| Dataset | MEP.MEP.ery_Pheno.cls #Group3_versus_Group4.MEP.ery_Pheno.cls #Group3_versus_Group4_repos |
| Phenotype | MEP.ery_Pheno.cls#Group3_versus_Group4_repos |
| Upregulated in class | 2 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.37800524 |
| Normalized Enrichment Score (NES) | 1.4469043 |
| Nominal p-value | 0.1125 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.642 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Cyp51 | 56 | 1.087 | 0.0275 | Yes |
| 2 | Ldlr | 59 | 1.076 | 0.0566 | Yes |
| 3 | Dhcr24 | 81 | 0.997 | 0.0829 | Yes |
| 4 | Insig1 | 116 | 0.919 | 0.1066 | Yes |
| 5 | Sytl2 | 220 | 0.811 | 0.1249 | Yes |
| 6 | Sqle | 223 | 0.810 | 0.1468 | Yes |
| 7 | Me1 | 402 | 0.721 | 0.1599 | Yes |
| 8 | Igfbp5 | 411 | 0.715 | 0.1790 | Yes |
| 9 | Stard4 | 425 | 0.709 | 0.1978 | Yes |
| 10 | Ak4 | 578 | 0.658 | 0.2101 | Yes |
| 11 | Cth | 581 | 0.656 | 0.2279 | Yes |
| 12 | Lgmn | 688 | 0.630 | 0.2411 | Yes |
| 13 | Bcat1 | 1213 | 0.531 | 0.2364 | Yes |
| 14 | Sc5d | 1303 | 0.516 | 0.2471 | Yes |
| 15 | Hmgcs1 | 1726 | 0.471 | 0.2445 | Yes |
| 16 | Hspa5 | 2051 | 0.438 | 0.2446 | Yes |
| 17 | Dhcr7 | 2205 | 0.429 | 0.2507 | Yes |
| 18 | Hmgcr | 2310 | 0.422 | 0.2584 | Yes |
| 19 | Tmem97 | 2316 | 0.422 | 0.2696 | Yes |
| 20 | Ebp | 2636 | 0.409 | 0.2691 | Yes |
| 21 | Slc7a11 | 2746 | 0.398 | 0.2759 | Yes |
| 22 | Calr | 2795 | 0.394 | 0.2849 | Yes |
| 23 | Idi1 | 2850 | 0.389 | 0.2934 | Yes |
| 24 | Elovl6 | 3082 | 0.374 | 0.2952 | Yes |
| 25 | Got1 | 3227 | 0.363 | 0.2998 | Yes |
| 26 | Tm7sf2 | 3281 | 0.359 | 0.3076 | Yes |
| 27 | Cfp | 3314 | 0.355 | 0.3160 | Yes |
| 28 | Sdf2l1 | 3424 | 0.346 | 0.3215 | Yes |
| 29 | Pik3r3 | 3712 | 0.330 | 0.3200 | Yes |
| 30 | Hsp90b1 | 3744 | 0.328 | 0.3277 | Yes |
| 31 | Cyb5b | 3979 | 0.312 | 0.3277 | Yes |
| 32 | Rit1 | 4104 | 0.302 | 0.3313 | Yes |
| 33 | Atp2a2 | 4362 | 0.298 | 0.3301 | Yes |
| 34 | Xbp1 | 4383 | 0.297 | 0.3374 | Yes |
| 35 | Ccnf | 4721 | 0.281 | 0.3327 | Yes |
| 36 | Aldoa | 4969 | 0.269 | 0.3310 | Yes |
| 37 | Etf1 | 5278 | 0.260 | 0.3268 | Yes |
| 38 | Tuba4a | 5300 | 0.258 | 0.3331 | Yes |
| 39 | Fgl2 | 5438 | 0.250 | 0.3349 | Yes |
| 40 | Acly | 5439 | 0.250 | 0.3417 | Yes |
| 41 | Pdk1 | 5483 | 0.248 | 0.3468 | Yes |
| 42 | Stip1 | 5594 | 0.244 | 0.3494 | Yes |
| 43 | Slc1a5 | 5614 | 0.243 | 0.3554 | Yes |
| 44 | Gsr | 5735 | 0.236 | 0.3574 | Yes |
| 45 | Actr2 | 5873 | 0.231 | 0.3587 | Yes |
| 46 | Psme3 | 6154 | 0.226 | 0.3546 | Yes |
| 47 | Ctsc | 6217 | 0.223 | 0.3584 | Yes |
| 48 | Nup205 | 6254 | 0.221 | 0.3631 | Yes |
| 49 | Slc7a5 | 7038 | 0.197 | 0.3399 | Yes |
| 50 | Wars1 | 7074 | 0.196 | 0.3439 | Yes |
| 51 | Tpi1 | 7097 | 0.196 | 0.3484 | Yes |
| 52 | Sec11a | 7154 | 0.193 | 0.3516 | Yes |
| 53 | Hspd1 | 7300 | 0.188 | 0.3514 | Yes |
| 54 | Egln3 | 7332 | 0.186 | 0.3554 | Yes |
| 55 | Ifi30 | 7336 | 0.186 | 0.3603 | Yes |
| 56 | Phgdh | 7361 | 0.185 | 0.3645 | Yes |
| 57 | Nufip1 | 7429 | 0.183 | 0.3670 | Yes |
| 58 | Gtf2h1 | 7514 | 0.181 | 0.3688 | Yes |
| 59 | Canx | 7710 | 0.173 | 0.3664 | Yes |
| 60 | Hk2 | 7824 | 0.168 | 0.3668 | Yes |
| 61 | Sla | 7874 | 0.166 | 0.3696 | Yes |
| 62 | Rpn1 | 7953 | 0.164 | 0.3712 | Yes |
| 63 | Txnrd1 | 8007 | 0.163 | 0.3737 | Yes |
| 64 | Plk1 | 8073 | 0.161 | 0.3756 | Yes |
| 65 | Acaca | 8127 | 0.158 | 0.3780 | Yes |
| 66 | Vldlr | 8333 | 0.150 | 0.3746 | No |
| 67 | Ppia | 8797 | 0.136 | 0.3614 | No |
| 68 | Cdkn1a | 9146 | 0.125 | 0.3521 | No |
| 69 | Gga2 | 9150 | 0.125 | 0.3554 | No |
| 70 | Add3 | 9202 | 0.124 | 0.3569 | No |
| 71 | Hspa4 | 9234 | 0.123 | 0.3591 | No |
| 72 | Gpi1 | 9342 | 0.119 | 0.3584 | No |
| 73 | Tomm40 | 9359 | 0.118 | 0.3610 | No |
| 74 | Mcm2 | 9609 | 0.110 | 0.3550 | No |
| 75 | Psat1 | 9681 | 0.108 | 0.3553 | No |
| 76 | Psmg1 | 9755 | 0.106 | 0.3555 | No |
| 77 | Psmd14 | 9978 | 0.100 | 0.3502 | No |
| 78 | Trib3 | 10235 | 0.093 | 0.3433 | No |
| 79 | Arpc5l | 10424 | 0.090 | 0.3389 | No |
| 80 | Actr3 | 10452 | 0.089 | 0.3404 | No |
| 81 | M6pr | 10482 | 0.088 | 0.3417 | No |
| 82 | Dhfr | 10492 | 0.088 | 0.3438 | No |
| 83 | Fkbp2 | 10606 | 0.085 | 0.3419 | No |
| 84 | Pgm1 | 10712 | 0.082 | 0.3403 | No |
| 85 | G6pdx | 10903 | 0.077 | 0.3355 | No |
| 86 | Uso1 | 11031 | 0.074 | 0.3329 | No |
| 87 | Cct6a | 11039 | 0.074 | 0.3346 | No |
| 88 | Fads2 | 11072 | 0.073 | 0.3354 | No |
| 89 | Immt | 11088 | 0.073 | 0.3369 | No |
| 90 | Mcm4 | 11126 | 0.072 | 0.3375 | No |
| 91 | Hspa9 | 11286 | 0.068 | 0.3335 | No |
| 92 | Abcf2 | 11317 | 0.067 | 0.3342 | No |
| 93 | Bub1 | 11346 | 0.066 | 0.3350 | No |
| 94 | Rpa1 | 11418 | 0.064 | 0.3341 | No |
| 95 | Adipor2 | 11450 | 0.063 | 0.3347 | No |
| 96 | Psmc6 | 11570 | 0.059 | 0.3320 | No |
| 97 | Cops5 | 11713 | 0.056 | 0.3283 | No |
| 98 | Nfyc | 11765 | 0.054 | 0.3279 | No |
| 99 | Qdpr | 11799 | 0.053 | 0.3282 | No |
| 100 | Slc1a4 | 11803 | 0.053 | 0.3295 | No |
| 101 | Prdx1 | 11878 | 0.051 | 0.3282 | No |
| 102 | Cdc25a | 11982 | 0.048 | 0.3258 | No |
| 103 | Ccng1 | 11999 | 0.048 | 0.3265 | No |
| 104 | Ldha | 12007 | 0.048 | 0.3275 | No |
| 105 | Acsl3 | 12042 | 0.047 | 0.3276 | No |
| 106 | Niban1 | 12154 | 0.044 | 0.3247 | No |
| 107 | Tfrc | 12160 | 0.044 | 0.3257 | No |
| 108 | Psmb5 | 12415 | 0.037 | 0.3175 | No |
| 109 | Polr3g | 12474 | 0.036 | 0.3163 | No |
| 110 | Shmt2 | 12519 | 0.034 | 0.3156 | No |
| 111 | Gmps | 12582 | 0.033 | 0.3143 | No |
| 112 | Rdh11 | 12801 | 0.027 | 0.3071 | No |
| 113 | Ifrd1 | 12855 | 0.026 | 0.3058 | No |
| 114 | Slc2a3 | 12928 | 0.024 | 0.3039 | No |
| 115 | Ddx39a | 13290 | 0.016 | 0.2911 | No |
| 116 | P4ha1 | 13392 | 0.013 | 0.2878 | No |
| 117 | Edem1 | 13644 | 0.010 | 0.2789 | No |
| 118 | Ero1a | 13745 | 0.008 | 0.2755 | No |
| 119 | Ube2d3 | 13755 | 0.008 | 0.2754 | No |
| 120 | Rrp9 | 13780 | 0.007 | 0.2747 | No |
| 121 | Pitpnb | 13789 | 0.007 | 0.2746 | No |
| 122 | Pfkl | 13820 | 0.006 | 0.2737 | No |
| 123 | Slc6a6 | 13853 | 0.006 | 0.2727 | No |
| 124 | Mthfd2 | 13945 | 0.004 | 0.2695 | No |
| 125 | Ykt6 | 14094 | 0.001 | 0.2641 | No |
| 126 | Slc37a4 | 14097 | 0.000 | 0.2640 | No |
| 127 | Stc1 | 14132 | 0.000 | 0.2628 | No |
| 128 | Serpinh1 | 14321 | 0.000 | 0.2559 | No |
| 129 | Atp6v1d | 14875 | -0.001 | 0.2358 | No |
| 130 | Tubg1 | 15027 | -0.005 | 0.2304 | No |
| 131 | Ufm1 | 15218 | -0.010 | 0.2238 | No |
| 132 | Eef1e1 | 15378 | -0.012 | 0.2183 | No |
| 133 | Lta4h | 15860 | -0.024 | 0.2014 | No |
| 134 | Rrm2 | 15910 | -0.025 | 0.2003 | No |
| 135 | Gsk3b | 15961 | -0.026 | 0.1991 | No |
| 136 | Psmd12 | 16070 | -0.029 | 0.1960 | No |
| 137 | Nfkbib | 16151 | -0.031 | 0.1939 | No |
| 138 | Ssr1 | 16386 | -0.037 | 0.1864 | No |
| 139 | Nampt | 16524 | -0.040 | 0.1825 | No |
| 140 | Glrx | 16546 | -0.041 | 0.1828 | No |
| 141 | Psph | 16718 | -0.046 | 0.1778 | No |
| 142 | Hspe1 | 16979 | -0.052 | 0.1698 | No |
| 143 | Nmt1 | 17218 | -0.058 | 0.1627 | No |
| 144 | Serp1 | 17330 | -0.061 | 0.1603 | No |
| 145 | Plod2 | 17370 | -0.063 | 0.1606 | No |
| 146 | Sqstm1 | 17624 | -0.067 | 0.1532 | No |
| 147 | Aurka | 17734 | -0.070 | 0.1511 | No |
| 148 | Pdap1 | 17740 | -0.070 | 0.1528 | No |
| 149 | Pgk1 | 17817 | -0.072 | 0.1520 | No |
| 150 | Bhlhe40 | 17930 | -0.075 | 0.1499 | No |
| 151 | Cxcr4 | 17966 | -0.076 | 0.1507 | No |
| 152 | Uchl5 | 18019 | -0.078 | 0.1510 | No |
| 153 | Map2k3 | 18072 | -0.079 | 0.1512 | No |
| 154 | Rab1a | 18186 | -0.082 | 0.1493 | No |
| 155 | Asns | 18247 | -0.083 | 0.1494 | No |
| 156 | Pno1 | 18298 | -0.084 | 0.1498 | No |
| 157 | Gclc | 18321 | -0.085 | 0.1513 | No |
| 158 | Psma3 | 18454 | -0.089 | 0.1489 | No |
| 159 | Psma4 | 18709 | -0.095 | 0.1423 | No |
| 160 | Slc2a1 | 18734 | -0.096 | 0.1440 | No |
| 161 | Tcea1 | 18790 | -0.097 | 0.1446 | No |
| 162 | Elovl5 | 18839 | -0.098 | 0.1456 | No |
| 163 | Ddit3 | 19010 | -0.103 | 0.1422 | No |
| 164 | Tbk1 | 19304 | -0.112 | 0.1345 | No |
| 165 | Ung | 19492 | -0.117 | 0.1308 | No |
| 166 | Fads1 | 19732 | -0.124 | 0.1255 | No |
| 167 | Skap2 | 19787 | -0.125 | 0.1269 | No |
| 168 | Mllt11 | 19847 | -0.127 | 0.1282 | No |
| 169 | Psmc2 | 19863 | -0.127 | 0.1311 | No |
| 170 | Sord | 19897 | -0.128 | 0.1334 | No |
| 171 | Psmd13 | 19907 | -0.129 | 0.1366 | No |
| 172 | Ppa1 | 19954 | -0.130 | 0.1384 | No |
| 173 | Itgb2 | 20093 | -0.135 | 0.1371 | No |
| 174 | Gbe1 | 20476 | -0.147 | 0.1271 | No |
| 175 | Pnp | 20731 | -0.156 | 0.1221 | No |
| 176 | Idh1 | 20836 | -0.159 | 0.1226 | No |
| 177 | Hmbs | 20849 | -0.159 | 0.1265 | No |
| 178 | Srd5a1 | 20989 | -0.163 | 0.1258 | No |
| 179 | Gla | 21073 | -0.167 | 0.1273 | No |
| 180 | Eif2s2 | 21088 | -0.167 | 0.1314 | No |
| 181 | Mthfd2l | 21198 | -0.171 | 0.1320 | No |
| 182 | Tes | 21678 | -0.188 | 0.1197 | No |
| 183 | Psmc4 | 21697 | -0.189 | 0.1241 | No |
| 184 | Coro1a | 22197 | -0.208 | 0.1116 | No |
| 185 | Nfil3 | 22533 | -0.219 | 0.1053 | No |
| 186 | Btg2 | 22860 | -0.224 | 0.0995 | No |
| 187 | Fdxr | 22868 | -0.225 | 0.1053 | No |
| 188 | Cacybp | 23823 | -0.261 | 0.0776 | No |
| 189 | Ddit4 | 23845 | -0.262 | 0.0840 | No |
| 190 | Cd9 | 24423 | -0.291 | 0.0708 | No |
| 191 | Nupr1 | 25459 | -0.351 | 0.0426 | No |
| 192 | Eno1b | 25594 | -0.364 | 0.0476 | No |
| 193 | Dapp1 | 26047 | -0.399 | 0.0419 | No |
| 194 | Ppp1r15a | 27135 | -0.543 | 0.0170 | No |

