| Dataset | MEP.MEP.ery_Pheno.cls #Group1_versus_Group4.MEP.ery_Pheno.cls #Group1_versus_Group4_repos |
| Phenotype | MEP.ery_Pheno.cls#Group1_versus_Group4_repos |
| Upregulated in class | 0 |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | 0.24585213 |
| Normalized Enrichment Score (NES) | 1.2463151 |
| Nominal p-value | 0.17729084 |
| FDR q-value | 0.9627616 |
| FWER p-Value | 0.919 |

| SYMBOL | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|
| 1 | Bcat1 | 12 | 1.388 | 0.0261 | Yes |
| 2 | Insig1 | 19 | 1.329 | 0.0512 | Yes |
| 3 | Cyp51 | 103 | 0.980 | 0.0669 | Yes |
| 4 | Dhcr24 | 119 | 0.950 | 0.0845 | Yes |
| 5 | Me1 | 216 | 0.835 | 0.0970 | Yes |
| 6 | Sytl2 | 261 | 0.804 | 0.1107 | Yes |
| 7 | Stard4 | 267 | 0.796 | 0.1258 | Yes |
| 8 | Sqle | 307 | 0.779 | 0.1392 | Yes |
| 9 | Ldlr | 565 | 0.674 | 0.1427 | Yes |
| 10 | Idi1 | 573 | 0.672 | 0.1553 | Yes |
| 11 | Igfbp5 | 1167 | 0.554 | 0.1443 | Yes |
| 12 | Mcm2 | 1268 | 0.539 | 0.1509 | Yes |
| 13 | Hspd1 | 1307 | 0.533 | 0.1597 | Yes |
| 14 | Canx | 1358 | 0.528 | 0.1680 | Yes |
| 15 | Ak4 | 1623 | 0.499 | 0.1679 | Yes |
| 16 | Hspa4 | 1953 | 0.467 | 0.1648 | Yes |
| 17 | Mcm4 | 1973 | 0.465 | 0.1730 | Yes |
| 18 | Stip1 | 2048 | 0.458 | 0.1791 | Yes |
| 19 | Acly | 2219 | 0.439 | 0.1812 | Yes |
| 20 | Dhcr7 | 2415 | 0.429 | 0.1823 | Yes |
| 21 | Atp2a2 | 2525 | 0.423 | 0.1864 | Yes |
| 22 | Gga2 | 2597 | 0.418 | 0.1918 | Yes |
| 23 | Hmgcr | 2609 | 0.416 | 0.1994 | Yes |
| 24 | Etf1 | 2618 | 0.416 | 0.2070 | Yes |
| 25 | Hspa5 | 2884 | 0.395 | 0.2049 | Yes |
| 26 | Ccnf | 2949 | 0.391 | 0.2100 | Yes |
| 27 | Hsp90b1 | 2974 | 0.389 | 0.2166 | Yes |
| 28 | Hmbs | 3076 | 0.384 | 0.2202 | Yes |
| 29 | Pik3r3 | 3079 | 0.383 | 0.2275 | Yes |
| 30 | Hspa9 | 3324 | 0.373 | 0.2257 | Yes |
| 31 | Rpa1 | 3593 | 0.359 | 0.2228 | Yes |
| 32 | Abcf2 | 3799 | 0.348 | 0.2219 | Yes |
| 33 | Cdc25a | 3828 | 0.345 | 0.2275 | Yes |
| 34 | Got1 | 4508 | 0.315 | 0.2088 | Yes |
| 35 | Sc5d | 4658 | 0.309 | 0.2092 | Yes |
| 36 | Bub1 | 4663 | 0.309 | 0.2150 | Yes |
| 37 | Nufip1 | 4693 | 0.308 | 0.2198 | Yes |
| 38 | Calr | 4713 | 0.307 | 0.2250 | Yes |
| 39 | Tfrc | 4906 | 0.296 | 0.2236 | Yes |
| 40 | Tm7sf2 | 4984 | 0.293 | 0.2264 | Yes |
| 41 | Ero1a | 4992 | 0.293 | 0.2317 | Yes |
| 42 | Edem1 | 5023 | 0.291 | 0.2362 | Yes |
| 43 | Nup205 | 5153 | 0.285 | 0.2369 | Yes |
| 44 | Elovl6 | 5161 | 0.284 | 0.2421 | Yes |
| 45 | Pdk1 | 5555 | 0.268 | 0.2329 | Yes |
| 46 | Slc1a5 | 5599 | 0.265 | 0.2364 | Yes |
| 47 | Psme3 | 5742 | 0.259 | 0.2362 | Yes |
| 48 | Actr2 | 5745 | 0.259 | 0.2411 | Yes |
| 49 | Lgmn | 5944 | 0.249 | 0.2386 | Yes |
| 50 | Uso1 | 5951 | 0.249 | 0.2431 | Yes |
| 51 | Gmps | 6006 | 0.247 | 0.2459 | Yes |
| 52 | Stc1 | 6392 | 0.229 | 0.2362 | No |
| 53 | Ppia | 7037 | 0.213 | 0.2167 | No |
| 54 | Cyb5b | 7055 | 0.212 | 0.2202 | No |
| 55 | Rrm2 | 7443 | 0.196 | 0.2098 | No |
| 56 | Hmgcs1 | 7474 | 0.195 | 0.2124 | No |
| 57 | Wars1 | 7523 | 0.193 | 0.2144 | No |
| 58 | Actr3 | 7703 | 0.186 | 0.2114 | No |
| 59 | Immt | 7781 | 0.183 | 0.2121 | No |
| 60 | Nfyc | 8103 | 0.171 | 0.2036 | No |
| 61 | Cct6a | 8266 | 0.164 | 0.2008 | No |
| 62 | Serpinh1 | 8596 | 0.155 | 0.1918 | No |
| 63 | Aurka | 8896 | 0.152 | 0.1838 | No |
| 64 | Plk1 | 8978 | 0.150 | 0.1837 | No |
| 65 | Cfp | 9082 | 0.146 | 0.1827 | No |
| 66 | Rrp9 | 9125 | 0.145 | 0.1840 | No |
| 67 | Fads2 | 9163 | 0.143 | 0.1854 | No |
| 68 | Ssr1 | 9250 | 0.141 | 0.1849 | No |
| 69 | Ddx39a | 9386 | 0.136 | 0.1826 | No |
| 70 | Tmem97 | 9484 | 0.133 | 0.1816 | No |
| 71 | Psmd14 | 9595 | 0.129 | 0.1800 | No |
| 72 | Pgk1 | 9726 | 0.125 | 0.1777 | No |
| 73 | Dhfr | 10057 | 0.116 | 0.1678 | No |
| 74 | P4ha1 | 10096 | 0.114 | 0.1686 | No |
| 75 | Tbk1 | 10185 | 0.111 | 0.1675 | No |
| 76 | Gsr | 10459 | 0.101 | 0.1595 | No |
| 77 | Rab1a | 10564 | 0.098 | 0.1576 | No |
| 78 | Fads1 | 10576 | 0.097 | 0.1590 | No |
| 79 | Rpn1 | 10627 | 0.096 | 0.1590 | No |
| 80 | Acaca | 10662 | 0.094 | 0.1596 | No |
| 81 | Cth | 10744 | 0.091 | 0.1584 | No |
| 82 | Slc7a11 | 10794 | 0.090 | 0.1583 | No |
| 83 | Ifrd1 | 10810 | 0.090 | 0.1595 | No |
| 84 | Gtf2h1 | 11041 | 0.082 | 0.1527 | No |
| 85 | Acsl3 | 11096 | 0.080 | 0.1522 | No |
| 86 | Nampt | 11552 | 0.064 | 0.1368 | No |
| 87 | Pno1 | 11602 | 0.063 | 0.1363 | No |
| 88 | Pitpnb | 11764 | 0.058 | 0.1315 | No |
| 89 | Gsk3b | 11916 | 0.052 | 0.1270 | No |
| 90 | Serp1 | 11973 | 0.050 | 0.1259 | No |
| 91 | Gclc | 11994 | 0.050 | 0.1261 | No |
| 92 | Psmc6 | 12232 | 0.041 | 0.1183 | No |
| 93 | Fgl2 | 12495 | 0.033 | 0.1093 | No |
| 94 | Pfkl | 12499 | 0.033 | 0.1098 | No |
| 95 | Asns | 12620 | 0.029 | 0.1060 | No |
| 96 | G6pdx | 12876 | 0.020 | 0.0971 | No |
| 97 | Gbe1 | 12878 | 0.020 | 0.0974 | No |
| 98 | Ykt6 | 12989 | 0.017 | 0.0938 | No |
| 99 | Aldoa | 13418 | 0.005 | 0.0782 | No |
| 100 | Ung | 14333 | -0.006 | 0.0450 | No |
| 101 | Txnrd1 | 14507 | -0.012 | 0.0389 | No |
| 102 | M6pr | 14580 | -0.014 | 0.0365 | No |
| 103 | Ube2d3 | 14685 | -0.017 | 0.0331 | No |
| 104 | Slc2a3 | 14775 | -0.021 | 0.0302 | No |
| 105 | Ufm1 | 14963 | -0.028 | 0.0240 | No |
| 106 | Add3 | 15145 | -0.035 | 0.0180 | No |
| 107 | Xbp1 | 15349 | -0.042 | 0.0114 | No |
| 108 | Slc7a5 | 15379 | -0.043 | 0.0112 | No |
| 109 | Sec11a | 15411 | -0.044 | 0.0109 | No |
| 110 | Tpi1 | 15494 | -0.047 | 0.0088 | No |
| 111 | Lta4h | 15644 | -0.051 | 0.0043 | No |
| 112 | Adipor2 | 15760 | -0.055 | 0.0012 | No |
| 113 | Gpi1 | 15816 | -0.056 | 0.0003 | No |
| 114 | Gla | 15882 | -0.058 | -0.0010 | No |
| 115 | Uchl5 | 15920 | -0.059 | -0.0012 | No |
| 116 | Mthfd2l | 16030 | -0.063 | -0.0040 | No |
| 117 | Nmt1 | 16031 | -0.063 | -0.0028 | No |
| 118 | Btg2 | 16173 | -0.067 | -0.0067 | No |
| 119 | Polr3g | 16400 | -0.072 | -0.0135 | No |
| 120 | Psmc2 | 16604 | -0.079 | -0.0194 | No |
| 121 | Eef1e1 | 17006 | -0.093 | -0.0323 | No |
| 122 | Tcea1 | 17177 | -0.100 | -0.0365 | No |
| 123 | Psmc4 | 17287 | -0.104 | -0.0385 | No |
| 124 | Pgm1 | 17430 | -0.110 | -0.0416 | No |
| 125 | Ccng1 | 17843 | -0.125 | -0.0543 | No |
| 126 | Rdh11 | 18123 | -0.129 | -0.0620 | No |
| 127 | Pnp | 18282 | -0.135 | -0.0652 | No |
| 128 | Hk2 | 18293 | -0.135 | -0.0629 | No |
| 129 | Atp6v1d | 18395 | -0.139 | -0.0640 | No |
| 130 | Ppp1r15a | 18563 | -0.145 | -0.0673 | No |
| 131 | Phgdh | 18570 | -0.146 | -0.0647 | No |
| 132 | Tomm40 | 18665 | -0.149 | -0.0653 | No |
| 133 | Ddit3 | 18680 | -0.149 | -0.0630 | No |
| 134 | Sord | 18791 | -0.154 | -0.0640 | No |
| 135 | Vldlr | 19524 | -0.184 | -0.0872 | No |
| 136 | Tuba4a | 19559 | -0.186 | -0.0849 | No |
| 137 | Srd5a1 | 19705 | -0.191 | -0.0866 | No |
| 138 | Psmd13 | 19956 | -0.196 | -0.0919 | No |
| 139 | Fdxr | 19992 | -0.198 | -0.0894 | No |
| 140 | Eno1b | 20024 | -0.199 | -0.0868 | No |
| 141 | Pdap1 | 20192 | -0.206 | -0.0889 | No |
| 142 | Mllt11 | 20217 | -0.207 | -0.0858 | No |
| 143 | Psmd12 | 20322 | -0.211 | -0.0856 | No |
| 144 | Skap2 | 20412 | -0.214 | -0.0848 | No |
| 145 | Sla | 20466 | -0.216 | -0.0826 | No |
| 146 | Slc1a4 | 20488 | -0.217 | -0.0792 | No |
| 147 | Psma3 | 20547 | -0.220 | -0.0771 | No |
| 148 | Plod2 | 20550 | -0.220 | -0.0730 | No |
| 149 | Sqstm1 | 20875 | -0.226 | -0.0805 | No |
| 150 | Ddit4 | 20884 | -0.227 | -0.0764 | No |
| 151 | Cxcr4 | 20935 | -0.229 | -0.0739 | No |
| 152 | Hspe1 | 21238 | -0.240 | -0.0803 | No |
| 153 | Ifi30 | 21289 | -0.243 | -0.0775 | No |
| 154 | Egln3 | 21324 | -0.245 | -0.0741 | No |
| 155 | Slc37a4 | 21358 | -0.246 | -0.0706 | No |
| 156 | Qdpr | 21372 | -0.246 | -0.0664 | No |
| 157 | Arpc5l | 21488 | -0.251 | -0.0658 | No |
| 158 | Elovl5 | 21621 | -0.257 | -0.0657 | No |
| 159 | Slc6a6 | 21823 | -0.261 | -0.0680 | No |
| 160 | Idh1 | 21824 | -0.261 | -0.0630 | No |
| 161 | Map2k3 | 21830 | -0.261 | -0.0582 | No |
| 162 | Cops5 | 22058 | -0.272 | -0.0613 | No |
| 163 | Rit1 | 22134 | -0.275 | -0.0588 | No |
| 164 | Fkbp2 | 22372 | -0.285 | -0.0620 | No |
| 165 | Prdx1 | 22498 | -0.288 | -0.0611 | No |
| 166 | Bhlhe40 | 22664 | -0.296 | -0.0614 | No |
| 167 | Slc2a1 | 22696 | -0.297 | -0.0569 | No |
| 168 | Ctsc | 23208 | -0.318 | -0.0695 | No |
| 169 | Psat1 | 23301 | -0.324 | -0.0666 | No |
| 170 | Mthfd2 | 23388 | -0.328 | -0.0635 | No |
| 171 | Tes | 23590 | -0.338 | -0.0644 | No |
| 172 | Eif2s2 | 23628 | -0.340 | -0.0592 | No |
| 173 | Psmg1 | 23671 | -0.342 | -0.0542 | No |
| 174 | Sdf2l1 | 23907 | -0.355 | -0.0560 | No |
| 175 | Shmt2 | 23991 | -0.359 | -0.0522 | No |
| 176 | Itgb2 | 24015 | -0.360 | -0.0462 | No |
| 177 | Tubg1 | 24174 | -0.367 | -0.0449 | No |
| 178 | Ppa1 | 24470 | -0.381 | -0.0484 | No |
| 179 | Glrx | 24496 | -0.382 | -0.0420 | No |
| 180 | Nfkbib | 24859 | -0.407 | -0.0474 | No |
| 181 | Psph | 25201 | -0.425 | -0.0518 | No |
| 182 | Ebp | 25226 | -0.426 | -0.0445 | No |
| 183 | Psma4 | 25461 | -0.441 | -0.0446 | No |
| 184 | Psmb5 | 25862 | -0.473 | -0.0502 | No |
| 185 | Nupr1 | 26005 | -0.487 | -0.0460 | No |
| 186 | Nfil3 | 26035 | -0.490 | -0.0377 | No |
| 187 | Ldha | 26050 | -0.491 | -0.0289 | No |
| 188 | Cacybp | 26377 | -0.523 | -0.0308 | No |
| 189 | Trib3 | 26777 | -0.579 | -0.0343 | No |
| 190 | Dapp1 | 26797 | -0.585 | -0.0238 | No |
| 191 | Niban1 | 26923 | -0.609 | -0.0167 | No |
| 192 | Cd9 | 26972 | -0.620 | -0.0066 | No |
| 193 | Coro1a | 27129 | -0.661 | 0.0003 | No |
| 194 | Cdkn1a | 27527 | -0.885 | 0.0027 | No |

