupr1 | 25459 | -0.351 | -0.1708 | Yes |
| 176 | Atf3 | 25554 | -0.360 | -0.1656 | Yes |
| 177 | Prmt2 | 25748 | -0.371 | -0.1637 | Yes |
| 178 | Cgrrf1 | 25771 | -0.374 | -0.1556 | Yes |
| 179 | Abat | 26216 | -0.414 | -0.1618 | Yes |
| 180 | Ndrg1 | 26334 | -0.424 | -0.1559 | Yes |
| 181 | Rrad | 26410 | -0.430 | -0.1483 | Yes |
| 182 | Fos | 26431 | -0.432 | -0.1387 | Yes |
| 183 | Socs1 | 26435 | -0.433 | -0.1284 | Yes |
| 184 | Ier5 | 26594 | -0.450 | -0.1234 | Yes |
| 185 | Tnfsf9 | 26691 | -0.462 | -0.1158 | Yes |
| 186 | Jag2 | 26721 | -0.466 | -0.1057 | Yes |
| 187 | H2ac25 | 26772 | -0.474 | -0.0961 | Yes |
| 188 | Tcn2 | 26782 | -0.476 | -0.0850 | Yes |
| 189 | Trp63 | 26812 | -0.482 | -0.0745 | Yes |
| 190 | Ier3 | 26821 | -0.483 | -0.0632 | Yes |
| 191 | Txnip | 26823 | -0.483 | -0.0517 | Yes |
| 192 | Ppp1r15a | 27135 | -0.543 | -0.0500 | Yes |
| 193 | Ctsf | 27221 | -0.570 | -0.0394 | Yes |
| 194 | Tax1bp3 | 27370 | -0.639 | -0.0295 | Yes |
| 195 | Mxd4 | 27528 | -0.786 | -0.0164 | Yes |
| 196 | Ccnd3 | 27529 | -0.794 | 0.0027 | Yes |

